Prof Leon AaronsBSc, MSc, PhD

Professor

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Publications

  1. 2018
  2. Published

    Establishment and validation of microsampling techniques in wild rodents for ecotoxicological research

    Imholt, C., Abdulla, T., Stevens, A., Edwards, P., Jacob, J., Woods, D., Rogers, E., Aarons, L. & Segelcke, D., Sep 2018, In : Journal of Applied Toxicology. 38, 9

    Research output: Contribution to journalArticle

  3. Published

    Ratifying the dosage and duration of levo-bupivacaine infusion by the caudal-epidural route in infants aged three to six months

    Vashisht, R., Bendon, A., Okonkwo, I., Darwich, A. & Aarons, L., May 2018, In : British Journal of Anaesthesia. 120, p. e11-e12 2 p.

    Research output: Contribution to journalMeeting Abstract

  4. Published

    A Study of the dosage and duration for levobupivacaine infusion by the caudal-epidural route in infants aged 3-6 months

    Vashisht, R., Bendon, A., Okonkwo, I., Patel, D., Fullwood, C., Ogungbenro, K., Aarons, L. & Darwich, A., 2018, In : Pediatric Anesthesia.

    Research output: Contribution to journalArticle

  5. Published

    Pharmacodynamic modelling of resistance to epidermal growth factor receptor inhibition in brain metastasis mouse models.

    Martin, E., Aarons, L. & Yates, J. W. T., 2018, In : Cancer Chemotherapy and Pharmacology.

    Research output: Contribution to journalArticle

  6. Published

    The Influence of Normalization Weight in Population Pharmacokinetic Covariate Models

    Goulooze, S. C., Voller, S., Valitalo, P. AJ., Calvier, E. AM., Aarons, L., Krekels, E. HJ. & Knibbe, C. A. J., 2018, In : Clinical Pharmacokinetics.

    Research output: Contribution to journalArticle

  7. Published

    Variance based global sensitivity analysis of physiologically based pharmacokinetic absorption models for BCS I–IV drugs

    Melillo, N., Aarons, L., Magni, P. & Darwich, A. S., 2018, In : Journal of pharmacokinetics and pharmacodynamics.

    Research output: Contribution to journalArticle

  8. 2017
  9. Published

    Whole body physiologically based modelling of β-blockers in the rat: events in tissues and plasma following an i.v. bolus dose

    Cheung, S. Y. A. ., Rodgers, T., Aarons, L., Gueorguieva, I., Dickinson, G. L., Murby, S., Brown, C., Collins, B. & Rowland, M., 22 Dec 2017, In : British Journal of Pharmacology . p. 1 17 p.

    Research output: Contribution to journalArticle

  10. Published

    Choosing an optimal input for an intravenous glucose tolerance test to aid parameter identification

    Martin, E., Yates, J. W. T., Ogungbenro, K. & Aarons, L., 5 Sep 2017, In : Journal of Pharmacy and Pharmacology. p. 1-9

    Research output: Contribution to journalArticle

  11. Published

    Assessment of Nevirapine Prophylactic and Therapeutic Dosing Regimens for Neonates

    Cressey, T. R., Punyawudho, B., Le Coeur, S., Jourdain, G., Saenjum, C., Capparelli, E. V., Jittayanun, K., Phanomcheong, S., Luvira, A., Borkird, T., Puangsombat, A., Aarons, L., Sukrakanchana, P. O., Urien, S., Lallemant, M., Sangsawang, S., Achalapong, J., Preedisripipat, K., Putiyanun, C., Wanchaitanawong, V. & 31 othersYuthavisuthi, P., Ngampiyaskul, C., Kanjanavikai, P., Chotivanich, N., Hongsiriwon, S., Suwankornsakul, W., Sreshthatat, P., Kanjanasing, A., Kwanchaipanich, R., Rawangban, B., Santadusit, S., Jarupanich, T., Warachit, B., Siriwachirachai, T., Rojanakarin, P., Vivatpatanakul, K., Hanpinitsak, S., Wanasiri, P., Srirojana, S., Kongpanichkul, R., Bunjongpak, S., Sabsanong, P., Liampongsabuddhi, P., Pongdetudom, K., Khamja, P., Akarathum, N., Phonin, S. A., Limpitikul, W., Jungpipun, J., Petprakorp, R. & The PHPT-5 study team, 15 Aug 2017, In : Journal of Acquired Immune Deficiency Syndromes. 75, 5, p. 554-560 7 p.

