Prof Leon AaronsBSc, MSc, PhD

Professor

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Publications

  1. 2001
  2. Published

    Role of modelling and simulation in Phase I drug development

    Aarons, L., Karlsson, M. O., Mentre, F., Rombout, F., Steimer, J. L. & Van Peer, A., 2001, In : European Journal of Pharmaceutical Sciences. 13, 2, p. 115-122 7 p.

    Research output: Contribution to journalArticle

  3. 2000
  4. Published

    Population pharmacokinetics of tiagabine in epileptic patients on monotherapy

    Ingwersen, S. H., Pedersen, P. C., Groes, L., Nielsen, K. K. & Aarons, L., Sep 2000, In : European Journal of Pharmaceutical Sciences. 11, 3, p. 247-254 7 p.

    Research output: Contribution to journalArticle

  5. Published

    A pharmacokinetic simulation model for ivabradine in healthy volunteers

    Duffull, S. B., Chabaud, S., Nony, P., Laveille, C., Girard, P. & Aarons, L., Jun 2000, In : European Journal of Pharmaceutical Sciences. 10, 4, p. 285-294 9 p.

    Research output: Contribution to journalArticle

  6. Published

    Development of a sequential linked pharmacokinetic and pharmacodynamic simulation model for ivabradine in healthy volunteers

    Duffull, S. B. & Aarons, L., Jun 2000, In : European Journal of Pharmaceutical Sciences. 10, 4, p. 275-284 9 p.

    Research output: Contribution to journalArticle

  7. Published

    Mefloquine pharmacokinetic-pharmacodynamic models: Implications for dosing and resistance

    Simpson, J. A., Watkins, E. R., Price, R. N., Aarons, L., Kyle, D. E. & White, N. J., 2000, In : Antimicrobial Agents and Chemotherapy. 44, 12, p. 3414-3424 10 p.

    Research output: Contribution to journalArticle

  8. 1999
  9. Published

    Editorial: Pharmacokinetic and pharmacodynamic modelling in drug development

    Aarons, L., Jun 1999, In : Statistical Methods in Medical Research. 8, 3, p. 181-182

    Research output: Contribution to journalArticle

  10. Published

    "Population modelling". In: Variability in Human Drug Response. Proceedings of the Esteve Foundation Symposium VIII.

    Aarons, L., 1999, In : Excerpta Medica, Amsterdam.

    Research output: Contribution to journalArticle

  11. Published

    "The Bayesian approach to population pharmacokinetic/pharmacodynamic modeling".

    Wakefield, J., Aarons, L. & Racine-Poon, A., 1999, Case Studies in Bayesian Statistics. Gatsonis, C., Kass, R., Carlin, B., Carriquiry, A., Gelman, A., Verdinelli, I. & West, M. (eds.). Springer Nature, (Lecture Notes in Statistics; vol. 140).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  12. Published

    A mechanistically based model for the relationship between the tissue distribution parameters and the lipophilicity of a homologous series of barbiturates in rats

    Nestorov, I., Aarons, L. & Rowland, M., 1999, Eur. J. Pharm. Sci.. Vol. 8.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  13. Published

    A pharmacokinetic model for tenidap in normal volunteers and rheumatoid arthritis patients

    Evans, L., Aarons, L. & Coates, P., 1999, In : Pharmaceutical Research. 16, 10, p. 1608-1615 7 p.

    Research output: Contribution to journalArticle

  14. Published

    Population pharmacokinetics of mefloquine in patients with acute falciparum malaria

    Simpson, J. A., Price, R., Ter Kuile, F., Teja-Isavatharm, P., Nosten, F., Chongsuphajaisiddhi, T., Looareesuwan, S., Aarons, L. & White, N. J., 1999, In : Clinical Pharmacology and Therapeutics. 66, 5, p. 472-484 12 p.

