Prof Leon AaronsBSc, MSc, PhD

Professor

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Publications

  1. Article › Research › Peer-reviewed
  2. Published

    "Population modelling". In: Variability in Human Drug Response. Proceedings of the Esteve Foundation Symposium VIII.

    Aarons, L., 1999, In : Excerpta Medica, Amsterdam.

    Research output: Contribution to journalArticle

  3. Published

    A Bayesian method based on clotting factor activity for the prediction of maintenance warfarin dosage regimens

    Pitsiu, M., Parker, E. M., Aarons, L. & Rowland, M., Feb 2003, In : Therapeutic Drug Monitoring. 25, 1, p. 36-40 4 p.

    Research output: Contribution to journalArticle

  4. Published

    A methodological framework for drug development in rare diseases.

    Volpert, V., Eymard, N., Kassai, B., Aarons, L., Bajard, A., Ballot, C., Bertrand, Y., Bretz, F., Caudri, D., Castellan, C., Malik, S., Chabaud, S., Cornu, C., Dufour, F., Dunger-Baldauf, C., Dupont, J-M., Fisch, R., Guerrini, R., Kassaï, B., Nony, P. & 12 others, Ogungbenro, K., Pérol, D., Pons, G., Tiddens, H., Rosati, A., Alberti, C., Chiron, C., Kurbatova, P., Nabbout, R., Jullien, V., Benquet, P. & Wendling, F., 2014, In : Orphanet Journal of Rare Diseases. 9

    Research output: Contribution to journalArticle

  5. Published

    A pharmacokinetic model for tenidap in normal volunteers and rheumatoid arthritis patients

    Evans, L., Aarons, L. & Coates, P., 1999, In : Pharmaceutical Research. 16, 10, p. 1608-1615 7 p.

    Research output: Contribution to journalArticle

  6. Published

    A pharmacokinetic simulation model for ivabradine in healthy volunteers

    Duffull, S. B., Chabaud, S., Nony, P., Laveille, C., Girard, P. & Aarons, L., Jun 2000, In : European Journal of Pharmaceutical Sciences. 10, 4, p. 285-294 9 p.

    Research output: Contribution to journalArticle

  7. Published

    A pharmacokinetic/pharmacodynamic model for a platelet activating factor antagonist based on data arising from Phase I studies

    Evans, L., Aarons, L. & Brearley, C., Feb 2005, In : Journal of Pharmacy and Pharmacology. 57, 2, p. 183-189 6 p.

    Research output: Contribution to journalArticle

  8. Published

    A Physiologically Based Pharmacokinetic Model for Clobazam and Stiripentol in Adults and Children

    Ogungbenro, K., Aarons, L. & Epi-CRESim Project Groups, 23 Jul 2014, In : Pharmaceutical Research. 32, 1, p. 144-157 13 p.

    Research output: Contribution to journalArticle

  9. Published

    A physiologically based pharmacokinetic model for Valproic acid in adults and children.

    Ogungbenro, K., Aarons, L., Bajard, A., Ballot, C., Bertrand, Y., Bretz, F., Caudri, D., Castellan, C., Chabaud, S., Cornu, C., Dufour, F., Eymard, N., Fisch, R., Guerrini, R., Jullien, V., Kassaï, B., Nony, P., Pérol, D., Pons, G., Tiddens, H. & 5 others, Rosati, A., Alberti, C., Chiron, C., Kurbatova, P. & Nabbout, R., 15 Oct 2014, In : European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 63, p. 45-52 7 p.

    Research output: Contribution to journalArticle

  10. Published

    A population pharmacokinetic model for doxorubicin and doxorubicinol in the presence of a novel MDR modulator, zosuquidar trihydrochloride (LY335979)

    Callies, S., De Alwis, D. P., Wright, J. G., Sandler, A., Burgess, M. & Aarons, L., 1 Feb 2003, In : Cancer Chemotherapy and Pharmacology. 51, 2, p. 107-118 11 p.

    Research output: Contribution to journalArticle

  11. Published

    A population pharmacokinetic model for paclitaxel in the presence of a novel P-gp modulator, Zosuquidar Trihydrochloride (LY335979)

    Callies, S., De Alwis, D. P., Harris, A., Vasey, P., Beijnen, J. H., Schellens, J. H., Burgess, M. & Aarons, L., 1 Jul 2003, In : British Journal of Clinical Pharmacology. 56, 1, p. 46-56 10 p.

    Research output: Contribution to journalArticle

  12. Published

    A program for individual and population optimal design for univariate and multivariate response pharmacokinetic-pharmacodynamic models

    Gueorguieva, I., Ogungbenro, K., Graham, G., Glatt, S. & Aarons, L., Apr 2007, In : Computer Methods and Programs in Biomedicine. 86, 1, p. 51-61 10 p.

