Prof James HoustonBSc, PhD, DSc

Emeritus Professor

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Publications

  1. Article › Research › Not peer-reviewed
  2. Published

    Comparison of intestinal and hepatic sulphation and glucuronidation for a range of drugs

    Cubitt, H., Houston, JB. & Galetin, A., 2009, In : Drug Metabolism Reviews. 41 (Suppl. 1)

    Research output: Contribution to journalArticle

  3. Published

    Prediction of the intestinal availability and associated inter-individual variability for drugs with high intestinal first-pass metabolism

    Gertz, M., Harrison, A., Davis, J., Houston, JB. & Galetin, A., 2009, In : Drug Metabolism Reviews. 41 (Suppl. 1): 50

    Research output: Contribution to journalArticle

  4. Article › Research › Peer-reviewed
  5. Published

    A comprehensive assessment of repaglinide metabolic pathways: Impact of choice of in vitro system and relative enzyme contribution to in vitro clearance

    Säll, C., Houston, J. B. & Galetin, A., Jul 2012, In : Drug Metabolism and Disposition. 40, 7, p. 1279-1289 10 p.

    Research output: Contribution to journalArticle

  6. Published

    A pragmatic randomized controlled trial of thiopurine methyltransferase genotyping prior to azathioprine treatment: The TARGET study

    Newman, W. G., Payne, K., Tricker, K., Roberts, S. A., Fargher, E., Pushpakom, S., Alder, J. E., Sidgwick, G. P., Payne, D., Elliott, R. A., Heise, M., Elles, R., Ramsden, S. C., Andrews, J., Houston, J. B., Qasim, F., Shaffer, J., Griffiths, C. E. M., Ray, D. W., Bruce, I. & 1 others, Ollier, W. E. R., Jun 2011, In : Pharmacogenomics. 12, 6, p. 815-826 11 p.

    Research output: Contribution to journalArticle

  7. Published

    Absorption of prednisolone in patients with Crohn's disease

    Shaffer, J. A., Williams, S. E., Turnberg, L. A., Houston, J. & Rowland, M., Mar 1983, In : Gut. 24, 3, p. 182-6 5 p.

    Research output: Contribution to journalArticle

  8. Published

    An integrated approach to the prediction of systemic toxicity using computer-based biokinetic models and biological in vitro test methods: Overview of a prevalidation study based on the ECITTS project

    Dejongh, J., Forsby, A., Houston, J. B., Beckman, M., Combes, R. & Blaauboer, B. J., Aug 1999, In : Toxicology in Vitro. 13, 4-5, p. 549-554 5 p.

    Research output: Contribution to journalArticle

  9. Published

    Application of a physiologically based pharmacokinetic model to assess propofol hepatic and renal glucuronidation in isolation: Utility of in vitro and in vivo data

    Gill, K. L., Gertz, M., Houston, J. B. & Galetin, A., Apr 2013, In : Drug Metabolism and Disposition. 41, 4, p. 744-753 9 p.

    Research output: Contribution to journalArticle

  10. Published

    Assessment of algorithms for predicting drug-drug interactions via inhibition mechanisms: Comparison of dynamic and static models

    Guest, E. J., Rowland-Yeo, K., Rostami-Hodjegan, A., Tucker, G. T., Houston, J. B. & Galetin, A., Jan 2011, In : British Journal of Clinical Pharmacology. 71, 1, p. 72-87 15 p.

    Research output: Contribution to journalArticle

  11. Published

    Binding of drugs to hepatic microsomes: Comment and assessment of current prediction methodology with recommendation for improvement [1]

    Hallifax, D. & Houston, J. B., Apr 2006, In : Drug Metabolism and Disposition. 34, 4, p. 724-726 2 p.

    Research output: Contribution to journalArticle

  12. Published
  13. Published

    Characterization of the comparative drug binding to intra- (liver fatty acid binding protein) and extra- (human serum albumin) cellular proteins

    Rowland, A., Hallifax, D., Nussio, M., Shapter, J., Mackenzie, P., Houston, J. B., Knights, K. M. & Miners, J. O., 24 Mar 2015, In : Xenobiotica. 45, 10, p. 847-857 10 p.

    Research output: Contribution to journalArticle

  14. Published

    Clearance-dependent underprediction of in vivo intrinsic clearance from human hepatocytes: Comparison with permeabilities from artificial membrane (PAMPA) assay, in silico and caco-2 assay, for 65 drugs

    Hallifax, D., Turlizzi, E., Zanelli, U. & Houston, J. B., 11 Apr 2012, In : European Journal of Pharmaceutical Sciences. 45, 5, p. 570-574 4 p.

