Prof Leon AaronsBSc, MSc, PhD

Professor

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Publications

  1. Published

    "Population modelling". In: Variability in Human Drug Response. Proceedings of the Esteve Foundation Symposium VIII.

    Aarons, L., 1999, In : Excerpta Medica, Amsterdam.

    Research output: Contribution to journalArticle

  2. Published

    "The Bayesian approach to population pharmacokinetic/pharmacodynamic modeling".

    Wakefield, J., Aarons, L. & Racine-Poon, A., 1999, Case Studies in Bayesian Statistics. Gatsonis, C., Kass, R., Carlin, B., Carriquiry, A., Gelman, A., Verdinelli, I. & West, M. (eds.). Springer Nature, (Lecture Notes in Statistics; vol. 140).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  3. Published

    A Bayesian method based on clotting factor activity for the prediction of maintenance warfarin dosage regimens

    Pitsiu, M., Parker, E. M., Aarons, L. & Rowland, M., Feb 2003, In : Therapeutic Drug Monitoring. 25, 1, p. 36-40 4 p.

    Research output: Contribution to journalArticle

  4. Published
  5. Published

    A mechanistically based model for the relationship between the tissue distribution parameters and the lipophilicity of a homologous series of barbiturates in rats

    Nestorov, I., Aarons, L. & Rowland, M., 1999, Eur. J. Pharm. Sci.. Vol. 8.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  6. Published

    A methodological framework for drug development in rare diseases.

    Volpert, V., Eymard, N., Kassai, B., Aarons, L., Bajard, A., Ballot, C., Bertrand, Y., Bretz, F., Caudri, D., Castellan, C., Malik, S., Chabaud, S., Cornu, C., Dufour, F., Dunger-Baldauf, C., Dupont, J-M., Fisch, R., Guerrini, R., Kassaï, B., Nony, P. & 12 others, Ogungbenro, K., Pérol, D., Pons, G., Tiddens, H., Rosati, A., Alberti, C., Chiron, C., Kurbatova, P., Nabbout, R., Jullien, V., Benquet, P. & Wendling, F., 2014, In : Orphanet Journal of Rare Diseases. 9

    Research output: Contribution to journalArticle

  7. Published

    A pharmacokinetic model for tenidap in normal volunteers and rheumatoid arthritis patients

    Evans, L., Aarons, L. & Coates, P., 1999, In : Pharmaceutical Research. 16, 10, p. 1608-1615 7 p.

    Research output: Contribution to journalArticle

  8. Published

    A pharmacokinetic simulation model for ivabradine in healthy volunteers

    Duffull, S. B., Chabaud, S., Nony, P., Laveille, C., Girard, P. & Aarons, L., Jun 2000, In : European Journal of Pharmaceutical Sciences. 10, 4, p. 285-294 9 p.

    Research output: Contribution to journalArticle

  9. Published

    A pharmacokinetic/pharmacodynamic model for a platelet activating factor antagonist based on data arising from Phase I studies

    Evans, L., Aarons, L. & Brearley, C., Feb 2005, In : Journal of Pharmacy and Pharmacology. 57, 2, p. 183-189 6 p.

    Research output: Contribution to journalArticle

  10. Published

    A Physiologically Based Pharmacokinetic Model for Clobazam and Stiripentol in Adults and Children

    Ogungbenro, K., Aarons, L. & Epi-CRESim Project Groups, 23 Jul 2014, In : Pharmaceutical Research. 32, 1, p. 144-157 13 p.

    Research output: Contribution to journalArticle

  11. Published

    A physiologically based pharmacokinetic model for Valproic acid in adults and children.

    Ogungbenro, K., Aarons, L., Bajard, A., Ballot, C., Bertrand, Y., Bretz, F., Caudri, D., Castellan, C., Chabaud, S., Cornu, C., Dufour, F., Eymard, N., Fisch, R., Guerrini, R., Jullien, V., Kassaï, B., Nony, P., Pérol, D., Pons, G., Tiddens, H. & 5 others, Rosati, A., Alberti, C., Chiron, C., Kurbatova, P. & Nabbout, R., 15 Oct 2014, In : European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 63, p. 45-52 7 p.

    Research output: Contribution to journalArticle

  12. Published

    A physiologically-based pharmacokinetic model for the distribution of barbiturates in rats. AAPS Tenth Anniversary Meeting, 27-31 October 1996, Seattle, Washington

    Nestorov, I., Blakey, G. A., Arundel, P. A., Aarons, L. & Rowland, M., 1996, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  13. Published

    A population pharmacokinetic model for doxorubicin and doxorubicinol in the presence of a novel MDR modulator, zosuquidar trihydrochloride (LY335979)

    Callies, S., De Alwis, D. P., Wright, J. G., Sandler, A., Burgess, M. & Aarons, L., 1 Feb 2003, In : Cancer Chemotherapy and Pharmacology. 51, 2, p. 107-118 11 p.

