Prof James HoustonBSc, PhD, DSc

Emeritus Professor

Full contact details
View graph of relations

Publications

  1. 2011
  2. Published
  3. Published

    Critique of the two-fold measure of prediction success for ratios: Application for the assessment of drug-drug interactions

    Guest, E. J., Aarons, L., Houston, J. B., Rostami-Hodjegan, A. & Galetin, A., Feb 2011, In : Drug Metabolism and Disposition. 39, 2, p. 170-173 3 p.

    Research output: Contribution to journalArticle

  4. Published

    Assessment of algorithms for predicting drug-drug interactions via inhibition mechanisms: Comparison of dynamic and static models

    Guest, E. J., Rowland-Yeo, K., Rostami-Hodjegan, A., Tucker, G. T., Houston, J. B. & Galetin, A., Jan 2011, In : British Journal of Clinical Pharmacology. 71, 1, p. 72-87 15 p.

    Research output: Contribution to journalArticle

  5. 2010
  6. Published

    Comparative use of isolated hepatocytes and hepatic microsomes for cytochrome P450 inhibition studies: Transporter-enzyme interplay

    Brown, H. S., Wilby, A. J., Alder, J. & Houston, J. B., Dec 2010, In : Drug Metabolism and Disposition. 38, 12, p. 2139-2146 7 p.

    Research output: Contribution to journalArticle

  7. Published

    Prediction of human metabolic clearance from in vitro systems: Retrospective analysis and prospective view

    Hallifax, D., Foster, J. A. & Houston, J. B., Oct 2010, In : Pharmaceutical Research. 27, 10, p. 2150-2161 11 p.

    Research output: Contribution to journalArticle

  8. Published

    Contribution of active uptake to the hepatic clearance of seven OATP substrates in rat and human plated hepatocytes

    Menochet, K., Kenworthy, K., Houston, JB. & Galetin, A., Sep 2010, host publication. Vol. 487.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  9. Published

    Drug clearance in different in vitro systems as a preliminary indicator of hepatic uptake

    Houston, J., Rostami-Hochaghan, A. & Galetin, A., Sep 2010, host publication. Vol. 510.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  10. Published

    Metabolite formation kinetics and intrinsic clearance of phenacetin, tolbutamide, alprazolam, and midazolam in adenoviral cytochrome P450-transfected HepG2 cells and comparison with hepatocytes and in vivo

    Donato, M. T., Hallifax, D., Picazo, L., Castell, J. V., Houston, J. B., Gomez-Lechón, M. J. & Lahoz, A., Sep 2010, In : Drug Metabolism and Disposition. 38, 9, p. 1449-1455 6 p.

    Research output: Contribution to journalArticle

  11. Published

    Physiologically-based pharmacokinetic modelling of hepatic transporter substrate rosuvastatin

    Tate, S., Jones, HM., Houston, JB. & Galetin, A., Sep 2010, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  12. Published
  13. Published

    Prediction of human intestinal first-pass metabolism of 25 CYP3A substrates from in vitro clearance and permeability data

    Gertz, M., Harrison, A., Houston, J. B. & Galetin, A., Jul 2010, In : Drug Metabolism and Disposition. 38, 7, p. 1147-1158 11 p.

    Research output: Contribution to journalArticle

  14. Published

    Transporters and cytochrome P450 interplay in defining hepatic drug clearance

    Houston, JB., Jun 2010.

    Research output: Contribution to conferenceOther

  15. Published

    IC50-based approaches as an alternative method for assessment of time-dependent inhibition of CYP3A4

    Burt, H. J., Galetin, A. & Houston, J. B., May 2010, In : Xenobiotica. 40, 5, p. 331-343 12 p.

    Research output: Contribution to journalArticle

  16. Published

    Pharmacokinetics of fexofenadine: Evaluation of a microdose and assessment of absolute oral bioavailability

    Lappin, G., Shishikura, Y., Jochemsen, R., Weaver, R. J., Gesson, C., Houston, B., Oosterhuis, B., Bjerrum, O. J., Rowland, M. & Garner, C., May 2010, In : European Journal of Pharmaceutical Sciences. 40, 2, p. 125-131 6 p.

    Research output: Contribution to journalArticle

  17. Published

    Application of different in vitro systems for prediction of in vivo induction drug-drug interactions

    Galetin, A. & Houston, J., 2010, host publication. Vol. 143.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  18. Published

    Contribution of intestinal cytochrome P450-mediated metabolism to drug-drug inhibition and induction interactions

    Galetin, A., Gertz, M. & Houston, J. B., 2010, In : Drug Metabolism and Pharmacokinetics. 25, 1, p. 28-47 19 p.

