Prof Leon AaronsBSc, MSc, PhD

Professor

Full contact details
View graph of relations

Publications

  1. 2018
  2. Published

    Establishment and validation of microsampling techniques in wild rodents for ecotoxicological research

    Imholt, C., Abdulla, T., Stevens, A., Edwards, P., Jacob, J., Woods, D., Rogers, E., Aarons, L. & Segelcke, D., Sep 2018, In : Journal of Applied Toxicology. 38, 9

    Research output: Contribution to journalArticle

  3. Published

    Ratifying the dosage and duration of levo-bupivacaine infusion by the caudal-epidural route in infants aged three to six months

    Vashisht, R., Bendon, A., Okonkwo, I., Darwich, A. & Aarons, L., May 2018, In : British Journal of Anaesthesia. 120, p. e11-e12 2 p.

    Research output: Contribution to journalMeeting Abstract

  4. Published

    A Study of the dosage and duration for levobupivacaine infusion by the caudal-epidural route in infants aged 3-6 months

    Vashisht, R., Bendon, A., Okonkwo, I., Patel, D., Fullwood, C., Ogungbenro, K., Aarons, L. & Darwich, A., 2018, In : Pediatric Anesthesia.

    Research output: Contribution to journalArticle

  5. Published

    Pharmacodynamic modelling of resistance to epidermal growth factor receptor inhibition in brain metastasis mouse models.

    Martin, E., Aarons, L. & Yates, J. W. T., 2018, In : Cancer Chemotherapy and Pharmacology.

    Research output: Contribution to journalArticle

  6. Published

    The Influence of Normalization Weight in Population Pharmacokinetic Covariate Models

    Goulooze, S. C., Voller, S., Valitalo, P. AJ., Calvier, E. AM., Aarons, L., Krekels, E. HJ. & Knibbe, C. A. J., 2018, In : Clinical Pharmacokinetics.

    Research output: Contribution to journalArticle

  7. Published

    Variance based global sensitivity analysis of physiologically based pharmacokinetic absorption models for BCS I–IV drugs

    Melillo, N., Aarons, L., Magni, P. & Darwich, A. S., 2018, In : Journal of pharmacokinetics and pharmacodynamics.

    Research output: Contribution to journalArticle

  8. 2017
  9. Published

    Whole body physiologically based modelling of β-blockers in the rat: events in tissues and plasma following an i.v. bolus dose

    Cheung, S. Y. A. ., Rodgers, T., Aarons, L., Gueorguieva, I., Dickinson, G. L., Murby, S., Brown, C., Collins, B. & Rowland, M., 22 Dec 2017, In : British Journal of Pharmacology . p. 1 17 p.

    Research output: Contribution to journalArticle

  10. Published

    Choosing an optimal input for an intravenous glucose tolerance test to aid parameter identification

    Martin, E., Yates, J. W. T., Ogungbenro, K. & Aarons, L., 5 Sep 2017, In : Journal of Pharmacy and Pharmacology. p. 1-9

    Research output: Contribution to journalArticle

  11. Published

    Assessment of Nevirapine Prophylactic and Therapeutic Dosing Regimens for Neonates

    Cressey, T. R., Punyawudho, B., Le Coeur, S., Jourdain, G., Saenjum, C., Capparelli, E. V., Jittayanun, K., Phanomcheong, S., Luvira, A., Borkird, T., Puangsombat, A., Aarons, L., Sukrakanchana, P. O., Urien, S., Lallemant, M., Sangsawang, S., Achalapong, J., Preedisripipat, K., Putiyanun, C., Wanchaitanawong, V. & 31 others, Yuthavisuthi, P., Ngampiyaskul, C., Kanjanavikai, P., Chotivanich, N., Hongsiriwon, S., Suwankornsakul, W., Sreshthatat, P., Kanjanasing, A., Kwanchaipanich, R., Rawangban, B., Santadusit, S., Jarupanich, T., Warachit, B., Siriwachirachai, T., Rojanakarin, P., Vivatpatanakul, K., Hanpinitsak, S., Wanasiri, P., Srirojana, S., Kongpanichkul, R., Bunjongpak, S., Sabsanong, P., Liampongsabuddhi, P., Pongdetudom, K., Khamja, P., Akarathum, N., Phonin, S. A., Limpitikul, W., Jungpipun, J., Petprakorp, R. & The PHPT-5 study team, 15 Aug 2017, In : Journal of Acquired Immune Deficiency Syndromes. 75, 5, p. 554-560 7 p.

    Research output: Contribution to journalArticle

  12. Published

    IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

    Darwich, A., Aarons, L., Galetin, A., Rostami-Hochaghan et al, A., Margolskee, A., Pepin, X., Carlert, S., Hammarberg, M., Hilgendorf, C., Johansson, P., Karlsson, E., Murphy, D., Tannergren, C., Thorn, H., Yasin, M., Mazuir, F., Nicolas, O., Ramusovic, S., Xu, C., Pathak, S. & 43 others, Korjamo, T., Laru, J., Malkki, J., Pappinen, S., Tuunainen, J., Dressman, J., Hansmann, S., Kostewicz, E. S., He, H., Heimbach, T., Wu, F., Hoft, C., Pang, Y., Bolger, M., Huehn, E., Heimbach, T., Wu, F., Hoft, C., Pang, Y., Bolger, M. B., Huehn, E., Lukacova, V., Mullin, J. M., Szeto, K. X., Costales, C., Lin, J., McAllister, M., Modi, S., Rotter, C., Varma, M., Wong, M., Mitra, A., Bevernage, J., Biewenga, J., Peer, A. V., Lloyd, R., Shardlow, C., Langguth, P., Mishenzon, I., Nguyen, M. A., Brown, J., Lennerans, H. & Abrahmsson, B., 1 Jan 2017, In : European Journal of Pharmaceutical Sciences. 96, p. 626-642 17 p.

    Research output: Contribution to journalArticle

  13. Published

    Modelling of atorvastatin pharmacokinetics and the identification of the effect of a BCRP polymorphism in the Japanese population

    Tsamandouras, N., Guo, Y., Wendling, T., Hall, S., Galetin, A. & Aarons, L., Jan 2017, In : Pharmacogenetics and Genomics. 27, 1, p. 27-38 12 p.

    Research output: Contribution to journalArticle

  14. Published

    Population Pharmacokinetics of Selumetinib and Its Metabolite N-desmethyl-selumetinib in Adult Patients With Advanced Solid Tumors and Children With Low-Grade Gliomas

    Patel, Y. T., Daryani, V. M., Patel, P., Zhou, D., Fangusaro, J., Carlile, D. J., Martin, P. D., Aarons, L. & Stewart, C. F., 2017, In : CPT: Pharmacometrics and Systems Pharmacology.

    Research output: Contribution to journalArticle

  15. Published

    Population pharmacokinetics of the MEK inhibitor selumetinib and its active N-desmethyl metabolite: Data from 10 phase I trials

    Patel, P., Howgate, E., Martin, P., Carlile, D. J., Aarons, L. & Zhou, D., 2017, In : British Journal of Clinical Pharmacology.

    Research output: Contribution to journalArticle

  16. Published

    Why has model-informed precision dosing not yet become common clinical reality? Lessons from the past and a roadmap for the future

    Darwich, A., Ogungbenro, K., Vinks, A. A., Powell, J. R., Reny, J-L., Marsousi, N., Daali, Y., Fairman, D., Cook, J., Lesko, L. J., McCune, J. S., Knibbe, C. A. J., de Wildt, S. N., Leeder, J. S., Neely, M. N., Zuppa, A. F., Vicini, P., Aarons, L., Johnson, T. N., Boiani, J. & 1 others, Rostami-Hodjegan, A., 2017, In : Clinical Pharmacology & Therapeutics.

    Research output: Contribution to journalArticle

  17. 2016
  18. Published

    Mathematical model of T-cell lymphoblastic lymphoma: disease, treatment, cure or relapse of a virtual cohort of patients

    Eymard, N., Volpert, V., Kurbatova, P., Bessonov, N., Ogungbenro, K., Aarons, L., Janiaud, P., Bajard, A., Chabaud, S., Bertrand, Y., Kassa¨i, B., Cornu, C. & Nony, P., 16 Dec 2016, In : Mathematical Medicine and Biology. 35, 1, p. 1-23

    Research output: Contribution to journalArticle

  19. Published

    Development of a novel simplified PBPK absorption model to explain the higher relative bioavailability of the OROS® formulation of oxybutynin

    Olivares-Morales, A., Ghosh, A., Aarons, L. & Rostami-Hodjegan, A., Nov 2016, In : The AAPS journal. 18, 6, p. 1532-1549 18 p.

