Prof Leon AaronsBSc, MSc, PhD

Professor

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Publications

  1. 2016
  2. Published

    Forecasting oral absorption across biopharmaceutics classification system classes with physiologically based pharmacokinetic models

    Hansmann, S., Darwich, A., Margolskee, A., Aarons, L. & Dressman, J., 2016, In : Journal of Pharmacy and Pharmacology.

    Research output: Contribution to journalArticle

  3. Published

    IMI – oral biopharmaceutics tools project – evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds

    Margolskee, A., Darwich, A., Pepin, X., Pathak, S. M., Bolger et al, M. B., Aarons, L., Rostami-Hochaghan, A., Angstenberger, J., Graf, F., Laplanche, L., Muller, T., Carlert, S., Daga, P., Murphy, D., Tannergren, C., Yasin, M., Greschat-Schade, S., Muck, W., Muenster, U., van der Mey, D. & 27 othersFrank, K., Lloyd, R., Adriaenssen, L., Bevernage, J., De Zwart, L., Swerts, D., Tistaert, C., Van Den Bergh, A., Van Peer, A., Beato, S., Nguyen-Trung, A-T., Bennett, J., McAllister, M., Wong, M., Zane, P., Ollier, C., Vicat, P., Kolhmann, M., Marker, A., Brun, P., Mazuir, F., Beilles, S., Venczel, M., Boulenc, X., Loos, P., Lennernas, H. & Abrahamsson, B., 2016, In : European Journal of Pharmaceutical Sciences.

    Research output: Contribution to journalArticle

  4. Published

    IMI – Oral Biopharmaceutics Tools project – Evaluation of Bottom-up PBPK Prediction Success Part 2: An Introduction to the Simulation Exercise and Overview of Results

    Margolskee, A., Darwich, A., Aarons, L., Galetin, A., Rostami-Hochaghan, A., Carlert, S., Hammarberg, M., Hilgendorf, C., Johansson, P., Karlsson, E., Murphy, D., Tannergren, C., Thorn, H., Yasin, M., Mazuir, F., Nicolas, O., Ramusovic, S., Xu, C., Pathak, S., Korjamo, T. & 37 othersLaru, J., Malkki, J., Pappinen, S., Tuunainen, J., Dressman, J., Hansmann, S., Kostewicz, E., He, H., Heimbach, T., Wu, F., Hoft, C., Laplanche, L., Pang, Y., Bolger, M. B., Huehn, E., Lukacova, V., Mullin, J. M., Szeto, K. X., Costales, C., Lin, J., McAllister, M., Modi, S., Rotter, C., Varma, M., Wong, M., Mitra, A., Bevernage, J., Biewenga, J., Van Peer, A., Lloyd, R., Shardlow, C., Langguth, P., Mishenzon, I., Nguyen, M. A., Brown, J., Lennernas, H. & Abrahamsson, B., 2016, In : European Journal of Pharmaceutical Sciences.

    Research output: Contribution to journalArticle

  5. 2015
  6. Published

    What do we mean by identifiability in mixed effects models?

    Lavielle, M. & Aarons, L., 10 Dec 2015, In : Journal of pharmacokinetics and pharmacodynamics.

    Research output: Contribution to journalArticle

  7. Published

    Reduction of a Whole-Body Physiologically Based Pharmacokinetic Model to Stabilise the Bayesian Analysis of Clinical Data.

    Wendling, T., Tsamandouras, N., Dumitras, S., Pigeolet, E., Ogungbenro, K. & Aarons, L., 4 Nov 2015, In : The AAPS journal. 18, 1

    Research output: Contribution to journalArticle

  8. Published

    Application of a Bayesian approach to physiological modelling of mavoglurant population pharmacokinetics

    Wendling, T., Dumitras, S., Ogungbenro, K. & Aarons, L., 1 Aug 2015, In : Journal of pharmacokinetics and pharmacodynamics. 42, 6, p. 639-657 18 p.

    Research output: Contribution to journalArticle

  9. Published

    Incorporation of stochastic variability in mechanistic population pharmacokinetic models: handling the physiological constraints using normal transformations

    Tsamandouras, N., Wendling, T., Rostami-Hochaghan, A., Galetin, A. & Aarons, L., Aug 2015, In : Journal of pharmacokinetics and pharmacodynamics. 42, 4, p. 349-373 24 p.

    Research output: Contribution to journalArticle

  10. Published

    Physiologically based pharmacokinetic model for 6-mercpatopurine: exploring the role of genetic polymorphism in TPMT enzyme activity.

    Ogungbenro, K., Aarons, L., Bajard, A., Ballot, C., Bertrand, Y., Bretz, F., Caudri, D., Castellan, C., Chabaud, S., Cornu, C., Dufour, F., Eymard, N., Fisch, R., Guerrini, R., Jullien, V., Kassaï, B., Nony, P., Pérol, D., Pons, G., Tiddens, H. & 5 othersRosati, A., Alberti, C., Chiron, C., Kurbatova, P. & Nabbout, R., Jul 2015, In : British Journal of Clinical Pharmacology. 80, 1

    Research output: Contribution to journalArticle

  11. Published

    A reduced physiologically-based pharmacokinetic (PBPK) model for the prediction of regional gastrointestinal (GI) drug absorption

    Olivares Morales, A., Aarons, L. & Rostami, A., 2 Jun 2015, PAGE. Abstracts of the Annual Meeting of the Population Approach Group in Europe.. http://www.page-meeting.org/default.asp?abstract=3449: Population Approach Group in Europe

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  12. Published

    Translating Human Effective Jejunal Intestinal Permeability to Surface-Dependent Intrinsic Permeability: a Pragmatic Method for a More Mechanistic Prediction of Regional Oral Drug Absorption

    Olivares-Morales, A., Lennernäs, H., Aarons, L. & Rostami-Hodjegan, A., 19 May 2015, In : The A A P S Journal. 17, 5, p. 1177-1192 15 p.

    Research output: Contribution to journalArticle

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