Prof James HoustonBSc, PhD, DSc

Emeritus Professor

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Publications

  1. Published

    "Time dependent" inhibition of hepatic uptake transporters in hepatocytes and implications on the assessment of transporter-mediated drug-drug interactions

    Kageyama, M., Houston, B. & Galetin, A., 2015, host publication. Vol. P43.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  2. Published

    . Physiologically-Based Pharmacokinetic Modelling of Hepatic Uptake of Pravastatin and Rosuvastatin

    Galetin, A., Houston, JB., Tate, S. & Jones, HM., 25 Nov 2009, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  3. Published

    A comprehensive assessment of repaglinide metabolic pathways: Impact of choice of in vitro system and relative enzyme contribution to in vitro clearance

    Säll, C., Houston, J. B. & Galetin, A., Jul 2012, In : Drug Metabolism and Disposition. 40, 7, p. 1279-1289 10 p.

    Research output: Contribution to journalArticle

  4. Published

    A pragmatic randomized controlled trial of thiopurine methyltransferase genotyping prior to azathioprine treatment: The TARGET study

    Newman, W. G., Payne, K., Tricker, K., Roberts, S. A., Fargher, E., Pushpakom, S., Alder, J. E., Sidgwick, G. P., Payne, D., Elliott, R. A., Heise, M., Elles, R., Ramsden, S. C., Andrews, J., Houston, J. B., Qasim, F., Shaffer, J., Griffiths, C. E. M., Ray, D. W., Bruce, I. & 1 others, Ollier, W. E. R., Jun 2011, In : Pharmacogenomics. 12, 6, p. 815-826 11 p.

    Research output: Contribution to journalArticle

  5. Published

    Absorption of prednisolone in patients with Crohn's disease

    Shaffer, J. A., Williams, S. E., Turnberg, L. A., Houston, J. & Rowland, M., Mar 1983, In : Gut. 24, 3, p. 182-6 5 p.

    Research output: Contribution to journalArticle

  6. Published

    Activation and inhibition of codeine metabolism by ketoconazole and quinine in rat liver microsomes.

    Proctor, N. J., Hallifax, D., Smith, D. A. & Houston, B., 2001.

    Research output: Contribution to conferencePoster

  7. Published

    Addressing the challenges of low clearance.

    Houston, J. B., Nov 2013.

    Research output: Contribution to conferenceOther

  8. Published

    An integrated approach to prediction of systemic toxicity by using biokinetic models and biological in vitro test methods.

    Blaauboeer, B. J., Forsby, A., Houston, B., Beckman, M., Combes, R. D. & DeJongh, J., 2000, Progress in the Reduction, Refinement and Replacement of Animal Experimentation. Balls, M., Zeller, A-M. & Halder, M. (eds.). Elsevier BV

    Research output: Chapter in Book/Report/Conference proceedingChapter

  9. Published

    An integrated approach to the prediction of systemic toxicity using computer-based biokinetic models and biological in vitro test methods: Overview of a prevalidation study based on the ECITTS project

    Dejongh, J., Forsby, A., Houston, J. B., Beckman, M., Combes, R. & Blaauboer, B. J., Aug 1999, In : Toxicology in Vitro. 13, 4-5, p. 549-554 5 p.

    Research output: Contribution to journalArticle

  10. Published

    Application of a physiologically based pharmacokinetic model to assess propofol hepatic and renal glucuronidation in isolation: Utility of in vitro and in vivo data

    Gill, K. L., Gertz, M., Houston, J. B. & Galetin, A., Apr 2013, In : Drug Metabolism and Disposition. 41, 4, p. 744-753 9 p.

    Research output: Contribution to journalArticle

  11. Published

    Application of different in vitro systems for prediction of in vivo induction drug-drug interactions

    Galetin, A. & Houston, J., 2010, host publication. Vol. 143.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  12. Published

    Assessing metabolic competence in isolated hepatocytes: Exploring the relationship between enzyme function and plasma membrane integrity via Saponin treatment

    Wood, F., Hallifax, D. & Houston, B., Jun 2015, host publication. Vol. P10.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  13. Published

    Assessment of Algorithms for Predicting Drug-Drug Interactions via Inhibition Mechanisms.

    Rostami-Hochaghan, A., Guest, EJ., Rowland, Y. K., Rostami-Hodjegan, A., Tucker, GT., Houston, JB. & Galetin, A., 23 Sep 2009, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  14. Published

    Assessment of algorithms for predicting drug-drug interactions via inhibition mechanisms: Comparison of dynamic and static models

    Guest, E. J., Rowland-Yeo, K., Rostami-Hodjegan, A., Tucker, G. T., Houston, J. B. & Galetin, A., Jan 2011, In : British Journal of Clinical Pharmacology. 71, 1, p. 72-87 15 p.

    Research output: Contribution to journalArticle

  15. Published
  16. Published

    Assessment of the contribution of transporter-mediated active uptake to the overall hepatic uptake clearance for a range of drugs

    Yabe, Y., Galetin, A. & Houston, JB., 2009, host publication. Vol. 41 (Suppl. 3): 39..

