Prof James HoustonBSc, PhD, DSc

Emeritus Professor

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Publications

  1. 1983
  2. Published

    Absorption of prednisolone in patients with Crohn's disease

    Shaffer, J. A., Williams, S. E., Turnberg, L. A., Houston, J. & Rowland, M., Mar 1983, In : Gut. 24, 3, p. 182-6 5 p.

    Research output: Contribution to journalArticle

  3. Published

    Pharmacokinetics of promethazine and its sulphoxide metabolite after intravenous and oral administration to man

    Taylor, G., Houston, J. B., Shaffer, J. & Mawer, G., Mar 1983, In : British Journal of Clinical Pharmacology. 15, 3, p. 287-93 7 p.

    Research output: Contribution to journalArticle

  4. 1985
  5. Published

    The effect of rifampicin on sulphapyridine plasma concentrations following sulphasalazine administration

    Shaffer, J. L. & Houston, J. B., Apr 1985, In : British Journal of Clinical Pharmacology. 19, 4, p. 526-8 3 p.

    Research output: Contribution to journalArticle

  6. 1986
  7. Published

    Disposition of metronidazole and its effects on sulphasalazine metabolism in patients with inflammatory bowel disease

    Shaffer, J. L., Kershaw, A. & Houston, J. B., Apr 1986, In : British Journal of Clinical Pharmacology. 21, 4, p. 431-5 5 p.

    Research output: Contribution to journalArticle

  8. 1994
  9. Published

    Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance’, Biochemical Pharmacology

    Houston, JB., 1994, In : Biochemical Pharmacology. 47, p. 1469-1479 10 p.

    Research output: Contribution to journalArticle

  10. 1996
  11. Published
  12. Published

    Diazepam-omepazole inhibition interaction: An in vitro investigation using human liver microsomes.

    Zomorodi, K. & Houston, B., 1996, In : Br. J. Clin. Pharmacol.. 42

    Research output: Contribution to journalArticle

  13. Published

    Effect of aminobenzotraizole on diazepam metabolism, Stoke Rochford.

    Hakooz, N. & Houston, B., 1996, 6th Stowe Symposium on Drug Metabolism.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  14. Published

    Kinetics of CYP2D6 and CYP3A4 catalyzed reactions in heterologous expression systems

    Randolph, N., Andrews, J., Chenery, R. & Houston, B., 1996, ISSX Proceedings. Vol. 10.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  15. Published

    Kinetics of drug metabolism in rat liver II. Comparison of clearance by slices and isolated hepatocytes.

    Worboys, P. D., Bradbury, A. & Houston, B., 1996, In : Drug Metab. Dispos.. 24

    Research output: Contribution to journalArticle

  16. Published

    Metabolism of midazolam in various expression systems for human CYP3A4.

    Randolph, N., Andrews, J., Chenery, R. & Houston, B., 1996, 6th Stowe Symposium, Stoke Rochford.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  17. Published

    Metabolism of ondansetron in rat. Comparison of hepatic microsomes, isolated hepatocytees and liver slices with in vivo disposition.

    Worboys, P. D., Bradbury, A. & Houston, B., 1996, In : Xenobiotica. 26

    Research output: Contribution to journalArticle

  18. Published

    Predicting the pharmacokinetics of CYP2C9 substrates in man from in vitro studies. Stoke, Rochford

    Carlile, D., Bayliss, M. K., Tarbit, M. H. & Houston, B., 1996, 6th Stowe Symposium on Drug Metabolism.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  19. Published

    Prediction of in vivo intrinsic clearance of ethoxycoumarin using drug depletion data from freshly isolated hepatocytes, Stoke Rochford

    Stevens, A. J. & Houston, B., 1996, 6th Stowe Symposium.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  20. Published

    The metabolism of diazepam, phenytoin, p-nitrophenol and coumarin by pig hepatic microsomes.

    Witherow, LL. E. & Houston, B., 1996, 6th Stowe Symposium.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  21. Published

    Characteristics of nonlinear uptake of lipophilic amine drugs into isolated rat hepatocytes.

    Hallifax, D., Smith, D. A. & Houston, B., Jul 1996.

    Research output: Contribution to conferencePoster

  22. Published

    The Use of Biokinetics and In Vitro Methods in Toxicological Risk Evaluation: The Report and Recommendations of ECVAM Workshop 15

    Blaauboer, B. J., Bayliss, M. K., Castell, J. V., Evelo, C. T. A., Frazier, J. M., Groen, K., Gülden, M., Guillouzo, A., Hissink, A. M., Houston, J. B., Johanson, G., De Jongh, J., Kedderis, G. L., Reinhardt, C. A., Van De Sandt, J. J. M. & Semino, G., Jul 1996, In : Alternatives to Laboratory Animals . 24, 4, p. 473-497 24 p.