    Research output: Contribution to journalArticle

  12. Published

    IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

    Darwich, A., Aarons, L., Galetin, A., Rostami-Hochaghan et al, A., Margolskee, A., Pepin, X., Carlert, S., Hammarberg, M., Hilgendorf, C., Johansson, P., Karlsson, E., Murphy, D., Tannergren, C., Thorn, H., Yasin, M., Mazuir, F., Nicolas, O., Ramusovic, S., Xu, C., Pathak, S. & 43 othersKorjamo, T., Laru, J., Malkki, J., Pappinen, S., Tuunainen, J., Dressman, J., Hansmann, S., Kostewicz, E. S., He, H., Heimbach, T., Wu, F., Hoft, C., Pang, Y., Bolger, M., Huehn, E., Heimbach, T., Wu, F., Hoft, C., Pang, Y., Bolger, M. B., Huehn, E., Lukacova, V., Mullin, J. M., Szeto, K. X., Costales, C., Lin, J., McAllister, M., Modi, S., Rotter, C., Varma, M., Wong, M., Mitra, A., Bevernage, J., Biewenga, J., Peer, A. V., Lloyd, R., Shardlow, C., Langguth, P., Mishenzon, I., Nguyen, M. A., Brown, J., Lennerans, H. & Abrahmsson, B., 1 Jan 2017, In : European Journal of Pharmaceutical Sciences. 96, p. 626-642 17 p.

    Research output: Contribution to journalArticle

  13. Published

    Modelling of atorvastatin pharmacokinetics and the identification of the effect of a BCRP polymorphism in the Japanese population

    Tsamandouras, N., Guo, Y., Wendling, T., Hall, S., Galetin, A. & Aarons, L., Jan 2017, In : Pharmacogenetics and Genomics. 27, 1, p. 27-38 12 p.

    Research output: Contribution to journalArticle

  14. Published

    Population Pharmacokinetics of Selumetinib and Its Metabolite N-desmethyl-selumetinib in Adult Patients With Advanced Solid Tumors and Children With Low-Grade Gliomas

    Patel, Y. T., Daryani, V. M., Patel, P., Zhou, D., Fangusaro, J., Carlile, D. J., Martin, P. D., Aarons, L. & Stewart, C. F., 2017, In : CPT: Pharmacometrics and Systems Pharmacology.

    Research output: Contribution to journalArticle

  15. Published

    Population pharmacokinetics of the MEK inhibitor selumetinib and its active N-desmethyl metabolite: Data from 10 phase I trials

    Patel, P., Howgate, E., Martin, P., Carlile, D. J., Aarons, L. & Zhou, D., 2017, In : British Journal of Clinical Pharmacology.

    Research output: Contribution to journalArticle

  16. Published

    Why has model-informed precision dosing not yet become common clinical reality? Lessons from the past and a roadmap for the future

    Darwich, A., Ogungbenro, K., Vinks, A. A., Powell, J. R., Reny, J-L., Marsousi, N., Daali, Y., Fairman, D., Cook, J., Lesko, L. J., McCune, J. S., Knibbe, C. A. J., de Wildt, S. N., Leeder, J. S., Neely, M. N., Zuppa, A. F., Vicini, P., Aarons, L., Johnson, T. N., Boiani, J. & 1 othersRostami-Hodjegan, A., 2017, In : Clinical Pharmacology & Therapeutics.

    Research output: Contribution to journalArticle

  17. 2016
  18. Published

    Mathematical model of T-cell lymphoblastic lymphoma: disease, treatment, cure or relapse of a virtual cohort of patients

    Eymard, N., Volpert, V., Kurbatova, P., Bessonov, N., Ogungbenro, K., Aarons, L., Janiaud, P., Bajard, A., Chabaud, S., Bertrand, Y., Kassa¨i, B., Cornu, C. & Nony, P., 16 Dec 2016, In : Mathematical Medicine and Biology. 35, 1, p. 1-23

    Research output: Contribution to journalArticle

  19. Published

    Development of a novel simplified PBPK absorption model to explain the higher relative bioavailability of the OROS® formulation of oxybutynin

    Olivares-Morales, A., Ghosh, A., Aarons, L. & Rostami-Hodjegan, A., Nov 2016, In : The AAPS journal. 18, 6, p. 1532-1549 18 p.

    Research output: Contribution to journalArticle

  20. Published

    Accounting for dropout in xenografted tumour efficacy studies: integrated endpoint analysis, reduced bias and better use of animals

    Martin, E., Aarons, L. & WT Yates, J., Jul 2016, In : Cancer Chemotherapy and Pharmacology. 78, 1, p. 131-141

    Research output: Contribution to journalArticle

  21. Published

    Predicting survival of pancreatic cancer patients treated with gemcitabine using longitudinal tumour size data

    Wendling, T., Mistry, H., Ogungbenro, K. & Aarons, L., 7 Mar 2016, In : Cancer Chemotherapy and Pharmacology. 77, 5, p. 927 938 p., 11.

    Research output: Contribution to journalArticle

  22. Published

    Deconvolution and IVIVC: Exploring the Role of Rate-Limiting Conditions

    Margolskee, A., Darwich, A. S., Galetin, A., Rostami, A. & Aarons, L., 2 Mar 2016, In : The A A P S Journal. 18, 2, p. 321-332 11 p.

    Research output: Contribution to journalArticle

  23. Published

    Designing More Efficient Preclinical Experiments: A Simulation Study in Chemotherapy-Induced Myelosupression

    Martin, E., Aarons, L. & Yates, J., 14 Feb 2016, In : Toxicological Sciences. 150, 1, p. 109-116 7 p.