    Research output: Contribution to journalArticle

  14. Published

    A population pharmacokinetic model for paclitaxel in the presence of a novel P-gp modulator, Zosuquidar Trihydrochloride (LY335979)

    Callies, S., De Alwis, D. P., Harris, A., Vasey, P., Beijnen, J. H., Schellens, J. H., Burgess, M. & Aarons, L., 1 Jul 2003, In : British Journal of Clinical Pharmacology. 56, 1, p. 46-56 10 p.

    Research output: Contribution to journalArticle

  15. Published

    A program for individual and population optimal design for univariate and multivariate response pharmacokinetic-pharmacodynamic models

    Gueorguieva, I., Ogungbenro, K., Graham, G., Glatt, S. & Aarons, L., Apr 2007, In : Computer Methods and Programs in Biomedicine. 86, 1, p. 51-61 10 p.

    Research output: Contribution to journalArticle

  16. Published

    A reduced physiologically-based pharmacokinetic (PBPK) model for the prediction of regional gastrointestinal (GI) drug absorption

    Olivares Morales, A., Aarons, L. & Rostami, A., 2 Jun 2015, PAGE. Abstracts of the Annual Meeting of the Population Approach Group in Europe.. http://www.page-meeting.org/default.asp?abstract=3449: Population Approach Group in Europe

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  17. Published

    A semi-mechanistic gastric emptying model for the population pharmacokinetic analysis of orally administered acetaminophen in critically ill patients

    Ogungbenro, K., Vasist, L., Maclaren, R., Dukes, G., Young, M. & Aarons, L., Feb 2011, In : Pharmaceutical Research. 28, 2, p. 394-404 10 p.

    Research output: Contribution to journalArticle

  18. Published

    A semi-mechanistic gastric emptying pharmacokinetic model for 13C-octanoic acid: An evaluation using simulation

    Ogungbenro, K. & Aarons, L., 14 Feb 2012, In : European Journal of Pharmaceutical Sciences. 45, 3, p. 302-310 8 p.

    Research output: Contribution to journalArticle

  19. Published

    A Study of the dosage and duration for levobupivacaine infusion by the caudal-epidural route in infants aged 3-6 months

    Vashisht, R., Bendon, A., Okonkwo, I., Patel, D., Fullwood, C., Ogungbenro, K., Aarons, L. & Darwich, A., 2018, In : Pediatric Anesthesia.

    Research output: Contribution to journalArticle

  20. Published

    Accounting for dropout in xenografted tumour efficacy studies: integrated endpoint analysis, reduced bias and better use of animals

    Martin, E., Aarons, L. & WT Yates, J., Jul 2016, In : Cancer Chemotherapy and Pharmacology. 78, 1, p. 131-141

    Research output: Contribution to journalArticle

  21. Published

    An effective approach for obtaining optimal sampling windows for population pharmacokinetic experiments

    Ogungbenro, K. & Aarons, L., Jan 2009, In : Journal of Biopharmaceutical Statistics. 19, 1, p. 174-189 15 p.

    Research output: Contribution to journalArticle

  22. Published
  23. Published

    An identifiability analysis of a parent-metabolite pharmacokinetic model for ivabradine

    Adams, N. D., Godfrey, K. R., Chapman, M. J., Chappell, M. J., Aarons, L. & Duffull, S. B., 2001, In : Journal of pharmacokinetics and pharmacodynamics. 28, 1, p. 93-105 12 p.

    Research output: Contribution to journalArticle

  24. Published
  25. Published

    Analysis of the impact of controlled release formulation on oral drug absorption, gut wall metabolism and relative bioavailability of CYP3A substrates using a physiologically-based pharmacokinetic model

    Olivares-Morales, A., Kamiyama, Y., Darwich, A. S., Aarons, L. & Rostami, A., 25 Jan 2015, In : European Journal of Pharmaceutical Sciences. 67, p. 32-44 12 p.

    Research output: Contribution to journalArticle

  26. Published

    Analytical expressions for combining population pharmacokinetic parameters from different studies

    Dokoumetzidis, A. & Aarons, L., Jul 2008, In : Journal of Biopharmaceutical Statistics. 18, 4, p. 662-676 14 p.

    Research output: Contribution to journalArticle

  27. Published

    Application of a Bayesian approach to physiological modelling of mavoglurant population pharmacokinetics

    Wendling, T., Dumitras, S., Ogungbenro, K. & Aarons, L., 1 Aug 2015, In : Journal of pharmacokinetics and pharmacodynamics. 42, 6, p. 639-657 18 p.