    Research output: Contribution to journalArticle

  23. 1997
  24. Published

    Microsomal prediction of intrinsic clearance for CYP2C9 substrates in man: Importance of Km.

    Carlile, DD. & Houston, B., 1997, ISSX Proceedings. Vol. 11.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  25. Published
  26. Published

    Pharmacokinetics in early drug discovery. The report recommendations of ECVAM Workshop 22.

    Leahy, D. E., Duncan, R., Ahr, H. J., Bayliss, M. K., de Boer, A. G., Darvas, F., Fentem, J. H., Fry, J. R., Hopkins, R., Houston, B., Karlsson, J., Kedderis, G. L., Pratten, M. K., Prieto, P., Smith, D. A. & Straughan, D. W., 1997, In : ATLA. 26

    Research output: Contribution to journalArticle

  27. Published

    Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices

    Brian Houston, J. & Carlile, D. J., 1997, In : Drug Metabolism Reviews. 29, 4, p. 891-922 31 p.

    Research output: Contribution to journalArticle

  28. Published

    Selectivity of omeprazole towards rat live cytochromes P450.

    Zomorodi, K. & Houston, B., 1997, In : Xenobiotica. 27

    Research output: Contribution to journalArticle

  29. Published

    Sigmoidal kinetics of CYP3A substrates: An approach for scaling dextromethorplan metabolism in rat microsomes and isolated heptatocytes to predict in vivo clearance.

    Witherow, LL. E. & Houston, B., 1997, ISSX Proceedings. Vol. 12.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  30. Published

    Kinetics of drug metabolism in rat liver slices: III. Relationship between metabolic clearance and slice uptake rate

    Worboys, P. D., Bradbury, A. & Houston, J. B., Apr 1997, In : Drug Metabolism and Disposition. 25, 4, p. 460-467 7 p.

    Research output: Contribution to journalArticle

  31. Published

    Scaling factors to relate drug metabolic clearance in hepatic microsomes, isolated hepatocytes, and the intact liver: Studies with induced livers involving diazepam

    Carlile, D. J., Zomorodi, K. & Houston, J. B., Aug 1997, In : Drug Metabolism and Disposition. 25, 8, p. 903-911 8 p.

    Research output: Contribution to journalArticle

  32. Published

    Incorporation of in vitro drug metabolism data into physiologically- based pharmacokinetic models

    Houston, J. B. & Carlile, D. J., Oct 1997, In : Toxicology in Vitro. 11, 5, p. 473-478 5 p.

    Research output: Contribution to journalArticle

  33. 1998
  34. Published

    Incorporating Variability and Uncertainty into the In Vitro - In Vivo Predictioon of Hepatic Clearance. Proc. 5th EUFEPS Conference: Optimising Drug Development: Fastracking into Human, Wiesbaden, Germany, December 1998

    Nestorov, I., Carlile, D., Houston, B. & Rowland, M., 1998, Eur. J. Pharmac. Sci..

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  35. Published

    Influence of slice thickness and culture conditions on metabolism in precision-cut liver slices.

    Price, R. J., Renwick, A. B., Barton, P. T., Houston, B. & Lake, B. G., 1998, In : ATLA. 26

    Research output: Contribution to journalArticle

  36. Published

    Inhibition of rat cytochrome P450-dependent 1 metabolism by ketoconazole and fluconazole. 16th European Drug Metabolism Workshop, Copenhagen

    Chadwick, AA. P., McKillop, D. & Houston, B., 1998, Proceedings.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  37. Published

    Inhibition of rat cytochrome P450-dependent metabolism by ketoconazole and fluconazole

    Chadwick, AA. P., McKillop, D. & Houston, B., 1998, Br. J. Clin. Pharmacol.. Vol. 45.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  38. Published

    Prediction of intrinsic clearance of CYP2C9 substrates in man using hepatic microsomes: imortance of Km.

    Carlile, D. J., Bayliss, M. K. & Houston, B., 1998, Br. J. Clin. Pharmacol.. Vol. 45.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  39. Published

    Product inhibition of phenytoin and diazepam metabolism and its significance in predicting intrinsic clearance in vitro.

    Nichols, G. & Houston, B., 1998, Br. J. Pharmac.. Vol. 45.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  40. Published
  41. Published

    Sigmoidal kinetics of CYP3A substrates in rat.

