Prof James HoustonBSc, PhD, DSc

Emeritus Professor

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Publications

  1. Published

    Comparison of clearance for three benzodiazepines determined by metabolite formation and substrate depletion methods in rat hepatic microsomes.

    Ahmed, S. & Houston, B., 2000, Drug Metabolism Reviews. Vol. 32, Suppl. 1.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  2. Published

    Sigmoidal kinetics in rat hepatic microsomes: studies with dextromethorphan, alprazolam and triazolam.

    Ahmed, S. & Houston, B., 1999, Proceeding of 7th Stowe School Symposium on Drug Metabolism.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  3. Published

    Comparative study of the metabolism of drug substrates by human cytochrome P450 3A4 expressed in bacterial, yeast and human lymphoblastoid cells

    Andrews, J., Abd-Ellah, M. F., Randolph, N. L., Kenworthy, K. E., Carlile, D. J., Friedberg, T. & Houston, J. B., 1 Nov 2002, In : Xenobiotica. 32, 11, p. 937-947 10 p.

    Research output: Contribution to journalArticle

  4. Published

    Pharmacogencomics and predictive drug metabolism

    Andrews, J., Pasksaleva, E., Galetin, A. & Houston, B., 2003, Pharmacogencomics and predictive drug metabolism. Pharmacogenomics Workshop, Annual Human Genome Meeting, Cancun, Mexico.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  5. Published

    In Silico Prediction of Hepatocellular Drug Binding

    Assmus, F., Houston, B. & Galetin, A., Jun 2015, host publication. Vol. A10.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  6. Published

    Incorporation of lysosomal sequestration in the mechanistic model for prediction of tissue distribution of basic drugs

    Assmus, F., Houston, J. & Galetin, A., 2017, In : European Journal of Pharmaceutical Sciences.

    Research output: Contribution to journalArticle

  7. Published

    Methodology for development of a physiological model incorporating CYP3A and P-glycoprotein for the prediction of intestinal drug absorption

    Badhan, R., Penny, J., Galetin, A. & Houston, J. B., Jun 2009, In : Journal of Pharmaceutical Sciences. 98, 6, p. 2180-2197 17 p.

    Research output: Contribution to journalArticle

  8. Published

    Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: Reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver

    Barter, Z. E., Bayliss, M. K., Beaune, P. H., Boobis, A. R., Carlile, D. J., Edwards, R. J., Houston, J. B., Lake, B. G., Lipscomb, J. C., Pelkonen, O. R., Tucker, G. T. & Rostami-Hodjegan, A., Jan 2007, In : Current Drug Metabolism. 8, 1, p. 33-45 12 p.

    Research output: Contribution to journalArticle

  9. Published

    Prediction of drug kinetic properties:diazepam in human liver microsomes versus cDNA expressed CYP3A4 and 2C19.

    Bicknell, H. A., Worboys, P. D., Evans, D. & Houston, B., 1999, Proceeding of 7th Stowe School Symposium on Drug Metabolism.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  10. Published

    Regioselective and stereoselective hydroxylations of warfarin in human liver microsomes and cDNA expressed cytochrome P450.

    Bicknell, H. A., Worboys, P. D. & Houston, B., 2000, Drug Metabolism Reviews. Vol. 32, Suppl. 1.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  11. Published

    An integrated approach to prediction of systemic toxicity by using biokinetic models and biological in vitro test methods.

    Blaauboeer, B. J., Forsby, A., Houston, B., Beckman, M., Combes, R. D. & DeJongh, J., 2000, Progress in the Reduction, Refinement and Replacement of Animal Experimentation. Balls, M., Zeller, A-M. & Halder, M. (eds.). Elsevier BV

    Research output: Chapter in Book/Report/Conference proceedingChapter

  12. Published

    The integrated use of alternative methods in toxicological risk evaluation

    Blaauboer, B. J., Barratt, M. D. & Houston, B., 1998, In : ATLA. 26

    Research output: Contribution to journalArticle

  13. Published

    The Use of Biokinetics and In Vitro Methods in Toxicological Risk Evaluation: The Report and Recommendations of ECVAM Workshop 15

    Blaauboer, B. J., Bayliss, M. K., Castell, J. V., Evelo, C. T. A., Frazier, J. M., Groen, K., Gülden, M., Guillouzo, A., Hissink, A. M., Houston, J. B., Johanson, G., De Jongh, J., Kedderis, G. L., Reinhardt, C. A., Van De Sandt, J. J. M. & Semino, G., Jul 1996, In : Alternatives to Laboratory Animals . 24, 4, p. 473-497 24 p.

    Research output: Contribution to journalArticle

  14. Published

    The integrated use of alternative methods in toxicological risk evaluation: ECVAM Integrated Testing Strategies Task Force Report I

    Blaauboer, B. J., Barratt, M. D. & Houston, J. B., Apr 1999, In : Alternatives to Laboratory Animals . 27, 2, p. 229-237 8 p.