    Research output: Contribution to journalArticle

  24. Published

    Forecasting oral absorption across biopharmaceutics classification system classes with physiologically based pharmacokinetic models

    Hansmann, S., Darwich, A., Margolskee, A., Aarons, L. & Dressman, J., 2016, In : Journal of Pharmacy and Pharmacology.

    Research output: Contribution to journalArticle

  25. Published

    IMI – oral biopharmaceutics tools project – evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds

    Margolskee, A., Darwich, A., Pepin, X., Pathak, S. M., Bolger et al, M. B., Aarons, L., Rostami-Hochaghan, A., Angstenberger, J., Graf, F., Laplanche, L., Muller, T., Carlert, S., Daga, P., Murphy, D., Tannergren, C., Yasin, M., Greschat-Schade, S., Muck, W., Muenster, U., van der Mey, D. & 27 othersFrank, K., Lloyd, R., Adriaenssen, L., Bevernage, J., De Zwart, L., Swerts, D., Tistaert, C., Van Den Bergh, A., Van Peer, A., Beato, S., Nguyen-Trung, A-T., Bennett, J., McAllister, M., Wong, M., Zane, P., Ollier, C., Vicat, P., Kolhmann, M., Marker, A., Brun, P., Mazuir, F., Beilles, S., Venczel, M., Boulenc, X., Loos, P., Lennernas, H. & Abrahamsson, B., 2016, In : European Journal of Pharmaceutical Sciences.

    Research output: Contribution to journalArticle

  26. Published

    IMI – Oral Biopharmaceutics Tools project – Evaluation of Bottom-up PBPK Prediction Success Part 2: An Introduction to the Simulation Exercise and Overview of Results

    Margolskee, A., Darwich, A., Aarons, L., Galetin, A., Rostami-Hochaghan, A., Carlert, S., Hammarberg, M., Hilgendorf, C., Johansson, P., Karlsson, E., Murphy, D., Tannergren, C., Thorn, H., Yasin, M., Mazuir, F., Nicolas, O., Ramusovic, S., Xu, C., Pathak, S., Korjamo, T. & 37 othersLaru, J., Malkki, J., Pappinen, S., Tuunainen, J., Dressman, J., Hansmann, S., Kostewicz, E., He, H., Heimbach, T., Wu, F., Hoft, C., Laplanche, L., Pang, Y., Bolger, M. B., Huehn, E., Lukacova, V., Mullin, J. M., Szeto, K. X., Costales, C., Lin, J., McAllister, M., Modi, S., Rotter, C., Varma, M., Wong, M., Mitra, A., Bevernage, J., Biewenga, J., Van Peer, A., Lloyd, R., Shardlow, C., Langguth, P., Mishenzon, I., Nguyen, M. A., Brown, J., Lennernas, H. & Abrahamsson, B., 2016, In : European Journal of Pharmaceutical Sciences.

    Research output: Contribution to journalArticle

  27. 2015
  28. Published

    What do we mean by identifiability in mixed effects models?

    Lavielle, M. & Aarons, L., 10 Dec 2015, In : Journal of pharmacokinetics and pharmacodynamics.

    Research output: Contribution to journalArticle

  29. Published

    Reduction of a Whole-Body Physiologically Based Pharmacokinetic Model to Stabilise the Bayesian Analysis of Clinical Data.

    Wendling, T., Tsamandouras, N., Dumitras, S., Pigeolet, E., Ogungbenro, K. & Aarons, L., 4 Nov 2015, In : The AAPS journal. 18, 1

    Research output: Contribution to journalArticle

  30. Published

    Application of a Bayesian approach to physiological modelling of mavoglurant population pharmacokinetics

    Wendling, T., Dumitras, S., Ogungbenro, K. & Aarons, L., 1 Aug 2015, In : Journal of pharmacokinetics and pharmacodynamics. 42, 6, p. 639-657 18 p.

    Research output: Contribution to journalArticle

  31. Published

    Incorporation of stochastic variability in mechanistic population pharmacokinetic models: handling the physiological constraints using normal transformations

    Tsamandouras, N., Wendling, T., Rostami-Hochaghan, A., Galetin, A. & Aarons, L., Aug 2015, In : Journal of pharmacokinetics and pharmacodynamics. 42, 4, p. 349-373 24 p.

    Research output: Contribution to journalArticle

  32. Published

    Physiologically based pharmacokinetic model for 6-mercpatopurine: exploring the role of genetic polymorphism in TPMT enzyme activity.