    Research output: Contribution to journalArticle

  15. Published

    Comparative analysis of CYP3A heteroactivation by steroid hormones and flavonoids in different in vitro systems and potential in vivo implications

    Henshall, J., Galetin, A., Harrison, A. & Houston, J. B., Jul 2008, In : Drug Metabolism and Disposition. 36, 7, p. 1332-1340 8 p.

    Research output: Contribution to journalArticle

  16. Published

    Comparative pharmacokinetics between a microdose and therapeutic dose for clarithromycin, sumatriptan, propafenone, paracetamol (acetaminophen), and phenobarbital in human volunteers

    Lappin, G., Shishikura, Y., Jochemsen, R., Weaver, R. J., Gesson, C., Brian Houston, J., Oosterhuis, B., Bjerrum, O. J., Grynkiewicz, G., Alder, J., Rowland, M. & Garner, C., 14 Jun 2011, In : European Journal of Pharmaceutical Sciences. 43, 3, p. 141-150 9 p.

    Research output: Contribution to journalArticle

  17. Published

    Comparative study of the metabolism of drug substrates by human cytochrome P450 3A4 expressed in bacterial, yeast and human lymphoblastoid cells

    Andrews, J., Abd-Ellah, M. F., Randolph, N. L., Kenworthy, K. E., Carlile, D. J., Friedberg, T. & Houston, J. B., 1 Nov 2002, In : Xenobiotica. 32, 11, p. 937-947 10 p.

    Research output: Contribution to journalArticle

  18. Published

    Comparative use of isolated hepatocytes and hepatic microsomes for cytochrome P450 inhibition studies: Transporter-enzyme interplay

    Brown, H. S., Wilby, A. J., Alder, J. & Houston, J. B., Dec 2010, In : Drug Metabolism and Disposition. 38, 12, p. 2139-2146 7 p.

    Research output: Contribution to journalArticle

  19. Published

    Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs

    Zanelli, U., Caradonna, N. P., Hallifax, D., Turlizzi, E. & Houston, J. B., Jan 2012, In : Drug Metabolism and Disposition. 40, 1, p. 104-110 6 p.

    Research output: Contribution to journalArticle

  20. Published

    Comparison of fresh and cryopreserved rat hepatocyte suspensions for the prediction of in vitro intrinsic clearance

    Griffin, S. J. & Houston, J. B., May 2004, In : Drug Metabolism and Disposition. 32, 5, p. 552-558 6 p.

    Research output: Contribution to journalArticle

  21. Published
  22. Published
  23. Published

    Comparison of the use of liver models for predicting drug clearance using in vitro kinetic data from hepatic microsomes and isolated hepatocytes

    Ito, K. & Houston, J. B., May 2004, In : Pharmaceutical Research. 21, 5, p. 785-792 7 p.

    Research output: Contribution to journalArticle

  24. Published

    Contribution of intestinal cytochrome P450-mediated metabolism to drug-drug inhibition and induction interactions

    Galetin, A., Gertz, M. & Houston, J. B., 2010, In : Drug Metabolism and Pharmacokinetics. 25, 1, p. 28-47 19 p.

    Research output: Contribution to journalArticle

  25. Published

    Critique of the two-fold measure of prediction success for ratios: Application for the assessment of drug-drug interactions

    Guest, E. J., Aarons, L., Houston, J. B., Rostami-Hodjegan, A. & Galetin, A., Feb 2011, In : Drug Metabolism and Disposition. 39, 2, p. 170-173 3 p.

    Research output: Contribution to journalArticle

  26. Published

    Cyclosporine inhibition of hepatic and intestinal CYP3A4, uptake and efflux transporters: Application of PBPK Modeling in the assessment of drug-drug interaction potential

    Gertz, M., Cartwright, C. M., Hobbs, M. J., Kenworthy, K. E., Rowland, M., Houston, J. B. & Galetin, A., Mar 2013, In : Pharmaceutical Research. 30, 3, p. 761-780 19 p.

    Research output: Contribution to journalArticle

  27. Published

    CYP3A4 drug interactions: correlation of ten in vitro probes substrates.

