Prof Leon AaronsBSc, MSc, PhD

Professor

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ORCID: 0000-0003-2704-6570
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Publications

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  1. Published

    The effect of cimetidine on the steady-state pharmacokinetics and pharmacodynamics of warfarin in humans

    Niopas, I., Toon, S., Aarons, L. & Rowland, M., 1999, In : European journal of clinical pharmacology. 55, 5, p. 399-404 5 p.

    Research output: Contribution to journal › Article

    DOI: 10.1007/s002280050647
  2. Published

    The Influence of Normalization Weight in Population Pharmacokinetic Covariate Models

    Goulooze, S. C., Voller, S., Valitalo, P. AJ., Calvier, E. AM., Aarons, L., Krekels, E. HJ. & Knibbe, C. A. J., 2018, In : Clinical Pharmacokinetics.

    Research output: Contribution to journal › Article

    DOI: 10.1007/s40262-018-0652-7
  3. Published

    The pharmacokinetics of saquinavir: A Markov chain Monte Carlo population analysis

    Lunn, D. J. & Aarons, L., 1998, In : Journal of pharmacokinetics and biopharmaceutics. 26, 1, p. 47-74 27 p.

    Research output: Contribution to journal › Article

    DOI: 10.1023/A:1023224824228
  4. Published

    The Population Approach: Measuring and Managing Variability in Response, Concentration and Dose, Commission of the European Community, Luxembourg

    Aarons, L., Rowland, M., Balant, L. P., Danhof, M., Gex-Fabry, M., Gundert-Remy, U. A., Karlsson, M. O., Mentre, F., Morselli, P. L., Rombout, F., Steimer, J. L. & Vozeh, S., 1997, No publisher name. (proceedings of a meeting, edited by authors and published as a book)

    Research output: Book/Report › Anthology

  5. Published

    The population pharmacokinetics of R- and S-warfarin: Effect of genetic and clinical factors

    Lane, S., Al-Zubiedi, S., Hatch, E., Matthews, I., Jorgensen, A. L., Deloukas, P., Daly, A. K., Park, B. K., Aarons, L., Ogungbenro, K., Kamali, F., Hughes, D. & Pirmohamed, M., Jan 2012, In : British Journal of Clinical Pharmacology. 73, 1, p. 66-76 10 p.

    Research output: Contribution to journal › Article

    DOI: 10.1111/j.1365-2125.2011.04051.x
  6. Published

    The use of a modified Fedorov exchange algorithm to optimise sampling times for population pharmacokinetic experiments

    Ogungbenro, K., Graham, G., Gueorguieva, I. & Aarons, L., Nov 2005, In : Computer Methods and Programs in Biomedicine. 80, 2, p. 115-125 10 p.

    Research output: Contribution to journal › Article

    DOI: 10.1016/j.cmpb.2005.07.001
  7. Published

    The use of population pharmacokinetics in drug development

    Vozeh, S., Steimer, J. L., Rowland, M., Morselli, P., Mentré, F., Balant, L. P. & Aarons, L., 1996, In : Clinical Pharmacokinetics. 30, 2, p. 81-93 12 p.

    Research output: Contribution to journal › Article

    DOI: 10.2165/00003088-199630020-00001
  8. Published

    The Use of ROC Analysis for the Qualitative Prediction of Human Oral Bioavailability from Animal Data

    Olivares-Morales, A., Hatley, O. J. D., Turner, D., Galetin, A., Aarons, L. & Rostami-Hodjegan, A., 27 Sep 2013, In : Pharmaceutical Research. 31, 3, p. 720-730 10 p.

    Research output: Contribution to journal › Article

    DOI: 10.1007/s11095-013-1193-2
  9. Published

    Translating Human Effective Jejunal Intestinal Permeability to Surface-Dependent Intrinsic Permeability: a Pragmatic Method for a More Mechanistic Prediction of Regional Oral Drug Absorption

    Olivares-Morales, A., Lennernäs, H., Aarons, L. & Rostami-Hodjegan, A., 19 May 2015, In : The A A P S Journal. 17, 5, p. 1177-1192 15 p.

    Research output: Contribution to journal › Article

    DOI: 10.1208/s12248-015-9758-0
  10. Published

    Use of nonlinear mixed-effects analysis for improved precision of early pharmacodynamic measures in tuberculosis treatment

    Davies, G. R., Brindle, R., Khoo, S. H. & Aarons, L. J., Sep 2006, In : Antimicrobial Agents and Chemotherapy. 50, 9, p. 3154-3156 2 p.

    Research output: Contribution to journal › Article

    DOI: 10.1128/AAC.00774-05
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Research Explorer downloads

287
IMI – oral biopharmaceutics tools project – evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds

Research output: Contribution to journal › Article

264
Why has model-informed precision dosing not yet become common clinical reality? Lessons from the past and a roadmap for the future

Research output: Contribution to journal › Article

233
IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

Research output: Contribution to journal › Article

214
IMI – Oral Biopharmaceutics Tools project – Evaluation of Bottom-up PBPK Prediction Success Part 2: An Introduction to the Simulation Exercise and Overview of Results

Research output: Contribution to journal › Article

153
Modelling of atorvastatin pharmacokinetics and the identification of the effect of a BCRP polymorphism in the Japanese population

Research output: Contribution to journal › Article