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  17. Published

    Assessment of the QGut Model As Predictive Tool For Intestinal Availability in human: Impact of the In Vitro Permeability and Clearance.

    Galetin, A., Houston, JB., Gertz, M., Fenner, KS., Harrison, A. & Davis, J., 6 Jul 2008, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  18. Published

    Auto- and heteroactivation of metabolism of a series of benzodiazepines in human hepatocytes.

    Hallifax, D., Rawden, H., Galetin, A., Brown, C. & Houston, JB., 2004.

    Research output: Contribution to conferencePoster

  19. Published

    Binding of drugs to hepatic microsomes: Comment and assessment of current prediction methodology with recommendation for improvement [1]

    Hallifax, D. & Houston, J. B., Apr 2006, In : Drug Metabolism and Disposition. 34, 4, p. 724-726 2 p.

    Research output: Contribution to journalArticle

  20. Published

    Bridging the gap between in vitro multi-site models and in vivo CYP3A4 drug-drug interactions

    Galetin, A. & Houston, B., 2003, Drug Metabolism Reviews. Suppl 2, Vol. 35.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  21. Published

    Characteristics of nonlinear uptake of lipophilic amine drugs into isolated rat hepatocytes.

    Hallifax, D., Smith, D. A. & Houston, B., Jul 1996.

    Research output: Contribution to conferencePoster

  22. Published
  23. Published

    Characterization of the comparative drug binding to intra- (liver fatty acid binding protein) and extra- (human serum albumin) cellular proteins

    Rowland, A., Hallifax, D., Nussio, M., Shapter, J., Mackenzie, P., Houston, J. B., Knights, K. M. & Miners, J. O., 24 Mar 2015, In : Xenobiotica. 45, 10, p. 847-857 10 p.

    Research output: Contribution to journalArticle

  24. Published

    Clearance prediction methodology needs fundamental improvement: Trends common to rat and human hepatocytes/microsomes and implications for experimental methodology

    Wood, F. L., Houston, J. B. & Hallifax, D., 1 Nov 2017, In : Drug Metabolism and Disposition. 45, 11, p. 1178-1188 11 p.

    Research output: Contribution to journalComment/debate

  25. Published

    Clearance-dependent underprediction of in vivo intrinsic clearance from human hepatocytes: Comparison with permeabilities from artificial membrane (PAMPA) assay, in silico and caco-2 assay, for 65 drugs

    Hallifax, D., Turlizzi, E., Zanelli, U. & Houston, J. B., 11 Apr 2012, In : European Journal of Pharmaceutical Sciences. 45, 5, p. 570-574 4 p.

    Research output: Contribution to journalArticle

  26. Published

    Comparative analysis of CYP3A heteroactivation by steroid hormones and flavonoids in different in vitro systems and potential in vivo implications

    Henshall, J., Galetin, A., Harrison, A. & Houston, J. B., Jul 2008, In : Drug Metabolism and Disposition. 36, 7, p. 1332-1340 8 p.

    Research output: Contribution to journalArticle

  27. Published

    Comparative pharmacokinetics between a microdose and therapeutic dose for clarithromycin, sumatriptan, propafenone, paracetamol (acetaminophen), and phenobarbital in human volunteers

    Lappin, G., Shishikura, Y., Jochemsen, R., Weaver, R. J., Gesson, C., Brian Houston, J., Oosterhuis, B., Bjerrum, O. J., Grynkiewicz, G., Alder, J., Rowland, M. & Garner, C., 14 Jun 2011, In : European Journal of Pharmaceutical Sciences. 43, 3, p. 141-150 9 p.

    Research output: Contribution to journalArticle

  28. Published

    Comparative study of the metabolism of drug substrates by human cytochrome P450 3A4 expressed in bacterial, yeast and human lymphoblastoid cells

    Andrews, J., Abd-Ellah, M. F., Randolph, N. L., Kenworthy, K. E., Carlile, D. J., Friedberg, T. & Houston, J. B., 1 Nov 2002, In : Xenobiotica. 32, 11, p. 937-947 10 p.

    Research output: Contribution to journalArticle

  29. Published

    Comparative use of isolated hepatocytes and hepatic microsomes for cytochrome P450 inhibition studies: Transporter-enzyme interplay

    Brown, H. S., Wilby, A. J., Alder, J. & Houston, J. B., Dec 2010, In : Drug Metabolism and Disposition. 38, 12, p. 2139-2146 7 p.

    Research output: Contribution to journalArticle

  30. Published

    Comparison of clearance for three benzodiazepines determined by metabolite formation and substrate depletion methods in rat hepatic microsomes.

    Ahmed, S. & Houston, B., 2000, Drug Metabolism Reviews. Vol. 32, Suppl. 1.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  31. Published

    Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs

    Zanelli, U., Caradonna, N. P., Hallifax, D., Turlizzi, E. & Houston, J. B., Jan 2012, In : Drug Metabolism and Disposition. 40, 1, p. 104-110 6 p.

