Prof Leon AaronsBSc, MSc, PhD

Professor

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Publications

  1. Published

    Population Pharmacokinetics of Selumetinib and Its Metabolite N-desmethyl-selumetinib in Adult Patients With Advanced Solid Tumors and Children With Low-Grade Gliomas

    Patel, Y. T., Daryani, V. M., Patel, P., Zhou, D., Fangusaro, J., Carlile, D. J., Martin, P. D., Aarons, L. & Stewart, C. F., 2017, In : CPT: Pharmacometrics and Systems Pharmacology.

    Research output: Contribution to journalArticle

  2. Published

    Population pharmacokinetics of the MEK inhibitor selumetinib and its active N-desmethyl metabolite: Data from 10 phase I trials

    Patel, P., Howgate, E., Martin, P., Carlile, D. J., Aarons, L. & Zhou, D., 2017, In : British Journal of Clinical Pharmacology.

    Research output: Contribution to journalArticle

  3. Published

    Corticosteroid-binding globulin regulates cortisol pharmacokinetics

    Perogamvros, I., Aarons, L., Miller, A. G., Trainer, P. J. & Ray, D. W., Jan 2011, In : Clinical Endocrinology. 74, 1, p. 30-36 6 p.

    Research output: Contribution to journalArticle

  4. Published

    Retrospective population pharmacokinetic analysis of cetirizine in children aged 6 months to 12 years

    Pitsiu, M., Hussein, Z., Majid, O., Aarons, L., De Longueville, M. & Stockis, A., Apr 2004, In : British Journal of Clinical Pharmacology. 57, 4, p. 402-411 9 p.

    Research output: Contribution to journalArticle

  5. Published

    A Bayesian method based on clotting factor activity for the prediction of maintenance warfarin dosage regimens

    Pitsiu, M., Parker, E. M., Aarons, L. & Rowland, M., Feb 2003, In : Therapeutic Drug Monitoring. 25, 1, p. 36-40 4 p.

    Research output: Contribution to journalArticle

  6. Published

    Phase I trial of AEG35156 administered as a 7-day and 3-day continuous intravenous infusion in patients with advanced refractory cancer

    Ranson, M., Dean, E., Jodrell, D., Connolly, K., Danson, S., Jolivet, J., Durkin, J., Morris, S., Jowle, D., Ward, T., Cummings, J., Dickinson, G., Aarons, L., LaCasse, E., Robson, L. & Dive, C., 1 Apr 2009, In : Journal of Clinical Oncology. 27, 10, p. 1660-1666 6 p.

    Research output: Contribution to journalArticle

  7. Published

    Modelling and simulation in the development and use of anti-cancer agents: An underused tool?

    Rombout, F., Aarons, L., Karlsson, M., Man, A., Mentré, F., Nygren, P., Racine, A., Schaefer, H., Steimer, J. L., Troconiz, I. & Van Peer, A., Dec 2004, In : Journal of pharmacokinetics and pharmacodynamics. 31, 6, p. 419-440 21 p.

    Research output: Contribution to journalArticle

  8. Published

    Precision criteria to derive sample size when designing pediatric pharmacokinetic studies: Which measure of variability should be used?

    Salem, F., Ogungbenro, K., Vajjah, P., Johnson, T. N., Aarons, L. & Rostami-Hodjegan, A., 2014, In : Journal of Clinical Pharmacology. 54, 3, p. 311-317 6 p.

    Research output: Contribution to journalArticle

  9. Published

    Mean residence time for drugs subject to enterohepatic cycling

    Shepard, T. A., Lockwood, G. F., Aarons, L. J. & Abrahams, I. D., Jun 1989, In : Journal of pharmacokinetics and biopharmaceutics. 17, 3, p. 327-345 18 p.

    Research output: Contribution to journalArticle

  10. Published

    Mefloquine pharmacokinetic-pharmacodynamic models: Implications for dosing and resistance

    Simpson, J. A., Watkins, E. R., Price, R. N., Aarons, L., Kyle, D. E. & White, N. J., 2000, In : Antimicrobial Agents and Chemotherapy. 44, 12, p. 3414-3424 10 p.

    Research output: Contribution to journalArticle