    Kenworthy, K. E., Bloomer, J., Clarke, S. E. & Houston, B., 1999, In : British Journal of Clinical Pharmacology. 48

    Research output: Contribution to journalArticle

  28. Published

    CYP3A4 substrate selection and substitution in the prediction of potential drug-drug interactions

    Galetin, A., Ito, K., Hallifax, D. & Houston, J. B., Jul 2005, In : Journal of Pharmacology and Experimental Therapeutics. 314, 1, p. 180-190 10 p.

    Research output: Contribution to journalArticle

  29. Published

    Defining the in vivo role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5

    Finn, R. D., McLaughlin, L. A., Ronseaux, S., Rosewell, I., Houston, J. B., Henderson, C. J. & Wolf, C. R., 14 Nov 2008, In : Journal of Biological Chemistry. 283, 46, p. 31385-31393 8 p.

    Research output: Contribution to journalArticle

  30. Published

    Determination of a human hepatic microsomal scaling factor for predicting in vivo drug clearance

    Hakooz, N., Ito, K., Rawden, H., Gill, H., Lemmers, L., Boobis, A. R., Edwards, R. J., Carlile, D. J., Lake, B. G. & Houston, J. B., Mar 2006, In : Pharmaceutical Research. 23, 3, p. 533-539 6 p.

    Research output: Contribution to journalArticle

  31. Published

    Diazepam-omepazole inhibition interaction: An in vitro investigation using human liver microsomes.

    Zomorodi, K. & Houston, B., 1996, In : Br. J. Clin. Pharmacol.. 42

    Research output: Contribution to journalArticle

  32. Published

    Direct and quantitative evaluation of the human CYP3A4 contribution (fm) to drug clearance using the in vitro SILENSOMES model

    Parmentier, Y., Pothier, C., Delmas, A., Caradec, F., Trancart, M. M., Guillet, F., Bouaita, B., Chesne, C., Walther, B. & Houston, J., 2016, In : Xenobiotica. p. 1-14 14 p.

    Research output: Contribution to journalArticle

  33. Published

    Disposition of metronidazole and its effects on sulphasalazine metabolism in patients with inflammatory bowel disease

    Shaffer, J. L., Kershaw, A. & Houston, J. B., Apr 1986, In : British Journal of Clinical Pharmacology. 21, 4, p. 431-5 5 p.

    Research output: Contribution to journalArticle

  34. Published

    Drug lipophilicity and microsomal protein concentration as determinants in the prediction of the fraction unbound in microsomal incubations

    Gertz, M., Kilford, P. J., Houston, J. B. & Galetin, A., Mar 2008, In : Drug Metabolism and Disposition. 36, 3, p. 535-542 7 p.

    Research output: Contribution to journalArticle

  35. Published

    Evaluation of cryopreserved human hepatocytes as an alternative in vitro system to microsomes for the prediction of metabolic clearance

    Brown, H. S., Griffin, M. & Houston, J. B., Feb 2007, In : Drug Metabolism and Disposition. 35, 2, p. 293-301 8 p.

    Research output: Contribution to journalArticle

  36. Published

    Evaluation of hepatic clearance prediction using in vitro data: Emphasis on fraction unbound in plasma and drug ionisation using a database of 107 drugs

    Hallifax, D. & Houston, J. B., Aug 2012, In : Journal of Pharmaceutical Sciences. 101, 8, p. 2645-2652 7 p.

    Research output: Contribution to journalArticle

  37. Published

    Evaluation of recombinant cytochrome p450 enzymes as an in vitro system for metabolic clearance predictions

    Stringer, R. A., Strain-Damerell, C., Nicklin, P. & Houston, J. B., May 2009, In : Drug Metabolism and Disposition. 37, 5, p. 1025-1034 9 p.

    Research output: Contribution to journalArticle

  38. Published

    Evaluation of the novel in vitro systems for hepatic drug clearance and assessment of their predictive utility

    Houston, J. B., Rowland-Yeo, K. & Zanelli, U., 2012, In : Toxicology in Vitro. 26, 8, p. 1265-71

    Research output: Contribution to journalArticle

  39. Published

    Evidence-based approach to assess passive diffusion and carrier-mediated drug transport

    Di, L., Artursson, P., Avdeef, A., Ecker, G. F., Faller, B., Fischer, H., Houston, J. B., Kansy, M., Kerns, E. H., Krämer, S. D., Lennernäs, H. & Sugano, K., Aug 2012, In : Drug discovery today. 17, 15-16, p. 905-912 7 p.

    Research output: Contribution to journalArticle

  40. Published

    Generation and Evaluation of a CYP2C9 Heteroactivation Pharmacophore

    Egnell, A. C., Eriksson, C., Albertson, N., Houston, B. & Boyer, S., Dec 2003, In : Journal of Pharmacology and Experimental Therapeutics. 307, 3, p. 878-887 9 p.

