Prof Leon AaronsBSc, MSc, PhD

Professor

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Publications

  1. 2018
  2. Published

    Establishment and validation of microsampling techniques in wild rodents for ecotoxicological research

    Imholt, C., Abdulla, T., Stevens, A., Edwards, P., Jacob, J., Woods, D., Rogers, E., Aarons, L. & Segelcke, D., Sep 2018, In : Journal of Applied Toxicology. 38, 9

    Research output: Contribution to journalArticle

  3. Published

    Ratifying the dosage and duration of levo-bupivacaine infusion by the caudal-epidural route in infants aged three to six months

    Vashisht, R., Bendon, A., Okonkwo, I., Darwich, A. & Aarons, L., May 2018, In : British Journal of Anaesthesia. 120, p. e11-e12 2 p.

    Research output: Contribution to journalMeeting Abstract

  4. Published

    A Study of the dosage and duration for levobupivacaine infusion by the caudal-epidural route in infants aged 3-6 months

    Vashisht, R., Bendon, A., Okonkwo, I., Patel, D., Fullwood, C., Ogungbenro, K., Aarons, L. & Darwich, A., 2018, In : Pediatric Anesthesia.

    Research output: Contribution to journalArticle

  5. Published

    Pharmacodynamic modelling of resistance to epidermal growth factor receptor inhibition in brain metastasis mouse models.

    Martin, E., Aarons, L. & Yates, J. W. T., 2018, In : Cancer Chemotherapy and Pharmacology.

    Research output: Contribution to journalArticle

  6. Published

    The Influence of Normalization Weight in Population Pharmacokinetic Covariate Models

    Goulooze, S. C., Voller, S., Valitalo, P. AJ., Calvier, E. AM., Aarons, L., Krekels, E. HJ. & Knibbe, C. A. J., 2018, In : Clinical Pharmacokinetics.

    Research output: Contribution to journalArticle

  7. Published

    Variance based global sensitivity analysis of physiologically based pharmacokinetic absorption models for BCS I–IV drugs

    Melillo, N., Aarons, L., Magni, P. & Darwich, A. S., 2018, In : Journal of pharmacokinetics and pharmacodynamics.

    Research output: Contribution to journalArticle

  8. 2017
  9. Published

    Whole body physiologically based modelling of β-blockers in the rat: events in tissues and plasma following an i.v. bolus dose

    Cheung, S. Y. A. ., Rodgers, T., Aarons, L., Gueorguieva, I., Dickinson, G. L., Murby, S., Brown, C., Collins, B. & Rowland, M., 22 Dec 2017, In : British Journal of Pharmacology . p. 1 17 p.

    Research output: Contribution to journalArticle

  10. Published

    Choosing an optimal input for an intravenous glucose tolerance test to aid parameter identification

    Martin, E., Yates, J. W. T., Ogungbenro, K. & Aarons, L., 5 Sep 2017, In : Journal of Pharmacy and Pharmacology. p. 1-9

    Research output: Contribution to journalArticle

  11. Published

    Assessment of Nevirapine Prophylactic and Therapeutic Dosing Regimens for Neonates

    Cressey, T. R., Punyawudho, B., Le Coeur, S., Jourdain, G., Saenjum, C., Capparelli, E. V., Jittayanun, K., Phanomcheong, S., Luvira, A., Borkird, T., Puangsombat, A., Aarons, L., Sukrakanchana, P. O., Urien, S., Lallemant, M., Sangsawang, S., Achalapong, J., Preedisripipat, K., Putiyanun, C., Wanchaitanawong, V. & 31 others, Yuthavisuthi, P., Ngampiyaskul, C., Kanjanavikai, P., Chotivanich, N., Hongsiriwon, S., Suwankornsakul, W., Sreshthatat, P., Kanjanasing, A., Kwanchaipanich, R., Rawangban, B., Santadusit, S., Jarupanich, T., Warachit, B., Siriwachirachai, T., Rojanakarin, P., Vivatpatanakul, K., Hanpinitsak, S., Wanasiri, P., Srirojana, S., Kongpanichkul, R., Bunjongpak, S., Sabsanong, P., Liampongsabuddhi, P., Pongdetudom, K., Khamja, P., Akarathum, N., Phonin, S. A., Limpitikul, W., Jungpipun, J., Petprakorp, R. & The PHPT-5 study team, 15 Aug 2017, In : Journal of Acquired Immune Deficiency Syndromes. 75, 5, p. 554-560 7 p.