    Research output: Contribution to journalArticle

  20. Published

    Accounting for dropout in xenografted tumour efficacy studies: integrated endpoint analysis, reduced bias and better use of animals

    Martin, E., Aarons, L. & WT Yates, J., Jul 2016, In : Cancer Chemotherapy and Pharmacology. 78, 1, p. 131-141

    Research output: Contribution to journalArticle

  21. Published

    Predicting survival of pancreatic cancer patients treated with gemcitabine using longitudinal tumour size data

    Wendling, T., Mistry, H., Ogungbenro, K. & Aarons, L., 7 Mar 2016, In : Cancer Chemotherapy and Pharmacology. 77, 5, p. 927 938 p., 11.

    Research output: Contribution to journalArticle

  22. Published

    Deconvolution and IVIVC: Exploring the Role of Rate-Limiting Conditions

    Margolskee, A., Darwich, A. S., Galetin, A., Rostami, A. & Aarons, L., 2 Mar 2016, In : The A A P S Journal. 18, 2, p. 321-332 11 p.

    Research output: Contribution to journalArticle

  23. Published

    Designing More Efficient Preclinical Experiments: A Simulation Study in Chemotherapy-Induced Myelosupression

    Martin, E., Aarons, L. & Yates, J., 14 Feb 2016, In : Toxicological Sciences. 150, 1, p. 109-116 7 p.

    Research output: Contribution to journalArticle

  24. Published

    Forecasting oral absorption across biopharmaceutics classification system classes with physiologically based pharmacokinetic models

    Hansmann, S., Darwich, A., Margolskee, A., Aarons, L. & Dressman, J., 2016, In : Journal of Pharmacy and Pharmacology.

    Research output: Contribution to journalArticle

  25. Published

    IMI – oral biopharmaceutics tools project – evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds

    Margolskee, A., Darwich, A., Pepin, X., Pathak, S. M., Bolger et al, M. B., Aarons, L., Rostami-Hochaghan, A., Angstenberger, J., Graf, F., Laplanche, L., Muller, T., Carlert, S., Daga, P., Murphy, D., Tannergren, C., Yasin, M., Greschat-Schade, S., Muck, W., Muenster, U., van der Mey, D. & 27 others, Frank, K., Lloyd, R., Adriaenssen, L., Bevernage, J., De Zwart, L., Swerts, D., Tistaert, C., Van Den Bergh, A., Van Peer, A., Beato, S., Nguyen-Trung, A-T., Bennett, J., McAllister, M., Wong, M., Zane, P., Ollier, C., Vicat, P., Kolhmann, M., Marker, A., Brun, P., Mazuir, F., Beilles, S., Venczel, M., Boulenc, X., Loos, P., Lennernas, H. & Abrahamsson, B., 2016, In : European Journal of Pharmaceutical Sciences.

    Research output: Contribution to journalArticle

  26. Published

    IMI – Oral Biopharmaceutics Tools project – Evaluation of Bottom-up PBPK Prediction Success Part 2: An Introduction to the Simulation Exercise and Overview of Results

    Margolskee, A., Darwich, A., Aarons, L., Galetin, A., Rostami-Hochaghan, A., Carlert, S., Hammarberg, M., Hilgendorf, C., Johansson, P., Karlsson, E., Murphy, D., Tannergren, C., Thorn, H., Yasin, M., Mazuir, F., Nicolas, O., Ramusovic, S., Xu, C., Pathak, S., Korjamo, T. & 37 others, Laru, J., Malkki, J., Pappinen, S., Tuunainen, J., Dressman, J., Hansmann, S., Kostewicz, E., He, H., Heimbach, T., Wu, F., Hoft, C., Laplanche, L., Pang, Y., Bolger, M. B., Huehn, E., Lukacova, V., Mullin, J. M., Szeto, K. X., Costales, C., Lin, J., McAllister, M., Modi, S., Rotter, C., Varma, M., Wong, M., Mitra, A., Bevernage, J., Biewenga, J., Van Peer, A., Lloyd, R., Shardlow, C., Langguth, P., Mishenzon, I., Nguyen, M. A., Brown, J., Lennernas, H. & Abrahamsson, B., 2016, In : European Journal of Pharmaceutical Sciences.

    Research output: Contribution to journalArticle

  27. 2015
  28. Published

    What do we mean by identifiability in mixed effects models?

    Lavielle, M. & Aarons, L., 10 Dec 2015, In : Journal of pharmacokinetics and pharmacodynamics.

    Research output: Contribution to journalArticle

  29. Published

    Reduction of a Whole-Body Physiologically Based Pharmacokinetic Model to Stabilise the Bayesian Analysis of Clinical Data.

    Wendling, T., Tsamandouras, N., Dumitras, S., Pigeolet, E., Ogungbenro, K. & Aarons, L., 4 Nov 2015, In : The AAPS journal. 18, 1

    Research output: Contribution to journalArticle

  30. Published

    Application of a Bayesian approach to physiological modelling of mavoglurant population pharmacokinetics

    Wendling, T., Dumitras, S., Ogungbenro, K. & Aarons, L., 1 Aug 2015, In : Journal of pharmacokinetics and pharmacodynamics. 42, 6, p. 639-657 18 p.

    Research output: Contribution to journalArticle

  31. Published

    Incorporation of stochastic variability in mechanistic population pharmacokinetic models: handling the physiological constraints using normal transformations

    Tsamandouras, N., Wendling, T., Rostami-Hochaghan, A., Galetin, A. & Aarons, L., Aug 2015, In : Journal of pharmacokinetics and pharmacodynamics. 42, 4, p. 349-373 24 p.

    Research output: Contribution to journalArticle

  32. Published

    Physiologically based pharmacokinetic model for 6-mercpatopurine: exploring the role of genetic polymorphism in TPMT enzyme activity.

    Ogungbenro, K., Aarons, L., Bajard, A., Ballot, C., Bertrand, Y., Bretz, F., Caudri, D., Castellan, C., Chabaud, S., Cornu, C., Dufour, F., Eymard, N., Fisch, R., Guerrini, R., Jullien, V., Kassaï, B., Nony, P., Pérol, D., Pons, G., Tiddens, H. & 5 others, Rosati, A., Alberti, C., Chiron, C., Kurbatova, P. & Nabbout, R., Jul 2015, In : British Journal of Clinical Pharmacology. 80, 1

    Research output: Contribution to journalArticle

  33. Published

    A reduced physiologically-based pharmacokinetic (PBPK) model for the prediction of regional gastrointestinal (GI) drug absorption

    Olivares Morales, A., Aarons, L. & Rostami, A., 2 Jun 2015, PAGE. Abstracts of the Annual Meeting of the Population Approach Group in Europe.. http://www.page-meeting.org/default.asp?abstract=3449: Population Approach Group in Europe

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  34. Published

    Translating Human Effective Jejunal Intestinal Permeability to Surface-Dependent Intrinsic Permeability: a Pragmatic Method for a More Mechanistic Prediction of Regional Oral Drug Absorption

    Olivares-Morales, A., Lennernäs, H., Aarons, L. & Rostami-Hodjegan, A., 19 May 2015, In : The A A P S Journal. 17, 5, p. 1177-1192 15 p.

    Research output: Contribution to journalArticle

  35. Published

    Model of mucociliary clearance in cystic fibrosis lungs.

    Kurbatova, P., Bessonov, N., Volpert, V., Tiddens, H. A. W. M., Cornu, C., Nony, P., Caudri, D., Aarons, L., Bajard, A., Bertrand, Y., Bretz, F., Castellan, C., Chabaud, S., Cornu, C., Dufour, F., Eymard, N., Fisch, R., Guerrini, R., Kassai, B., Kurbatova, P. & 13 others, Malik, S., Nony, P., Ogungbenro, K., Pérol, D., Pons, G., Tiddens, H., Rosati, A., Alberti, C., Chiron, C., Nabbout, R., Jullien, V., Benquet, P. & Wendling, F., 7 May 2015, In : Journal of Theoretical Biology. 372

    Research output: Contribution to journalArticle

  36. Published

    Model-based evaluation of the impact of formulation and food intake on the complex oral absorption of mavoglurant in healthy subjects.