    Research output: Contribution to journalArticle

  41. Published

    Grapefruit juice-drug interaction studies as a method to assess the extent of intestinal availability: Utility and limitations

    Gertz, M., Davis, J. D., Harrison, A., Houston, J. B. & Galetin, A., 2008, In : Current Drug Metabolism. 9, 8, p. 785-795 10 p.

    Research output: Contribution to journalArticle

  42. Published

    Hepatic OATP-mediated clearance in the Beagle dog: assessing in vitro-in vivo relationships and applying cross species empirical scaling factors to improve prediction of human clearance

    Matsunaga, N., Ufuk, A., Morse, B. L., Bedwell, D. W., Bao, J., Mohutsky, M. A., Hillgren, K. M., Hall, S. D., Houston, J. B. & Galetin, A., 2018, In : Drug Metabolism and Disposition.

    Research output: Contribution to journalArticle

  43. Published
  44. Published

    Hepatocellular binding of drugs: Correction for unbound fraction in hepatocyte incubations using microsomal binding or drug lipophilicity data

    Kilford, P. J., Gertz, M., Houston, J. B. & Galetin, A., Jul 2008, In : Drug Metabolism and Disposition. 36, 7, p. 1194-1197 3 p.

    Research output: Contribution to journalArticle

  45. Published

    IC50-based approaches as an alternative method for assessment of time-dependent inhibition of CYP3A4

    Burt, H. J., Galetin, A. & Houston, J. B., May 2010, In : Xenobiotica. 40, 5, p. 331-343 12 p.

    Research output: Contribution to journalArticle

  46. Published

    Impact of end-product inhibition on the determination of in vitro metabolic clearance

    Jones, H. M., Nicholls, G. & Houston, J. B., May 2005, In : Xenobiotica. 35, 5, p. 439-454 15 p.

    Research output: Contribution to journalArticle

  47. Published

    Impact of parallel pathways of drug elimination and multiple cytochrome P450 involvement on drug-drug interactions: CYP2D6 paradigm

    Ito, K., Hallifax, D., Obach, R. S. & Houston, J. B., Jun 2005, In : Drug Metabolism and Disposition. 33, 6, p. 837-844 7 p.

    Research output: Contribution to journalArticle

  48. Published

    Importance of the unstirred water layer and hepatocyte membrane integrity in vitro for quantification of intrinsic metabolic clearance

    Wood, F., Houston, J. & Hallifax, D., 1 Jan 2018, In : Drug Metabolism and Disposition. 46, 1

    Research output: Contribution to journalArticle

  49. Published

    In vitro and in silico tools to assess extent of cellular uptake and lysosomal sequestration of respiratory drugs in human alveolar macrophages

    Ufuk, A., Assmus, F., Francis, L., Plumb, J., Damian, V., Gertz, M., Houston, J. & Galetin, A., 2017, In : Molecular Pharmaceutics. 14, 4

    Research output: Contribution to journalArticle

  50. Published

    In vitro assessment of uptake and lysosomal sequestration of respiratory drugs in alveolar macrophage cell line NR8383

    Ufuk, A., Somers, G., Houston, J. & Galetin, A., Dec 2015, In : Pharmaceutical Research. 32, 12, p. 3937–3951 14 p.

    Research output: Contribution to journalArticle

  51. Published

    In vitro cytochrome P450 inhibition data and the prediction of drug-drug interactions: Qualitative relationships, quantitative predictions, and the rank-order approach

    Obach, R. S., Walsky, R. L., Venkatakrishnan, K., Houston, J. B. & Tremaine, L. M., Dec 2005, In : Clinical Pharmacology and Therapeutics. 78, 6, p. 582-e7

    Research output: Contribution to journalArticle

  52. Published

    In vitro human tissue models in risk assessment: Report of a consensus-building workshop

    MacGregor, J. T., Collins, J. M., Sugiyama, Y., Tyson, C. A., Dean, J., Smith, L., Andersen, M., Curren, R. D., Houston, J. B., Kadlubar, F. F., Kedderis, G. L., Krishnan, K., Li, A. P., Parchment, R. E., Thummel, K., Tomaszewski, J. E., Ulrich, R., Vickers, A. E. M. & Wrighton, S. A., 2001, In : Toxicological Sciences. 59, 1, p. 17-36 19 p.

    Research output: Contribution to journalArticle

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