Prof Leon AaronsBSc, MSc, PhD

Professor

Full contact details
View graph of relations

Publications

  1. Published

    Ethnic differences in the population pharmacokinetics and pharmacodynamics of warfarin

    Yuen, E., Gueorguieva, I., Wise, S., Soon, D. & Aarons, L., Feb 2010, In : Journal of pharmacokinetics and pharmacodynamics. 37, 1, p. 3-24 21 p.

    Research output: Contribution to journalArticle

  2. Published

    Population pharmacokinetic/pharmacodynamic models for duloxetine in the treatment of diabetic peripheral neuropathic pain

    Yuen, E., Gueorguieva, I., Bueno-Burgos, L., Iyengar, S. & Aarons, L., Mar 2013, In : European Journal of Pain. 17, 3, p. 382-393 11 p.

    Research output: Contribution to journalArticle

  3. Published

    Handling Missing Data in a Duloxetine Population Pharmacokinetic/Pharmacodynamic Model - Imputation Methods and Selection Models

    Yuen, E., Gueorguieva, I. & Aarons, L., 3 May 2014, In : Pharmaceutical Research.

    Research output: Contribution to journalArticle

  4. Published

    Pharmacokinetic studies of linezolid and teicoplanin in the critically ill

    Whitehouse, T., Cepeda, J. A., Shulman, R., Aarons, L., Nalda-Molina, R., Tobin, C., MacGowan, A., Shaw, S., Kibbler, C., Singer, M. & Wilson, A. P. R., Mar 2005, In : Journal of Antimicrobial Chemotherapy. 55, 3, p. 333-340 7 p.

    Research output: Contribution to journalArticle

  5. Published

    Model-based evaluation of the impact of formulation and food intake on the complex oral absorption of mavoglurant in healthy subjects.

    Wendling, T., Ogungbenro, K., Pigeolet, E., Dumitras, S., Woessner, R. & Aarons, L., May 2015, In : Pharmaceutical Research. 32, 5, p. 1764-1778 14 p.

    Research output: Contribution to journalArticle

  6. Published

    Predicting survival of pancreatic cancer patients treated with gemcitabine using longitudinal tumour size data

    Wendling, T., Mistry, H., Ogungbenro, K. & Aarons, L., 7 Mar 2016, In : Cancer Chemotherapy and Pharmacology. 77, 5, p. 927 938 p., 11.

    Research output: Contribution to journalArticle

  7. Published

    Reduction of a Whole-Body Physiologically Based Pharmacokinetic Model to Stabilise the Bayesian Analysis of Clinical Data.

    Wendling, T., Tsamandouras, N., Dumitras, S., Pigeolet, E., Ogungbenro, K. & Aarons, L., 4 Nov 2015, In : The AAPS journal. 18, 1

    Research output: Contribution to journalArticle

  8. Published

    Application of a Bayesian approach to physiological modelling of mavoglurant population pharmacokinetics

    Wendling, T., Dumitras, S., Ogungbenro, K. & Aarons, L., 1 Aug 2015, In : Journal of pharmacokinetics and pharmacodynamics. 42, 6, p. 639-657 18 p.

    Research output: Contribution to journalArticle

  9. Published

    Pharmacokinetics of a single bolus of propofol in Chinese children of different ages

    Wang, N. S., Lian, Q., Aarons, L., Matthews, I., Wang, Z., Chen, X., Freemantle, N. & Smith, F. G., Jan 2006, In : Anesthesiology. 104, 1, p. 27-32 5 p.

    Research output: Contribution to journalArticle

  10. Published

    "The Bayesian approach to population pharmacokinetic/pharmacodynamic modeling".

    Wakefield, J., Aarons, L. & Racine-Poon, A., 1999, Case Studies in Bayesian Statistics. Gatsonis, C., Kass, R., Carlin, B., Carriquiry, A., Gelman, A., Verdinelli, I. & West, M. (eds.). Springer Nature, (Lecture Notes in Statistics; vol. 140).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  11. Published

    The use of population pharmacokinetics in drug development

    Vozeh, S., Steimer, J. L., Rowland, M., Morselli, P., Mentré, F., Balant, L. P. & Aarons, L., 1996, In : Clinical Pharmacokinetics. 30, 2, p. 81-93 12 p.

