Prof Leon AaronsBSc, MSc, PhD

Professor

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Publications

  1. Published

    A Bayesian method based on clotting factor activity for the prediction of maintenance warfarin dosage regimens

    Pitsiu, M., Parker, E. M., Aarons, L. & Rowland, M., Feb 2003, In : Therapeutic Drug Monitoring. 25, 1, p. 36-40 4 p.

    Research output: Contribution to journalArticle

  2. Published

    Corticosteroid-binding globulin regulates cortisol pharmacokinetics

    Perogamvros, I., Aarons, L., Miller, A. G., Trainer, P. J. & Ray, D. W., Jan 2011, In : Clinical Endocrinology. 74, 1, p. 30-36 6 p.

    Research output: Contribution to journalArticle

  3. Published

    Population Pharmacokinetics of Selumetinib and Its Metabolite N-desmethyl-selumetinib in Adult Patients With Advanced Solid Tumors and Children With Low-Grade Gliomas

    Patel, Y. T., Daryani, V. M., Patel, P., Zhou, D., Fangusaro, J., Carlile, D. J., Martin, P. D., Aarons, L. & Stewart, C. F., 2017, In : CPT: Pharmacometrics and Systems Pharmacology.

    Research output: Contribution to journalArticle

  4. Published

    Population pharmacokinetics of the MEK inhibitor selumetinib and its active N-desmethyl metabolite: Data from 10 phase I trials

    Patel, P., Howgate, E., Martin, P., Carlile, D. J., Aarons, L. & Zhou, D., 2017, In : British Journal of Clinical Pharmacology.

    Research output: Contribution to journalArticle

  5. Published

    Analysis of the impact of controlled release formulation on oral drug absorption, gut wall metabolism and relative bioavailability of CYP3A substrates using a physiologically-based pharmacokinetic model

    Olivares-Morales, A., Kamiyama, Y., Darwich, A. S., Aarons, L. & Rostami, A., 25 Jan 2015, In : European Journal of Pharmaceutical Sciences. 67, p. 32-44 12 p.

    Research output: Contribution to journalArticle

  6. Published

    Translating Human Effective Jejunal Intestinal Permeability to Surface-Dependent Intrinsic Permeability: a Pragmatic Method for a More Mechanistic Prediction of Regional Oral Drug Absorption

    Olivares-Morales, A., Lennernäs, H., Aarons, L. & Rostami-Hodjegan, A., 19 May 2015, In : The A A P S Journal. 17, 5, p. 1177-1192 15 p.

    Research output: Contribution to journalArticle

  7. Published

    The Use of ROC Analysis for the Qualitative Prediction of Human Oral Bioavailability from Animal Data

    Olivares-Morales, A., Hatley, O. J. D., Turner, D., Galetin, A., Aarons, L. & Rostami-Hodjegan, A., 27 Sep 2013, In : Pharmaceutical Research. 31, 3, p. 720-730 10 p.

    Research output: Contribution to journalArticle

  8. Published

    Qualitative model for the prediction of high/low human oral bioavailability from animal bioavailability data employing ROC analysis

    Olivares-Morales, A., Hatley, OJD., Turner, D., Galetin, A., Aarons, L. & Rostami, A., Nov 2013.

    Research output: Contribution to conferencePoster

  9. Published

    Development of a novel simplified PBPK absorption model to explain the higher relative bioavailability of the OROS® formulation of oxybutynin

    Olivares-Morales, A., Ghosh, A., Aarons, L. & Rostami-Hodjegan, A., Nov 2016, In : The AAPS journal. 18, 6, p. 1532-1549 18 p.

    Research output: Contribution to journalArticle

  10. Published

    Qualitative prediction of human oral bioavailability from animal oral bioavailability data employing ROC analysis

    Olivares Morales, A., Hatley, OJD., Turner, D., Galetin, A., Aarons, L. & Rostami, A., 14 Jun 2013.

    Research output: Contribution to conferencePoster

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