Prof Leon AaronsBSc, MSc, PhD

Professor

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Publications

  1. 2008
  2. Published

    Incorporating correlation in interindividual variability for the optimal design of multiresponse pharmacokinetic experiments

    Ogungbenro, K., Graham, G., Gueorguieva, I. & Aarons, L., Mar 2008, In : Journal of Biopharmaceutical Statistics. 18, 2, p. 342-358 16 p.

    Research output: Contribution to journalArticle

  3. Published

    Population pharmacokinetics of ritonavir-boosted saquinavir regimens in HIV-infected individuals

    Dickinson, L., Boffito, M., Back, D. J., Khoo, S. H., Pozniak, A. L., Mugyenyi, P., Merry, C., Autar, R. S., Burger, D. M. & Aarons, L. J., 2008, In : Journal of Antimicrobial Chemotherapy. 62, 6, p. 1344-1355 11 p.

    Research output: Contribution to journalArticle

  4. 2007
  5. Published
  6. Published

    Design of population pharmacokinetic experiments using prior information

    Ogungbenro, K. & Aarons, L., Oct 2007, In : Xenobiotica. 37, 10-11, p. 1311-1330 19 p.

    Research output: Contribution to journalArticle

  7. Published

    Bayesian optimal designs for pharmacokinetic models: Sensitivity to uncertainty

    Dokoumetzidis, A. & Aarons, L., Sep 2007, In : Journal of Biopharmaceutical Statistics. 17, 5, p. 851-867 16 p.

    Research output: Contribution to journalArticle

  8. Published

    Optimal design for multiresponse pharmacokinetic-pharmacodynamic models - Dealing with unbalanced designs

    Ogungbenro, K., Gueorguieva, I., Majid, O., Graham, G. & Aarons, L., Jun 2007, In : Journal of pharmacokinetics and pharmacodynamics. 34, 3, p. 313-331 18 p.

    Research output: Contribution to journalArticle

  9. Published
  10. Published

    Linking preclinical and clinical whole-body physiologically based pharmacokinetic models with prior distributions in NONMEM

    Langdon, G., Gueorguieva, I., Aarons, L. & Karlsson, M., May 2007, In : European journal of clinical pharmacology. 63, 5, p. 485-498 13 p.

    Research output: Contribution to journalArticle

  11. Published
  12. Published

    A program for individual and population optimal design for univariate and multivariate response pharmacokinetic-pharmacodynamic models

    Gueorguieva, I., Ogungbenro, K., Graham, G., Glatt, S. & Aarons, L., Apr 2007, In : Computer Methods and Programs in Biomedicine. 86, 1, p. 51-61 10 p.

    Research output: Contribution to journalArticle

  13. Published

    Molecular analysis of the subgingival microbiota in health and disease.

    Ledder, R. G., Gilbert, P., Huws, S. A., Aarons, L., Ashley, M. P., Hull, P. S. & McBain, A. J., Jan 2007, In : Applied and environmental microbiology. 73, 2, p. 516-523 7 p.

    Research output: Contribution to journalArticle

  14. 2006
  15. Published

    Optimum blood sampling time windows for parameter estimation in population pharmacokinetic experiments

    Graham, G. & Aarons, L., 15 Dec 2006, In : Statistics in medicine. 25, 23, p. 4004-4019 15 p.

    Research output: Contribution to journalArticle

  16. Published

    Use of nonlinear mixed-effects analysis for improved precision of early pharmacodynamic measures in tuberculosis treatment

    Davies, G. R., Brindle, R., Khoo, S. H. & Aarons, L. J., Sep 2006, In : Antimicrobial Agents and Chemotherapy. 50, 9, p. 3154-3156 2 p.

    Research output: Contribution to journalArticle

  17. Published
  18. Published

    Population pharmacokinetic and pharmacodynamic modelling of the antimalarial chemotherapy chlorproguanil/dapsone

    Simpson, J. A., Hughes, D., Manyando, C., Bojang, K., Aarons, L., Winstanley, P., Edwards, G., Watkins, W. A. & Ward, S., Mar 2006, In : British Journal of Clinical Pharmacology. 61, 3, p. 289-300 11 p.

