Dr John Knight

Lecturer in Cancer Biology

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Publications

  1. 2021
  2. Published

    Rpl24Bst mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K

    Knight, J. R. P., Vlahov, N., Gay, D. M., Ridgway, R. A., Faller, W. J., Proud, C., Mallucci, G. R., von der Haar, T., Smales, C. M., Willis, A. E. & Sansom, O. J., Dec 2021, In: eLife. 10, e69729.

    Research output: Contribution to journalArticlepeer-review

  3. Published

    MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression

    Knight, J. R. P., Alexandrou, C., Skalka, G. L., Vlahov, N., Pennel, K., Officer, L., Teodosio, A., Kanellos, G., Gay, D. M., May-Wilson, S., Smith, E. M., Najumudeen, A. K., Gilroy, K., Ridgway, R. A., Flanagan, D. J., Smith, R. C. L., McDonald, L., MacKay, C., Cheasty, A., McArthur, K. & 19 others, Stanway, E., Leach, J. D., Jackstadt, R., Waldron, J. A., Campbell, A. D., Vlachogiannis, G., Valeri, N., Haigis, K. M., Sonenberg, N., Proud, C. G., Jones, N. P., Swarbrick, M. E., McKinnon, H. J., Faller, W. J., Quesne, J. L., Edwards, J., Willis, A. E., Bushell, M. & Sansom, O. J., 1 May 2021, In: Cancer discovery. 11, 5, p. 1228-1247 20 p.

    Research output: Contribution to journalArticlepeer-review

  4. Published

    Tuning protein synthesis for cancer therapy

    Knight, J. R. P. & Sansom, O. J., 4 Mar 2021, In: Molecular & cellular oncology.

    Research output: Contribution to journalReview articlepeer-review

  5. Published

    Translation initiation in cancer at a glance

    Smith, R. C. L., Kanellos, G., Vlahov, N., Alexandrou, C., Willis, A. E., Knight, J. R. P. & Sansom, O. J., 13 Jan 2021, In: Journal of Cell Science. 134, 1, jcs248476.

    Research output: Contribution to journalArticlepeer-review

  6. Published

    The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer

    CRUK Rosetta Grand Challenge Consortium, 7 Jan 2021, In: Nature Genetics. 53, 1, p. 16-26 11 p.

    Research output: Contribution to journalArticlepeer-review

  7. 2020
  8. Published

    Control of translation elongation in health and disease

    Knight, J., Garland, G., Pöyry, T., Mead, E., Vlahov, N., Sfakianos, A., Grosso, S., De-Lima-Hedayioglu, F., Mallucci, G., von der Haar, T., Smales, C. M., Sansom, O. J. & Willis, A. E., 1 Mar 2020, In: Disease Models & Mechanisms. 13, 3

    Research output: Contribution to journalReview articlepeer-review

  9. Published

    BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration

    Loveridge, C. J., Slater, S., Campbell, K. J., Nam, N. A., Knight, J., Ahmad, I., Hedley, A., Lilla, S., Repiscak, P., Patel, R., Salji, M., Fleming, J., Mitchell, L., Nixon, C., Strathdee, D., Neilson, M., Ntala, C., Bryson, S., Zanivan, S., Edwards, J. & 4 others, Robson, C. N., Goodyear, C. S., Blyth, K. & Leung, H. Y., 20 Feb 2020, In: Oncogene. 39, 8, p. 1797-1806 10 p.

    Research output: Contribution to journalArticlepeer-review

  10. 2019
  11. Published

    Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas

    Liko, D., Mitchell, L., Campbell, K. J., Ridgway, R. A., Jones, C., Dudek, K., King, A., Bryson, S., Stevenson, D. A., Blyth, K., Strathdee, D., Morton, J. P., Bird, T. G., Knight, J. R. P., Willis, A. E. & Sansom, O. J., 1 Dec 2019, In: Cell Death and Differentiation. 26, 12, p. 2535-2550 16 p.

    Research output: Contribution to journalArticlepeer-review

  12. Published

    A MYC–GCN2–eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer

    Schmidt, S., Gay, D., Uthe, F. W., Denk, S., Paauwe, M., Matthes, N., Diefenbacher, M. E., Bryson, S., Warrander, F. C., Erhard, F., Ade, C. P., Baluapuri, A., Walz, S., Jackstadt, R., Ford, C., Vlachogiannis, G., Valeri, N., Otto, C., Schülein-Völk, C., Maurus, K. & 10 others, Schmitz, W., Knight, J. R. P., Wolf, E., Strathdee, D., Schulze, A., Germer, C. T., Rosenwald, A., Sansom, O. J., Eilers, M. & Wiegering, A., 1 Nov 2019, In: Nature Cell Biology. 21, 11, p. 1413-1424 12 p.

    Research output: Contribution to journalArticlepeer-review

  13. Published

    Hypoxic cancer-associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling

    Kugeratski, F. G., Atkinson, S. J., Neilson, L. J., Lilla, S., Knight, J. R. P., Serneels, J., Juin, A., Ismail, S., Bryant, D. M., Markert, E. K., Machesky, L. M., Mazzone, M., Sansom, O. J. & Zanivan, S., 5 Feb 2019, In: Science Signaling. 12, 567, eaan8247.

    Research output: Contribution to journalArticlepeer-review

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Publications highlights

Research output: Contribution to journalArticlepeer-review

Research output: Contribution to journalArticlepeer-review

Research output: Contribution to journalReview articlepeer-review

Research output: Contribution to journalArticlepeer-review

Research output: Contribution to journalArticlepeer-review

Research output: Contribution to journalArticlepeer-review