    Research output: Contribution to journalArticle

  28. Published

    Application of optimal design methodologies in clinical pharmacology experiments

    Ogungbenro, K., Dokoumetzidis, A. & Aarons, L., Jul 2009, In : Pharmaceutical Statistics. 8, 3, p. 239-252 13 p.

    Research output: Contribution to journalArticle

  29. Published

    Assessment of Nevirapine Prophylactic and Therapeutic Dosing Regimens for Neonates

    Cressey, T. R., Punyawudho, B., Le Coeur, S., Jourdain, G., Saenjum, C., Capparelli, E. V., Jittayanun, K., Phanomcheong, S., Luvira, A., Borkird, T., Puangsombat, A., Aarons, L., Sukrakanchana, P. O., Urien, S., Lallemant, M., Sangsawang, S., Achalapong, J., Preedisripipat, K., Putiyanun, C., Wanchaitanawong, V. & 31 others, Yuthavisuthi, P., Ngampiyaskul, C., Kanjanavikai, P., Chotivanich, N., Hongsiriwon, S., Suwankornsakul, W., Sreshthatat, P., Kanjanasing, A., Kwanchaipanich, R., Rawangban, B., Santadusit, S., Jarupanich, T., Warachit, B., Siriwachirachai, T., Rojanakarin, P., Vivatpatanakul, K., Hanpinitsak, S., Wanasiri, P., Srirojana, S., Kongpanichkul, R., Bunjongpak, S., Sabsanong, P., Liampongsabuddhi, P., Pongdetudom, K., Khamja, P., Akarathum, N., Phonin, S. A., Limpitikul, W., Jungpipun, J., Petprakorp, R. & The PHPT-5 study team, 15 Aug 2017, In : Journal of Acquired Immune Deficiency Syndromes. 75, 5, p. 554-560 7 p.

    Research output: Contribution to journalArticle

  30. Published

    Bayesian optimal designs for pharmacokinetic models: Sensitivity to uncertainty

    Dokoumetzidis, A. & Aarons, L., Sep 2007, In : Journal of Biopharmaceutical Statistics. 17, 5, p. 851-867 16 p.

    Research output: Contribution to journalArticle

  31. Published

    Can BDDCS Class be used to explain differences in the prediction of human oral bioavailability from animal data using a threshold-based model?

    Olivares Morales, A., Hatley, OJD., Turner, D., Galetin, A., Aarons, L. & Rostami, A., Nov 2013.

    Research output: Contribution to conferencePoster

  32. Published

    Choosing an optimal input for an intravenous glucose tolerance test to aid parameter identification

    Martin, E., Yates, J. W. T., Ogungbenro, K. & Aarons, L., 5 Sep 2017, In : Journal of Pharmacy and Pharmacology. p. 1-9

    Research output: Contribution to journalArticle

  33. Published

    Combining the "bottom-up" and "top-down" approaches in pharmacokinetic modelling: Fitting PBPK models to observed clinical data

    Tsamandouras, N., Rostami-Hochaghan, A. & Aarons, L., 2015, In : British Journal of Clinical Pharmacology. 79, 1, p. 48-55 7 p.

    Research output: Contribution to journalArticle

  34. Published

    Comparison of in vivo and in silico methods to predict tissue:plasma partition coefficients in rat

    Graham, H., Jones, O., Galetin, A. & Aarons, L., 25 Nov 2009, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  35. Published

    Comparison of in-vivo and in-silico methods used for prediction of tissue: Plasma partition coefficients in rat

    Graham, H., Walker, M., Jones, O., Yates, J., Galetin, A. & Aarons, L., Mar 2012, In : Journal of Pharmacy and Pharmacology. 64, 3, p. 383-396 13 p.

    Research output: Contribution to journalArticle

  36. Published

    Computer Assisted Design of Phase II(b) Oral Dose Ranging Trial for Naratriptan - Results of a Pilot Study. Scientific Conference "Pharmacokinetics - UK", Manchester, UK. November 4-6, 1998

    Duffull, S., Nestorov, I. & Aarons, L., 1998, Conference Proceedings.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  37. Published

    Computer-assisted clinical trial simulation: a phase II case study with naraptriptan

    Nestorov, I., Graham, G., Duffell, S., Aarons, L., Fuseau, E. & Coates, P., 2001, In : Pharmacol. Toxicol.. 89 (suppl. 1)

    Research output: Contribution to journalArticle

  38. Published

    Corticosteroid-binding globulin regulates cortisol pharmacokinetics

    Perogamvros, I., Aarons, L., Miller, A. G., Trainer, P. J. & Ray, D. W., Jan 2011, In : Clinical Endocrinology. 74, 1, p. 30-36 6 p.