    Research output: Contribution to journalArticle

  19. Published

    Sample size calculations based on generalized estimating equations for population pharmacokinetic experiments

    Ogungbenro, K., Aarons, L. & Graham, G., Mar 2006, In : Journal of Biopharmaceutical Statistics. 16, 2, p. 135-150 15 p.

    Research output: Contribution to journalArticle

  20. Published

    Propagation of population PK and PD information using a Bayesian approach: Dealing with non-exchangeability

    Dokoumetzidis, A. & Aarons, L., Feb 2006, In : Journal of pharmacokinetics and pharmacodynamics. 33, 1, p. 29-48 19 p.

    Research output: Contribution to journalArticle

  21. Published

    Pharmacokinetics of a single bolus of propofol in Chinese children of different ages

    Wang, N. S., Lian, Q., Aarons, L., Matthews, I., Wang, Z., Chen, X., Freemantle, N. & Smith, F. G., Jan 2006, In : Anesthesiology. 104, 1, p. 27-32 5 p.

    Research output: Contribution to journalArticle

  22. 2005
  23. Published

    Optimal blood sampling time windows for parameter estimation using a population approach: Design of a phase II clinical trial

    Chenel, M., Ogungbenro, K., Duval, V., Laveille, C., Jochemsen, R. & Aarons, L., Dec 2005, In : Journal of pharmacokinetics and pharmacodynamics. 32, 5-6, p. 737-756 19 p.

    Research output: Contribution to journalArticle

  24. Published

    The use of a modified Fedorov exchange algorithm to optimise sampling times for population pharmacokinetic experiments

    Ogungbenro, K., Graham, G., Gueorguieva, I. & Aarons, L., Nov 2005, In : Computer Methods and Programs in Biomedicine. 80, 2, p. 115-125 10 p.

    Research output: Contribution to journalArticle

  25. Published

    Propagation of population pharmacokinetic information using a Bayesian approach: Comparison with meta-analysis

    Dokoumetzidis, A. & Aarons, L., Aug 2005, In : Journal of pharmacokinetics and pharmacodynamics. 32, 3-4, p. 401-418 17 p.

    Research output: Contribution to journalArticle

  26. Published

    Pharmacokinetic studies of linezolid and teicoplanin in the critically ill

    Whitehouse, T., Cepeda, J. A., Shulman, R., Aarons, L., Nalda-Molina, R., Tobin, C., MacGowan, A., Shaw, S., Kibbler, C., Singer, M. & Wilson, A. P. R., Mar 2005, In : Journal of Antimicrobial Chemotherapy. 55, 3, p. 333-340 7 p.

    Research output: Contribution to journalArticle

  27. Published

    A pharmacokinetic/pharmacodynamic model for a platelet activating factor antagonist based on data arising from Phase I studies

    Evans, L., Aarons, L. & Brearley, C., Feb 2005, In : Journal of Pharmacy and Pharmacology. 57, 2, p. 183-189 6 p.

    Research output: Contribution to journalArticle

  28. Published

    Estimation of population pharmacokinetic parameters of free-phenytoin in adult epileptic patients

    Aarons, L., Ahmed, I. A. & Deleu, D., Jan 2005, In : Archives of Medical Research. 36, 1, p. 49-53 4 p.

    Research output: Contribution to journalArticle

  29. Published

    Retrospective population pharmacokinetics of levocetirizine in atopic children receiving cetirizine: The ETAC® study

    Hussein, Z., Pitsiu, M., Majid, O., Aarons, L., De Longueville, M. & Stockis, A., Jan 2005, In : British Journal of Clinical Pharmacology. 59, 1, p. 28-37 9 p.

    Research output: Contribution to journalArticle

  30. 2004
  31. Published

    Modelling and simulation in the development and use of anti-cancer agents: An underused tool?