    Research output: Contribution to journalArticle

  15. Published

    Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices

    Brian Houston, J. & Carlile, D. J., 1997, In : Drug Metabolism Reviews. 29, 4, p. 891-922 31 p.

    Research output: Contribution to journalArticle

  16. Published

    Prediction of in vivo drug-drug interactions from in vitro data: Impact of incorporating parallel pathways of drug elimination and inhibitor absorption rate constant

    Brown, H. S., Ito, K., Galetin, A. & Houston, J. B., Nov 2005, In : British Journal of Clinical Pharmacology. 60, 5, p. 508-518 10 p.

    Research output: Contribution to journalArticle

  17. Published

    Evaluation of cryopreserved human hepatocytes as an alternative in vitro system to microsomes for the prediction of metabolic clearance

    Brown, H. S., Griffin, M. & Houston, J. B., Feb 2007, In : Drug Metabolism and Disposition. 35, 2, p. 293-301 8 p.

    Research output: Contribution to journalArticle

  18. Published
  19. Published

    Comparative use of isolated hepatocytes and hepatic microsomes for cytochrome P450 inhibition studies: Transporter-enzyme interplay

    Brown, H. S., Wilby, A. J., Alder, J. & Houston, J. B., Dec 2010, In : Drug Metabolism and Disposition. 38, 12, p. 2139-2146 7 p.

    Research output: Contribution to journalArticle

  20. Published

    Cynomoglus monkey as a preclinical model for the investigation of hepatic uptake of OATP substrates

    Bruyn, T. D., Barton, H. A., Bi, Y-A., Cantrill, C., Galetin, A., Houston, B., Lin, J. & Kosa, R., 2015, host publication. Vol. P11.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  21. Published

    Progress curve mechanistic modeling approach for assessing time-dependent inhibition of CYP3A4

    Burt, H. J., Pertinez, H., Säll, C., Collins, C., Hyland, R., Houston, J. B. & Galetin, A., Sep 2012, In : Drug Metabolism and Disposition. 40, 9, p. 1658-1667 9 p.

    Research output: Contribution to journalArticle

  22. Published

    Time-dependent inhibition of CYP3A4 by mibefradil in recombinant CYP3A4 and human liver microsomes and impact on in vivo predictions.

    Burt, H., Galetin, A. & Houston, JB., 2006, host publication. Drug Metab Rev, Vol. 38 (Suppl. 1):.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  23. Published

    IC50-based approaches as an alternative method for assessment of time-dependent inhibition of CYP3A4

    Burt, H. J., Galetin, A. & Houston, J. B., May 2010, In : Xenobiotica. 40, 5, p. 331-343 12 p.

    Research output: Contribution to journalArticle

  24. Published

    Understanding the Interplay Between Uptake and Efflux Transporters Within In Vitro Systems in Defining Hepatocellular Drug Concentrations

    Cantrill, C. & Houston, J. B., Sep 2017, In : Journal of Pharmaceutical Sciences. 106, 9

    Research output: Contribution to journalArticle

  25. Published

    Scaling factors to relate drug metabolic clearance in hepatic microsomes, isolated hepatocytes, and the intact liver: Studies with induced livers involving diazepam

    Carlile, D. J., Zomorodi, K. & Houston, J. B., Aug 1997, In : Drug Metabolism and Disposition. 25, 8, p. 903-911 8 p.

    Research output: Contribution to journalArticle

  26. Published

    Prediction of intrinsic clearance of CYP2C9 substrates in man using hepatic microsomes: imortance of Km.

    Carlile, D. J., Bayliss, M. K. & Houston, B., 1998, Br. J. Clin. Pharmacol.. Vol. 45.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  27. Published

    Predicting the pharmacokinetics of CYP2C9 substrates in man from in vitro studies. Stoke, Rochford

    Carlile, D., Bayliss, M. K., Tarbit, M. H. & Houston, B., 1996, 6th Stowe Symposium on Drug Metabolism.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  28. Published

    Microsomal prediction of intrinsic clearance for CYP2C9 substrates in man: Importance of Km.

    Carlile, DD. & Houston, B., 1997, ISSX Proceedings. Vol. 11.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  29. Published
  30. Published

    In vivo clearance of ethoxycoumarin and its prediction from in vitro systems: Use of drug depletion and metabolite formation methods in hepatic microsomes and isolated hepatocytes

    Carlile, D. J., Stevens, A. J., Ashforth, E. I. L., Waghela, D. & Houston, J. B., Mar 1998, In : Drug Metabolism and Disposition. 26, 3, p. 216-221 5 p.

    Research output: Contribution to journalArticle

  31. Published

    Microsomal prediction of in vivo clearance of CYP2C9 substrates in humans

    Carlile, D. J., Hakooz, N., Bayliss, M. K. & Houston, J. B., 1999, In : British Journal of Clinical Pharmacology. 47, 6, p. 625-635 10 p.