    Wendling, T., Ogungbenro, K., Pigeolet, E., Dumitras, S., Woessner, R. & Aarons, L., May 2015, In : Pharmaceutical Research. 32, 5, p. 1764-1778 14 p.

    Research output: Contribution to journalArticle

  37. Published

    Analysis of the impact of controlled release formulation on oral drug absorption, gut wall metabolism and relative bioavailability of CYP3A substrates using a physiologically-based pharmacokinetic model

    Olivares-Morales, A., Kamiyama, Y., Darwich, A. S., Aarons, L. & Rostami, A., 25 Jan 2015, In : European Journal of Pharmaceutical Sciences. 67, p. 32-44 12 p.

    Research output: Contribution to journalArticle

  38. Published

    Empirical and semi-mechanistic modelling of double-peaked pharmacokinetic profile phenomenon due to gastric emptying.

    Ogungbenro, K., Pertinez, H. & Aarons, L., Jan 2015, In : The AAPS journal. 17, 1

    Research output: Contribution to journalArticle

  39. Published

    Combining the "bottom-up" and "top-down" approaches in pharmacokinetic modelling: Fitting PBPK models to observed clinical data

    Tsamandouras, N., Rostami-Hochaghan, A. & Aarons, L., 2015, In : British Journal of Clinical Pharmacology. 79, 1, p. 48-55 7 p.

    Research output: Contribution to journalArticle

  40. Published

    Development and Application of a Mechanistic Pharmacokinetic Model for Simvastatin and its Active Metabolite Simvastatin Acid Using an Integrated Population PBPK Approach

    Tsamandouras, N., Dickinson, G., Guo, Y., Hall, S., Rostami-Hochaghan, A., Galetin, A. & Aarons, L., 2015, In : Pharmaceutical Research. 32, 6, p. 1864-1883 19 p., 1573-904X.

    Research output: Contribution to journalArticle

  41. 2014
  42. Published
  43. Published

    A physiologically based pharmacokinetic model for Valproic acid in adults and children.

    Ogungbenro, K., Aarons, L., Bajard, A., Ballot, C., Bertrand, Y., Bretz, F., Caudri, D., Castellan, C., Chabaud, S., Cornu, C., Dufour, F., Eymard, N., Fisch, R., Guerrini, R., Jullien, V., Kassaï, B., Nony, P., Pérol, D., Pons, G., Tiddens, H. & 5 others, Rosati, A., Alberti, C., Chiron, C., Kurbatova, P. & Nabbout, R., 15 Oct 2014, In : European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 63, p. 45-52 7 p.

    Research output: Contribution to journalArticle

  44. Published

    A Physiologically Based Pharmacokinetic Model for Clobazam and Stiripentol in Adults and Children

    Ogungbenro, K., Aarons, L. & Epi-CRESim Project Groups, 23 Jul 2014, In : Pharmaceutical Research. 32, 1, p. 144-157 13 p.

    Research output: Contribution to journalArticle

  45. Published

    Critical Analysis and Communication: an alternative to the final year project

    Barber, J., Demonacos, C., Aarons, L., Steinke, D. & Tully, M., 30 Jun 2014, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  46. Published

    Oral biopharmaceutics tools - Time for a new initiative - An introduction to the IMI project OrBiTo

    Lennernäs, H., Aarons, L., Augustijns, P., Beato, S., Bolger, M., Box, K., Brewster, M., Butler, J., Dressman, J., Holm, R., Julia Frank, K., Kendall, R., Langguth, P., Sydor, J., Lindahl, A., McAllister, M., Muenster, U., Müllertz, A., Ojala, K., Pepin, X. & 7 others, Reppas, C., Rostami-Hodjegan, A., Verwei, M., Weitschies, W., Wilson, C., Karlsson, C. & Abrahamsson, B., 16 Jun 2014, In : European Journal of Pharmaceutical Sciences. 57, 1, p. 292-299 7 p.

    Research output: Contribution to journalArticle

  47. Published

    PBPK models for the prediction of in vivo performance of oral dosage forms

    Kostewicz, E. S., Aarons, L., Bergstrand, M., Bolger, M. B., Galetin, A., Hatley, O., Jamei, M., Lloyd, R., Pepin, X., Rostami-Hodjegan, A., Sjögren, E., Tannergren, C., Turner, D. B., Wagner, C., Weitschies, W. & Dressman, J., 16 Jun 2014, In : European Journal of Pharmaceutical Sciences. 57, 1, p. 300-321 21 p.

    Research output: Contribution to journalArticle

  48. Published
  49. Published

    Handling Missing Data in a Duloxetine Population Pharmacokinetic/Pharmacodynamic Model - Imputation Methods and Selection Models

    Yuen, E., Gueorguieva, I. & Aarons, L., 3 May 2014, In : Pharmaceutical Research.

    Research output: Contribution to journalArticle

  50. Published

    Physiologically based pharmacokinetic modelling of methotrexate and 6-mercaptopurine in adults and children. Part 1: methotrexate.

    Ogungbenro, K. & Aarons, L., Apr 2014, In : Journal of pharmacokinetics and pharmacodynamics. 41, 2, p. 159-171 12 p.

    Research output: Contribution to journalArticle

  51. Published

    Physiologically based pharmacokinetic modelling of methotrexate and 6-mercaptopurine in adults and children. Part 2: 6-mercaptopurine and its interaction with methotrexate.

    Ogungbenro, K. & Aarons, L., Apr 2014, In : Journal of pharmacokinetics and pharmacodynamics. 41, 2, p. 173-185 12 p.

    Research output: Contribution to journalArticle

  52. Published

    A methodological framework for drug development in rare diseases.

    Volpert, V., Eymard, N., Kassai, B., Aarons, L., Bajard, A., Ballot, C., Bertrand, Y., Bretz, F., Caudri, D., Castellan, C., Malik, S., Chabaud, S., Cornu, C., Dufour, F., Dunger-Baldauf, C., Dupont, J-M., Fisch, R., Guerrini, R., Kassaï, B., Nony, P. & 12 others, Ogungbenro, K., Pérol, D., Pons, G., Tiddens, H., Rosati, A., Alberti, C., Chiron, C., Kurbatova, P., Nabbout, R., Jullien, V., Benquet, P. & Wendling, F., 2014, In : Orphanet Journal of Rare Diseases. 9

    Research output: Contribution to journalArticle

  53. Published

    Critical Analysis and Communication: An Alternative to the Research Project

    Demonacos, C., Aarons, L. & Barber, J., 2014, In : Health & Social Care Education. p. 1-5 4 p.

    Research output: Contribution to journalArticle

  54. Published

    Identification of the effect of multiple polymorphisms on the pharmacokinetics of Simvastatin and Simvastatin acid using a population-modeling approach

    Tsamandouras, N., Dickinson, G., Guo, Y., Hall, S., Rostami-Hodjegan, A., Galetin, A. & Aarons, L., 2014, In : Clinical Pharmacology and Therapeutics. 96, 1, p. 90-100 10 p.

    Research output: Contribution to journalArticle

  55. Published

    Precision criteria to derive sample size when designing pediatric pharmacokinetic studies: Which measure of variability should be used?

    Salem, F., Ogungbenro, K., Vajjah, P., Johnson, T. N., Aarons, L. & Rostami-Hodjegan, A., 2014, In : Journal of Clinical Pharmacology. 54, 3, p. 311-317 6 p.

    Research output: Contribution to journalArticle

  56. 2013
  57. Published

    Can BDDCS Class be used to explain differences in the prediction of human oral bioavailability from animal data using a threshold-based model?

    Olivares Morales, A., Hatley, OJD., Turner, D., Galetin, A., Aarons, L. & Rostami, A., Nov 2013.

    Research output: Contribution to conferencePoster

  58. Published

    Qualitative model for the prediction of high/low human oral bioavailability from animal bioavailability data employing ROC analysis

    Olivares-Morales, A., Hatley, OJD., Turner, D., Galetin, A., Aarons, L. & Rostami, A., Nov 2013.

    Research output: Contribution to conferencePoster

  59. Published

    Development and evaluation of a classification tool for the qualitative prediction of oral bioavailability from animal data

    Olivares Morales, A., Hatley, OJD., Turner, D., Galetin, A., Aarons, L. & Rostami, A., Oct 2013.