    Rombout, F., Aarons, L., Karlsson, M., Man, A., Mentré, F., Nygren, P., Racine, A., Schaefer, H., Steimer, J. L., Troconiz, I. & Van Peer, A., Dec 2004, In : Journal of pharmacokinetics and pharmacodynamics. 31, 6, p. 419-440 21 p.

    Research output: Contribution to journalArticle

  32. Published

    Pharmacodynamics of controlled release verapamil in patients with hypertension: An analysis using spline functions

    Aarons, L., Baxter, C. & Gupta, S., Jul 2004, In : Biopharmaceutics and Drug Disposition. 25, 5, p. 219-225 6 p.

    Research output: Contribution to journalArticle

  33. Published

    Population pharmacokinetic model for daunorubicin and daunorubicinol coadministered with zosuquidar.3HCI (LY335979)

    Callies, S., De Alwis, D. P., Mehta, A., Burgess, M. & Aarons, L., Jul 2004, In : Cancer Chemotherapy and Pharmacology. 54, 1, p. 39-48 9 p.

    Research output: Contribution to journalArticle

  34. Published

    Design of Population Pharmacokinetic Studies: Sample size Determination

    Ogungbenro, K., Graham, G. & Aarons, L., Jun 2004.

    Research output: Contribution to conferencePoster

  35. Published

    Retrospective population pharmacokinetic analysis of cetirizine in children aged 6 months to 12 years

    Pitsiu, M., Hussein, Z., Majid, O., Aarons, L., De Longueville, M. & Stockis, A., Apr 2004, In : British Journal of Clinical Pharmacology. 57, 4, p. 402-411 9 p.

    Research output: Contribution to journalArticle

  36. Published

    Population pharmacokinetics of artemether and dihydroartemisinin following single intramuscular dosing of artemether in African children with severe falciparum malaria

    Mithwani, S., Aarons, L., Kokwaro, G. O., Majid, O., Muchohi, S., Edwards, G., Mohamed, S., Marsh, K. & Watkins, W., Feb 2004, In : British Journal of Clinical Pharmacology. 57, 2, p. 146-152 6 p.

    Research output: Contribution to journalArticle

  37. 2003
  38. Published

    Design of Population Pharmacokinetic Studies: Sample size Determination

    Ogungbenro, K., Graham, G. & Aarons, L., Nov 2003.

    Research output: Contribution to conferenceOther

  39. Published

    A population pharmacokinetic model for paclitaxel in the presence of a novel P-gp modulator, Zosuquidar Trihydrochloride (LY335979)

    Callies, S., De Alwis, D. P., Harris, A., Vasey, P., Beijnen, J. H., Schellens, J. H., Burgess, M. & Aarons, L., 1 Jul 2003, In : British Journal of Clinical Pharmacology. 56, 1, p. 46-56 10 p.

    Research output: Contribution to journalArticle

  40. Published
  41. Published

    A population pharmacokinetic model for doxorubicin and doxorubicinol in the presence of a novel MDR modulator, zosuquidar trihydrochloride (LY335979)

    Callies, S., De Alwis, D. P., Wright, J. G., Sandler, A., Burgess, M. & Aarons, L., 1 Feb 2003, In : Cancer Chemotherapy and Pharmacology. 51, 2, p. 107-118 11 p.

    Research output: Contribution to journalArticle

  42. Published

    A Bayesian method based on clotting factor activity for the prediction of maintenance warfarin dosage regimens

    Pitsiu, M., Parker, E. M., Aarons, L. & Rowland, M., Feb 2003, In : Therapeutic Drug Monitoring. 25, 1, p. 36-40 4 p.

    Research output: Contribution to journalArticle

  43. Published

    Prediction of serum tobramycin in patients with NONMEM and simulated annealing.