    Research output: Contribution to journalArticle

  13. Published

    A semi-mechanistic gastric emptying model for the population pharmacokinetic analysis of orally administered acetaminophen in critically ill patients

    Ogungbenro, K., Vasist, L., Maclaren, R., Dukes, G., Young, M. & Aarons, L., Feb 2011, In : Pharmaceutical Research. 28, 2, p. 394-404 10 p.

    Research output: Contribution to journalArticle

  14. Published

    A semi-mechanistic gastric emptying pharmacokinetic model for 13C-octanoic acid: An evaluation using simulation

    Ogungbenro, K. & Aarons, L., 14 Feb 2012, In : European Journal of Pharmaceutical Sciences. 45, 3, p. 302-310 8 p.

    Research output: Contribution to journalArticle

  15. Published

    A Study of the dosage and duration for levobupivacaine infusion by the caudal-epidural route in infants aged 3-6 months

    Vashisht, R., Bendon, A., Okonkwo, I., Patel, D., Fullwood, C., Ogungbenro, K., Aarons, L. & Darwich, A., 2018, In : Pediatric Anesthesia.

    Research output: Contribution to journalArticle

  16. Published

    Accounting for dropout in xenografted tumour efficacy studies: integrated endpoint analysis, reduced bias and better use of animals

    Martin, E., Aarons, L. & WT Yates, J., Jul 2016, In : Cancer Chemotherapy and Pharmacology. 78, 1, p. 131-141

    Research output: Contribution to journalArticle

  17. Published

    An effective approach for obtaining optimal sampling windows for population pharmacokinetic experiments

    Ogungbenro, K. & Aarons, L., Jan 2009, In : Journal of Biopharmaceutical Statistics. 19, 1, p. 174-189 15 p.

    Research output: Contribution to journalArticle

  18. Published

    An identifiability analysis of a parent-metabolite pharmacokinetic model for ivabradine

    Adams, N. D., Godfrey, K. R., Chapman, M. J., Chappell, M. J., Aarons, L. & Duffull, S. B., 2001, In : Journal of pharmacokinetics and pharmacodynamics. 28, 1, p. 93-105 12 p.

    Research output: Contribution to journalArticle

  19. Published

    Analysis of the impact of controlled release formulation on oral drug absorption, gut wall metabolism and relative bioavailability of CYP3A substrates using a physiologically-based pharmacokinetic model

    Olivares-Morales, A., Kamiyama, Y., Darwich, A. S., Aarons, L. & Rostami, A., 25 Jan 2015, In : European Journal of Pharmaceutical Sciences. 67, p. 32-44 12 p.

    Research output: Contribution to journalArticle

  20. Published

    Analytical expressions for combining population pharmacokinetic parameters from different studies

    Dokoumetzidis, A. & Aarons, L., Jul 2008, In : Journal of Biopharmaceutical Statistics. 18, 4, p. 662-676 14 p.

    Research output: Contribution to journalArticle

  21. Published

    Application of a Bayesian approach to physiological modelling of mavoglurant population pharmacokinetics

    Wendling, T., Dumitras, S., Ogungbenro, K. & Aarons, L., 1 Aug 2015, In : Journal of pharmacokinetics and pharmacodynamics. 42, 6, p. 639-657 18 p.

    Research output: Contribution to journalArticle

  22. Published

    Application of optimal design methodologies in clinical pharmacology experiments

    Ogungbenro, K., Dokoumetzidis, A. & Aarons, L., Jul 2009, In : Pharmaceutical Statistics. 8, 3, p. 239-252 13 p.

    Research output: Contribution to journalArticle

  23. Published

    Assessment of Nevirapine Prophylactic and Therapeutic Dosing Regimens for Neonates

    Cressey, T. R., Punyawudho, B., Le Coeur, S., Jourdain, G., Saenjum, C., Capparelli, E. V., Jittayanun, K., Phanomcheong, S., Luvira, A., Borkird, T., Puangsombat, A., Aarons, L., Sukrakanchana, P. O., Urien, S., Lallemant, M., Sangsawang, S., Achalapong, J., Preedisripipat, K., Putiyanun, C., Wanchaitanawong, V. & 31 others, Yuthavisuthi, P., Ngampiyaskul, C., Kanjanavikai, P., Chotivanich, N., Hongsiriwon, S., Suwankornsakul, W., Sreshthatat, P., Kanjanasing, A., Kwanchaipanich, R., Rawangban, B., Santadusit, S., Jarupanich, T., Warachit, B., Siriwachirachai, T., Rojanakarin, P., Vivatpatanakul, K., Hanpinitsak, S., Wanasiri, P., Srirojana, S., Kongpanichkul, R., Bunjongpak, S., Sabsanong, P., Liampongsabuddhi, P., Pongdetudom, K., Khamja, P., Akarathum, N., Phonin, S. A., Limpitikul, W., Jungpipun, J., Petprakorp, R. & The PHPT-5 study team, 15 Aug 2017, In : Journal of Acquired Immune Deficiency Syndromes. 75, 5, p. 554-560 7 p.