    Ogungbenro, K., Aarons, L., Bajard, A., Ballot, C., Bertrand, Y., Bretz, F., Caudri, D., Castellan, C., Chabaud, S., Cornu, C., Dufour, F., Eymard, N., Fisch, R., Guerrini, R., Jullien, V., Kassaï, B., Nony, P., Pérol, D., Pons, G., Tiddens, H. & 5 othersRosati, A., Alberti, C., Chiron, C., Kurbatova, P. & Nabbout, R., Jul 2015, In : British Journal of Clinical Pharmacology. 80, 1

    Research output: Contribution to journalArticle

  33. Published

    A reduced physiologically-based pharmacokinetic (PBPK) model for the prediction of regional gastrointestinal (GI) drug absorption

    Olivares Morales, A., Aarons, L. & Rostami, A., 2 Jun 2015, PAGE. Abstracts of the Annual Meeting of the Population Approach Group in Europe.. http://www.page-meeting.org/default.asp?abstract=3449: Population Approach Group in Europe

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  34. Published

    Translating Human Effective Jejunal Intestinal Permeability to Surface-Dependent Intrinsic Permeability: a Pragmatic Method for a More Mechanistic Prediction of Regional Oral Drug Absorption

    Olivares-Morales, A., Lennernäs, H., Aarons, L. & Rostami-Hodjegan, A., 19 May 2015, In : The A A P S Journal. 17, 5, p. 1177-1192 15 p.

    Research output: Contribution to journalArticle

  35. Published

    Model of mucociliary clearance in cystic fibrosis lungs.

    Kurbatova, P., Bessonov, N., Volpert, V., Tiddens, H. A. W. M., Cornu, C., Nony, P., Caudri, D., Aarons, L., Bajard, A., Bertrand, Y., Bretz, F., Castellan, C., Chabaud, S., Cornu, C., Dufour, F., Eymard, N., Fisch, R., Guerrini, R., Kassai, B., Kurbatova, P. & 13 othersMalik, S., Nony, P., Ogungbenro, K., Pérol, D., Pons, G., Tiddens, H., Rosati, A., Alberti, C., Chiron, C., Nabbout, R., Jullien, V., Benquet, P. & Wendling, F., 7 May 2015, In : Journal of Theoretical Biology. 372

    Research output: Contribution to journalArticle

  36. Published

    Model-based evaluation of the impact of formulation and food intake on the complex oral absorption of mavoglurant in healthy subjects.

    Wendling, T., Ogungbenro, K., Pigeolet, E., Dumitras, S., Woessner, R. & Aarons, L., May 2015, In : Pharmaceutical Research. 32, 5, p. 1764-1778 14 p.

    Research output: Contribution to journalArticle

  37. Published

    Analysis of the impact of controlled release formulation on oral drug absorption, gut wall metabolism and relative bioavailability of CYP3A substrates using a physiologically-based pharmacokinetic model

    Olivares-Morales, A., Kamiyama, Y., Darwich, A. S., Aarons, L. & Rostami, A., 25 Jan 2015, In : European Journal of Pharmaceutical Sciences. 67, p. 32-44 12 p.

    Research output: Contribution to journalArticle

  38. Published

    Empirical and semi-mechanistic modelling of double-peaked pharmacokinetic profile phenomenon due to gastric emptying.

    Ogungbenro, K., Pertinez, H. & Aarons, L., Jan 2015, In : The AAPS journal. 17, 1

    Research output: Contribution to journalArticle

  39. Published

    Combining the "bottom-up" and "top-down" approaches in pharmacokinetic modelling: Fitting PBPK models to observed clinical data

    Tsamandouras, N., Rostami-Hochaghan, A. & Aarons, L., 2015, In : British Journal of Clinical Pharmacology. 79, 1, p. 48-55 7 p.

    Research output: Contribution to journalArticle

  40. Published

    Development and Application of a Mechanistic Pharmacokinetic Model for Simvastatin and its Active Metabolite Simvastatin Acid Using an Integrated Population PBPK Approach

    Tsamandouras, N., Dickinson, G., Guo, Y., Hall, S., Rostami-Hochaghan, A., Galetin, A. & Aarons, L., 2015, In : Pharmaceutical Research. 32, 6, p. 1864-1883 19 p., 1573-904X.

    Research output: Contribution to journalArticle

  41. 2014
  42. Published
  43. Published

    A physiologically based pharmacokinetic model for Valproic acid in adults and children.

    Ogungbenro, K., Aarons, L., Bajard, A., Ballot, C., Bertrand, Y., Bretz, F., Caudri, D., Castellan, C., Chabaud, S., Cornu, C., Dufour, F., Eymard, N., Fisch, R., Guerrini, R., Jullien, V., Kassaï, B., Nony, P., Pérol, D., Pons, G., Tiddens, H. & 5 othersRosati, A., Alberti, C., Chiron, C., Kurbatova, P. & Nabbout, R., 15 Oct 2014, In : European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 63, p. 45-52 7 p.

    Research output: Contribution to journalArticle

  44. Published

    A Physiologically Based Pharmacokinetic Model for Clobazam and Stiripentol in Adults and Children

    Ogungbenro, K., Aarons, L. & Epi-CRESim Project Groups, 23 Jul 2014, In : Pharmaceutical Research. 32, 1, p. 144-157 13 p.

