Dr Manikandan KadirvelBPharm, MPhil, PhD, MRSC, FHEA

Extended Project Post (Research Fellow), Lecturer in Medicinal Chemistry

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Research interests

I have been working in the area of  synthetic organic chemistry since 1999. At WMIC using my chemistry skills I am helping the preclinical/clinical scientists in the development of new labelling strategies for molecular imaging of cancer (4-[18F]Fluoroglutamine; metabolic imaging agent, [18F]DMPO; oxidative damage, [18F]ML-10; apoptotic marker, [11C]Temozolamide; brain tumour, [64Cu]/[68Ga]labelled peptides for small cell lung cancer) and dementia ([18F]labelled VCAM-1 nanobodies) using Positron Emission Tomography (PET) research. In addition I have been developing optical imaging probes (fluorescence and bioluminescence) for in vitro evaluation of cancer cells and organic contrast agents for MR imaging. I have developed a potent inhibitor of Auto Inducers (AI-2) signaling (prevention of biofilm formation). My research interests have also included the synthesis of aminoacids (fluorinated derivatives), peptides, polymers (Acrylate 30D copolymer for micro encapsulation), heterocyclic compounds (anti psychotic and anti cancer drugs). Isolation of bioflavonoids from tropical plants of India.

Projects

Research and projects

No current projects are available for public display