    Research output: Contribution to journalArticle

  39. Published

    COST B15: modelling in drug development

    Aarons, L., Balant, L. & Boobis, A., Jul 2001, In : British Journal of Clinical Pharmacology. 52, 1, p. 118-119

    Research output: Contribution to journalArticle

  40. Published

    Critical Analysis and Communication: an alternative to the final year project

    Barber, J., Demonacos, C., Aarons, L., Steinke, D. & Tully, M., 30 Jun 2014, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  41. Published

    Critical Analysis and Communication: An Alternative to the Research Project

    Demonacos, C., Aarons, L. & Barber, J., 2014, In : Health & Social Care Education. p. 1-5 4 p.

    Research output: Contribution to journalArticle

  42. Published

    Critique of the two-fold measure of prediction success for ratios: Application for the assessment of drug-drug interactions

    Guest, E. J., Aarons, L., Houston, J. B., Rostami-Hodjegan, A. & Galetin, A., Feb 2011, In : Drug Metabolism and Disposition. 39, 2, p. 170-173 3 p.

    Research output: Contribution to journalArticle

  43. Published

    Deconvolution and IVIVC: Exploring the Role of Rate-Limiting Conditions

    Margolskee, A., Darwich, A. S., Galetin, A., Rostami, A. & Aarons, L., 2 Mar 2016, In : The A A P S Journal. 18, 2, p. 321-332 11 p.

    Research output: Contribution to journalArticle

  44. Published
  45. Published

    Design of population pharmacokinetic experiments using prior information

    Ogungbenro, K. & Aarons, L., Oct 2007, In : Xenobiotica. 37, 10-11, p. 1311-1330 19 p.

    Research output: Contribution to journalArticle

  46. Published

    Design of Population Pharmacokinetic Studies: Sample size Determination

    Ogungbenro, K., Graham, G. & Aarons, L., Jun 2004.

    Research output: Contribution to conferencePoster

  47. Published

    Design of Population Pharmacokinetic Studies: Sample size Determination

    Ogungbenro, K., Graham, G. & Aarons, L., Nov 2003.

    Research output: Contribution to conferenceOther

  48. Published

    Designing More Efficient Preclinical Experiments: A Simulation Study in Chemotherapy-Induced Myelosupression

    Martin, E., Aarons, L. & Yates, J., 14 Feb 2016, In : Toxicological Sciences. 150, 1, p. 109-116 7 p.

    Research output: Contribution to journalArticle

  49. Published

    Determination of an optimal dosage regimen using a Bayesian decision analysis of efficacy and adverse effect data

    Graham, G., Gupta, S. & Aarons, L., 2002, In : Journal of pharmacokinetics and pharmacodynamics. 29, 1, p. 67-88 21 p.

    Research output: Contribution to journalArticle

  50. Published

    Development and Application of a Mechanistic Pharmacokinetic Model for Simvastatin and its Active Metabolite Simvastatin Acid Using an Integrated Population PBPK Approach

    Tsamandouras, N., Dickinson, G., Guo, Y., Hall, S., Rostami-Hochaghan, A., Galetin, A. & Aarons, L., 2015, In : Pharmaceutical Research. 32, 6, p. 1864-1883 19 p., 1573-904X.

    Research output: Contribution to journalArticle

  51. Published
  52. Published

    Development and evaluation of a classification tool for the qualitative prediction of oral bioavailability from animal data

    Olivares Morales, A., Hatley, OJD., Turner, D., Galetin, A., Aarons, L. & Rostami, A., Oct 2013.

    Research output: Contribution to conferenceOther

  53. Published

    Development of a novel method for updating the predicted partition coefficient values generated by an existing in silico prediction method

    Graham, H., Yates, J., Galetin, A. & Aarons, L., Nov 2010, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  54. Published

    Development of a novel simplified PBPK absorption model to explain the higher relative bioavailability of the OROS® formulation of oxybutynin

    Olivares-Morales, A., Ghosh, A., Aarons, L. & Rostami-Hodjegan, A., Nov 2016, In : The AAPS journal. 18, 6, p. 1532-1549 18 p.

    Research output: Contribution to journalArticle

  55. Published

    Development of a sequential linked pharmacokinetic and pharmacodynamic simulation model for ivabradine in healthy volunteers

    Duffull, S. B. & Aarons, L., Jun 2000, In : European Journal of Pharmaceutical Sciences. 10, 4, p. 275-284 9 p.

    Research output: Contribution to journalArticle

  56. Published
  57. Published

    Drug-drug interaction predictions with PBPK models and optimal multiresponse sampling time designs: Application to midazolam and a phase i compound. Part 2: Clinical trial results

    Chenel, M., Bouzom, F., Cazade, F., Ogungbenro, K., Aarons, L. & Mentré, F., Dec 2008, In : Journal of pharmacokinetics and pharmacodynamics. 35, 6, p. 661-681 20 p.

