Prof Kaye Williams BSc PhD

Research interests

Kaye currently leads a multi-disciplinary team who work towards producing proof of concept data to support the translation of novel anti-cancer approaches into patients. She has specific interests in the tumour microenvironment, particularly the condition of hypoxia, and how to therapeutically target this to improve cancer outcomes. Kaye also has a keen interest in the use of molecular targeted and/or biological therapies in combination with radiation treatment. In particular she has investigated the impact of novel agents on the underlying mechanisms that govern radiation response to enable their optimal application in a clinical radiotherapy context. These studies have underpinned ongoing clinical trials within The Christie, Manchester, and nationally that are showing positive patient benefit. Kaye has a lead role in the development of pre-clinical imaging for oncology applications within the Manchester Cancer Research Centre. The focus here is to develop, validate and apply image derived biomarkers to assess changes in tumour biology and therapeutic response.

Patents filed and approved

• Therapeutic combinations comprising poly (ADP-ribose) polymerases inhibitor. 05801173.5-2123-IB2005002900, filed Sept 2005
• Carbonic anhydrase inhibitors. PCT/EP2011/052156, filed Feb 2011

If you would like to apply for a PhD under the supervision of Professor Williams, please visit this page.