    Research output: Contribution to journalArticle

  15. Published

    Quantitative characterization of therapeutic index: Application of mixed-effects modeling to evaluate oxybutynin dose-efficacy and dose-side effect relationships

    Gupta, S. K., Sathyan, G., Lindemulder, E. A., Ho, P. L., Sheiner, L. B. & Aarons, L., 1999, In : Clinical Pharmacology and Therapeutics. 65, 6, p. 672-684 12 p.

    Research output: Contribution to journalArticle

  16. Published

    Software for population pharmacokinetics and pharmacodynamics

    Aarons, L., 1999, In : Clinical Pharmacokinetics. 36, 4, p. 255-264 9 p.

    Research output: Contribution to journalArticle

  17. Published

    The analysis of categorical/count data

    Graham, G., Aarons, L. & Gupta, S. K., 1999, In : Eur. J. Pharm. Sci.. 8(2)

    Research output: Contribution to journalArticle

  18. Published

    The effect of cimetidine on the steady-state pharmacokinetics and pharmacodynamics of warfarin in humans

    Niopas, I., Toon, S., Aarons, L. & Rowland, M., 1999, In : European journal of clinical pharmacology. 55, 5, p. 399-404 5 p.

    Research output: Contribution to journalArticle

  19. 1998
  20. Published

    Plasma and tonsillar tissue pharmacokinetics of teicoplanin following intramuscular administration to children

    Aarons, L., Rowland, M., Khan, A., Taborelli, G., Ferrea, G., Tarantino, V., Fioredda, F., Rosina-Parenti, R., Cavenaghi, L. & Borgonovi, M., 1 Oct 1998, In : European Journal of Pharmaceutical Sciences. 6, 4, p. 265-270 5 p.

    Research output: Contribution to journalArticle

  21. Published

    Quantitative structure-pharmacokinetics relationships II. Mechanistically based model for the relationship between the tissue distribution parameters and the lipophilicity of the compounds.

    Nestorov, I., Aarons, L. & Rowland, M., Oct 1998, In : Journal of pharmacokinetics and biopharmaceutics. 26, 5, p. 521-545

    Research output: Contribution to journalArticle

  22. Published

    Computer Assisted Design of Phase II(b) Oral Dose Ranging Trial for Naratriptan - Results of a Pilot Study. Scientific Conference "Pharmacokinetics - UK", Manchester, UK. November 4-6, 1998

    Duffull, S., Nestorov, I. & Aarons, L., 1998, Conference Proceedings.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  23. Published

    Lumping of whole-body physiologically based pharmacokinetic models

    Nestorov, I. A., Aarons, L. J., Arundel, P. A. & Rowland, M., 1998, In : Journal of pharmacokinetics and biopharmaceutics. 26, 1, p. 21-46 25 p.

    Research output: Contribution to journalArticle

  24. Published

    Optimal experimental design for precise estimation of the parameters of the axial dispersion model of hepatic elimination

    Chou, C. H., Aarons, L. & Rowland, M., 1998, In : Journal of pharmacokinetics and biopharmaceutics. 26, 5, p. 595-615 20 p.

    Research output: Contribution to journalArticle

  25. Published

    Population pharmacokinetics of cyclosporine: Influence of covariables and assessment of cyclosporine absorption in kidney, lung, heart and heart + lung transplanted patients

    Kyhl, L. E. B., Rasmussen, S. N., Aarons, L. & Jensen, S. B., 1998, Transplantation Proceedings|Transplant. Proc.. Vol. 30. p. 1680

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  26. Published

    Population pharmacokinetics of ondansetron: A covariate analysis

    De Alwis, D. P., Aarons, L. & Palmer, J. L., 1998, In : British Journal of Clinical Pharmacology. 46, 2, p. 117-125 8 p.

    Research output: Contribution to journalArticle

  27. Published

    The pharmacokinetics of saquinavir: A Markov chain Monte Carlo population analysis

    Lunn, D. J. & Aarons, L., 1998, In : Journal of pharmacokinetics and biopharmaceutics. 26, 1, p. 47-74 27 p.