    Research output: Contribution to conferenceOther

  60. Published

    The Use of ROC Analysis for the Qualitative Prediction of Human Oral Bioavailability from Animal Data

    Olivares-Morales, A., Hatley, O. J. D., Turner, D., Galetin, A., Aarons, L. & Rostami-Hodjegan, A., 27 Sep 2013, In : Pharmaceutical Research. 31, 3, p. 720-730 10 p.

    Research output: Contribution to journalArticle

  61. Published

    Qualitative prediction of human oral bioavailability from animal oral bioavailability data employing ROC analysis

    Olivares Morales, A., Hatley, OJD., Turner, D., Galetin, A., Aarons, L. & Rostami, A., 14 Jun 2013.

    Research output: Contribution to conferencePoster

  62. Published

    Qualitative model for the prediction of high/low human oral bioavailability from animal bioavailability data employing ROC analysis

    Olivares Morales, A., Hatley, OJD., Turner, D., Galetin, A., Aarons, L. & Rostami, A., Jun 2013.

    Research output: Contribution to conferencePoster

  63. Published

    Population pharmacokinetic/pharmacodynamic models for duloxetine in the treatment of diabetic peripheral neuropathic pain

    Yuen, E., Gueorguieva, I., Bueno-Burgos, L., Iyengar, S. & Aarons, L., Mar 2013, In : European Journal of Pain. 17, 3, p. 382-393 11 p.

    Research output: Contribution to journalArticle

  64. Published

    Modeling and simulation in clinical pharmacology and dose finding

    Staab, A., Rook, E., Maliepaard, M., Aarons, L. & Benson, C., Feb 2013, In : CPT: Pharmacometrics and Systems Pharmacology. 2, 2, e29.

    Research output: Contribution to journalArticle

  65. Published

    The design and analysis of parallel experiments to produce structurally identifiable models

    Cheung, S. Y. A., Yates, J. W. T. & Aarons, L., Feb 2013, In : Journal of pharmacokinetics and pharmacodynamics. 40, 1, p. 93-100 7 p.

    Research output: Contribution to journalArticle

  66. 2012
  67. Published

    Population pharmacokinetics of halofantrine in healthy volunteers and patients with symptomatic falciparum malaria

    Klein, K., Aarons, L., Ter Kuile, F. O., Nosten, F., White, N. J., Edstein, M. D. & Teja-Isavadharm, P., Nov 2012, In : Journal of Pharmacy and Pharmacology. 64, 11, p. 1603-1613 10 p.

    Research output: Contribution to journalArticle

  68. Published

    Structural identifiability analysis and reparameterisation (parameter reduction) of a cardiovascular feedback model

    Cheung, S. Y. A., Majid, O., Yates, J. W. T. & Aarons, L., 16 Jul 2012, In : European Journal of Pharmaceutical Sciences. 46, 4, p. 259-271 12 p.

    Research output: Contribution to journalArticle

  69. Published

    Population pharmacokinetic modelling of S-warfarin to evaluate the design of drug-drug interaction studies for CYP2C9

    Klein, K., Gueorguieva, I. & Aarons, L., Apr 2012, In : Journal of pharmacokinetics and pharmacodynamics. 39, 2, p. 147-160 13 p.

    Research output: Contribution to journalArticle

  70. Published

    Comparison of in-vivo and in-silico methods used for prediction of tissue: Plasma partition coefficients in rat

    Graham, H., Walker, M., Jones, O., Yates, J., Galetin, A. & Aarons, L., Mar 2012, In : Journal of Pharmacy and Pharmacology. 64, 3, p. 383-396 13 p.

    Research output: Contribution to journalArticle

  71. Published

    A semi-mechanistic gastric emptying pharmacokinetic model for 13C-octanoic acid: An evaluation using simulation

    Ogungbenro, K. & Aarons, L., 14 Feb 2012, In : European Journal of Pharmaceutical Sciences. 45, 3, p. 302-310 8 p.

    Research output: Contribution to journalArticle

  72. Published

    The population pharmacokinetics of R- and S-warfarin: Effect of genetic and clinical factors

    Lane, S., Al-Zubiedi, S., Hatch, E., Matthews, I., Jorgensen, A. L., Deloukas, P., Daly, A. K., Park, B. K., Aarons, L., Ogungbenro, K., Kamali, F., Hughes, D. & Pirmohamed, M., Jan 2012, In : British Journal of Clinical Pharmacology. 73, 1, p. 66-76 10 p.

    Research output: Contribution to journalArticle

  73. 2011
  74. Published

    Population pharmacokinetic analysis of ropivacaine and its metabolite 2′,6′-pipecoloxylidide from pooled data in neonates, infants, and children

    Aarons, L., Sadler, B., Pitsiu, M., Sjövall, J., Henriksson, J. & Molnár, V., Sep 2011, In : British Journal of Anaesthesia. 107, 3, p. 409-424 15 p.

    Research output: Contribution to journalArticle

  75. Published

    Population Fisher information matrix and optimal design of discrete data responses in population pharmacodynamic experiments

    Ogungbenro, K. & Aarons, L., Aug 2011, In : Journal of pharmacokinetics and pharmacodynamics. 38, 4, p. 449-469 20 p.

    Research output: Contribution to journalArticle

  76. Published

    Sequential population pharmacokinetic modeling of lopinavir and ritonavir in healthy volunteers and assessment of different dosing strategies

    Dickinson, L., Boffito, M., Back, D., Else, L., Von Hentig, N., Davies, G., Khoo, S., Pozniak, A., Moyle, G. & Aarons, L., Jun 2011, In : Antimicrobial Agents and Chemotherapy. 55, 6, p. 2775-2782 7 p.

    Research output: Contribution to journalArticle

  77. Published

    Structural identifiability analysis of pharmacokinetic models using DAISY: Semi-mechanistic gastric emptying models for 13C-octanoic acid

    Ogungbenro, K. & Aarons, L., Apr 2011, In : Journal of pharmacokinetics and pharmacodynamics. 38, 2, p. 279-292 13 p.

    Research output: Contribution to journalArticle

  78. Published

    A semi-mechanistic gastric emptying model for the population pharmacokinetic analysis of orally administered acetaminophen in critically ill patients

    Ogungbenro, K., Vasist, L., Maclaren, R., Dukes, G., Young, M. & Aarons, L., Feb 2011, In : Pharmaceutical Research. 28, 2, p. 394-404 10 p.

    Research output: Contribution to journalArticle

  79. Published

    Critique of the two-fold measure of prediction success for ratios: Application for the assessment of drug-drug interactions

    Guest, E. J., Aarons, L., Houston, J. B., Rostami-Hodjegan, A. & Galetin, A., Feb 2011, In : Drug Metabolism and Disposition. 39, 2, p. 170-173 3 p.

    Research output: Contribution to journalArticle

  80. Published

    Intravenous anakinra can achieve experimentally effective concentrations in the central nervous system within a therapeutic time window: Results of a dose-ranging study

    Galea, J., Ogungbenro, K., Hulme, S., Greenhalgh, A., Aarons, L., Scarth, S., Hutchinson, P., Grainger, S., King, A., Hopkins, S. J., Rothwell, N. & Tyrrell, P., Feb 2011, In : Journal of Cerebral Blood Flow and Metabolism. 31, 2, p. 439-447 8 p.

    Research output: Contribution to journalArticle

  81. Published

    Corticosteroid-binding globulin regulates cortisol pharmacokinetics

    Perogamvros, I., Aarons, L., Miller, A. G., Trainer, P. J. & Ray, D. W., Jan 2011, In : Clinical Endocrinology. 74, 1, p. 30-36 6 p.

    Research output: Contribution to journalArticle

  82. Published

    Phase I pharmacokinetic and pharmacodynamic study of the bioreductive drug RH1

    Danson, S. J., Johnson, P., Ward, T. H., Dawson, M., Denneny, O., Dickinson, G., Aarons, L., Watson, A., Jowle, D., Cummings, J., Robson, L., Halbert, G., Dive, C. & Ranson, M., 2011, In : Annals of Oncology. 22, 7, p. 1653-1660 7 p.

