Prof James HoustonBSc, PhD, DSc

Emeritus Professor

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Publications

  1. 2004
  2. Published

    Utility of recombinant enzyme kinetics in prediction of human clearance: Impact of variability, CYP3A5, and CYP2C19 on CYP3A4 probe substrates

    Galetin, A., Brown, C., Hallifax, D., Ito, K. & Houston, J. B., Dec 2004, In : Drug Metabolism and Disposition. 32, 12, p. 1411-1420 9 p.

    Research output: Contribution to journalArticle

  3. Published

    Substrate depletion approach for determining in vitro metabolic clearance: Time dependencies in hepatocyte and microsomal incubations

    Jones, H. M. & Houston, J. B., Sep 2004, In : Drug Metabolism and Disposition. 32, 9, p. 973-982 9 p.

    Research output: Contribution to journalArticle

  4. Published

    Comparison of fresh and cryopreserved rat hepatocyte suspensions for the prediction of in vitro intrinsic clearance

    Griffin, S. J. & Houston, J. B., May 2004, In : Drug Metabolism and Disposition. 32, 5, p. 552-558 6 p.

    Research output: Contribution to journalArticle

  5. Published

    Comparison of the use of liver models for predicting drug clearance using in vitro kinetic data from hepatic microsomes and isolated hepatocytes

    Ito, K. & Houston, J. B., May 2004, In : Pharmaceutical Research. 21, 5, p. 785-792 7 p.

    Research output: Contribution to journalArticle

  6. Published

    Quantitative prediction of the in vivo inhibition of diazepam metabolism by omeprazole using rat liver microsomes and hepatocytes

    Jones, H. M., Hallifax, D. & Houston, J. B., May 2004, In : Drug Metabolism and Disposition. 32, 5, p. 572-580 8 p.

    Research output: Contribution to journalArticle

  7. Published

    Auto- and heteroactivation of metabolism of a series of benzodiazepines in human hepatocytes.

    Hallifax, D., Rawden, H., Galetin, A., Brown, C. & Houston, JB., 2004.

    Research output: Contribution to conferencePoster

  8. 2003
  9. Published

    Generation and Evaluation of a CYP2C9 Heteroactivation Pharmacophore

    Egnell, A. C., Eriksson, C., Albertson, N., Houston, B. & Boyer, S., Dec 2003, In : Journal of Pharmacology and Experimental Therapeutics. 307, 3, p. 878-887 9 p.

    Research output: Contribution to journalArticle

  10. Published

    Isoform selectivity and kinetics of morphine 3- and 6-glucuronidation by human UDP-glucuronosyltransferases: Evidence for atypical glucuronidation kinetics by UGT2B7

    Stone, A. N., Mackenzie, P. I., Galetin, A., Houston, J. B. & Miners, J. O., 1 Sep 2003, In : Drug Metabolism and Disposition. 31, 9, p. 1086-1089 3 p.

    Research output: Contribution to journalArticle

  11. Published

    Multisite kinetic analysis of interactions between prototypical CYP3A4 subgroup substrates: Midazolam, testosterone, and nifedipine

    Galetin, A., Clarke, S. E. & Houston, J. B., 1 Sep 2003, In : Drug Metabolism and Disposition. 31, 9, p. 1108-1116 8 p.

    Research output: Contribution to journalArticle

  12. Published

    In vivo CYP3A4 heteroactivation is a possible mechanism for the drug interaction between felbamate and carbamazepine

    Egnell, A. C., Houston, B. & Boyer, S., 1 Jun 2003, In : Journal of Pharmacology and Experimental Therapeutics. 305, 3, p. 1251-1262 11 p.

    Research output: Contribution to journalArticle

  13. Published
  14. Published

    Bridging the gap between in vitro multi-site models and in vivo CYP3A4 drug-drug interactions

    Galetin, A. & Houston, B., 2003, Drug Metabolism Reviews. Suppl 2, Vol. 35.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  15. Published

    Database analysis for drug-drug interactions involving CYP2D6 inhibition.

    Ito, K., Hallifax, D., Obach, R. S. & Houston, B., 2003.

    Research output: Contribution to conferencePoster

  16. Published

    Evidence for atypical glucuronidation kinetics by human UDP-glucuronosyltransferase isoforms

    Miners, J. O., Uchaipichat, V., Mackenzie, PI., Galetin, A. & Houston, B., 2003, Evidence for atypical glucuronidation kinetics by human UDP-glucuronosyltransferase isoforms. ASCEPT, Sydney.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  17. Published

    Pharmacogencomics and predictive drug metabolism

    Andrews, J., Pasksaleva, E., Galetin, A. & Houston, B., 2003, Pharmacogencomics and predictive drug metabolism. Pharmacogenomics Workshop, Annual Human Genome Meeting, Cancun, Mexico.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  18. Published

    Progress Towards Prediction of Human Pharmacokinetic Parameters from In Vitro Technologies

    Houston, J. B. & Galetin, A., 2003, In : Drug Metabolism Reviews. 35, 4, p. 393-415 22 p.

