Prof James HoustonBSc, PhD, DSc

Emeritus Professor

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Publications

  1. 2008
  2. Published

    Drug lipophilicity and microsomal protein concentration as determinants in the prediction of the fraction unbound in microsomal incubations

    Gertz, M., Kilford, P. J., Houston, J. B. & Galetin, A., Mar 2008, In : Drug Metabolism and Disposition. 36, 3, p. 535-542 7 p.

    Research output: Contribution to journalArticle

  3. Published

    Comparison of Hepatic and Intestinal Glucuronidation

    Cubitt, H., Houston, JB. & Galetin, A., 2008, host publication. Drug Metab Rev, Vol. 40 (Suppl. 1): 37..

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  4. Published

    Comparison of the extent of sulphation and glucuronidation in the intestine and liver for a range of drugs

    Cubitt, H., Houston, JB. & Galetin, A., 2008, host publication. Vol. 140.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  5. Published

    Grapefruit juice-drug interaction studies as a method to assess the extent of intestinal availability: Utility and limitations

    Gertz, M., Davis, J. D., Harrison, A., Houston, J. B. & Galetin, A., 2008, In : Current Drug Metabolism. 9, 8, p. 785-795 10 p.

    Research output: Contribution to journalArticle

  6. Published

    Impact of permeability on in vitro predictions of intestinal availability in the QGut model

    Gertz, M., Fenner, KS., Harrison, A., Davis, J., Houston, JB. & Galetin, A., 2008, host publication. Drug Metab Rev, Vol. 40 (Suppl. 1): 92.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  7. Published

    Methods for predicting in vivo pharmacokinetics using data from in vitro assays

    Houston, J. B. & Galetin, A., 2008, In : Current Drug Metabolism. 9, 9, p. 940-951 11 p.

    Research output: Contribution to journalArticle

  8. Published

    Uptake of repaglinide in HEK293 cells expressing OATP1B1 and plated human hepatocytes

    Hinton, LK., Thomas, JS., Kenworthy, KE., Somers, GI., Manchee, G., Galetin, A. & Houston, J., 2008, host publication. Drug Metab Rev, Vol. 40 (Suppl. 1):.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  9. 2007
  10. Published

    Maximal inhibition of intestinal first-pass metabolism as a pragmatic indicator of intestinal contribution to the drug-drug interactions for CYP3A4 cleared drugs

    Galetin, A., Hinton, L. K., Burt, H., Obach, R. S. & Houston, J. B., Oct 2007, In : Current Drug Metabolism. 8, 7, p. 685-693 8 p.

    Research output: Contribution to journalArticle

  11. Published

    Saturable uptake of lipophilic amine drugs into isolated hepatocytes: Mechanisms and consequences for quantitative clearance prediction

    Hallifax, D. & Houston, J. B., Aug 2007, In : Drug Metabolism and Disposition. 35, 8, p. 1325-1332 7 p.

    Research output: Contribution to journalArticle

  12. Published
  13. Published
  14. Published

    Evaluation of cryopreserved human hepatocytes as an alternative in vitro system to microsomes for the prediction of metabolic clearance

    Brown, H. S., Griffin, M. & Houston, J. B., Feb 2007, In : Drug Metabolism and Disposition. 35, 2, p. 293-301 8 p.

    Research output: Contribution to journalArticle

  15. Published

    Primary hepatocytes: Current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies

    Hewitt, N. J., Lechón, M. J. G., Houston, J. B., Hallifax, D., Brown, H. S., Maurel, P., Kenna, J. G., Gustavsson, L., Lohmann, C., Skonberg, C., Guillouzo, A., Tuschl, G., Li, A. P., Lecluyse, E., Groothuis, G. M. M. & Hengstler, J. G., Jan 2007, In : Drug Metabolism Reviews. 39, 1, p. 159-234 75 p.