    Research output: Contribution to journalArticle

  12. Published

    A methodological framework for drug development in rare diseases.

    Volpert, V., Eymard, N., Kassai, B., Aarons, L., Bajard, A., Ballot, C., Bertrand, Y., Bretz, F., Caudri, D., Castellan, C., Malik, S., Chabaud, S., Cornu, C., Dufour, F., Dunger-Baldauf, C., Dupont, J-M., Fisch, R., Guerrini, R., Kassaï, B., Nony, P. & 12 others, Ogungbenro, K., Pérol, D., Pons, G., Tiddens, H., Rosati, A., Alberti, C., Chiron, C., Kurbatova, P., Nabbout, R., Jullien, V., Benquet, P. & Wendling, F., 2014, In : Orphanet Journal of Rare Diseases. 9

    Research output: Contribution to journalArticle

  13. Published

    A Study of the dosage and duration for levobupivacaine infusion by the caudal-epidural route in infants aged 3-6 months

    Vashisht, R., Bendon, A., Okonkwo, I., Patel, D., Fullwood, C., Ogungbenro, K., Aarons, L. & Darwich, A., 2018, In : Pediatric Anesthesia.

    Research output: Contribution to journalArticle

  14. Published

    Ratifying the dosage and duration of levo-bupivacaine infusion by the caudal-epidural route in infants aged three to six months

    Vashisht, R., Bendon, A., Okonkwo, I., Darwich, A. & Aarons, L., May 2018, In : British Journal of Anaesthesia. 120, p. e11-e12 2 p.

    Research output: Contribution to journalMeeting Abstract

  15. Published

    Combining the "bottom-up" and "top-down" approaches in pharmacokinetic modelling: Fitting PBPK models to observed clinical data

    Tsamandouras, N., Rostami-Hochaghan, A. & Aarons, L., 2015, In : British Journal of Clinical Pharmacology. 79, 1, p. 48-55 7 p.

    Research output: Contribution to journalArticle

  16. Published

    Development and Application of a Mechanistic Pharmacokinetic Model for Simvastatin and its Active Metabolite Simvastatin Acid Using an Integrated Population PBPK Approach

    Tsamandouras, N., Dickinson, G., Guo, Y., Hall, S., Rostami-Hochaghan, A., Galetin, A. & Aarons, L., 2015, In : Pharmaceutical Research. 32, 6, p. 1864-1883 19 p., 1573-904X.

    Research output: Contribution to journalArticle

  17. Published

    Identification of the effect of multiple polymorphisms on the pharmacokinetics of Simvastatin and Simvastatin acid using a population-modeling approach

    Tsamandouras, N., Dickinson, G., Guo, Y., Hall, S., Rostami-Hodjegan, A., Galetin, A. & Aarons, L., 2014, In : Clinical Pharmacology and Therapeutics. 96, 1, p. 90-100 10 p.

    Research output: Contribution to journalArticle

  18. Published

    Incorporation of stochastic variability in mechanistic population pharmacokinetic models: handling the physiological constraints using normal transformations

    Tsamandouras, N., Wendling, T., Rostami-Hochaghan, A., Galetin, A. & Aarons, L., Aug 2015, In : Journal of pharmacokinetics and pharmacodynamics. 42, 4, p. 349-373 24 p.

    Research output: Contribution to journalArticle

  19. Published

    Modelling of atorvastatin pharmacokinetics and the identification of the effect of a BCRP polymorphism in the Japanese population

    Tsamandouras, N., Guo, Y., Wendling, T., Hall, S., Galetin, A. & Aarons, L., Jan 2017, In : Pharmacogenetics and Genomics. 27, 1, p. 27-38 12 p.

    Research output: Contribution to journalArticle

  20. Published

    Modeling and simulation in clinical pharmacology and dose finding

    Staab, A., Rook, E., Maliepaard, M., Aarons, L. & Benson, C., Feb 2013, In : CPT: Pharmacometrics and Systems Pharmacology. 2, 2, e29.

    Research output: Contribution to journalArticle

Previous 1 2 3 4 5 6 7 8 ...10 Next