    Research output: Contribution to journalArticle

  45. Published

    Critical Analysis and Communication: an alternative to the final year project

    Barber, J., Demonacos, C., Aarons, L., Steinke, D. & Tully, M., 30 Jun 2014, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  46. Published

    Oral biopharmaceutics tools - Time for a new initiative - An introduction to the IMI project OrBiTo

    Lennernäs, H., Aarons, L., Augustijns, P., Beato, S., Bolger, M., Box, K., Brewster, M., Butler, J., Dressman, J., Holm, R., Julia Frank, K., Kendall, R., Langguth, P., Sydor, J., Lindahl, A., McAllister, M., Muenster, U., Müllertz, A., Ojala, K., Pepin, X. & 7 othersReppas, C., Rostami-Hodjegan, A., Verwei, M., Weitschies, W., Wilson, C., Karlsson, C. & Abrahamsson, B., 16 Jun 2014, In : European Journal of Pharmaceutical Sciences. 57, 1, p. 292-299 7 p.

    Research output: Contribution to journalArticle

  47. Published

    PBPK models for the prediction of in vivo performance of oral dosage forms

    Kostewicz, E. S., Aarons, L., Bergstrand, M., Bolger, M. B., Galetin, A., Hatley, O., Jamei, M., Lloyd, R., Pepin, X., Rostami-Hodjegan, A., Sjögren, E., Tannergren, C., Turner, D. B., Wagner, C., Weitschies, W. & Dressman, J., 16 Jun 2014, In : European Journal of Pharmaceutical Sciences. 57, 1, p. 300-321 21 p.

    Research output: Contribution to journalArticle

  48. Published
  49. Published

    Handling Missing Data in a Duloxetine Population Pharmacokinetic/Pharmacodynamic Model - Imputation Methods and Selection Models

    Yuen, E., Gueorguieva, I. & Aarons, L., 3 May 2014, In : Pharmaceutical Research.

    Research output: Contribution to journalArticle

  50. Published

    Physiologically based pharmacokinetic modelling of methotrexate and 6-mercaptopurine in adults and children. Part 1: methotrexate.

    Ogungbenro, K. & Aarons, L., Apr 2014, In : Journal of pharmacokinetics and pharmacodynamics. 41, 2, p. 159-171 12 p.

    Research output: Contribution to journalArticle

  51. Published

    Physiologically based pharmacokinetic modelling of methotrexate and 6-mercaptopurine in adults and children. Part 2: 6-mercaptopurine and its interaction with methotrexate.

    Ogungbenro, K. & Aarons, L., Apr 2014, In : Journal of pharmacokinetics and pharmacodynamics. 41, 2, p. 173-185 12 p.

    Research output: Contribution to journalArticle

  52. Published

    A methodological framework for drug development in rare diseases.

    Volpert, V., Eymard, N., Kassai, B., Aarons, L., Bajard, A., Ballot, C., Bertrand, Y., Bretz, F., Caudri, D., Castellan, C., Malik, S., Chabaud, S., Cornu, C., Dufour, F., Dunger-Baldauf, C., Dupont, J-M., Fisch, R., Guerrini, R., Kassaï, B., Nony, P. & 12 othersOgungbenro, K., Pérol, D., Pons, G., Tiddens, H., Rosati, A., Alberti, C., Chiron, C., Kurbatova, P., Nabbout, R., Jullien, V., Benquet, P. & Wendling, F., 2014, In : Orphanet Journal of Rare Diseases. 9

    Research output: Contribution to journalArticle

  53. Published

    Critical Analysis and Communication: An Alternative to the Research Project

    Demonacos, C., Aarons, L. & Barber, J., 2014, In : Health & Social Care Education. p. 1-5 4 p.

    Research output: Contribution to journalArticle

  54. Published

    Identification of the effect of multiple polymorphisms on the pharmacokinetics of Simvastatin and Simvastatin acid using a population-modeling approach

    Tsamandouras, N., Dickinson, G., Guo, Y., Hall, S., Rostami-Hodjegan, A., Galetin, A. & Aarons, L., 2014, In : Clinical Pharmacology and Therapeutics. 96, 1, p. 90-100 10 p.

    Research output: Contribution to journalArticle

  55. Published

    Precision criteria to derive sample size when designing pediatric pharmacokinetic studies: Which measure of variability should be used?

    Salem, F., Ogungbenro, K., Vajjah, P., Johnson, T. N., Aarons, L. & Rostami-Hodjegan, A., 2014, In : Journal of Clinical Pharmacology. 54, 3, p. 311-317 6 p.

    Research output: Contribution to journalArticle

  56. 2013
  57. Published

    Can BDDCS Class be used to explain differences in the prediction of human oral bioavailability from animal data using a threshold-based model?

    Olivares Morales, A., Hatley, OJD., Turner, D., Galetin, A., Aarons, L. & Rostami, A., Nov 2013.

    Research output: Contribution to conferencePoster

  58. Published

    Qualitative model for the prediction of high/low human oral bioavailability from animal bioavailability data employing ROC analysis

    Olivares-Morales, A., Hatley, OJD., Turner, D., Galetin, A., Aarons, L. & Rostami, A., Nov 2013.