    Research output: Contribution to journalArticle

  16. Published

    Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: Reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver

    Barter, Z. E., Bayliss, M. K., Beaune, P. H., Boobis, A. R., Carlile, D. J., Edwards, R. J., Houston, J. B., Lake, B. G., Lipscomb, J. C., Pelkonen, O. R., Tucker, G. T. & Rostami-Hodjegan, A., Jan 2007, In : Current Drug Metabolism. 8, 1, p. 33-45 12 p.

    Research output: Contribution to journalArticle

  17. Published

    Determination of the fraction metabolised by phase II (UGT) enzymes using human cryopreserved hepatocytes and 1-aminobenzo-triazole (ABT)

    Kilford, P., Stringer, R., Sohal, B., Houston, JB. & Galetin, A., 2007, host publication. Vol. 39(1).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  18. Published

    Prediction of hepatic uptake transporter (OATP1B1) drug-drug interactions

    Hinton, LK., Thomas, JS., Kenworthy, KE., Somers, GI., Manchee, G., Galetin, A. & Houston, JB., 2007, host publication. Vol. 39.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  19. Published

    Prediction of intestinal first-pass from in vitro metabolism and transport data.

    Gertz, M., Harrison, A., Davis, J., Houston, JB. & Galetin, A., 2007, host publication. Vol. 39 (1). 2 p.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  20. 2006
  21. Published

    Heteroactivation of carbamazepine metabolism by endogenous steroids in human liver microsomes and cryopreserved human hepatocytes.

    Galetin, A., Houston, JB., Henshall, A. & Harrison, A., Sep 2006, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  22. Published

    Inhibition of Repaglinide Metabolism by Gemfibrozil in Microsomes and Hepatocytes.

    Galetin, A., Houston, JB. & Gibbons, LK., Sep 2006, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  23. Published

    Maximal FG ratio as a pragmatic indicator of the extent of intestinal CYP3A4 inhibition interactions.

    Galetin, A., Houston, JB., Gibbons, L., Burt, H. & Obach, RS., Sep 2006, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  24. Published
  25. Published
  26. Published

    In vitro-in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: Pitfalls and promises

    Miners, J. O., Knights, K. M., Houston, J. B. & Mackenzie, P. I., 28 May 2006, In : Biochemical Pharmacology. 71, 11, p. 1531-1539 8 p.

    Research output: Contribution to journalArticle

  27. Published

    Binding of drugs to hepatic microsomes: Comment and assessment of current prediction methodology with recommendation for improvement [1]

    Hallifax, D. & Houston, J. B., Apr 2006, In : Drug Metabolism and Disposition. 34, 4, p. 724-726 2 p.

    Research output: Contribution to journalArticle

  28. Published

    Determination of a human hepatic microsomal scaling factor for predicting in vivo drug clearance

    Hakooz, N., Ito, K., Rawden, H., Gill, H., Lemmers, L., Boobis, A. R., Edwards, R. J., Carlile, D. J., Lake, B. G. & Houston, J. B., Mar 2006, In : Pharmaceutical Research. 23, 3, p. 533-539 6 p.

    Research output: Contribution to journalArticle

  29. Published

    Prediction of time-dependent CYP3A4 drug-drug interactions: Impact of enzyme degradation, parallel elimination pathways, and intestinal inhibition

    Galetin, A., Burt, H., Gibbons, L. & Houston, J. B., Jan 2006, In : Drug Metabolism and Disposition. 34, 1, p. 166-175 9 p.

    Research output: Contribution to journalArticle

  30. Published

    The utility of in vitro cytochrome P450 inhibition data in the prediction of drug-drug interactions

    Obach, R. S., Walsky, R. L., Venkatakrishnan, K., Gaman, E. A., Houston, J. B. & Tremaine, L. M., Jan 2006, In : Journal of Pharmacology and Experimental Therapeutics. 316, 1, p. 336-348 12 p.

