My interests lie in understanding the mechanistic links between the circadian clock and inflammation. My previous work has demonstrated that immune cells possess internal timers which dictate their amplitude of response to inflammatory stimuli. These cellular timers can be critical in restraining inflammation and allowing resolution. By mapping the connections between the circadian clock and inflammatory pathways we will gain a greater understanding of clock control of inflammation, and identify potential new therapeutic targets.
My expertise includes in the use of animal models of inflammatory disease and the development of transgenic mice lacking clocks in various immune cells. The use of these tools allows me to explore the role of biological timers within the immune system in regulating the dynamics of inflammatory disease.