    Witherow, L. E. & Houston, B., 1998, Br. J. Clin. Pharmacol.. Vol. 45.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  42. Published

    Sigmoidal kinetics of CYP3A4: the simultaneous metabolism and binding of testosterone and diazepam.

    Kenworthy, KK. E., Clarke, S. E., Andrews, J. & Houston, B., 1998, Br. J. Clin. Pharmacol.. Vol. 45.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  43. Published

    The integrated use of alternative methods in toxicological risk evaluation

    Blaauboer, B. J., Barratt, M. D. & Houston, B., 1998, In : ATLA. 26

    Research output: Contribution to journalArticle

  44. Published

    The simultaneous metabolism and binding of testosterone and diazepam in a recombinant CYP3A4 enzyme system. At 12th International Symposium on Microsomes and Drug Oxidations, Montpellier, France.

    Kenworthy, KK. E., Clarke, S. E., Andrews, J. & Houston, B., 1998, Proceedings.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  45. Published

    Validation of computational prediction techniques

    Worth, A. P., Barratt, M. D. & Houston, B., 1998, In : ATLA. 26

    Research output: Contribution to journalArticle

  46. Published

    In vivo clearance of ethoxycoumarin and its prediction from in vitro systems: Use of drug depletion and metabolite formation methods in hepatic microsomes and isolated hepatocytes

    Carlile, D. J., Stevens, A. J., Ashforth, E. I. L., Waghela, D. & Houston, J. B., Mar 1998, In : Drug Metabolism and Disposition. 26, 3, p. 216-221 5 p.

    Research output: Contribution to journalArticle

  47. 1999
  48. Published
  49. Published

    CYP3A4 drug interactions: correlation of ten in vitro probes substrates.

    Kenworthy, K. E., Bloomer, J., Clarke, S. E. & Houston, B., 1999, In : British Journal of Clinical Pharmacology. 48

    Research output: Contribution to journalArticle

  50. Published

    Inhibition of terfenadine metabolism by CYP3A4: evidence for substrate inhibition reflects multiple binding sites.

    Kenworthy, K. E., Bloomer, J., Clarke, S. E. & Houston, B., 1999, Proceeding of 7th Stowe School Symposium on Drug Metabolism.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  51. Published
  52. Published

    Microsomal prediction of in vivo clearance of CYP2C9 substrates in humans

    Carlile, D. J., Hakooz, N., Bayliss, M. K. & Houston, J. B., 1999, In : British Journal of Clinical Pharmacology. 47, 6, p. 625-635 10 p.

    Research output: Contribution to journalArticle

  53. Published

    No significant effects of sodium aurothiomalate on haem metabolism and mixed function oxidase activity in patients with rheumatoid arthritis.

    Herrick, A. L., Hodgkiss, R., Reed, P., Weinkove, C., Jayson, M. I. V. & Houston, B., 1999, In : Clin. Exper. Rheumatol.. 17

    Research output: Contribution to journalArticle

  54. Published

    Prediction of drug kinetic properties:diazepam in human liver microsomes versus cDNA expressed CYP3A4 and 2C19.

    Bicknell, H. A., Worboys, P. D., Evans, D. & Houston, B., 1999, Proceeding of 7th Stowe School Symposium on Drug Metabolism.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  55. Published

    Prediction of hepatic clearance of benzodiazepines in rats: comparison of isolated hepatocytes and microsomes.

    Hussein, Z., Carlile, D., Murby, S., Duffy, J., Houston, B. & Rowland, M., 1999, Eur. J. Pharm. Sci.. Vol. 8.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  56. Published

    Sigmoidal kinetics in rat hepatic microsomes: studies with dextromethorphan, alprazolam and triazolam.

    Ahmed, S. & Houston, B., 1999, Proceeding of 7th Stowe School Symposium on Drug Metabolism.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  57. Published

    The integrated use of alternative methods in toxicological risk evaluation: ECVAM Integrated Testing Strategies Task Force Report I

    Blaauboer, B. J., Barratt, M. D. & Houston, J. B., Apr 1999, In : Alternatives to Laboratory Animals . 27, 2, p. 229-237 8 p.

    Research output: Contribution to journalArticle

  58. Published

    Sigmoidal kinetics of CYP3A substrates: An approach for scaling dextromethorphan metabolism in hepatic microsomes and isolated hepatocytes to predict in vivo clearance in rat

    Witherow, L. E. & Houston, J. B., Jul 1999, In : Journal of Pharmacology and Experimental Therapeutics. 290, 1, p. 58-65 7 p.

    Research output: Contribution to journalArticle

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