    Research output: Contribution to journalArticle

  31. Published

    Comparison of Metabolism and Transporter Models for Predicting Gemfibrozil Drug-Drug Interactions.

    Gibbons, LK., Galetin, A. & Houston, JB., 2006, host publication. Drug Metab Rev, Vol. 38 (Suppl. 1).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  32. Published

    Intestinal and hepatic metabolic activity of five cytochrome P450 enzymes: Impact on prediction of first-pass metabolism

    Galetin, A. & Houston, J. B., 2006, In : Journal of Pharmacology and Experimental Therapeutics. 318, 3, p. 1220-1229 9 p.

    Research output: Contribution to journalArticle

  33. Published

    Maximal FG ratio as a pragmatic indicator of the magnitude of intestinal CYP3A4 inhibition

    Galetin, A., Gibbons, LK., Burt, H., Obach, RS. & Houston, JB., 2006, host publication. Drug Metab Rev, Vol. 38 (Suppl. 1): 44.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  34. Published

    Multisite kinetic modelling of interactions between UDP-glucuronosyltransferase 2B7 (UGT2B7) substrates.

    Galetin, A., Uchaipichat, V., Mackenzie, PI., Houston, JB. & Miners, JO., 2006, host publication. Drug Metab Rev, Vol. 38 (Suppl. 1): 45.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  35. Published

    Time-dependent inhibition of CYP3A4 by mibefradil in recombinant CYP3A4 and human liver microsomes and impact on in vivo predictions.

    Burt, H., Galetin, A. & Houston, JB., 2006, host publication. Drug Metab Rev, Vol. 38 (Suppl. 1):.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  36. Published

    Uptake and intracellular binding of lipophilic amine drugs by isolated rat hepatocytes and implications for prediction of in vivo metabolic clearance

    Hallifax, D. & Houston, J. B., 2006, In : Drug Metabolism and Disposition. 34, 11, p. 1829-1836 7 p.

    Research output: Contribution to journalArticle

  37. Published

    Variability in Heteroactivation of Carbamazepine Metabolism by Endogenous Steroids: Comparison of CYP3A4 and CYP3A5 Response.

    Henshall, J., Galetin, A., Harrison, A. & Houston, JB., 2006, host publication. Drug Metab Rev, Vol. 38 (Suppl. 1):.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  38. 2005
  39. Published

    In vitro cytochrome P450 inhibition data and the prediction of drug-drug interactions: Qualitative relationships, quantitative predictions, and the rank-order approach

    Obach, R. S., Walsky, R. L., Venkatakrishnan, K., Houston, J. B. & Tremaine, L. M., Dec 2005, In : Clinical Pharmacology and Therapeutics. 78, 6, p. 582-e7

    Research output: Contribution to journalArticle

  40. Published

    Prediction of metabolic clearance using cryopreserved human hepatocytes: Kinetic characteristics for five benzodiazepines

    Hallifax, D., Rawden, H. C., Hakooz, N. & Houston, J. B., Dec 2005, In : Drug Metabolism and Disposition. 33, 12, p. 1852-1858 6 p.

    Research output: Contribution to journalArticle

  41. Published

    Prediction of in vivo drug-drug interactions from in vitro data: Impact of incorporating parallel pathways of drug elimination and inhibitor absorption rate constant

    Brown, H. S., Ito, K., Galetin, A. & Houston, J. B., Nov 2005, In : British Journal of Clinical Pharmacology. 60, 5, p. 508-518 10 p.

    Research output: Contribution to journalArticle

  42. Published

    CYP3A4 substrate selection and substitution in the prediction of potential drug-drug interactions

    Galetin, A., Ito, K., Hallifax, D. & Houston, J. B., Jul 2005, In : Journal of Pharmacology and Experimental Therapeutics. 314, 1, p. 180-190 10 p.

