Prof Leon AaronsBSc, MSc, PhD

Professor

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Publications

  1. 2017
  2. Published

    Modelling of atorvastatin pharmacokinetics and the identification of the effect of a BCRP polymorphism in the Japanese population

    Tsamandouras, N., Guo, Y., Wendling, T., Hall, S., Galetin, A. & Aarons, L., Jan 2017, In : Pharmacogenetics and Genomics. 27, 1, p. 27-38 12 p.

    Research output: Contribution to journalArticle

  3. Published

    Population Pharmacokinetics of Selumetinib and Its Metabolite N-desmethyl-selumetinib in Adult Patients With Advanced Solid Tumors and Children With Low-Grade Gliomas

    Patel, Y. T., Daryani, V. M., Patel, P., Zhou, D., Fangusaro, J., Carlile, D. J., Martin, P. D., Aarons, L. & Stewart, C. F., 2017, In : CPT: Pharmacometrics and Systems Pharmacology.

    Research output: Contribution to journalArticle

  4. Published

    Population pharmacokinetics of the MEK inhibitor selumetinib and its active N-desmethyl metabolite: Data from 10 phase I trials

    Patel, P., Howgate, E., Martin, P., Carlile, D. J., Aarons, L. & Zhou, D., 2017, In : British Journal of Clinical Pharmacology.

    Research output: Contribution to journalArticle

  5. Published

    Why has model-informed precision dosing not yet become common clinical reality? Lessons from the past and a roadmap for the future

    Darwich, A., Ogungbenro, K., Vinks, A. A., Powell, J. R., Reny, J-L., Marsousi, N., Daali, Y., Fairman, D., Cook, J., Lesko, L. J., McCune, J. S., Knibbe, C. A. J., de Wildt, S. N., Leeder, J. S., Neely, M. N., Zuppa, A. F., Vicini, P., Aarons, L., Johnson, T. N., Boiani, J. & 1 othersRostami-Hodjegan, A., 2017, In : Clinical Pharmacology & Therapeutics.

    Research output: Contribution to journalArticle

  6. 2016
  7. Published

    Mathematical model of T-cell lymphoblastic lymphoma: disease, treatment, cure or relapse of a virtual cohort of patients

    Eymard, N., Volpert, V., Kurbatova, P., Bessonov, N., Ogungbenro, K., Aarons, L., Janiaud, P., Bajard, A., Chabaud, S., Bertrand, Y., Kassa¨i, B., Cornu, C. & Nony, P., 16 Dec 2016, In : Mathematical Medicine and Biology. 35, 1, p. 1-23

    Research output: Contribution to journalArticle

  8. Published

    Development of a novel simplified PBPK absorption model to explain the higher relative bioavailability of the OROS® formulation of oxybutynin

    Olivares-Morales, A., Ghosh, A., Aarons, L. & Rostami-Hodjegan, A., Nov 2016, In : The AAPS journal. 18, 6, p. 1532-1549 18 p.

    Research output: Contribution to journalArticle

  9. Published

    Accounting for dropout in xenografted tumour efficacy studies: integrated endpoint analysis, reduced bias and better use of animals

    Martin, E., Aarons, L. & WT Yates, J., Jul 2016, In : Cancer Chemotherapy and Pharmacology. 78, 1, p. 131-141

    Research output: Contribution to journalArticle

  10. Published

    Predicting survival of pancreatic cancer patients treated with gemcitabine using longitudinal tumour size data

    Wendling, T., Mistry, H., Ogungbenro, K. & Aarons, L., 7 Mar 2016, In : Cancer Chemotherapy and Pharmacology. 77, 5, p. 927 938 p., 11.

    Research output: Contribution to journalArticle

  11. Published

    Deconvolution and IVIVC: Exploring the Role of Rate-Limiting Conditions

    Margolskee, A., Darwich, A. S., Galetin, A., Rostami, A. & Aarons, L., 2 Mar 2016, In : The A A P S Journal. 18, 2, p. 321-332 11 p.

    Research output: Contribution to journalArticle

  12. Published

    Designing More Efficient Preclinical Experiments: A Simulation Study in Chemotherapy-Induced Myelosupression

    Martin, E., Aarons, L. & Yates, J., 14 Feb 2016, In : Toxicological Sciences. 150, 1, p. 109-116 7 p.

    Research output: Contribution to journalArticle

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