    Research output: Contribution to journalArticle

  58. Published

    Editorial: Pharmacokinetic and pharmacodynamic modelling in drug development

    Aarons, L., Jun 1999, In : Statistical Methods in Medical Research. 8, 3, p. 181-182

    Research output: Contribution to journalArticle

  59. Published

    Empirical and semi-mechanistic modelling of double-peaked pharmacokinetic profile phenomenon due to gastric emptying.

    Ogungbenro, K., Pertinez, H. & Aarons, L., Jan 2015, In : The AAPS journal. 17, 1

    Research output: Contribution to journalArticle

  60. Published

    Establishment and validation of microsampling techniques in wild rodents for ecotoxicological research

    Imholt, C., Abdulla, T., Stevens, A., Edwards, P., Jacob, J., Woods, D., Rogers, E., Aarons, L. & Segelcke, D., Sep 2018, In : Journal of Applied Toxicology. 38, 9

    Research output: Contribution to journalArticle

  61. Published

    Estimation of population pharmacokinetic parameters of free-phenytoin in adult epileptic patients

    Aarons, L., Ahmed, I. A. & Deleu, D., Jan 2005, In : Archives of Medical Research. 36, 1, p. 49-53 4 p.

    Research output: Contribution to journalArticle

  62. Published

    Ethnic differences in the population pharmacokinetics and pharmacodynamics of warfarin

    Yuen, E., Gueorguieva, I., Wise, S., Soon, D. & Aarons, L., Feb 2010, In : Journal of pharmacokinetics and pharmacodynamics. 37, 1, p. 3-24 21 p.

    Research output: Contribution to journalArticle

  63. Published

    Forecasting oral absorption across biopharmaceutics classification system classes with physiologically based pharmacokinetic models

    Hansmann, S., Darwich, A., Margolskee, A., Aarons, L. & Dressman, J., 2016, In : Journal of Pharmacy and Pharmacology.

    Research output: Contribution to journalArticle

  64. Published

    Handling Missing Data in a Duloxetine Population Pharmacokinetic/Pharmacodynamic Model - Imputation Methods and Selection Models

    Yuen, E., Gueorguieva, I. & Aarons, L., 3 May 2014, In : Pharmaceutical Research.

    Research output: Contribution to journalArticle

  65. Published

    How can we do pharmacokinetic studies in the tropics?

    Simpson, J. A., Aarons, L. & White, N. J., 2001, In : Transactions of the Royal Society of Tropical Medicine and Hygiene. 95, 4, p. 347-351 4 p.

    Research output: Contribution to journalArticle

  66. Published

    How many subjects are necessary for population pharmacokinetic experiments? Confidence interval approach

    Ogungbenro, K. & Aarons, L., Jul 2008, In : European journal of clinical pharmacology. 64, 7, p. 705-713 8 p.

    Research output: Contribution to journalArticle

  67. Published

    Identification of the effect of multiple polymorphisms on the pharmacokinetics of Simvastatin and Simvastatin acid using a population-modeling approach

    Tsamandouras, N., Dickinson, G., Guo, Y., Hall, S., Rostami-Hodjegan, A., Galetin, A. & Aarons, L., 2014, In : Clinical Pharmacology and Therapeutics. 96, 1, p. 90-100 10 p.

    Research output: Contribution to journalArticle

  68. Published

    IMI – oral biopharmaceutics tools project – evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds

    Margolskee, A., Darwich, A., Pepin, X., Pathak, S. M., Bolger et al, M. B., Aarons, L., Rostami-Hochaghan, A., Angstenberger, J., Graf, F., Laplanche, L., Muller, T., Carlert, S., Daga, P., Murphy, D., Tannergren, C., Yasin, M., Greschat-Schade, S., Muck, W., Muenster, U., van der Mey, D. & 27 others, Frank, K., Lloyd, R., Adriaenssen, L., Bevernage, J., De Zwart, L., Swerts, D., Tistaert, C., Van Den Bergh, A., Van Peer, A., Beato, S., Nguyen-Trung, A-T., Bennett, J., McAllister, M., Wong, M., Zane, P., Ollier, C., Vicat, P., Kolhmann, M., Marker, A., Brun, P., Mazuir, F., Beilles, S., Venczel, M., Boulenc, X., Loos, P., Lennernas, H. & Abrahamsson, B., 2016, In : European Journal of Pharmaceutical Sciences.