    Research output: Contribution to journalArticle

  83. 2010
  84. Published

    Development of a novel method for updating the predicted partition coefficient values generated by an existing in silico prediction method

    Graham, H., Yates, J., Galetin, A. & Aarons, L., Nov 2010, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  85. Published

    Sample-size calculations for multi-group comparison in population pharmacokinetic experiments

    Ogungbenro, K. & Aarons, L., Oct 2010, In : Pharmaceutical Statistics. 9, 4, p. 255-268 13 p.

    Research output: Contribution to journalArticle

  86. Published

    Sample size/power calculations for population pharmacodynamic experiments involving repeated-count measurements

    Ogungbenro, K. & Aarons, L., Sep 2010, In : Journal of Biopharmaceutical Statistics. 20, 5, p. 1026-1042 16 p.

    Research output: Contribution to journalArticle

  87. Published

    Optimal design of pharmacokinetic studies

    Aarons, L. & Ogungbenro, K., Mar 2010, In : Basic and Clinical Pharmacology and Toxicology. 106, 3, p. 250-255 5 p.

    Research output: Contribution to journalArticle

  88. Published
  89. Published

    Ethnic differences in the population pharmacokinetics and pharmacodynamics of warfarin

    Yuen, E., Gueorguieva, I., Wise, S., Soon, D. & Aarons, L., Feb 2010, In : Journal of pharmacokinetics and pharmacodynamics. 37, 1, p. 3-24 21 p.

    Research output: Contribution to journalArticle

  90. Published

    Sample size/power calculations for repeated ordinal measurements in population pharmacodynamic experiments

    Ogungbenro, K. & Aarons, L., Feb 2010, In : Journal of pharmacokinetics and pharmacodynamics. 37, 1, p. 67-83 16 p.

    Research output: Contribution to journalArticle

  91. Published

    Population Pharmacokinetic Modeling of Acetaminophen (APAP), A Surrogate for Gastric Emptying, in Critically Ill Patients Tolerant And Intolerant To Enteral Nutrition

    Ogungbenro, K., MacLaren, R., Dukes, G., Young, M., Aarons, L. & Vasist, LS., 2010, In : Clinical Pharmacology and Therapeutics. 87, p. S1-S7

    Research output: Contribution to journalArticle

  92. 2009
  93. Published

    Comparison of in vivo and in silico methods to predict tissue:plasma partition coefficients in rat

    Graham, H., Jones, O., Galetin, A. & Aarons, L., 25 Nov 2009, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  94. Published
  95. Published
  96. Published

    Population pharmacokinetics and optimal design of paediatric studies for famciclovir

    Ogungbenro, K., Matthews, I., Looby, M., Kaiser, G., Graham, G. & Aarons, L., Oct 2009, In : British Journal of Clinical Pharmacology. 68, 4, p. 546-560 14 p.

    Research output: Contribution to journalArticle

  97. Published

    Application of optimal design methodologies in clinical pharmacology experiments

    Ogungbenro, K., Dokoumetzidis, A. & Aarons, L., Jul 2009, In : Pharmaceutical Statistics. 8, 3, p. 239-252 13 p.

    Research output: Contribution to journalArticle

  98. Published
  99. Published

    Phase I trial of AEG35156 administered as a 7-day and 3-day continuous intravenous infusion in patients with advanced refractory cancer

    Ranson, M., Dean, E., Jodrell, D., Connolly, K., Danson, S., Jolivet, J., Durkin, J., Morris, S., Jowle, D., Ward, T., Cummings, J., Dickinson, G., Aarons, L., LaCasse, E., Robson, L. & Dive, C., 1 Apr 2009, In : Journal of Clinical Oncology. 27, 10, p. 1660-1666 6 p.

    Research output: Contribution to journalArticle

  100. Published
  101. Published

    An effective approach for obtaining optimal sampling windows for population pharmacokinetic experiments

    Ogungbenro, K. & Aarons, L., Jan 2009, In : Journal of Biopharmaceutical Statistics. 19, 1, p. 174-189 15 p.

    Research output: Contribution to journalArticle

  102. Published

    Population pharmacokinetics of ritonavir-boosted atazanavir in HIV-infected patients and healthy volunteers

    Dickinson, L., Boffito, M., Back, D., Waters, L., Else, L., Davies, G., Khoo, S., Pozniak, A. & Aarons, L., 2009, In : Journal of Antimicrobial Chemotherapy. 63, 6, p. 1233-1243 10 p.

    Research output: Contribution to journalArticle

  103. 2008
  104. Published
  105. Published

    Drug-drug interaction predictions with PBPK models and optimal multiresponse sampling time designs: Application to midazolam and a phase i compound. Part 2: Clinical trial results

    Chenel, M., Bouzom, F., Cazade, F., Ogungbenro, K., Aarons, L. & Mentré, F., Dec 2008, In : Journal of pharmacokinetics and pharmacodynamics. 35, 6, p. 661-681 20 p.

    Research output: Contribution to journalArticle

  106. Published

    Sample size calculations for population pharmacodynamic experiments involving repeated dichotomous observations

    Ogungbenro, K. & Aarons, L., Nov 2008, In : Journal of Biopharmaceutical Statistics. 18, 6, p. 1212-1227 15 p.

    Research output: Contribution to journalArticle

  107. Published

    Optimisation of sampling windows design for population pharmacokinetic experiments

    Ogungbenro, K. & Aarons, L., Aug 2008, In : Journal of pharmacokinetics and pharmacodynamics. 35, 4, p. 465-482 17 p.

    Research output: Contribution to journalArticle

  108. Published

    Analytical expressions for combining population pharmacokinetic parameters from different studies

    Dokoumetzidis, A. & Aarons, L., Jul 2008, In : Journal of Biopharmaceutical Statistics. 18, 4, p. 662-676 14 p.

    Research output: Contribution to journalArticle

  109. Published

    How many subjects are necessary for population pharmacokinetic experiments? Confidence interval approach

    Ogungbenro, K. & Aarons, L., Jul 2008, In : European journal of clinical pharmacology. 64, 7, p. 705-713 8 p.

    Research output: Contribution to journalArticle

  110. Published

    Pharmacokinetic analysis to assess forgiveness of boosted saquinavir regimens for missed or late dosing

    Dickinson, L., Boffito, M., Khoo, S. H., Schutz, M., Aarons, L. J., Pozniak, A. L. & Back, D. J., Jul 2008, In : Journal of Antimicrobial Chemotherapy. 62, 1, p. 161-167 6 p.

    Research output: Contribution to journalArticle

  111. Published
  112. Published

    Incorporating correlation in interindividual variability for the optimal design of multiresponse pharmacokinetic experiments

    Ogungbenro, K., Graham, G., Gueorguieva, I. & Aarons, L., Mar 2008, In : Journal of Biopharmaceutical Statistics. 18, 2, p. 342-358 16 p.

    Research output: Contribution to journalArticle

  113. Published

    Population pharmacokinetics of ritonavir-boosted saquinavir regimens in HIV-infected individuals

    Dickinson, L., Boffito, M., Back, D. J., Khoo, S. H., Pozniak, A. L., Mugyenyi, P., Merry, C., Autar, R. S., Burger, D. M. & Aarons, L. J., 2008, In : Journal of Antimicrobial Chemotherapy. 62, 6, p. 1344-1355 11 p.

    Research output: Contribution to journalArticle

  114. 2007
  115. Published
  116. Published

    Design of population pharmacokinetic experiments using prior information

    Ogungbenro, K. & Aarons, L., Oct 2007, In : Xenobiotica. 37, 10-11, p. 1311-1330 19 p.

    Research output: Contribution to journalArticle

  117. Published

    Bayesian optimal designs for pharmacokinetic models: Sensitivity to uncertainty

    Dokoumetzidis, A. & Aarons, L., Sep 2007, In : Journal of Biopharmaceutical Statistics. 17, 5, p. 851-867 16 p.

    Research output: Contribution to journalArticle

  118. Published

    Optimal design for multiresponse pharmacokinetic-pharmacodynamic models - Dealing with unbalanced designs

    Ogungbenro, K., Gueorguieva, I., Majid, O., Graham, G. & Aarons, L., Jun 2007, In : Journal of pharmacokinetics and pharmacodynamics. 34, 3, p. 313-331 18 p.

    Research output: Contribution to journalArticle

  119. Published
  120. Published

    Linking preclinical and clinical whole-body physiologically based pharmacokinetic models with prior distributions in NONMEM

    Langdon, G., Gueorguieva, I., Aarons, L. & Karlsson, M., May 2007, In : European journal of clinical pharmacology. 63, 5, p. 485-498 13 p.