    Research output: Contribution to conferencePoster

  59. Published

    Development and evaluation of a classification tool for the qualitative prediction of oral bioavailability from animal data

    Olivares Morales, A., Hatley, OJD., Turner, D., Galetin, A., Aarons, L. & Rostami, A., Oct 2013.

    Research output: Contribution to conferenceOther

  60. Published

    The Use of ROC Analysis for the Qualitative Prediction of Human Oral Bioavailability from Animal Data

    Olivares-Morales, A., Hatley, O. J. D., Turner, D., Galetin, A., Aarons, L. & Rostami-Hodjegan, A., 27 Sep 2013, In : Pharmaceutical Research. 31, 3, p. 720-730 10 p.

    Research output: Contribution to journalArticle

  61. Published

    Qualitative prediction of human oral bioavailability from animal oral bioavailability data employing ROC analysis

    Olivares Morales, A., Hatley, OJD., Turner, D., Galetin, A., Aarons, L. & Rostami, A., 14 Jun 2013.

    Research output: Contribution to conferencePoster

  62. Published

    Qualitative model for the prediction of high/low human oral bioavailability from animal bioavailability data employing ROC analysis

    Olivares Morales, A., Hatley, OJD., Turner, D., Galetin, A., Aarons, L. & Rostami, A., Jun 2013.

    Research output: Contribution to conferencePoster

  63. Published

    Population pharmacokinetic/pharmacodynamic models for duloxetine in the treatment of diabetic peripheral neuropathic pain

    Yuen, E., Gueorguieva, I., Bueno-Burgos, L., Iyengar, S. & Aarons, L., Mar 2013, In : European Journal of Pain. 17, 3, p. 382-393 11 p.

    Research output: Contribution to journalArticle

  64. Published

    Modeling and simulation in clinical pharmacology and dose finding

    Staab, A., Rook, E., Maliepaard, M., Aarons, L. & Benson, C., Feb 2013, In : CPT: Pharmacometrics and Systems Pharmacology. 2, 2, e29.

    Research output: Contribution to journalArticle

  65. Published

    The design and analysis of parallel experiments to produce structurally identifiable models

    Cheung, S. Y. A., Yates, J. W. T. & Aarons, L., Feb 2013, In : Journal of pharmacokinetics and pharmacodynamics. 40, 1, p. 93-100 7 p.

    Research output: Contribution to journalArticle

  66. 2012
  67. Published

    Population pharmacokinetics of halofantrine in healthy volunteers and patients with symptomatic falciparum malaria

    Klein, K., Aarons, L., Ter Kuile, F. O., Nosten, F., White, N. J., Edstein, M. D. & Teja-Isavadharm, P., Nov 2012, In : Journal of Pharmacy and Pharmacology. 64, 11, p. 1603-1613 10 p.

    Research output: Contribution to journalArticle

  68. Published

    Structural identifiability analysis and reparameterisation (parameter reduction) of a cardiovascular feedback model

    Cheung, S. Y. A., Majid, O., Yates, J. W. T. & Aarons, L., 16 Jul 2012, In : European Journal of Pharmaceutical Sciences. 46, 4, p. 259-271 12 p.

    Research output: Contribution to journalArticle

  69. Published

    Population pharmacokinetic modelling of S-warfarin to evaluate the design of drug-drug interaction studies for CYP2C9

    Klein, K., Gueorguieva, I. & Aarons, L., Apr 2012, In : Journal of pharmacokinetics and pharmacodynamics. 39, 2, p. 147-160 13 p.

    Research output: Contribution to journalArticle

  70. Published

    Comparison of in-vivo and in-silico methods used for prediction of tissue: Plasma partition coefficients in rat

    Graham, H., Walker, M., Jones, O., Yates, J., Galetin, A. & Aarons, L., Mar 2012, In : Journal of Pharmacy and Pharmacology. 64, 3, p. 383-396 13 p.

    Research output: Contribution to journalArticle

  71. Published

    A semi-mechanistic gastric emptying pharmacokinetic model for 13C-octanoic acid: An evaluation using simulation

    Ogungbenro, K. & Aarons, L., 14 Feb 2012, In : European Journal of Pharmaceutical Sciences. 45, 3, p. 302-310 8 p.

    Research output: Contribution to journalArticle

  72. Published

    The population pharmacokinetics of R- and S-warfarin: Effect of genetic and clinical factors

    Lane, S., Al-Zubiedi, S., Hatch, E., Matthews, I., Jorgensen, A. L., Deloukas, P., Daly, A. K., Park, B. K., Aarons, L., Ogungbenro, K., Kamali, F., Hughes, D. & Pirmohamed, M., Jan 2012, In : British Journal of Clinical Pharmacology. 73, 1, p. 66-76 10 p.

    Research output: Contribution to journalArticle

  73. 2011
  74. Published

    Population pharmacokinetic analysis of ropivacaine and its metabolite 2′,6′-pipecoloxylidide from pooled data in neonates, infants, and children

    Aarons, L., Sadler, B., Pitsiu, M., Sjövall, J., Henriksson, J. & Molnár, V., Sep 2011, In : British Journal of Anaesthesia. 107, 3, p. 409-424 15 p.