    Research output: Contribution to journalArticle

  69. Published

    IMI – Oral Biopharmaceutics Tools project – Evaluation of Bottom-up PBPK Prediction Success Part 2: An Introduction to the Simulation Exercise and Overview of Results

    Margolskee, A., Darwich, A., Aarons, L., Galetin, A., Rostami-Hochaghan, A., Carlert, S., Hammarberg, M., Hilgendorf, C., Johansson, P., Karlsson, E., Murphy, D., Tannergren, C., Thorn, H., Yasin, M., Mazuir, F., Nicolas, O., Ramusovic, S., Xu, C., Pathak, S., Korjamo, T. & 37 others, Laru, J., Malkki, J., Pappinen, S., Tuunainen, J., Dressman, J., Hansmann, S., Kostewicz, E., He, H., Heimbach, T., Wu, F., Hoft, C., Laplanche, L., Pang, Y., Bolger, M. B., Huehn, E., Lukacova, V., Mullin, J. M., Szeto, K. X., Costales, C., Lin, J., McAllister, M., Modi, S., Rotter, C., Varma, M., Wong, M., Mitra, A., Bevernage, J., Biewenga, J., Van Peer, A., Lloyd, R., Shardlow, C., Langguth, P., Mishenzon, I., Nguyen, M. A., Brown, J., Lennernas, H. & Abrahamsson, B., 2016, In : European Journal of Pharmaceutical Sciences.

    Research output: Contribution to journalArticle

  70. Published

    IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

    Darwich, A., Aarons, L., Galetin, A., Rostami-Hochaghan et al, A., Margolskee, A., Pepin, X., Carlert, S., Hammarberg, M., Hilgendorf, C., Johansson, P., Karlsson, E., Murphy, D., Tannergren, C., Thorn, H., Yasin, M., Mazuir, F., Nicolas, O., Ramusovic, S., Xu, C., Pathak, S. & 43 others, Korjamo, T., Laru, J., Malkki, J., Pappinen, S., Tuunainen, J., Dressman, J., Hansmann, S., Kostewicz, E. S., He, H., Heimbach, T., Wu, F., Hoft, C., Pang, Y., Bolger, M., Huehn, E., Heimbach, T., Wu, F., Hoft, C., Pang, Y., Bolger, M. B., Huehn, E., Lukacova, V., Mullin, J. M., Szeto, K. X., Costales, C., Lin, J., McAllister, M., Modi, S., Rotter, C., Varma, M., Wong, M., Mitra, A., Bevernage, J., Biewenga, J., Peer, A. V., Lloyd, R., Shardlow, C., Langguth, P., Mishenzon, I., Nguyen, M. A., Brown, J., Lennerans, H. & Abrahmsson, B., 1 Jan 2017, In : European Journal of Pharmaceutical Sciences. 96, p. 626-642 17 p.

    Research output: Contribution to journalArticle

  71. Published

    Incorporating correlation in interindividual variability for the optimal design of multiresponse pharmacokinetic experiments

    Ogungbenro, K., Graham, G., Gueorguieva, I. & Aarons, L., Mar 2008, In : Journal of Biopharmaceutical Statistics. 18, 2, p. 342-358 16 p.

    Research output: Contribution to journalArticle

  72. Published

    Incorporation of stochastic variability in mechanistic population pharmacokinetic models: handling the physiological constraints using normal transformations

    Tsamandouras, N., Wendling, T., Rostami-Hochaghan, A., Galetin, A. & Aarons, L., Aug 2015, In : Journal of pharmacokinetics and pharmacodynamics. 42, 4, p. 349-373 24 p.

    Research output: Contribution to journalArticle

  73. Published

    Intravenous anakinra can achieve experimentally effective concentrations in the central nervous system within a therapeutic time window: Results of a dose-ranging study

    Galea, J., Ogungbenro, K., Hulme, S., Greenhalgh, A., Aarons, L., Scarth, S., Hutchinson, P., Grainger, S., King, A., Hopkins, S. J., Rothwell, N. & Tyrrell, P., Feb 2011, In : Journal of Cerebral Blood Flow and Metabolism. 31, 2, p. 439-447 8 p.

    Research output: Contribution to journalArticle

  74. Published

    Linking preclinical and clinical whole-body physiologically based pharmacokinetic models with prior distributions in NONMEM

    Langdon, G., Gueorguieva, I., Aarons, L. & Karlsson, M., May 2007, In : European journal of clinical pharmacology. 63, 5, p. 485-498 13 p.

    Research output: Contribution to journalArticle

  75. Published

    Lumping of whole-body physiologically based pharmacokinetic models

    Nestorov, I. A., Aarons, L. J., Arundel, P. A. & Rowland, M., 1998, In : Journal of pharmacokinetics and biopharmaceutics. 26, 1, p. 21-46 25 p.