    Research output: Contribution to journalArticle

  121. Published
  122. Published

    A program for individual and population optimal design for univariate and multivariate response pharmacokinetic-pharmacodynamic models

    Gueorguieva, I., Ogungbenro, K., Graham, G., Glatt, S. & Aarons, L., Apr 2007, In : Computer Methods and Programs in Biomedicine. 86, 1, p. 51-61 10 p.

    Research output: Contribution to journalArticle

  123. Published

    Molecular analysis of the subgingival microbiota in health and disease.

    Ledder, R. G., Gilbert, P., Huws, S. A., Aarons, L., Ashley, M. P., Hull, P. S. & McBain, A. J., Jan 2007, In : Applied and environmental microbiology. 73, 2, p. 516-523 7 p.

    Research output: Contribution to journalArticle

  124. 2006
  125. Published

    Optimum blood sampling time windows for parameter estimation in population pharmacokinetic experiments

    Graham, G. & Aarons, L., 15 Dec 2006, In : Statistics in medicine. 25, 23, p. 4004-4019 15 p.

    Research output: Contribution to journalArticle

  126. Published

    Use of nonlinear mixed-effects analysis for improved precision of early pharmacodynamic measures in tuberculosis treatment

    Davies, G. R., Brindle, R., Khoo, S. H. & Aarons, L. J., Sep 2006, In : Antimicrobial Agents and Chemotherapy. 50, 9, p. 3154-3156 2 p.

    Research output: Contribution to journalArticle

  127. Published
  128. Published

    Population pharmacokinetic and pharmacodynamic modelling of the antimalarial chemotherapy chlorproguanil/dapsone

    Simpson, J. A., Hughes, D., Manyando, C., Bojang, K., Aarons, L., Winstanley, P., Edwards, G., Watkins, W. A. & Ward, S., Mar 2006, In : British Journal of Clinical Pharmacology. 61, 3, p. 289-300 11 p.

    Research output: Contribution to journalArticle

  129. Published

    Sample size calculations based on generalized estimating equations for population pharmacokinetic experiments

    Ogungbenro, K., Aarons, L. & Graham, G., Mar 2006, In : Journal of Biopharmaceutical Statistics. 16, 2, p. 135-150 15 p.

    Research output: Contribution to journalArticle

  130. Published

    Propagation of population PK and PD information using a Bayesian approach: Dealing with non-exchangeability

    Dokoumetzidis, A. & Aarons, L., Feb 2006, In : Journal of pharmacokinetics and pharmacodynamics. 33, 1, p. 29-48 19 p.

    Research output: Contribution to journalArticle

  131. Published

    Pharmacokinetics of a single bolus of propofol in Chinese children of different ages

    Wang, N. S., Lian, Q., Aarons, L., Matthews, I., Wang, Z., Chen, X., Freemantle, N. & Smith, F. G., Jan 2006, In : Anesthesiology. 104, 1, p. 27-32 5 p.

    Research output: Contribution to journalArticle

  132. 2005
  133. Published

    Optimal blood sampling time windows for parameter estimation using a population approach: Design of a phase II clinical trial

    Chenel, M., Ogungbenro, K., Duval, V., Laveille, C., Jochemsen, R. & Aarons, L., Dec 2005, In : Journal of pharmacokinetics and pharmacodynamics. 32, 5-6, p. 737-756 19 p.

    Research output: Contribution to journalArticle

  134. Published

    The use of a modified Fedorov exchange algorithm to optimise sampling times for population pharmacokinetic experiments

    Ogungbenro, K., Graham, G., Gueorguieva, I. & Aarons, L., Nov 2005, In : Computer Methods and Programs in Biomedicine. 80, 2, p. 115-125 10 p.

    Research output: Contribution to journalArticle

  135. Published

    Propagation of population pharmacokinetic information using a Bayesian approach: Comparison with meta-analysis

    Dokoumetzidis, A. & Aarons, L., Aug 2005, In : Journal of pharmacokinetics and pharmacodynamics. 32, 3-4, p. 401-418 17 p.

    Research output: Contribution to journalArticle

  136. Published

    Pharmacokinetic studies of linezolid and teicoplanin in the critically ill

    Whitehouse, T., Cepeda, J. A., Shulman, R., Aarons, L., Nalda-Molina, R., Tobin, C., MacGowan, A., Shaw, S., Kibbler, C., Singer, M. & Wilson, A. P. R., Mar 2005, In : Journal of Antimicrobial Chemotherapy. 55, 3, p. 333-340 7 p.

    Research output: Contribution to journalArticle

  137. Published

    A pharmacokinetic/pharmacodynamic model for a platelet activating factor antagonist based on data arising from Phase I studies

    Evans, L., Aarons, L. & Brearley, C., Feb 2005, In : Journal of Pharmacy and Pharmacology. 57, 2, p. 183-189 6 p.

    Research output: Contribution to journalArticle

  138. Published

    Estimation of population pharmacokinetic parameters of free-phenytoin in adult epileptic patients

    Aarons, L., Ahmed, I. A. & Deleu, D., Jan 2005, In : Archives of Medical Research. 36, 1, p. 49-53 4 p.

    Research output: Contribution to journalArticle

  139. Published

    Retrospective population pharmacokinetics of levocetirizine in atopic children receiving cetirizine: The ETAC® study

    Hussein, Z., Pitsiu, M., Majid, O., Aarons, L., De Longueville, M. & Stockis, A., Jan 2005, In : British Journal of Clinical Pharmacology. 59, 1, p. 28-37 9 p.

    Research output: Contribution to journalArticle

  140. 2004
  141. Published

    Modelling and simulation in the development and use of anti-cancer agents: An underused tool?

    Rombout, F., Aarons, L., Karlsson, M., Man, A., Mentré, F., Nygren, P., Racine, A., Schaefer, H., Steimer, J. L., Troconiz, I. & Van Peer, A., Dec 2004, In : Journal of pharmacokinetics and pharmacodynamics. 31, 6, p. 419-440 21 p.

    Research output: Contribution to journalArticle

  142. Published

    Pharmacodynamics of controlled release verapamil in patients with hypertension: An analysis using spline functions

    Aarons, L., Baxter, C. & Gupta, S., Jul 2004, In : Biopharmaceutics and Drug Disposition. 25, 5, p. 219-225 6 p.

    Research output: Contribution to journalArticle

  143. Published

    Population pharmacokinetic model for daunorubicin and daunorubicinol coadministered with zosuquidar.3HCI (LY335979)

    Callies, S., De Alwis, D. P., Mehta, A., Burgess, M. & Aarons, L., Jul 2004, In : Cancer Chemotherapy and Pharmacology. 54, 1, p. 39-48 9 p.

    Research output: Contribution to journalArticle

  144. Published

    Design of Population Pharmacokinetic Studies: Sample size Determination

    Ogungbenro, K., Graham, G. & Aarons, L., Jun 2004.

    Research output: Contribution to conferencePoster

  145. Published

    Retrospective population pharmacokinetic analysis of cetirizine in children aged 6 months to 12 years

    Pitsiu, M., Hussein, Z., Majid, O., Aarons, L., De Longueville, M. & Stockis, A., Apr 2004, In : British Journal of Clinical Pharmacology. 57, 4, p. 402-411 9 p.

    Research output: Contribution to journalArticle

  146. Published

    Population pharmacokinetics of artemether and dihydroartemisinin following single intramuscular dosing of artemether in African children with severe falciparum malaria

    Mithwani, S., Aarons, L., Kokwaro, G. O., Majid, O., Muchohi, S., Edwards, G., Mohamed, S., Marsh, K. & Watkins, W., Feb 2004, In : British Journal of Clinical Pharmacology. 57, 2, p. 146-152 6 p.

    Research output: Contribution to journalArticle

  147. 2003
  148. Published

    Design of Population Pharmacokinetic Studies: Sample size Determination

    Ogungbenro, K., Graham, G. & Aarons, L., Nov 2003.

    Research output: Contribution to conferenceOther

  149. Published

    A population pharmacokinetic model for paclitaxel in the presence of a novel P-gp modulator, Zosuquidar Trihydrochloride (LY335979)

    Callies, S., De Alwis, D. P., Harris, A., Vasey, P., Beijnen, J. H., Schellens, J. H., Burgess, M. & Aarons, L., 1 Jul 2003, In : British Journal of Clinical Pharmacology. 56, 1, p. 46-56 10 p.