    Research output: Contribution to journalArticle

  19. Published

    In vitro techniques to study drug-drug interactions of drug metabolism: Cytochrome P450

    Houston, J. B. & Galetin, A., 2010, Enzyme- and Transporter-Based Drug-Drug Interactions: Progress and Future Challenges|Enz.- and Transporter-Based Drug-Drug Interac.: Progress and Fut. Chall.. USA: Springer Nature, p. 169-215 46 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  20. Published

    Inhibition of Drug Metabolizing Enzymes in Gastrointestinal Tract and its Influence on the Drug-Drug Interaction Prediction, in Enzyme Inhibition in Drug Discovery and Development

    Galetin, A., Houston, JB., Lu, C. (ed.) & A. P. Li, S. (ed.), 2010, host publication. John Wiley & Sons Ltd, p. 315-343

    Research output: Chapter in Book/Report/Conference proceedingChapter

  21. Published

    Physiologically-based pharmacokinetic modelling approach to assess the uptake transporter-mediated drug-drug interaction potential of cyclosporine.

    Galetin, A. & Houston, J., 2010, host publication. Vol. 149.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  22. Published

    Prediction of clearance from the HepaRG cell system: comparison with human hepatocytes for a range of substrates.

    Zanelli, U., Caradonna, NP., Hallifax, D. & Houston, JB., 2010, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  23. 2009
  24. Published

    . Physiologically-Based Pharmacokinetic Modelling of Hepatic Uptake of Pravastatin and Rosuvastatin

    Galetin, A., Houston, JB., Tate, S. & Jones, HM., 25 Nov 2009, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  25. Published

    Assessment of Algorithms for Predicting Drug-Drug Interactions via Inhibition Mechanisms.

    Rostami-Hochaghan, A., Guest, EJ., Rowland, Y. K., Rostami-Hodjegan, A., Tucker, GT., Houston, JB. & Galetin, A., 23 Sep 2009, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  26. Published

    Transporters and cytochrome P450 interplay in defining hepatic drug clearance

    Houston, JB., Sep 2009.

    Research output: Contribution to conferenceOther

  27. Published

    Methodology for development of a physiological model incorporating CYP3A and P-glycoprotein for the prediction of intestinal drug absorption

    Badhan, R., Penny, J., Galetin, A. & Houston, J. B., Jun 2009, In : Journal of Pharmaceutical Sciences. 98, 6, p. 2180-2197 17 p.

    Research output: Contribution to journalArticle

  28. Published

    How good is prediction of in vivo metabolic clearance from established in vitro systems?

    Foster, JA., Hallifax, D. & Houston, B., 17 May 2009.

    Research output: Contribution to conferencePoster

  29. Published

    Involvement of drug uptake in hepatic clearance

    Jigorel, EE. & Houston, B., 17 May 2009, Drug Metab Rev. Vol. Rev 41 (Suppl 1).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  30. Published

    Evaluation of recombinant cytochrome p450 enzymes as an in vitro system for metabolic clearance predictions

    Stringer, R. A., Strain-Damerell, C., Nicklin, P. & Houston, J. B., May 2009, In : Drug Metabolism and Disposition. 37, 5, p. 1025-1034 9 p.

    Research output: Contribution to journalArticle

  31. Published

    Relative Importance of Intestinal and Hepatic Glucuronidation-Impact on the Prediction of Drug Clearance

    Cubitt, H. E., Houston, J. B. & Galetin, A., May 2009, In : Pharmaceutical Research. 26, 5, p. 1073-1083 10 p.

    Research output: Contribution to journalArticle

  32. Published

    QGut Model as a Predictive Tool for Intestinal Availability in Human: Impact of In Vitro Permeability and Clearance

    Gertz, M., Fenner, KS., Harrison, A., Davis, J., Houston, JB. & Galetin, A., 6 Feb 2009, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  33. Published

    Prediction of drug clearance by glucuronidation from in vitro data: Use of combined cytochrome P450 and UDP-glucuronosyltransferase cofactors in alamethicin-activated human liver microsomes

    Kilford, P. J., Stringer, R., Sohal, B., Houston, J. B. & Galetin, A., Jan 2009, In : Drug Metabolism and Disposition. 37, 1, p. 82-89 7 p.

    Research output: Contribution to journalArticle

  34. Published

    Assessment of the contribution of transporter-mediated active uptake to the overall hepatic uptake clearance for a range of drugs

    Yabe, Y., Galetin, A. & Houston, JB., 2009, host publication. Vol. 41 (Suppl. 3): 39..

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  35. Published

    Comparison of intestinal and hepatic sulphation and glucuronidation for a range of drugs

    Cubitt, H., Houston, JB. & Galetin, A., 2009, In : Drug Metabolism Reviews. 41 (Suppl. 1)

    Research output: Contribution to journalArticle

  36. Published

    Evaluation of the transporter-mediated hepatic uptake in fresh rat hepatocytes

    Yabe, Y., Galetin, A. & Houston, JB., 2009, host publication. Drug Metab Rev, Vol. 41 (Suppl. 1).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  37. Published

    Impact of saturation of CYP3A4 and P-glycoprotein in vivo on the prediction of intestinal availability

    Gertz, M., Harrison, A., Davis, J., Houston, JB. & Galetin, A., 2009, host publication. Vol. 41 (Suppl. 3): 29..