    Research output: Contribution to journalArticle

  32. Published

    Comparison of fresh and cryopreserved rat hepatocyte suspensions for the prediction of in vitro intrinsic clearance

    Griffin, S. J. & Houston, J. B., May 2004, In : Drug Metabolism and Disposition. 32, 5, p. 552-558 6 p.

    Research output: Contribution to journalArticle

  33. Published

    Comparison of hepatic and intestinal Glucuronidation

    Galetin, A. & Houston, J., May 2008, host publication. 10th European Regional ISSX Meeting, Vol. 37-38.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  34. Published

    Comparison of Hepatic and Intestinal Glucuronidation

    Cubitt, H., Houston, JB. & Galetin, A., 2008, host publication. Drug Metab Rev, Vol. 40 (Suppl. 1): 37..

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  35. Published

    Comparison of hepatocyte models for predicting in vitro intrinsic clearance using diazepam and tolbutamide.

    Griffin, S. J., Carlile, D. J. & Houston, B., 2001, Proceedings of the Hepatocyte User's Group, Stanstead.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  36. Published

    Comparison of hepatocyte models for predicting in vitro intrinsic clearance using diazepam and tolbutamide.

    Griffin, S. J., Carlile, D. & Houston, B., 2001, Drug Metabolism Reviews. Vol. 33, Suppl. 1.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  37. Published

    Comparison of intestinal and hepatic sulphation and glucuronidation for a range of drugs

    Cubitt, H., Houston, JB. & Galetin, A., 2009, In : Drug Metabolism Reviews. 41 (Suppl. 1)

    Research output: Contribution to journalArticle

  38. Published
  39. Published

    Comparison of liver models for predicting drug clearance in rats.

    Ito, K. & Houston, B., 2002, Proceedings of Swedish Academy of Pharmaceutical Sciences Roseno meeting..

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  40. Published

    Comparison of Metabolism and Transporter Models for Predicting Gemfibrozil Drug-Drug Interactions.

    Gibbons, LK., Galetin, A. & Houston, JB., 2006, host publication. Drug Metab Rev, Vol. 38 (Suppl. 1).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  41. Published

    Comparison of respiratory drug accumulation and lysosomal sequestration in NR8383 and primary human al veolar macrophages

    Ufuk, A., Plumb, J., Houston, B. & Galetin, A., 2015, host publication. Vol. A11.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  42. Published

    Comparison of the extent of sulphation and glucuronidation in the intestine and liver for a range of drugs

    Cubitt, H., Houston, JB. & Galetin, A., 2008, host publication. Vol. 140.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  43. Published
  44. Published

    Comparison of the use of liver models for predicting drug clearance using in vitro kinetic data from hepatic microsomes and isolated hepatocytes

    Ito, K. & Houston, J. B., May 2004, In : Pharmaceutical Research. 21, 5, p. 785-792 7 p.

    Research output: Contribution to journalArticle

  45. Published

    Contribution of active uptake to the hepatic clearance of seven OATP substrates in rat and human plated hepatocytes

    Menochet, K., Kenworthy, K., Houston, JB. & Galetin, A., Sep 2010, host publication. Vol. 487.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  46. Published

    Contribution of intestinal cytochrome P450-mediated metabolism to drug-drug inhibition and induction interactions

    Galetin, A., Gertz, M. & Houston, J. B., 2010, In : Drug Metabolism and Pharmacokinetics. 25, 1, p. 28-47 19 p.

    Research output: Contribution to journalArticle

  47. Published

    Critique of the two-fold measure of prediction success for ratios: Application for the assessment of drug-drug interactions

    Guest, E. J., Aarons, L., Houston, J. B., Rostami-Hodjegan, A. & Galetin, A., Feb 2011, In : Drug Metabolism and Disposition. 39, 2, p. 170-173 3 p.

    Research output: Contribution to journalArticle

  48. Published

    Cyclosporine inhibition of hepatic and intestinal CYP3A4, uptake and efflux transporters: Application of PBPK Modeling in the assessment of drug-drug interaction potential

    Gertz, M., Cartwright, C. M., Hobbs, M. J., Kenworthy, K. E., Rowland, M., Houston, J. B. & Galetin, A., Mar 2013, In : Pharmaceutical Research. 30, 3, p. 761-780 19 p.

    Research output: Contribution to journalArticle

  49. Published

    Cynomoglus monkey as a preclinical model for the investigation of hepatic uptake of OATP substrates

    Bruyn, T. D., Barton, H. A., Bi, Y-A., Cantrill, C., Galetin, A., Houston, B., Lin, J. & Kosa, R., 2015, host publication. Vol. P11.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  50. Published

    CYP3A4 drug interactions: correlation of ten in vitro probes substrates.

    Kenworthy, K. E., Bloomer, J., Clarke, S. E. & Houston, B., 1999, In : British Journal of Clinical Pharmacology. 48

    Research output: Contribution to journalArticle

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