    Research output: Contribution to journalArticle

  76. Published

    Markov chain Monte Carlo techniques for studying interoccasion and intersubject variability: Application to pharmacokinetic data

    Lunn, D. J. & Aarons, L. J., 1997, In : Journal of the Royal Statistical Society. Series C: Applied Statistics. 46, 1, p. 73-91 18 p.

    Research output: Contribution to journalArticle

  77. Published

    Mathematical model of T-cell lymphoblastic lymphoma: disease, treatment, cure or relapse of a virtual cohort of patients

    Eymard, N., Volpert, V., Kurbatova, P., Bessonov, N., Ogungbenro, K., Aarons, L., Janiaud, P., Bajard, A., Chabaud, S., Bertrand, Y., Kassa¨i, B., Cornu, C. & Nony, P., 16 Dec 2016, In : Mathematical Medicine and Biology. 35, 1, p. 1-23

    Research output: Contribution to journalArticle

  78. Published

    Mean residence time for drugs subject to enterohepatic cycling

    Shepard, T. A., Lockwood, G. F., Aarons, L. J. & Abrahams, I. D., Jun 1989, In : Journal of pharmacokinetics and biopharmaceutics. 17, 3, p. 327-345 18 p.

    Research output: Contribution to journalArticle

  79. Published

    Mefloquine pharmacokinetic-pharmacodynamic models: Implications for dosing and resistance

    Simpson, J. A., Watkins, E. R., Price, R. N., Aarons, L., Kyle, D. E. & White, N. J., 2000, In : Antimicrobial Agents and Chemotherapy. 44, 12, p. 3414-3424 10 p.

    Research output: Contribution to journalArticle

  80. Published

    Methodological approaches to the population analysis of toxicity data

    Aarons, L. & Graham, G., 31 Mar 2001, In : Toxicology Letters. 120, 1-3, p. 405-410 5 p.

    Research output: Contribution to journalArticle

  81. Published

    Mixed effects modelling of toxicokinetic data

    Aarons, L., 2002, In : The Toxicologist. 66 (1-S)

    Research output: Contribution to journalArticle

  82. Published

    Model of mucociliary clearance in cystic fibrosis lungs.

    Kurbatova, P., Bessonov, N., Volpert, V., Tiddens, H. A. W. M., Cornu, C., Nony, P., Caudri, D., Aarons, L., Bajard, A., Bertrand, Y., Bretz, F., Castellan, C., Chabaud, S., Cornu, C., Dufour, F., Eymard, N., Fisch, R., Guerrini, R., Kassai, B., Kurbatova, P. & 13 others, Malik, S., Nony, P., Ogungbenro, K., Pérol, D., Pons, G., Tiddens, H., Rosati, A., Alberti, C., Chiron, C., Nabbout, R., Jullien, V., Benquet, P. & Wendling, F., 7 May 2015, In : Journal of Theoretical Biology. 372

    Research output: Contribution to journalArticle

  83. Published

    Model-based evaluation of the impact of formulation and food intake on the complex oral absorption of mavoglurant in healthy subjects.

    Wendling, T., Ogungbenro, K., Pigeolet, E., Dumitras, S., Woessner, R. & Aarons, L., May 2015, In : Pharmaceutical Research. 32, 5, p. 1764-1778 14 p.

    Research output: Contribution to journalArticle

  84. Published

    Modeling and simulation for clinical trial design involving a categorical response: A phase ii case study with naratriptan

    Nestorov, I., Graham, G., Duffull, S., Aarons, L., Fuseau, E. & Coates, P., 2001, In : Pharmaceutical Research. 18, 8, p. 1210-1219 9 p.

    Research output: Contribution to journalArticle

  85. Published

    Modeling and simulation in clinical pharmacology and dose finding

    Staab, A., Rook, E., Maliepaard, M., Aarons, L. & Benson, C., Feb 2013, In : CPT: Pharmacometrics and Systems Pharmacology. 2, 2, e29.

    Research output: Contribution to journalArticle

  86. Published

    Modelling and simulation in the development and use of anti-cancer agents: An underused tool?

    Rombout, F., Aarons, L., Karlsson, M., Man, A., Mentré, F., Nygren, P., Racine, A., Schaefer, H., Steimer, J. L., Troconiz, I. & Van Peer, A., Dec 2004, In : Journal of pharmacokinetics and pharmacodynamics. 31, 6, p. 419-440 21 p.

    Research output: Contribution to journalArticle

  87. Published

    Modelling of atorvastatin pharmacokinetics and the identification of the effect of a BCRP polymorphism in the Japanese population

    Tsamandouras, N., Guo, Y., Wendling, T., Hall, S., Galetin, A. & Aarons, L., Jan 2017, In : Pharmacogenetics and Genomics. 27, 1, p. 27-38 12 p.

    Research output: Contribution to journalArticle

  88. Published

    Molecular analysis of the subgingival microbiota in health and disease.