    Research output: Contribution to journalArticle

  150. Published
  151. Published

    A population pharmacokinetic model for doxorubicin and doxorubicinol in the presence of a novel MDR modulator, zosuquidar trihydrochloride (LY335979)

    Callies, S., De Alwis, D. P., Wright, J. G., Sandler, A., Burgess, M. & Aarons, L., 1 Feb 2003, In : Cancer Chemotherapy and Pharmacology. 51, 2, p. 107-118 11 p.

    Research output: Contribution to journalArticle

  152. Published

    A Bayesian method based on clotting factor activity for the prediction of maintenance warfarin dosage regimens

    Pitsiu, M., Parker, E. M., Aarons, L. & Rowland, M., Feb 2003, In : Therapeutic Drug Monitoring. 25, 1, p. 36-40 4 p.

    Research output: Contribution to journalArticle

  153. Published

    Prediction of serum tobramycin in patients with NONMEM and simulated annealing.

    Mengov, G., St, H. & Aarons, L., 2003, In : Comptes Rendus de l'Academie Bulgare des Sciences.. 56, 5, p. 47-50

    Research output: Contribution to journalArticle

  154. 2002
  155. Published

    Determination of an optimal dosage regimen using a Bayesian decision analysis of efficacy and adverse effect data

    Graham, G., Gupta, S. & Aarons, L., 2002, In : Journal of pharmacokinetics and pharmacodynamics. 29, 1, p. 67-88 21 p.

    Research output: Contribution to journalArticle

  156. Published

    Mixed effects modelling of toxicokinetic data

    Aarons, L., 2002, In : The Toxicologist. 66 (1-S)

    Research output: Contribution to journalArticle

  157. Published

    Pharmacokinetics of controlled-release verapamil in healthy volunteers and patients with hypertension or angina

    Gupta, S., Modi, N. B., Sathyan, G., Ho, P. L. & Aarons, L., 2002, In : Biopharmaceutics and Drug Disposition. 23, 1, p. 17-31 14 p.

    Research output: Contribution to journalArticle

  158. Published

    Population dynamics of untreated Plasmodium falciparum malaria within the adult human host during the expansion phase of the infection

    Simpson, J. A., Aarons, L., Collins, W. E., Jeffery, G. M. & White, N. J., 2002, In : Parasitology. 124, 3, p. 247-263 16 p.

    Research output: Contribution to journalArticle

  159. Published

    Sample Size Calculation for Pharmacokinetic Studies

    Ogungbenro, K., Graham, G. & Aarons, L., 2002.

    Research output: Contribution to conferencePoster

  160. Published

    Study of the phamacokinetic profile of anti-epileptic drugs in an adult Omani epileptic population using NONMEM.

    Deleu, D., Aarons, L. & Ahmed, I. A., 2002, In : EPILEPSIA. 43

    Research output: Contribution to journalArticle

  161. 2001
  162. Published

    COST B15: modelling in drug development

    Aarons, L., Balant, L. & Boobis, A., Jul 2001, In : British Journal of Clinical Pharmacology. 52, 1, p. 118-119

    Research output: Contribution to journalArticle

  163. Published

    Methodological approaches to the population analysis of toxicity data

    Aarons, L. & Graham, G., 31 Mar 2001, In : Toxicology Letters. 120, 1-3, p. 405-410 5 p.

    Research output: Contribution to journalArticle

  164. Published

    An identifiability analysis of a parent-metabolite pharmacokinetic model for ivabradine

    Adams, N. D., Godfrey, K. R., Chapman, M. J., Chappell, M. J., Aarons, L. & Duffull, S. B., 2001, In : Journal of pharmacokinetics and pharmacodynamics. 28, 1, p. 93-105 12 p.

    Research output: Contribution to journalArticle

  165. Published

    Computer-assisted clinical trial simulation: a phase II case study with naraptriptan

    Nestorov, I., Graham, G., Duffell, S., Aarons, L., Fuseau, E. & Coates, P., 2001, In : Pharmacol. Toxicol.. 89 (suppl. 1)

    Research output: Contribution to journalArticle

  166. Published

    How can we do pharmacokinetic studies in the tropics?

    Simpson, J. A., Aarons, L. & White, N. J., 2001, In : Transactions of the Royal Society of Tropical Medicine and Hygiene. 95, 4, p. 347-351 4 p.

    Research output: Contribution to journalArticle

  167. Published

    Modeling and simulation for clinical trial design involving a categorical response: A phase ii case study with naratriptan

    Nestorov, I., Graham, G., Duffull, S., Aarons, L., Fuseau, E. & Coates, P., 2001, In : Pharmaceutical Research. 18, 8, p. 1210-1219 9 p.

    Research output: Contribution to journalArticle

  168. Published

    Population pharmacokinetics of free carbamazepine in adult Omani epileptic patients

    Deleu, D., Aarons, L. & Ahmed, I. A., 2001, In : European journal of clinical pharmacology. 57, 3, p. 243-248 5 p.

    Research output: Contribution to journalArticle

  169. Published

    Role of modelling and simulation in Phase I drug development

    Aarons, L., Karlsson, M. O., Mentre, F., Rombout, F., Steimer, J. L. & Van Peer, A., 2001, In : European Journal of Pharmaceutical Sciences. 13, 2, p. 115-122 7 p.

    Research output: Contribution to journalArticle

  170. 2000
  171. Published

    Population pharmacokinetics of tiagabine in epileptic patients on monotherapy

    Ingwersen, S. H., Pedersen, P. C., Groes, L., Nielsen, K. K. & Aarons, L., Sep 2000, In : European Journal of Pharmaceutical Sciences. 11, 3, p. 247-254 7 p.

    Research output: Contribution to journalArticle

  172. Published

    A pharmacokinetic simulation model for ivabradine in healthy volunteers

    Duffull, S. B., Chabaud, S., Nony, P., Laveille, C., Girard, P. & Aarons, L., Jun 2000, In : European Journal of Pharmaceutical Sciences. 10, 4, p. 285-294 9 p.

    Research output: Contribution to journalArticle

  173. Published

    Development of a sequential linked pharmacokinetic and pharmacodynamic simulation model for ivabradine in healthy volunteers

    Duffull, S. B. & Aarons, L., Jun 2000, In : European Journal of Pharmaceutical Sciences. 10, 4, p. 275-284 9 p.

    Research output: Contribution to journalArticle

  174. Published

    Mefloquine pharmacokinetic-pharmacodynamic models: Implications for dosing and resistance

    Simpson, J. A., Watkins, E. R., Price, R. N., Aarons, L., Kyle, D. E. & White, N. J., 2000, In : Antimicrobial Agents and Chemotherapy. 44, 12, p. 3414-3424 10 p.

    Research output: Contribution to journalArticle

  175. 1999
  176. Published

    Editorial: Pharmacokinetic and pharmacodynamic modelling in drug development

    Aarons, L., Jun 1999, In : Statistical Methods in Medical Research. 8, 3, p. 181-182

    Research output: Contribution to journalArticle

  177. Published

    "Population modelling". In: Variability in Human Drug Response. Proceedings of the Esteve Foundation Symposium VIII.

    Aarons, L., 1999, In : Excerpta Medica, Amsterdam.

    Research output: Contribution to journalArticle

  178. Published

    "The Bayesian approach to population pharmacokinetic/pharmacodynamic modeling".

    Wakefield, J., Aarons, L. & Racine-Poon, A., 1999, Case Studies in Bayesian Statistics. Gatsonis, C., Kass, R., Carlin, B., Carriquiry, A., Gelman, A., Verdinelli, I. & West, M. (eds.). Springer Nature, (Lecture Notes in Statistics; vol. 140).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  179. Published

    A mechanistically based model for the relationship between the tissue distribution parameters and the lipophilicity of a homologous series of barbiturates in rats

    Nestorov, I., Aarons, L. & Rowland, M., 1999, Eur. J. Pharm. Sci.. Vol. 8.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  180. Published

    A pharmacokinetic model for tenidap in normal volunteers and rheumatoid arthritis patients

    Evans, L., Aarons, L. & Coates, P., 1999, In : Pharmaceutical Research. 16, 10, p. 1608-1615 7 p.

