Prof Leon AaronsBSc, MSc, PhD

Professor

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Publications

  1. 2018
  2. Published

    The Influence of Normalization Weight in Population Pharmacokinetic Covariate Models

    Goulooze, S. C., Voller, S., Valitalo, P. A. J., Calvier, E. A. M., Aarons, L., Krekels, E. H. J. & Knibbe, C. A. J. 2018 In : Clinical Pharmacokinetics.

    Research output: Contribution to journalArticle

  3. 2017
  4. Published

    Whole body physiologically based modelling of β-blockers in the rat: events in tissues and plasma following an i.v. bolus dose

    Cheung, . S. Y. A., Rodgers, T., Aarons, L., Gueorguieva, I., Dickinson, G. L., Murby, S., Brown, C., Collins, B. & Rowland, M. 22 Dec 2017 In : British Journal of Pharmacology . p. 1 17 p.

    Research output: Contribution to journalArticle

  5. Published

    Choosing an optimal input for an intravenous glucose tolerance test to aid parameter identification

    Martin, E., Yates, J. W. T., Ogungbenro, K. & Aarons, L. 5 Sep 2017 In : Journal of Pharmacy and Pharmacology. p. 1-9

    Research output: Contribution to journalArticle

  6. Published

    Assessment of Nevirapine Prophylactic and Therapeutic Dosing Regimens for Neonates

    Cressey, T. R. , Punyawudho, B. , Le Coeur, S. , Jourdain, G. , Saenjum, C. , Capparelli, E. V. , Jittayanun, K. , Phanomcheong, S. , Luvira, A. , Borkird, T. , Puangsombat, A. , Aarons, L. , Sukrakanchana, P. O. , Urien, S. , Lallemant, M. , Sangsawang, S. , Achalapong, J. , Preedisripipat, K. , Putiyanun, C. , Wanchaitanawong, V. & 31 others Yuthavisuthi, P., Ngampiyaskul, C., Kanjanavikai, P., Chotivanich, N., Hongsiriwon, S., Suwankornsakul, W., Sreshthatat, P., Kanjanasing, A., Kwanchaipanich, R., Rawangban, B., Santadusit, S., Jarupanich, T., Warachit, B., Siriwachirachai, T., Rojanakarin, P., Vivatpatanakul, K., Hanpinitsak, S., Wanasiri, P., Srirojana, S., Kongpanichkul, R., Bunjongpak, S., Sabsanong, P., Liampongsabuddhi, P., Pongdetudom, K., Khamja, P., Akarathum, N., Phonin, S. A., Limpitikul, W., Jungpipun, J., Petprakorp, R. & The PHPT-5 study team 15 Aug 2017 In : Journal of Acquired Immune Deficiency Syndromes. 75, 5, p. 554-560 7 p.

    Research output: Contribution to journalArticle

  7. Published

    IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

    Darwich, A. , Aarons, L. , Galetin, A. , Rostami-Hochaghan et al, A. , Margolskee, A. , Pepin, X. , Carlert, S. , Hammarberg, M. , Hilgendorf, C. , Johansson, P. , Karlsson, E. , Murphy, D. , Tannergren, C. , Thorn, H. , Yasin, M. , Mazuir, F. , Nicolas, O. , Ramusovic, S. , Xu, C. , Pathak, S. & 43 others Korjamo, T., Laru, J., Malkki, J., Pappinen, S., Tuunainen, J., Dressman, J., Hansmann, S., Kostewicz, E. S., He, H., Heimbach, T., Wu, F., Hoft, C., Pang, Y., Bolger, M., Huehn, E., Heimbach, T., Wu, F., Hoft, C., Pang, Y., Bolger, M. B., Huehn, E., Lukacova, V., Mullin, J. M., Szeto, K. X., Costales, C., Lin, J., McAllister, M., Modi, S., Rotter, C., Varma, M., Wong, M., Mitra, A., Bevernage, J., Biewenga, J., Peer, A. V., Lloyd, R., Shardlow, C., Langguth, P., Mishenzon, I., Nguyen, M. A., Brown, J., Lennerans, H. & Abrahmsson, B. 1 Jan 2017 In : European Journal of Pharmaceutical Sciences. 96, p. 626-642 17 p.

    Research output: Contribution to journalArticle

  8. Published

    Modelling of atorvastatin pharmacokinetics and the identification of the effect of a BCRP polymorphism in the Japanese population

    Tsamandouras, N., Guo, Y., Wendling, T., Hall, S., Galetin, A. & Aarons, L. Jan 2017 In : Pharmacogenetics and Genomics. 27, 1, p. 27-38 12 p.

    Research output: Contribution to journalArticle

  9. Published

    Population Pharmacokinetics of Selumetinib and Its Metabolite N-desmethyl-selumetinib in Adult Patients With Advanced Solid Tumors and Children With Low-Grade Gliomas

    Patel, Y. T., Daryani, V. M., Patel, P., Zhou, D., Fangusaro, J., Carlile, D. J., Martin, P. D., Aarons, L. & Stewart, C. F. 2017 In : CPT: Pharmacometrics and Systems Pharmacology.

    Research output: Contribution to journalArticle

  10. Published

    Population pharmacokinetics of the MEK inhibitor selumetinib and its active N-desmethyl metabolite: Data from 10 phase I trials

    Patel, P., Howgate, E., Martin, P., Carlile, D. J., Aarons, L. & Zhou, D. 2017 In : British Journal of Clinical Pharmacology.

    Research output: Contribution to journalArticle

  11. Published

    Why has model-informed precision dosing not yet become common clinical reality?: Lessons from the past and a roadmap for the future

    Darwich, A. , Ogungbenro, K. , Vinks, A. A. , Powell, J. R. , Reny, J-L. , Marsousi, N. , Daali, Y. , Fairman, D. , Cook, J. , Lesko, L. J. , McCune, J. S. , Knibbe, C. A. J. , de Wildt, S. N. , Leeder, J. S. , Neely, M. N. , Zuppa, A. F. , Vicini, P. , Aarons, L. , Johnson, T. N. , Boiani, J. & 1 others Rostami-Hodjegan, A. 2017 In : Clinical Pharmacology & Therapeutics.

    Research output: Contribution to journalArticle

  12. 2016
  13. Published

    Mathematical model of T-cell lymphoblastic lymphoma: disease, treatment, cure or relapse of a virtual cohort of patients

    Eymard, N., Volpert, V., Kurbatova, P., Bessonov, N., Ogungbenro, K., Aarons, L., Janiaud, P., Bajard, A., Chabaud, S., Bertrand, Y., Kassa¨i, B., Cornu, C. & Nony, P. 16 Dec 2016 In : Mathematical Medicine and Biology. 00, p. 1-23

    Research output: Contribution to journalArticle

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