    Mengov, G., St, H. & Aarons, L., 2003, In : Comptes Rendus de l'Academie Bulgare des Sciences.. 56, 5, p. 47-50

    Research output: Contribution to journalArticle

  44. 2002
  45. Published

    Determination of an optimal dosage regimen using a Bayesian decision analysis of efficacy and adverse effect data

    Graham, G., Gupta, S. & Aarons, L., 2002, In : Journal of pharmacokinetics and pharmacodynamics. 29, 1, p. 67-88 21 p.

    Research output: Contribution to journalArticle

  46. Published

    Mixed effects modelling of toxicokinetic data

    Aarons, L., 2002, In : The Toxicologist. 66 (1-S)

    Research output: Contribution to journalArticle

  47. Published

    Pharmacokinetics of controlled-release verapamil in healthy volunteers and patients with hypertension or angina

    Gupta, S., Modi, N. B., Sathyan, G., Ho, P. L. & Aarons, L., 2002, In : Biopharmaceutics and Drug Disposition. 23, 1, p. 17-31 14 p.

    Research output: Contribution to journalArticle

  48. Published

    Population dynamics of untreated Plasmodium falciparum malaria within the adult human host during the expansion phase of the infection

    Simpson, J. A., Aarons, L., Collins, W. E., Jeffery, G. M. & White, N. J., 2002, In : Parasitology. 124, 3, p. 247-263 16 p.

    Research output: Contribution to journalArticle

  49. Published

    Sample Size Calculation for Pharmacokinetic Studies

    Ogungbenro, K., Graham, G. & Aarons, L., 2002.

    Research output: Contribution to conferencePoster

  50. Published

    Study of the phamacokinetic profile of anti-epileptic drugs in an adult Omani epileptic population using NONMEM.

    Deleu, D., Aarons, L. & Ahmed, I. A., 2002, In : EPILEPSIA. 43

    Research output: Contribution to journalArticle

  51. 2001
  52. Published

    COST B15: modelling in drug development

    Aarons, L., Balant, L. & Boobis, A., Jul 2001, In : British Journal of Clinical Pharmacology. 52, 1, p. 118-119

    Research output: Contribution to journalArticle

  53. Published

    Methodological approaches to the population analysis of toxicity data

    Aarons, L. & Graham, G., 31 Mar 2001, In : Toxicology Letters. 120, 1-3, p. 405-410 5 p.

    Research output: Contribution to journalArticle

  54. Published

    An identifiability analysis of a parent-metabolite pharmacokinetic model for ivabradine

    Adams, N. D., Godfrey, K. R., Chapman, M. J., Chappell, M. J., Aarons, L. & Duffull, S. B., 2001, In : Journal of pharmacokinetics and pharmacodynamics. 28, 1, p. 93-105 12 p.

    Research output: Contribution to journalArticle

  55. Published

    Computer-assisted clinical trial simulation: a phase II case study with naraptriptan

    Nestorov, I., Graham, G., Duffell, S., Aarons, L., Fuseau, E. & Coates, P., 2001, In : Pharmacol. Toxicol.. 89 (suppl. 1)

    Research output: Contribution to journalArticle

  56. Published

    How can we do pharmacokinetic studies in the tropics?

    Simpson, J. A., Aarons, L. & White, N. J., 2001, In : Transactions of the Royal Society of Tropical Medicine and Hygiene. 95, 4, p. 347-351 4 p.

    Research output: Contribution to journalArticle

  57. Published

    Modeling and simulation for clinical trial design involving a categorical response: A phase ii case study with naratriptan

    Nestorov, I., Graham, G., Duffull, S., Aarons, L., Fuseau, E. & Coates, P., 2001, In : Pharmaceutical Research. 18, 8, p. 1210-1219 9 p.

    Research output: Contribution to journalArticle

  58. Published

    Population pharmacokinetics of free carbamazepine in adult Omani epileptic patients

    Deleu, D., Aarons, L. & Ahmed, I. A., 2001, In : European journal of clinical pharmacology. 57, 3, p. 243-248 5 p.

    Research output: Contribution to journalArticle