    Research output: Contribution to journalArticle

  75. Published

    Population Fisher information matrix and optimal design of discrete data responses in population pharmacodynamic experiments

    Ogungbenro, K. & Aarons, L., Aug 2011, In : Journal of pharmacokinetics and pharmacodynamics. 38, 4, p. 449-469 20 p.

    Research output: Contribution to journalArticle

  76. Published

    Sequential population pharmacokinetic modeling of lopinavir and ritonavir in healthy volunteers and assessment of different dosing strategies

    Dickinson, L., Boffito, M., Back, D., Else, L., Von Hentig, N., Davies, G., Khoo, S., Pozniak, A., Moyle, G. & Aarons, L., Jun 2011, In : Antimicrobial Agents and Chemotherapy. 55, 6, p. 2775-2782 7 p.

    Research output: Contribution to journalArticle

  77. Published

    Structural identifiability analysis of pharmacokinetic models using DAISY: Semi-mechanistic gastric emptying models for 13C-octanoic acid

    Ogungbenro, K. & Aarons, L., Apr 2011, In : Journal of pharmacokinetics and pharmacodynamics. 38, 2, p. 279-292 13 p.

    Research output: Contribution to journalArticle

  78. Published

    A semi-mechanistic gastric emptying model for the population pharmacokinetic analysis of orally administered acetaminophen in critically ill patients

    Ogungbenro, K., Vasist, L., Maclaren, R., Dukes, G., Young, M. & Aarons, L., Feb 2011, In : Pharmaceutical Research. 28, 2, p. 394-404 10 p.

    Research output: Contribution to journalArticle

  79. Published

    Critique of the two-fold measure of prediction success for ratios: Application for the assessment of drug-drug interactions

    Guest, E. J., Aarons, L., Houston, J. B., Rostami-Hodjegan, A. & Galetin, A., Feb 2011, In : Drug Metabolism and Disposition. 39, 2, p. 170-173 3 p.

    Research output: Contribution to journalArticle

  80. Published

    Intravenous anakinra can achieve experimentally effective concentrations in the central nervous system within a therapeutic time window: Results of a dose-ranging study

    Galea, J., Ogungbenro, K., Hulme, S., Greenhalgh, A., Aarons, L., Scarth, S., Hutchinson, P., Grainger, S., King, A., Hopkins, S. J., Rothwell, N. & Tyrrell, P., Feb 2011, In : Journal of Cerebral Blood Flow and Metabolism. 31, 2, p. 439-447 8 p.

    Research output: Contribution to journalArticle

  81. Published

    Corticosteroid-binding globulin regulates cortisol pharmacokinetics

    Perogamvros, I., Aarons, L., Miller, A. G., Trainer, P. J. & Ray, D. W., Jan 2011, In : Clinical Endocrinology. 74, 1, p. 30-36 6 p.

    Research output: Contribution to journalArticle

  82. Published

    Phase I pharmacokinetic and pharmacodynamic study of the bioreductive drug RH1

    Danson, S. J., Johnson, P., Ward, T. H., Dawson, M., Denneny, O., Dickinson, G., Aarons, L., Watson, A., Jowle, D., Cummings, J., Robson, L., Halbert, G., Dive, C. & Ranson, M., 2011, In : Annals of Oncology. 22, 7, p. 1653-1660 7 p.

    Research output: Contribution to journalArticle

  83. 2010
  84. Published

    Development of a novel method for updating the predicted partition coefficient values generated by an existing in silico prediction method

    Graham, H., Yates, J., Galetin, A. & Aarons, L., Nov 2010, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  85. Published

    Sample-size calculations for multi-group comparison in population pharmacokinetic experiments

    Ogungbenro, K. & Aarons, L., Oct 2010, In : Pharmaceutical Statistics. 9, 4, p. 255-268 13 p.

    Research output: Contribution to journalArticle

  86. Published

    Sample size/power calculations for population pharmacodynamic experiments involving repeated-count measurements

    Ogungbenro, K. & Aarons, L., Sep 2010, In : Journal of Biopharmaceutical Statistics. 20, 5, p. 1026-1042 16 p.

    Research output: Contribution to journalArticle

  87. Published

    Optimal design of pharmacokinetic studies

    Aarons, L. & Ogungbenro, K., Mar 2010, In : Basic and Clinical Pharmacology and Toxicology. 106, 3, p. 250-255 5 p.

    Research output: Contribution to journalArticle

  88. Published
  89. Published

    Ethnic differences in the population pharmacokinetics and pharmacodynamics of warfarin

    Yuen, E., Gueorguieva, I., Wise, S., Soon, D. & Aarons, L., Feb 2010, In : Journal of pharmacokinetics and pharmacodynamics. 37, 1, p. 3-24 21 p.