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  38. Published

    Methodological uncertainty in quantitative prediction of human hepatic clearance from in vitro experimental systems

    Hallifax, D. & Houston, J. B., 2009, In : Current Drug Metabolism. 10, 3, p. 307-321 14 p.

    Research output: Contribution to journalArticle

  39. Published

    Prediction of the intestinal availability and associated inter-individual variability for drugs with high intestinal first-pass metabolism

    Gertz, M., Harrison, A., Davis, J., Houston, JB. & Galetin, A., 2009, In : Drug Metabolism Reviews. 41 (Suppl. 1): 50

    Research output: Contribution to journalArticle

  40. 2008
  41. Published

    Defining the in vivo role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5

    Finn, R. D., McLaughlin, L. A., Ronseaux, S., Rosewell, I., Houston, J. B., Henderson, C. J. & Wolf, C. R., 14 Nov 2008, In : Journal of Biological Chemistry. 283, 46, p. 31385-31393 8 p.

    Research output: Contribution to journalArticle

  42. Published

    Kinetic modeling of the interactions between 4-methylumbelliferone, 1-naphthol, and zidovudine glucuronidation by UDP-glucuronosyltransferase 2B7 (UGT2B7) provides evidence for multiple substrate binding and effector sites

    Uchaipichat, V., Galetin, A., Houston, J. B., Mackenzie, P. I., Williams, J. A. & Miners, J. O., Oct 2008, In : Molecular pharmacology. 74, 4, p. 1152-1162 10 p.

    Research output: Contribution to journalArticle

  43. Published

    Reliability of human cryopreserved hepatocytes and liver microsomes as in vitro systems to predict metabolic clearance

    Stringer, R., Nicklin, P. L. & Houston, J. B., Oct 2008, In : Xenobiotica. 38, 10, p. 1313-1329 16 p.

    Research output: Contribution to journalArticle

  44. Published

    Transporters and enzyme interplay in defining hepatic clearance

    Houston, JB., Oct 2008.

    Research output: Contribution to conferenceOther

  45. Published

    Assessment of the QGut Model As Predictive Tool For Intestinal Availability in human: Impact of the In Vitro Permeability and Clearance.

    Galetin, A., Houston, JB., Gertz, M., Fenner, KS., Harrison, A. & Davis, J., 6 Jul 2008, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  46. Published

    Comparative analysis of CYP3A heteroactivation by steroid hormones and flavonoids in different in vitro systems and potential in vivo implications

    Henshall, J., Galetin, A., Harrison, A. & Houston, J. B., Jul 2008, In : Drug Metabolism and Disposition. 36, 7, p. 1332-1340 8 p.

    Research output: Contribution to journalArticle

  47. Published

    Effect of Albumin on Prediction of Glucuronidation Clearance Using Alamethicin Activated Human Liver Microsomes.

    Galetin, A., Houston, JB., Kilford, P., Stringer, R. & Sohal, B., Jul 2008, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  48. Published

    Hepatocellular binding of drugs: Correction for unbound fraction in hepatocyte incubations using microsomal binding or drug lipophilicity data

    Kilford, P. J., Gertz, M., Houston, J. B. & Galetin, A., Jul 2008, In : Drug Metabolism and Disposition. 36, 7, p. 1194-1197 3 p.

    Research output: Contribution to journalArticle

  49. Published

    Potential role of intestinal first-pass metabolism in the prediction of drug-drug interactions

    Galetin, A., Gertz, M. & Houston, J. B., Jul 2008, In : Expert Opinion on Drug Metabolism and Toxicology. 4, 7, p. 909-922 13 p.

    Research output: Contribution to journalArticle

  50. Published

    Rate-limiting steps in hepatic drug clearance: comparison of hepatocellular uptake and metabolism with microsomal metabolism of saquinavir, nelfinavir, and ritonavir

    Parker, A. J. & Houston, J. B., Jul 2008, In : Drug Metabolism and Disposition. 36, 7, p. 1375-1384 9 p.

    Research output: Contribution to journalArticle

  51. Published

    Comparison of hepatic and intestinal Glucuronidation

    Galetin, A. & Houston, J., May 2008, host publication. 10th European Regional ISSX Meeting, Vol. 37-38.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  52. Published

    Multiple inhibition mechanisms and prediction of drug-drug interactions: Status of metabolism and transporter models as exemplified by gemfibrozil-drug interactions

    Hinton, L. K., Galetin, A. & Houston, J. B., May 2008, In : Pharmaceutical Research. 25, 5, p. 1063-1074 11 p.

    Research output: Contribution to journalArticle

  53. Published

    Prediction of Glucuronidation (UGT) clearance using alamethicin activated human liver microsomes

    Kilford, P., Stringer, R., Sohal, B., Houston, JB. & Galetin, A., May 2008, Drug Metabolism Reviews. Suppl. 1 ed. Vol. 40 . p. 51-52 2 p. 79

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  54. Published