    Research output: Contribution to journalArticle

  24. Published

    Bayesian optimal designs for pharmacokinetic models: Sensitivity to uncertainty

    Dokoumetzidis, A. & Aarons, L., Sep 2007, In : Journal of Biopharmaceutical Statistics. 17, 5, p. 851-867 16 p.

    Research output: Contribution to journalArticle

  25. Published

    Choosing an optimal input for an intravenous glucose tolerance test to aid parameter identification

    Martin, E., Yates, J. W. T., Ogungbenro, K. & Aarons, L., 5 Sep 2017, In : Journal of Pharmacy and Pharmacology. p. 1-9

    Research output: Contribution to journalArticle

  26. Published

    Combining the "bottom-up" and "top-down" approaches in pharmacokinetic modelling: Fitting PBPK models to observed clinical data

    Tsamandouras, N., Rostami-Hochaghan, A. & Aarons, L., 2015, In : British Journal of Clinical Pharmacology. 79, 1, p. 48-55 7 p.

    Research output: Contribution to journalArticle

  27. Published

    Comparison of in-vivo and in-silico methods used for prediction of tissue: Plasma partition coefficients in rat

    Graham, H., Walker, M., Jones, O., Yates, J., Galetin, A. & Aarons, L., Mar 2012, In : Journal of Pharmacy and Pharmacology. 64, 3, p. 383-396 13 p.

    Research output: Contribution to journalArticle

  28. Published

    Computer-assisted clinical trial simulation: a phase II case study with naraptriptan

    Nestorov, I., Graham, G., Duffell, S., Aarons, L., Fuseau, E. & Coates, P., 2001, In : Pharmacol. Toxicol.. 89 (suppl. 1)

    Research output: Contribution to journalArticle

  29. Published

    Corticosteroid-binding globulin regulates cortisol pharmacokinetics

    Perogamvros, I., Aarons, L., Miller, A. G., Trainer, P. J. & Ray, D. W., Jan 2011, In : Clinical Endocrinology. 74, 1, p. 30-36 6 p.

    Research output: Contribution to journalArticle

  30. Published

    COST B15: modelling in drug development

    Aarons, L., Balant, L. & Boobis, A., Jul 2001, In : British Journal of Clinical Pharmacology. 52, 1, p. 118-119

    Research output: Contribution to journalArticle

  31. Published

    Critical Analysis and Communication: An Alternative to the Research Project

    Demonacos, C., Aarons, L. & Barber, J., 2014, In : Health & Social Care Education. p. 1-5 4 p.

    Research output: Contribution to journalArticle

  32. Published

    Critique of the two-fold measure of prediction success for ratios: Application for the assessment of drug-drug interactions

    Guest, E. J., Aarons, L., Houston, J. B., Rostami-Hodjegan, A. & Galetin, A., Feb 2011, In : Drug Metabolism and Disposition. 39, 2, p. 170-173 3 p.

    Research output: Contribution to journalArticle

  33. Published

    Deconvolution and IVIVC: Exploring the Role of Rate-Limiting Conditions

    Margolskee, A., Darwich, A. S., Galetin, A., Rostami, A. & Aarons, L., 2 Mar 2016, In : The A A P S Journal. 18, 2, p. 321-332 11 p.

    Research output: Contribution to journalArticle

  34. Published

    Design of population pharmacokinetic experiments using prior information

    Ogungbenro, K. & Aarons, L., Oct 2007, In : Xenobiotica. 37, 10-11, p. 1311-1330 19 p.

    Research output: Contribution to journalArticle

  35. Published

    Designing More Efficient Preclinical Experiments: A Simulation Study in Chemotherapy-Induced Myelosupression

    Martin, E., Aarons, L. & Yates, J., 14 Feb 2016, In : Toxicological Sciences. 150, 1, p. 109-116 7 p.

    Research output: Contribution to journalArticle

  36. Published

    Determination of an optimal dosage regimen using a Bayesian decision analysis of efficacy and adverse effect data

    Graham, G., Gupta, S. & Aarons, L., 2002, In : Journal of pharmacokinetics and pharmacodynamics. 29, 1, p. 67-88 21 p.