    Research output: Contribution to journalArticle

  12. Published

    IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

    Darwich, A., Aarons, L., Galetin, A., Rostami-Hochaghan et al, A., Margolskee, A., Pepin, X., Carlert, S., Hammarberg, M., Hilgendorf, C., Johansson, P., Karlsson, E., Murphy, D., Tannergren, C., Thorn, H., Yasin, M., Mazuir, F., Nicolas, O., Ramusovic, S., Xu, C., Pathak, S. & 43 others, Korjamo, T., Laru, J., Malkki, J., Pappinen, S., Tuunainen, J., Dressman, J., Hansmann, S., Kostewicz, E. S., He, H., Heimbach, T., Wu, F., Hoft, C., Pang, Y., Bolger, M., Huehn, E., Heimbach, T., Wu, F., Hoft, C., Pang, Y., Bolger, M. B., Huehn, E., Lukacova, V., Mullin, J. M., Szeto, K. X., Costales, C., Lin, J., McAllister, M., Modi, S., Rotter, C., Varma, M., Wong, M., Mitra, A., Bevernage, J., Biewenga, J., Peer, A. V., Lloyd, R., Shardlow, C., Langguth, P., Mishenzon, I., Nguyen, M. A., Brown, J., Lennerans, H. & Abrahmsson, B., 1 Jan 2017, In : European Journal of Pharmaceutical Sciences. 96, p. 626-642 17 p.

    Research output: Contribution to journalArticle

  13. Published

    Modelling of atorvastatin pharmacokinetics and the identification of the effect of a BCRP polymorphism in the Japanese population

    Tsamandouras, N., Guo, Y., Wendling, T., Hall, S., Galetin, A. & Aarons, L., Jan 2017, In : Pharmacogenetics and Genomics. 27, 1, p. 27-38 12 p.

    Research output: Contribution to journalArticle

  14. Published

    Population Pharmacokinetics of Selumetinib and Its Metabolite N-desmethyl-selumetinib in Adult Patients With Advanced Solid Tumors and Children With Low-Grade Gliomas

    Patel, Y. T., Daryani, V. M., Patel, P., Zhou, D., Fangusaro, J., Carlile, D. J., Martin, P. D., Aarons, L. & Stewart, C. F., 2017, In : CPT: Pharmacometrics and Systems Pharmacology.

    Research output: Contribution to journalArticle

  15. Published

    Population pharmacokinetics of the MEK inhibitor selumetinib and its active N-desmethyl metabolite: Data from 10 phase I trials

    Patel, P., Howgate, E., Martin, P., Carlile, D. J., Aarons, L. & Zhou, D., 2017, In : British Journal of Clinical Pharmacology.

    Research output: Contribution to journalArticle

  16. Published

    Why has model-informed precision dosing not yet become common clinical reality? Lessons from the past and a roadmap for the future

    Darwich, A., Ogungbenro, K., Vinks, A. A., Powell, J. R., Reny, J-L., Marsousi, N., Daali, Y., Fairman, D., Cook, J., Lesko, L. J., McCune, J. S., Knibbe, C. A. J., de Wildt, S. N., Leeder, J. S., Neely, M. N., Zuppa, A. F., Vicini, P., Aarons, L., Johnson, T. N., Boiani, J. & 1 others, Rostami-Hodjegan, A., 2017, In : Clinical Pharmacology & Therapeutics.

    Research output: Contribution to journalArticle

  17. 2016
  18. Published

    Mathematical model of T-cell lymphoblastic lymphoma: disease, treatment, cure or relapse of a virtual cohort of patients

    Eymard, N., Volpert, V., Kurbatova, P., Bessonov, N., Ogungbenro, K., Aarons, L., Janiaud, P., Bajard, A., Chabaud, S., Bertrand, Y., Kassa¨i, B., Cornu, C. & Nony, P., 16 Dec 2016, In : Mathematical Medicine and Biology. 35, 1, p. 1-23

    Research output: Contribution to journalArticle

  19. Published

    Development of a novel simplified PBPK absorption model to explain the higher relative bioavailability of the OROS® formulation of oxybutynin

    Olivares-Morales, A., Ghosh, A., Aarons, L. & Rostami-Hodjegan, A., Nov 2016, In : The AAPS journal. 18, 6, p. 1532-1549 18 p.

    Research output: Contribution to journalArticle

  20. Published

    Accounting for dropout in xenografted tumour efficacy studies: integrated endpoint analysis, reduced bias and better use of animals

    Martin, E., Aarons, L. & WT Yates, J., Jul 2016, In : Cancer Chemotherapy and Pharmacology. 78, 1, p. 131-141

    Research output: Contribution to journalArticle

  21. Published

    Predicting survival of pancreatic cancer patients treated with gemcitabine using longitudinal tumour size data

    Wendling, T., Mistry, H., Ogungbenro, K. & Aarons, L., 7 Mar 2016, In : Cancer Chemotherapy and Pharmacology. 77, 5, p. 927 938 p., 11.

    Research output: Contribution to journalArticle

  22. Published

    Deconvolution and IVIVC: Exploring the Role of Rate-Limiting Conditions

    Margolskee, A., Darwich, A. S., Galetin, A., Rostami, A. & Aarons, L., 2 Mar 2016, In : The A A P S Journal. 18, 2, p. 321-332 11 p.

    Research output: Contribution to journalArticle

  23. Published

    Designing More Efficient Preclinical Experiments: A Simulation Study in Chemotherapy-Induced Myelosupression

    Martin, E., Aarons, L. & Yates, J., 14 Feb 2016, In : Toxicological Sciences. 150, 1, p. 109-116 7 p.

    Research output: Contribution to journalArticle

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