Prof Leon AaronsBSc, MSc, PhD

Professor

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Publications

  1. Published

    Incorporating correlation in interindividual variability for the optimal design of multiresponse pharmacokinetic experiments

    Ogungbenro, K., Graham, G., Gueorguieva, I. & Aarons, L., Mar 2008, In : Journal of Biopharmaceutical Statistics. 18, 2, p. 342-358 16 p.

    Research output: Contribution to journalArticle

  2. Published

    Incorporation of stochastic variability in mechanistic population pharmacokinetic models: handling the physiological constraints using normal transformations

    Tsamandouras, N., Wendling, T., Rostami-Hochaghan, A., Galetin, A. & Aarons, L., Aug 2015, In : Journal of pharmacokinetics and pharmacodynamics. 42, 4, p. 349-373 24 p.

    Research output: Contribution to journalArticle

  3. Published

    Intravenous anakinra can achieve experimentally effective concentrations in the central nervous system within a therapeutic time window: Results of a dose-ranging study

    Galea, J., Ogungbenro, K., Hulme, S., Greenhalgh, A., Aarons, L., Scarth, S., Hutchinson, P., Grainger, S., King, A., Hopkins, S. J., Rothwell, N. & Tyrrell, P., Feb 2011, In : Journal of Cerebral Blood Flow and Metabolism. 31, 2, p. 439-447 8 p.

    Research output: Contribution to journalArticle

  4. Published

    Linking preclinical and clinical whole-body physiologically based pharmacokinetic models with prior distributions in NONMEM

    Langdon, G., Gueorguieva, I., Aarons, L. & Karlsson, M., May 2007, In : European journal of clinical pharmacology. 63, 5, p. 485-498 13 p.

    Research output: Contribution to journalArticle

  5. Published

    Lumping of whole-body physiologically based pharmacokinetic models

    Nestorov, I. A., Aarons, L. J., Arundel, P. A. & Rowland, M., 1998, In : Journal of pharmacokinetics and biopharmaceutics. 26, 1, p. 21-46 25 p.

    Research output: Contribution to journalArticle

  6. Published

    Markov chain Monte Carlo techniques for studying interoccasion and intersubject variability: Application to pharmacokinetic data

    Lunn, D. J. & Aarons, L. J., 1997, In : Journal of the Royal Statistical Society. Series C: Applied Statistics. 46, 1, p. 73-91 18 p.

    Research output: Contribution to journalArticle

  7. Published

    Mathematical model of T-cell lymphoblastic lymphoma: disease, treatment, cure or relapse of a virtual cohort of patients

    Eymard, N., Volpert, V., Kurbatova, P., Bessonov, N., Ogungbenro, K., Aarons, L., Janiaud, P., Bajard, A., Chabaud, S., Bertrand, Y., Kassa¨i, B., Cornu, C. & Nony, P., 16 Dec 2016, In : Mathematical Medicine and Biology. 35, 1, p. 1-23

    Research output: Contribution to journalArticle

  8. Published

    Mean residence time for drugs subject to enterohepatic cycling

    Shepard, T. A., Lockwood, G. F., Aarons, L. J. & Abrahams, I. D., Jun 1989, In : Journal of pharmacokinetics and biopharmaceutics. 17, 3, p. 327-345 18 p.

    Research output: Contribution to journalArticle

  9. Published

    Mefloquine pharmacokinetic-pharmacodynamic models: Implications for dosing and resistance

    Simpson, J. A., Watkins, E. R., Price, R. N., Aarons, L., Kyle, D. E. & White, N. J., 2000, In : Antimicrobial Agents and Chemotherapy. 44, 12, p. 3414-3424 10 p.

    Research output: Contribution to journalArticle

  10. Published

    Methodological approaches to the population analysis of toxicity data

    Aarons, L. & Graham, G., 31 Mar 2001, In : Toxicology Letters. 120, 1-3, p. 405-410 5 p.

    Research output: Contribution to journalArticle

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