    Research output: Contribution to journalArticle

  19. Published

    Quantative prediction of CYP3A4 drug-drug interactions: extending the strategy.

    Galetin, A., Hallifax, D., Ito, K. & Houston, B., 2003.

    Research output: Contribution to conferencePoster

  20. Published

    Typical and atypical enzyme kinetics, in Drug metabolism enzymes: Cytochrome P450 and other enzymes in drug discovery and development.

    Houston, B., Kenworthy, K. E. & Galetin, A., 2003, No publisher name. (Fontis Media, Lausanne.)

    Research output: Book/ReportBook

  21. 2002
  22. Published

    Comparative study of the metabolism of drug substrates by human cytochrome P450 3A4 expressed in bacterial, yeast and human lymphoblastoid cells

    Andrews, J., Abd-Ellah, M. F., Randolph, N. L., Kenworthy, K. E., Carlile, D. J., Friedberg, T. & Houston, J. B., 1 Nov 2002, In : Xenobiotica. 32, 11, p. 937-947 10 p.

    Research output: Contribution to journalArticle

  23. Published

    Comparison of liver models for predicting drug clearance in rats.

    Ito, K. & Houston, B., 2002, Proceedings of Swedish Academy of Pharmaceutical Sciences Roseno meeting..

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  24. Published

    Heteroactivation of cytochrome P450 by marked drugs at concentrations relevant in vivo - quantitative association with a clinical drug interaction.

    Egnell, A. C., Houston, B. & Boyer, S., 2002, Proceedings of Swedish Academy of Pharmaceutical Sciences Roseno meeting..

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  25. Published

    Incorporating measures of variability and uncertainty into the prediction of in vivo hepatic clearance from in vitro data

    Nestorov, I., Gueorguieva, I., Jones, H. M., Houston, B. & Rowland, M., 2002, In : Drug Metabolism and Disposition. 30, 3, p. 276-282 6 p.

    Research output: Contribution to journalArticle

  26. Published

    Prediction of human drug clearance from in vitro and preclinical data using physiological-based and empirical approaches.

    Ito, K. & Houston, B., 2002, Eur J Pharmac Sci. 17 (Supl.1 )

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  27. Published

    Prediction of ketoconazole and fluconazole drug-drug interactions with a range of CYP3A4 substrates.

    Galetin, A., Hallifax, D., Ito, K. & Houston, B., 2002.

    Research output: Contribution to conferencePoster

  28. Published

    Variability of intrinsic clearance: The effect of heteroactivation by testosterone in human liver microsomes.

    Rawden, H. C., Tindall, A. J., Hallifax, D. & Houston, B., 2002.

    Research output: Contribution to conferencePoster

  29. 2001
  30. Published

    Activation and inhibition of codeine metabolism by ketoconazole and quinine in rat liver microsomes.

    Proctor, N. J., Hallifax, D., Smith, D. A. & Houston, B., 2001.

    Research output: Contribution to conferencePoster

  31. Published

    Comparison of hepatocyte models for predicting in vitro intrinsic clearance using diazepam and tolbutamide.

    Griffin, S. J., Carlile, D. & Houston, B., 2001, Drug Metabolism Reviews. Vol. 33, Suppl. 1.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  32. Published

    Comparison of hepatocyte models for predicting in vitro intrinsic clearance using diazepam and tolbutamide.

    Griffin, S. J., Carlile, D. J. & Houston, B., 2001, Proceedings of the Hepatocyte User's Group, Stanstead.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  33. Published

    Heteroactivation of CYP3A4 substrates. Impact on intrinsic clearance and interindividual variability.

    Rawden, H. C., Tindall, A., Hallifax, D. & Houston, B., 2001.

    Research output: Contribution to conferencePoster

  34. Published

    In vitro human tissue models in risk assessment: Report of a consensus-building workshop

    MacGregor, J. T., Collins, J. M., Sugiyama, Y., Tyson, C. A., Dean, J., Smith, L., Andersen, M., Curren, R. D., Houston, J. B., Kadlubar, F. F., Kedderis, G. L., Krishnan, K., Li, A. P., Parchment, R. E., Thummel, K., Tomaszewski, J. E., Ulrich, R., Vickers, A. E. M. & Wrighton, S. A., 2001, In : Toxicological Sciences. 59, 1, p. 17-36 19 p.

    Research output: Contribution to journalArticle

  35. Published

    Metabolism in isolated rat hepatocyte suspensions, monolayer culture and hepatic microsomes: kinetics of nordiazepam metabolism.

    Parker, A. J. & Houston, B., 2001, Proceedings of the Hepatocyte User's Group, Stanstead.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  36. Published

    Multisite kinetic models for CYP3A4: Simultaneous activation and inhibition of diazepam and testosterone metabolism

    Kenworthy, K. E., Clarke, S. E., Andrews, J. & Houston, J. B., 2001, In : Drug Metabolism and Disposition. 29, 12, p. 1644-1651 7 p.