    Research output: Contribution to journalArticle

  28. 1997
  29. Published

    Physiologically-based pharmacokinetic modelling of a homologous series of barbiturates in the rat: A sensitivity analysis

    Nestorov, I. A., Aarons, L. & Rowland, M., Aug 1997, In : Journal of pharmacokinetics and biopharmaceutics. 25, 4, p. 413-449

    Research output: Contribution to journalArticle

  30. Published

    Population pharmacokinetics of rufloxacin in patients with acute exacerbations of chronic bronchitis

    Imbimbo, B. P., Klietmann, W., Broccali, G. P., Cesana, M. & Aarons, L., 1 Jan 1997, In : European Journal of Pharmaceutical Sciences. 5, 1, p. 37-42 5 p.

    Research output: Contribution to journalArticle

  31. Published

    Markov chain Monte Carlo techniques for studying interoccasion and intersubject variability: Application to pharmacokinetic data

    Lunn, D. J. & Aarons, L. J., 1997, In : Journal of the Royal Statistical Society. Series C: Applied Statistics. 46, 1, p. 73-91 18 p.

    Research output: Contribution to journalArticle

  32. Published

    Physiologically based pharmacokinetc modeling of a homologous series of barbiturates in the rat. II. A Sensitivity analysis of the model.

    Nestorov, I. A., Aarons, L. & Rowland, M., 1997, In : Journal of pharmacokinetics and biopharmaceutics. 25

    Research output: Contribution to journalArticle

  33. Published

    Quantitative structure-pharmacokinetic relationships. I. Development of a whole body physiologically based model to characterise changes in pharmacokinetics across a homologous series of barbiturates in the rat.

    Blakey, G. M., Al, N. I., Arundel, P. A., Aarons, L. & Rowland, M., 1997, In : J. Pharmaco. Biopharm.. 25 (3)

    Research output: Contribution to journalArticle

  34. Published

    The Population Approach: Measuring and Managing Variability in Response, Concentration and Dose, Commission of the European Community, Luxembourg

    Aarons, L., Rowland, M., Balant, L. P., Danhof, M., Gex-Fabry, M., Gundert-Remy, U. A., Karlsson, M. O., Mentre, F., Morselli, P. L., Rombout, F., Steimer, J. L. & Vozeh, S., 1997, No publisher name. (proceedings of a meeting, edited by authors and published as a book)

    Research output: Book/ReportAnthology

  35. 1996
  36. Published

    Population approaches/sparse data analysis for human variability in kinetics and dynamics

    Aarons, L., 15 Oct 1996, In : Environmental Toxicology and Pharmacology. 2, 2-3, p. 197-199 2 p.

    Research output: Contribution to journalArticle

  37. Published

    Practical experience and issues in designing and performing population pharmacokinetic/pharmacodynamic studies

    Aarons, L., Rowland, M., Balant, L. P., Mentré, F., Morselli, P. L., Steimer, J. L. & Vozeh, S., Jan 1996, European Journal of Clinical Pharmacology|Eur J Clin Pharmacol. Springer Nature, Vol. 49. p. 251-254 3 p.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  38. Published

    A physiologically-based pharmacokinetic model for the distribution of barbiturates in rats. AAPS Tenth Anniversary Meeting, 27-31 October 1996, Seattle, Washington

    Nestorov, I., Blakey, G. A., Arundel, P. A., Aarons, L. & Rowland, M., 1996, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  39. Published

    The use of population pharmacokinetics in drug development

    Vozeh, S., Steimer, J. L., Rowland, M., Morselli, P., Mentré, F., Balant, L. P. & Aarons, L., 1996, In : Clinical Pharmacokinetics. 30, 2, p. 81-93 12 p.

    Research output: Contribution to journalArticle

  40. 1989
  41. Published

    Mean residence time for drugs subject to enterohepatic cycling

    Shepard, T. A., Lockwood, G. F., Aarons, L. J. & Abrahams, I. D., Jun 1989, In : Journal of pharmacokinetics and biopharmaceutics. 17, 3, p. 327-345 18 p.

    Research output: Contribution to journalArticle

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