    Research output: Contribution to journalArticle

  181. Published

    Population pharmacokinetics of mefloquine in patients with acute falciparum malaria

    Simpson, J. A., Price, R., Ter Kuile, F., Teja-Isavatharm, P., Nosten, F., Chongsuphajaisiddhi, T., Looareesuwan, S., Aarons, L. & White, N. J., 1999, In : Clinical Pharmacology and Therapeutics. 66, 5, p. 472-484 12 p.

    Research output: Contribution to journalArticle

  182. Published

    Quantitative characterization of therapeutic index: Application of mixed-effects modeling to evaluate oxybutynin dose-efficacy and dose-side effect relationships

    Gupta, S. K., Sathyan, G., Lindemulder, E. A., Ho, P. L., Sheiner, L. B. & Aarons, L., 1999, In : Clinical Pharmacology and Therapeutics. 65, 6, p. 672-684 12 p.

    Research output: Contribution to journalArticle

  183. Published

    Software for population pharmacokinetics and pharmacodynamics

    Aarons, L., 1999, In : Clinical Pharmacokinetics. 36, 4, p. 255-264 9 p.

    Research output: Contribution to journalArticle

  184. Published

    The analysis of categorical/count data

    Graham, G., Aarons, L. & Gupta, S. K., 1999, In : Eur. J. Pharm. Sci.. 8(2)

    Research output: Contribution to journalArticle

  185. Published

    The effect of cimetidine on the steady-state pharmacokinetics and pharmacodynamics of warfarin in humans

    Niopas, I., Toon, S., Aarons, L. & Rowland, M., 1999, In : European journal of clinical pharmacology. 55, 5, p. 399-404 5 p.

    Research output: Contribution to journalArticle

  186. 1998
  187. Published

    Plasma and tonsillar tissue pharmacokinetics of teicoplanin following intramuscular administration to children

    Aarons, L., Rowland, M., Khan, A., Taborelli, G., Ferrea, G., Tarantino, V., Fioredda, F., Rosina-Parenti, R., Cavenaghi, L. & Borgonovi, M., 1 Oct 1998, In : European Journal of Pharmaceutical Sciences. 6, 4, p. 265-270 5 p.

    Research output: Contribution to journalArticle

  188. Published

    Quantitative structure-pharmacokinetics relationships II. Mechanistically based model for the relationship between the tissue distribution parameters and the lipophilicity of the compounds.

    Nestorov, I., Aarons, L. & Rowland, M., Oct 1998, In : Journal of pharmacokinetics and biopharmaceutics. 26, 5, p. 521-545

    Research output: Contribution to journalArticle

  189. Published

    Computer Assisted Design of Phase II(b) Oral Dose Ranging Trial for Naratriptan - Results of a Pilot Study. Scientific Conference "Pharmacokinetics - UK", Manchester, UK. November 4-6, 1998

    Duffull, S., Nestorov, I. & Aarons, L., 1998, Conference Proceedings.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  190. Published

    Lumping of whole-body physiologically based pharmacokinetic models

    Nestorov, I. A., Aarons, L. J., Arundel, P. A. & Rowland, M., 1998, In : Journal of pharmacokinetics and biopharmaceutics. 26, 1, p. 21-46 25 p.

    Research output: Contribution to journalArticle

  191. Published

    Optimal experimental design for precise estimation of the parameters of the axial dispersion model of hepatic elimination

    Chou, C. H., Aarons, L. & Rowland, M., 1998, In : Journal of pharmacokinetics and biopharmaceutics. 26, 5, p. 595-615 20 p.

    Research output: Contribution to journalArticle

  192. Published

    Population pharmacokinetics of cyclosporine: Influence of covariables and assessment of cyclosporine absorption in kidney, lung, heart and heart + lung transplanted patients

    Kyhl, L. E. B., Rasmussen, S. N., Aarons, L. & Jensen, S. B., 1998, Transplantation Proceedings|Transplant. Proc.. Vol. 30. p. 1680

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  193. Published

    Population pharmacokinetics of ondansetron: A covariate analysis

    De Alwis, D. P., Aarons, L. & Palmer, J. L., 1998, In : British Journal of Clinical Pharmacology. 46, 2, p. 117-125 8 p.

    Research output: Contribution to journalArticle

  194. Published

    The pharmacokinetics of saquinavir: A Markov chain Monte Carlo population analysis

    Lunn, D. J. & Aarons, L., 1998, In : Journal of pharmacokinetics and biopharmaceutics. 26, 1, p. 47-74 27 p.

    Research output: Contribution to journalArticle

  195. 1997
  196. Published

    Physiologically-based pharmacokinetic modelling of a homologous series of barbiturates in the rat: A sensitivity analysis

    Nestorov, I. A., Aarons, L. & Rowland, M., Aug 1997, In : Journal of pharmacokinetics and biopharmaceutics. 25, 4, p. 413-449

    Research output: Contribution to journalArticle

  197. Published

    Population pharmacokinetics of rufloxacin in patients with acute exacerbations of chronic bronchitis

    Imbimbo, B. P., Klietmann, W., Broccali, G. P., Cesana, M. & Aarons, L., 1 Jan 1997, In : European Journal of Pharmaceutical Sciences. 5, 1, p. 37-42 5 p.

    Research output: Contribution to journalArticle

  198. Published

    Markov chain Monte Carlo techniques for studying interoccasion and intersubject variability: Application to pharmacokinetic data

    Lunn, D. J. & Aarons, L. J., 1997, In : Journal of the Royal Statistical Society. Series C: Applied Statistics. 46, 1, p. 73-91 18 p.

    Research output: Contribution to journalArticle

  199. Published

    Physiologically based pharmacokinetc modeling of a homologous series of barbiturates in the rat. II. A Sensitivity analysis of the model.

    Nestorov, I. A., Aarons, L. & Rowland, M., 1997, In : Journal of pharmacokinetics and biopharmaceutics. 25

    Research output: Contribution to journalArticle

  200. Published

    Quantitative structure-pharmacokinetic relationships. I. Development of a whole body physiologically based model to characterise changes in pharmacokinetics across a homologous series of barbiturates in the rat.

    Blakey, G. M., Al, N. I., Arundel, P. A., Aarons, L. & Rowland, M., 1997, In : J. Pharmaco. Biopharm.. 25 (3)

    Research output: Contribution to journalArticle

  201. Published

    The Population Approach: Measuring and Managing Variability in Response, Concentration and Dose, Commission of the European Community, Luxembourg

    Aarons, L., Rowland, M., Balant, L. P., Danhof, M., Gex-Fabry, M., Gundert-Remy, U. A., Karlsson, M. O., Mentre, F., Morselli, P. L., Rombout, F., Steimer, J. L. & Vozeh, S., 1997, No publisher name. (proceedings of a meeting, edited by authors and published as a book)

    Research output: Book/ReportAnthology

  202. 1996
  203. Published

    Population approaches/sparse data analysis for human variability in kinetics and dynamics

    Aarons, L., 15 Oct 1996, In : Environmental Toxicology and Pharmacology. 2, 2-3, p. 197-199 2 p.

    Research output: Contribution to journalArticle

  204. Published

    Practical experience and issues in designing and performing population pharmacokinetic/pharmacodynamic studies

    Aarons, L., Rowland, M., Balant, L. P., Mentré, F., Morselli, P. L., Steimer, J. L. & Vozeh, S., Jan 1996, European Journal of Clinical Pharmacology|Eur J Clin Pharmacol. Springer Nature, Vol. 49. p. 251-254 3 p.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  205. Published

    A physiologically-based pharmacokinetic model for the distribution of barbiturates in rats. AAPS Tenth Anniversary Meeting, 27-31 October 1996, Seattle, Washington

    Nestorov, I., Blakey, G. A., Arundel, P. A., Aarons, L. & Rowland, M., 1996, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  206. Published

    The use of population pharmacokinetics in drug development

    Vozeh, S., Steimer, J. L., Rowland, M., Morselli, P., Mentré, F., Balant, L. P. & Aarons, L., 1996, In : Clinical Pharmacokinetics. 30, 2, p. 81-93 12 p.

    Research output: Contribution to journalArticle

  207. 1989
  208. Published

    Mean residence time for drugs subject to enterohepatic cycling

    Shepard, T. A., Lockwood, G. F., Aarons, L. J. & Abrahams, I. D., Jun 1989, In : Journal of pharmacokinetics and biopharmaceutics. 17, 3, p. 327-345 18 p.

    Research output: Contribution to journalArticle