Prof Kaye Williams BSc PhD

Chair Experimental Therapeutics

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Phone: +44 (0) 161 275 2428
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ORCID: 0000-0001-7708-3770
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Research interests

Kaye currently leads a multi-disciplinary team who work towards producing proof of concept data to support the translation of novel anti-cancer approaches into patients. She has specific interests in the tumour microenvironment, particularly the condition of hypoxia, and how to therapeutically target this to improve cancer outcomes. Kaye also has a keen interest in the use of molecular targeted and/or biological therapies in combination with radiation treatment. In particular she has investigated the impact of novel agents on the underlying mechanisms that govern radiation response to enable their optimal application in a clinical radiotherapy context. These studies have underpinned ongoing clinical trials within The Christie, Manchester, and nationally that are showing positive patient benefit. Kaye has a lead role in the development of pre-clinical imaging for oncology applications within the Manchester Cancer Research Centre. The focus here is to develop, validate and apply image derived biomarkers to assess changes in tumour biology and therapeutic response.

Patents filed and approved

  • Therapeutic combinations comprising poly (ADP-ribose) polymerases inhibitor. 05801173.5-2123-IB2005002900, filed Sept 2005
  • Carbonic anhydrase inhibitors. PCT/EP2011/052156, filed Feb 2011

If you would like to apply for a PhD under the supervision of Professor Williams, please visit this page.

Projects

Research and projects

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  1. MAnchester RESearch Transforming Radiation Oncology (MAESTRO) Programme as Part of CRUK RadNet.

    Bristow, R., Burnet, N., Choudhury, A., Dive, C., Faivre-Finn, C., Hagan, I., Hoskin, P., Hussell, T., Illidge, T., Kirkby, K., Kostarelos, K., O'Connor, J., Peek, N., Rattray, M., Taylor, S., Thornton, D., Van Herk, M., West, C., Whetton, A., Williams, K. & Yorke, J.

    1/11/19 → 31/10/24

    Project: Research

  2. Understanding how ERK5 Controls Osteosarcoma Development and Response to Treatment.

    Finegan, K., McMahon, A. & Williams, K.

    1/09/19 → 31/08/22

    Project: Research

  3. Novel Dual CXCR4/CXCR7 Receptor Drugs: Targeting Secondary Disease Progression and Resistance to Immunotherapy in Breast Cancer.

    Williams, K., Clarke, R. & Khan, A.

    1/08/19 → 31/07/22

    Project: Research

  4. Developing a Novel Class of ERK5 Inhibitors for the Treatment of Triple-Negative Breast Cancer.

    Finegan, K., Butterworth, S., Houston, J. & Williams, K.

    1/09/18 → 31/10/21

    Project: Research

  5. Targeting the Akt Pathway with AZD5363 in Combination with Radiotherapy to Improve Tumour Control in Head and Neck Cancer.

    Searle, E., Illidge, T., Metcalf, R. & Williams, K.

    1/09/17 → 28/02/21

    Project: Research

  6. Development of a Biologically-Relevant Preclinical Radiotherapy Dosimetry Phantom.

    Kirkby, K., Chadwick, A., Oh, A. & Williams, K.

    1/04/17 → 31/03/20

    Project: Research

  7. CRUK Imaging Centres.

    Jackson, A., Asselin, M., Coope, D., Dive, C., Faivre-Finn, C., Herholz, K., Hinz, R., Illidge, T., Manoharan, P., Marais, R., Matthews, J., McMahon, A., O'Connor, J., Parker, G., Stivaros, S., Thacker, N., Williams, K. & Withers, P.

    1/12/13 → 30/11/19

    Project: Research