    Research output: Contribution to journalArticle

  43. Published

    Impact of parallel pathways of drug elimination and multiple cytochrome P450 involvement on drug-drug interactions: CYP2D6 paradigm

    Ito, K., Hallifax, D., Obach, R. S. & Houston, J. B., Jun 2005, In : Drug Metabolism and Disposition. 33, 6, p. 837-844 7 p.

    Research output: Contribution to journalArticle

  44. Published

    Microsomal prediction of in vivo clearance and associated interindividual variability of six benzodiazepines in humans

    Rawden, H. C., Carlile, D. J., Tindall, A., Hallifax, D., Galetin, A., Ito, K. & Houston, J. B., Jun 2005, In : Xenobiotica. 35, 6, p. 603-625 22 p.

    Research output: Contribution to journalArticle

  45. Published

    Role of hepatic cytochrome P450s in the pharmacokinetics and toxicity of cyclophosphamide: Studies with the hepatic cytochrome P450 reductase null mouse

    Pass, G. J., Carrie, D., Boylan, M., Lorimore, S., Wright, E., Houston, B., Henderson, C. J. & Wolf, C. R., 15 May 2005, In : Cancer Research. 65, 10, p. 4211-4217 6 p.

    Research output: Contribution to journalArticle

  46. Published

    Impact of end-product inhibition on the determination of in vitro metabolic clearance

    Jones, H. M., Nicholls, G. & Houston, J. B., May 2005, In : Xenobiotica. 35, 5, p. 439-454 15 p.

    Research output: Contribution to journalArticle

  47. Published

    Predictive models of CYP3A4 heteroactivation: In vitro-in vivo scaling and pharmacophore modeling

    Egnell, A. C., Houston, J. B. & Boyer, C. S., Mar 2005, In : Journal of Pharmacology and Experimental Therapeutics. 312, 3, p. 926-937 11 p.

    Research output: Contribution to journalArticle

  48. Published

    Modelling atypical CYP3A4 kinetics: Principles and pragmatism

    Houston, J. B. & Galetin, A., 15 Jan 2005, In : Archives of Biochemistry and Biophysics. 433, 2, p. 351-360 9 p.

    Research output: Contribution to journalArticle

  49. Published

    Prediction of human drug clearance from in vitro and preclinical data using physiologically based and empirical approaches

    Ito, K. & Houston, J. B., Jan 2005, In : Pharmaceutical Research. 22, 1, p. 103-112 9 p.

    Research output: Contribution to journalArticle

  50. Published

    Prediction of in vitro intrinsic clearance from hepatocytes: Comparison of suspensions and monolayer cultures

    Griffin, S. J. & Houston, J. B., Jan 2005, In : Drug Metabolism and Disposition. 33, 1, p. 115-120 5 p.

    Research output: Contribution to journalArticle

  51. Published
  52. Published

    Prediction of time-dependant drug-drug interactions - impact of parallel pathways, enzyme degradation and intestinal inhibition

    Galetin, A., Burt, H. & Houston, B., 2005, Drug Metabolism Reviews. Suppl 2 ed. Vol. 38.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  53. Published

    Research Governance: What is reasonable protection?

    Payne, K., Fargher, EA., Tricker, K., Newman, WG., Qasim, FF., Poulton, K., Andrews, J., Houston, J., Elliott, RA., Elles, R., Ray, D., Shaffer, JL., Griffiths, CEM., Bruce, I., Roberts, S. & Ollier, WER., 2005, In : BMJ Rapid response.

    Research output: Contribution to journalLetter

  54. Published

    The TARGET (TPMT: Azathioprine Response to Genotyping and Enzyme Testing) study

    Newman, WG., Payne, K., Poulton, K., Andrews, J., Houston, B., Elliott, RA., Elles, RG., Ray, DW., Shaffer, J., Griffiths, CEM., Bruce, IN., Roberts, S. A., Qasim, F. & Ollier, WER., 2005, In : Bmj.

    Research output: Contribution to journalLetter