    Research output: Contribution to journalArticle

  37. Published

    Development and Application of a Mechanistic Pharmacokinetic Model for Simvastatin and its Active Metabolite Simvastatin Acid Using an Integrated Population PBPK Approach

    Tsamandouras, N., Dickinson, G., Guo, Y., Hall, S., Rostami-Hochaghan, A., Galetin, A. & Aarons, L., 2015, In : Pharmaceutical Research. 32, 6, p. 1864-1883 19 p., 1573-904X.

    Research output: Contribution to journalArticle

  38. Published

    Development of a novel simplified PBPK absorption model to explain the higher relative bioavailability of the OROS® formulation of oxybutynin

    Olivares-Morales, A., Ghosh, A., Aarons, L. & Rostami-Hodjegan, A., Nov 2016, In : The AAPS journal. 18, 6, p. 1532-1549 18 p.

    Research output: Contribution to journalArticle

  39. Published

    Development of a sequential linked pharmacokinetic and pharmacodynamic simulation model for ivabradine in healthy volunteers

    Duffull, S. B. & Aarons, L., Jun 2000, In : European Journal of Pharmaceutical Sciences. 10, 4, p. 275-284 9 p.

    Research output: Contribution to journalArticle

  40. Published
  41. Published

    Drug-drug interaction predictions with PBPK models and optimal multiresponse sampling time designs: Application to midazolam and a phase i compound. Part 2: Clinical trial results

    Chenel, M., Bouzom, F., Cazade, F., Ogungbenro, K., Aarons, L. & Mentré, F., Dec 2008, In : Journal of pharmacokinetics and pharmacodynamics. 35, 6, p. 661-681 20 p.

    Research output: Contribution to journalArticle

  42. Published

    Editorial: Pharmacokinetic and pharmacodynamic modelling in drug development

    Aarons, L., Jun 1999, In : Statistical Methods in Medical Research. 8, 3, p. 181-182

    Research output: Contribution to journalArticle

  43. Published

    Empirical and semi-mechanistic modelling of double-peaked pharmacokinetic profile phenomenon due to gastric emptying.

    Ogungbenro, K., Pertinez, H. & Aarons, L., Jan 2015, In : The AAPS journal. 17, 1

    Research output: Contribution to journalArticle

  44. Published

    Establishment and validation of microsampling techniques in wild rodents for ecotoxicological research

    Imholt, C., Abdulla, T., Stevens, A., Edwards, P., Jacob, J., Woods, D., Rogers, E., Aarons, L. & Segelcke, D., Sep 2018, In : Journal of Applied Toxicology. 38, 9

    Research output: Contribution to journalArticle

  45. Published

    Estimation of population pharmacokinetic parameters of free-phenytoin in adult epileptic patients

    Aarons, L., Ahmed, I. A. & Deleu, D., Jan 2005, In : Archives of Medical Research. 36, 1, p. 49-53 4 p.

    Research output: Contribution to journalArticle

  46. Published

    Ethnic differences in the population pharmacokinetics and pharmacodynamics of warfarin

    Yuen, E., Gueorguieva, I., Wise, S., Soon, D. & Aarons, L., Feb 2010, In : Journal of pharmacokinetics and pharmacodynamics. 37, 1, p. 3-24 21 p.

    Research output: Contribution to journalArticle

  47. Published

    Forecasting oral absorption across biopharmaceutics classification system classes with physiologically based pharmacokinetic models

    Hansmann, S., Darwich, A., Margolskee, A., Aarons, L. & Dressman, J., 2016, In : Journal of Pharmacy and Pharmacology.

    Research output: Contribution to journalArticle

  48. Published

    Handling Missing Data in a Duloxetine Population Pharmacokinetic/Pharmacodynamic Model - Imputation Methods and Selection Models

    Yuen, E., Gueorguieva, I. & Aarons, L., 3 May 2014, In : Pharmaceutical Research.

    Research output: Contribution to journalArticle

  49. Published

    How can we do pharmacokinetic studies in the tropics?

    Simpson, J. A., Aarons, L. & White, N. J., 2001, In : Transactions of the Royal Society of Tropical Medicine and Hygiene. 95, 4, p. 347-351 4 p.

    Research output: Contribution to journalArticle

  50. Published

    How many subjects are necessary for population pharmacokinetic experiments? Confidence interval approach

    Ogungbenro, K. & Aarons, L., Jul 2008, In : European journal of clinical pharmacology. 64, 7, p. 705-713 8 p.

    Research output: Contribution to journalArticle

  51. Published

    Identification of the effect of multiple polymorphisms on the pharmacokinetics of Simvastatin and Simvastatin acid using a population-modeling approach

    Tsamandouras, N., Dickinson, G., Guo, Y., Hall, S., Rostami-Hodjegan, A., Galetin, A. & Aarons, L., 2014, In : Clinical Pharmacology and Therapeutics. 96, 1, p. 90-100 10 p.

    Research output: Contribution to journalArticle

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