    Research output: Contribution to journalArticle

  90. Published

    Sample size/power calculations for repeated ordinal measurements in population pharmacodynamic experiments

    Ogungbenro, K. & Aarons, L., Feb 2010, In : Journal of pharmacokinetics and pharmacodynamics. 37, 1, p. 67-83 16 p.

    Research output: Contribution to journalArticle

  91. Published

    Population Pharmacokinetic Modeling of Acetaminophen (APAP), A Surrogate for Gastric Emptying, in Critically Ill Patients Tolerant And Intolerant To Enteral Nutrition

    Ogungbenro, K., MacLaren, R., Dukes, G., Young, M., Aarons, L. & Vasist, LS., 2010, In : Clinical Pharmacology and Therapeutics. 87, p. S1-S7

    Research output: Contribution to journalArticle

  92. 2009
  93. Published

    Comparison of in vivo and in silico methods to predict tissue:plasma partition coefficients in rat

    Graham, H., Jones, O., Galetin, A. & Aarons, L., 25 Nov 2009, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  94. Published
  95. Published
  96. Published

    Population pharmacokinetics and optimal design of paediatric studies for famciclovir

    Ogungbenro, K., Matthews, I., Looby, M., Kaiser, G., Graham, G. & Aarons, L., Oct 2009, In : British Journal of Clinical Pharmacology. 68, 4, p. 546-560 14 p.

    Research output: Contribution to journalArticle

  97. Published

    Application of optimal design methodologies in clinical pharmacology experiments

    Ogungbenro, K., Dokoumetzidis, A. & Aarons, L., Jul 2009, In : Pharmaceutical Statistics. 8, 3, p. 239-252 13 p.

    Research output: Contribution to journalArticle

  98. Published
  99. Published

    Phase I trial of AEG35156 administered as a 7-day and 3-day continuous intravenous infusion in patients with advanced refractory cancer

    Ranson, M., Dean, E., Jodrell, D., Connolly, K., Danson, S., Jolivet, J., Durkin, J., Morris, S., Jowle, D., Ward, T., Cummings, J., Dickinson, G., Aarons, L., LaCasse, E., Robson, L. & Dive, C., 1 Apr 2009, In : Journal of Clinical Oncology. 27, 10, p. 1660-1666 6 p.

    Research output: Contribution to journalArticle

  100. Published
  101. Published

    An effective approach for obtaining optimal sampling windows for population pharmacokinetic experiments

    Ogungbenro, K. & Aarons, L., Jan 2009, In : Journal of Biopharmaceutical Statistics. 19, 1, p. 174-189 15 p.

    Research output: Contribution to journalArticle

  102. Published

    Population pharmacokinetics of ritonavir-boosted atazanavir in HIV-infected patients and healthy volunteers

    Dickinson, L., Boffito, M., Back, D., Waters, L., Else, L., Davies, G., Khoo, S., Pozniak, A. & Aarons, L., 2009, In : Journal of Antimicrobial Chemotherapy. 63, 6, p. 1233-1243 10 p.

    Research output: Contribution to journalArticle

  103. 2008
  104. Published
  105. Published

    Drug-drug interaction predictions with PBPK models and optimal multiresponse sampling time designs: Application to midazolam and a phase i compound. Part 2: Clinical trial results

    Chenel, M., Bouzom, F., Cazade, F., Ogungbenro, K., Aarons, L. & Mentré, F., Dec 2008, In : Journal of pharmacokinetics and pharmacodynamics. 35, 6, p. 661-681 20 p.

    Research output: Contribution to journalArticle

  106. Published

    Sample size calculations for population pharmacodynamic experiments involving repeated dichotomous observations

    Ogungbenro, K. & Aarons, L., Nov 2008, In : Journal of Biopharmaceutical Statistics. 18, 6, p. 1212-1227 15 p.

    Research output: Contribution to journalArticle

  107. Published

    Optimisation of sampling windows design for population pharmacokinetic experiments

    Ogungbenro, K. & Aarons, L., Aug 2008, In : Journal of pharmacokinetics and pharmacodynamics. 35, 4, p. 465-482 17 p.

    Research output: Contribution to journalArticle

  108. Published

    Analytical expressions for combining population pharmacokinetic parameters from different studies

    Dokoumetzidis, A. & Aarons, L., Jul 2008, In : Journal of Biopharmaceutical Statistics. 18, 4, p. 662-676 14 p.

    Research output: Contribution to journalArticle

  109. Published

    How many subjects are necessary for population pharmacokinetic experiments? Confidence interval approach

    Ogungbenro, K. & Aarons, L., Jul 2008, In : European journal of clinical pharmacology. 64, 7, p. 705-713 8 p.

    Research output: Contribution to journalArticle

  110. Published

    Pharmacokinetic analysis to assess forgiveness of boosted saquinavir regimens for missed or late dosing

    Dickinson, L., Boffito, M., Khoo, S. H., Schutz, M., Aarons, L. J., Pozniak, A. L. & Back, D. J., Jul 2008, In : Journal of Antimicrobial Chemotherapy. 62, 1, p. 161-167 6 p.

    Research output: Contribution to journalArticle

  111. Published
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