    Research output: Contribution to journalArticle

  37. Published

    Optimising drug development: Strategies to assess drug metabolism/transporter interaction potential - Towards a consensus

    Tucker, G. T., Houston, J. B. & Huang, S. M., 2001, In : European Journal of Pharmaceutical Sciences. 13, 4, p. 417-428 11 p.

    Research output: Contribution to journalArticle

  38. Published

    Optimizing drug development: Strategies to assess drug metabolism/transporter interaction potential - Toward a consensus

    Tucker, G. T., Houston, J. B. & Huang, S. M., 2001, In : Pharmaceutical Research. 18, 8, p. 1071-1080 9 p.

    Research output: Contribution to journalArticle

  39. Published

    Optimizing drug development: Strategies to assess drug metabolism/transporter interaction potential - Towards a consensus

    Tucker, G. T., Houston, J. B. & Huang, S. M., 2001, In : British Journal of Clinical Pharmacology. 52, 1, p. 107-117 10 p.

    Research output: Contribution to journalArticle

  40. Published

    The effects of product inhibition of product inhibition and cytochrome P450 loss on the depletion of triazolam in rat liver microsomes and hepatocytes.

    Jones, H. M. & Houston, B., 2001, Drug Metabolism Reviews. Vol. 33, Suppl. 1.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  41. 2000
  42. Published

    An integrated approach to prediction of systemic toxicity by using biokinetic models and biological in vitro test methods.

    Blaauboeer, B. J., Forsby, A., Houston, B., Beckman, M., Combes, R. D. & DeJongh, J., 2000, Progress in the Reduction, Refinement and Replacement of Animal Experimentation. Balls, M., Zeller, A-M. & Halder, M. (eds.). Elsevier BV

    Research output: Chapter in Book/Report/Conference proceedingChapter

  43. Published

    Comparison of clearance for three benzodiazepines determined by metabolite formation and substrate depletion methods in rat hepatic microsomes.

    Ahmed, S. & Houston, B., 2000, Drug Metabolism Reviews. Vol. 32, Suppl. 1.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  44. Published

    In vitro-in vivo scaling of cyp kinetic data not consistent with the classical Michaelis-Menten model

    Houston, J. B. & Kenworthy, K. E., 2000, In : Drug Metabolism and Disposition. 28, 3, p. 246-254 8 p.

    Research output: Contribution to journalArticle

  45. Published

    Incorporating variability and uncertainty into interspecies scaling of pharmacokinetics. In IFAC "Modelling and Control in Biomedical systems".(Edited by E.Carlson & E. Ssalzsieder)

    Nesterov, I., Carlile, D. J., Jones, H., Houston, B. & Rowland, M., 2000, IFAC "Modelling and Control in Biomedical systems. Carlson, E. & Ssalsieder, E. (eds.). Elsevier BV

    Research output: Chapter in Book/Report/Conference proceedingChapter

  46. Published

    Predicting the biological fate of methacrylate esters in rats using physiological based pharmacokinetic modelling and quantitative structure property relationships.

    Jones, O., Green, T. & Houston, B., 2000, Drug Metabolism Reviews. Vol. 32, Suppl. 1.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  47. Published

    Predicting the in vivo clearance of sildenafil from microsomal stability studies.

    Stringer, R. A., Howes, C., Nicklin, P. L. & Houston, B., 2000, Drug Metabolism Reviews. Vol. 32, Suppl. 1.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  48. Published

    Prediction of hepatic clearance of benzodiazapines from human liver microsomes via substrate depletion.

    Rawden, H. C. & Houston, B., 2000, Drug Metabolism Reviews. Vol. 32, Suppl. 1.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  49. Published

    Prediction of in vivo clearance from in vitro systems using rat hepatic microsomes and hepatocyte data.

    Jones, H. M., Carlile, D. J. & Houston, B., 2000, Drug Metabolism Reviews. Vol. 32, Suppl. 1.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  50. Published
  51. Published
  52. Published
  53. Published

    Regioselective and stereoselective hydroxylations of warfarin in human liver microsomes and cDNA expressed cytochrome P450.

    Bicknell, H. A., Worboys, P. D. & Houston, B., 2000, Drug Metabolism Reviews. Vol. 32, Suppl. 1.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  54. 1999
  55. Published

    An integrated approach to the prediction of systemic toxicity using computer-based biokinetic models and biological in vitro test methods: Overview of a prevalidation study based on the ECITTS project

    Dejongh, J., Forsby, A., Houston, J. B., Beckman, M., Combes, R. & Blaauboer, B. J., Aug 1999, In : Toxicology in Vitro. 13, 4-5, p. 549-554 5 p.

    Research output: Contribution to journalArticle

  56. Published

    Sigmoidal kinetics of CYP3A substrates: An approach for scaling dextromethorphan metabolism in hepatic microsomes and isolated hepatocytes to predict in vivo clearance in rat

    Witherow, L. E. & Houston, J. B., Jul 1999, In : Journal of Pharmacology and Experimental Therapeutics. 290, 1, p. 58-65 7 p.

    Research output: Contribution to journalArticle