Professor Yorke’s programme of research applies all aspects of the MRC framework for the development and evaluation of complex interventions. A such, she has experience in leading funded projects using a variety a research approaches including systematic reviews, exploratory studies using qualitative, quantitative and mixed methods designs, pilot/feasibility RCT’s and phase 3 RCT’s. She also has expertise in the development and validation of Patient Reported Outcome Measures (PROMS) using advanced psychometric approaches, including Rasch analysis.
Her work involves patients living with malignant and non-malignant conditions including lung cancer, COPD, asthma, pulmonary fibrosis and pulmonary hypertension. She has received numerous awards and invitations to present her work on the global stage. Examples include the American Thoracic Society 2016, 2015, 2014 and ATS Nursing Year in Review 2012; International Scholar visits to Singapore, USA and Australia; European Respiratory Society Travel Scholarship 2010; British Lung Foundation Travel Fellowship 2009; Dyspnea-Central USA Scholarship 2009 and the Royal College of Nursing Early Researcher Award 2008.
Examples of current/recent research:
A randomised controlled trial to determine the clinical and cost effectiveness of a self-management intervention for the respiratory distress symptom cluster (breathlessness-cough-fatigue) in lung cancer. Funded by NIHR Research for Patient Benefit, start April 2016.
Development of a quality of life PROM in severe asthma. Funded by Centre of Excellence in Severe Asthma, University of Newcastle, start May 2016.
Adaption of an assessment tool of supportive and palliative care needs of people with interstitial lung disease. Funded by Marie Curie, currently recruiting.
Cancer-related information needs and decision making preferences in people with dementia, their carers and cancer clinicians. Funded by MICRA and Age UK, currently recruiting.
Evaluating the impact of respiratory nurse specialists on patient health outcomes. Funded by British Thoracic Society, currently recruiting.
Longitudinal cohort study of living with pulmonary hypertension. Funded by Pulmonary Hypertension Association, completed 2015.
Development of a pulmonary hypertension quality of life measure: the emPHasis-10. Funded by Pulmonary Hypertension Association, completed 2014.
Development of a programme of patient reported outcome measures for the identification of COPD clinical phenotypes and evaluation of stratified medicines. Funded by MRC and Technology Strategy Board, completed 2014.
A randomised controlled feasibility trial of a complex intervention for managing the cluster of respiratory distress symptoms (breathlessness-cough-fatigue) in lung cancer. Funded by Marie Curie, completed June 2014.
A randomised controlled feasibility trial of Group-CBT in severe asthma. Asthma UK, completed 2014.