    Ledder, R. G., Gilbert, P., Huws, S. A., Aarons, L., Ashley, M. P., Hull, P. S. & McBain, A. J., Jan 2007, In : Applied and environmental microbiology. 73, 2, p. 516-523 7 p.

    Research output: Contribution to journalArticle

  89. Published

    Optimal blood sampling time windows for parameter estimation using a population approach: Design of a phase II clinical trial

    Chenel, M., Ogungbenro, K., Duval, V., Laveille, C., Jochemsen, R. & Aarons, L., Dec 2005, In : Journal of pharmacokinetics and pharmacodynamics. 32, 5-6, p. 737-756 19 p.

    Research output: Contribution to journalArticle

  90. Published
  91. Published

    Optimal design for multiresponse pharmacokinetic-pharmacodynamic models - Dealing with unbalanced designs

    Ogungbenro, K., Gueorguieva, I., Majid, O., Graham, G. & Aarons, L., Jun 2007, In : Journal of pharmacokinetics and pharmacodynamics. 34, 3, p. 313-331 18 p.

    Research output: Contribution to journalArticle

  92. Published

    Optimal design of pharmacokinetic studies

    Aarons, L. & Ogungbenro, K., Mar 2010, In : Basic and Clinical Pharmacology and Toxicology. 106, 3, p. 250-255 5 p.

    Research output: Contribution to journalArticle

  93. Published

    Optimal experimental design for precise estimation of the parameters of the axial dispersion model of hepatic elimination

    Chou, C. H., Aarons, L. & Rowland, M., 1998, In : Journal of pharmacokinetics and biopharmaceutics. 26, 5, p. 595-615 20 p.

    Research output: Contribution to journalArticle

  94. Published

    Optimisation of sampling windows design for population pharmacokinetic experiments

    Ogungbenro, K. & Aarons, L., Aug 2008, In : Journal of pharmacokinetics and pharmacodynamics. 35, 4, p. 465-482 17 p.

    Research output: Contribution to journalArticle

  95. Published

    Optimum blood sampling time windows for parameter estimation in population pharmacokinetic experiments

    Graham, G. & Aarons, L., 15 Dec 2006, In : Statistics in medicine. 25, 23, p. 4004-4019 15 p.

    Research output: Contribution to journalArticle

  96. Published

    Oral biopharmaceutics tools - Time for a new initiative - An introduction to the IMI project OrBiTo

    Lennernäs, H., Aarons, L., Augustijns, P., Beato, S., Bolger, M., Box, K., Brewster, M., Butler, J., Dressman, J., Holm, R., Julia Frank, K., Kendall, R., Langguth, P., Sydor, J., Lindahl, A., McAllister, M., Muenster, U., Müllertz, A., Ojala, K., Pepin, X. & 7 others, Reppas, C., Rostami-Hodjegan, A., Verwei, M., Weitschies, W., Wilson, C., Karlsson, C. & Abrahamsson, B., 16 Jun 2014, In : European Journal of Pharmaceutical Sciences. 57, 1, p. 292-299 7 p.

    Research output: Contribution to journalArticle

  97. Published

    PBPK models for the prediction of in vivo performance of oral dosage forms

    Kostewicz, E. S., Aarons, L., Bergstrand, M., Bolger, M. B., Galetin, A., Hatley, O., Jamei, M., Lloyd, R., Pepin, X., Rostami-Hodjegan, A., Sjögren, E., Tannergren, C., Turner, D. B., Wagner, C., Weitschies, W. & Dressman, J., 16 Jun 2014, In : European Journal of Pharmaceutical Sciences. 57, 1, p. 300-321 21 p.

    Research output: Contribution to journalArticle

  98. Published

    Pharmacodynamic modelling of resistance to epidermal growth factor receptor inhibition in brain metastasis mouse models.

    Martin, E., Aarons, L. & Yates, J. W. T., 2018, In : Cancer Chemotherapy and Pharmacology.

    Research output: Contribution to journalArticle

  99. Published

    Pharmacodynamics of controlled release verapamil in patients with hypertension: An analysis using spline functions

    Aarons, L., Baxter, C. & Gupta, S., Jul 2004, In : Biopharmaceutics and Drug Disposition. 25, 5, p. 219-225 6 p.

    Research output: Contribution to journalArticle

  100. Published

    Pharmacokinetic analysis to assess forgiveness of boosted saquinavir regimens for missed or late dosing

    Dickinson, L., Boffito, M., Khoo, S. H., Schutz, M., Aarons, L. J., Pozniak, A. L. & Back, D. J., Jul 2008, In : Journal of Antimicrobial Chemotherapy. 62, 1, p. 161-167 6 p.

    Research output: Contribution to journalArticle

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