    Research output: Contribution to journalArticle

  32. Published
  33. Published

    Inhibition of rat cytochrome P450-dependent 1 metabolism by ketoconazole and fluconazole. 16th European Drug Metabolism Workshop, Copenhagen

    Chadwick, AA. P., McKillop, D. & Houston, B., 1998, Proceedings.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  34. Published

    Inhibition of rat cytochrome P450-dependent metabolism by ketoconazole and fluconazole

    Chadwick, AA. P., McKillop, D. & Houston, B., 1998, Br. J. Clin. Pharmacol.. Vol. 45.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  35. Published

    Comparison of the extent of sulphation and glucuronidation in the intestine and liver for a range of drugs

    Cubitt, H., Houston, JB. & Galetin, A., 2008, host publication. Vol. 140.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  36. Published

    Relative Importance of Intestinal and Hepatic Glucuronidation-Impact on the Prediction of Drug Clearance

    Cubitt, H. E., Houston, J. B. & Galetin, A., May 2009, In : Pharmaceutical Research. 26, 5, p. 1073-1083 10 p.

    Research output: Contribution to journalArticle

  37. Published

    Comparison of Hepatic and Intestinal Glucuronidation

    Cubitt, H., Houston, JB. & Galetin, A., 2008, host publication. Drug Metab Rev, Vol. 40 (Suppl. 1): 37..

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  38. Published

    Prediction of human drug clearance by multiple metabolic pathways: Integration of hepatic and intestinal microsomal and cytosolic data

    Cubitt, H. E., Houston, J. B. & Galetin, A., May 2011, In : Drug Metabolism and Disposition. 39, 5, p. 864-873 9 p.

    Research output: Contribution to journalArticle

  39. Published

    Comparison of intestinal and hepatic sulphation and glucuronidation for a range of drugs

    Cubitt, H., Houston, JB. & Galetin, A., 2009, In : Drug Metabolism Reviews. 41 (Suppl. 1)

    Research output: Contribution to journalArticle

  40. Published

    Investigation into LiverChipTM as a 3D hepatocyte model for clearance prediction

    De Bruyn, T., Kageyama, M., Ufuk, A., Hallifax, D., Houston, J. B. & Galetin, A., 2015

    Research output: Other contribution

  41. Published

    Predicting human clearance of organic anion transporting polypeptide substrates using cynomolgus monkey: In vitro-in vivo scaling of hepatic uptake clearance

    De Bruyn, T., Ufuk, A., Cantrill, C., Kosa, R. E., Bi, Y. A., Niosi, M., Modi, S., Rodrigues, A. D., Tremaine, L. M., Varma, M. V. S., Galetin, A. & Houston, J. B., Jul 2018, In : Drug Metabolism and Disposition. 46, 7, p. 989-1000 12 p.

    Research output: Contribution to journalArticle

  42. Published

    An integrated approach to the prediction of systemic toxicity using computer-based biokinetic models and biological in vitro test methods: Overview of a prevalidation study based on the ECITTS project

    Dejongh, J., Forsby, A., Houston, J. B., Beckman, M., Combes, R. & Blaauboer, B. J., Aug 1999, In : Toxicology in Vitro. 13, 4-5, p. 549-554 5 p.

    Research output: Contribution to journalArticle

  43. Published

    Evidence-based approach to assess passive diffusion and carrier-mediated drug transport

    Di, L., Artursson, P., Avdeef, A., Ecker, G. F., Faller, B., Fischer, H., Houston, J. B., Kansy, M., Kerns, E. H., Krämer, S. D., Lennernäs, H. & Sugano, K., Aug 2012, In : Drug discovery today. 17, 15-16, p. 905-912 7 p.

    Research output: Contribution to journalArticle

  44. Published

    Metabolite formation kinetics and intrinsic clearance of phenacetin, tolbutamide, alprazolam, and midazolam in adenoviral cytochrome P450-transfected HepG2 cells and comparison with hepatocytes and in vivo

    Donato, M. T., Hallifax, D., Picazo, L., Castell, J. V., Houston, J. B., Gomez-Lechón, M. J. & Lahoz, A., Sep 2010, In : Drug Metabolism and Disposition. 38, 9, p. 1449-1455 6 p.

    Research output: Contribution to journalArticle

  45. Published

    Generation and Evaluation of a CYP2C9 Heteroactivation Pharmacophore

    Egnell, A. C., Eriksson, C., Albertson, N., Houston, B. & Boyer, S., Dec 2003, In : Journal of Pharmacology and Experimental Therapeutics. 307, 3, p. 878-887 9 p.

    Research output: Contribution to journalArticle

  46. Published

    Heteroactivation of cytochrome P450 by marked drugs at concentrations relevant in vivo - quantitative association with a clinical drug interaction.

    Egnell, A. C., Houston, B. & Boyer, S., 2002, Proceedings of Swedish Academy of Pharmaceutical Sciences Roseno meeting..

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  47. Published

    In vivo CYP3A4 heteroactivation is a possible mechanism for the drug interaction between felbamate and carbamazepine

    Egnell, A. C., Houston, B. & Boyer, S., 1 Jun 2003, In : Journal of Pharmacology and Experimental Therapeutics. 305, 3, p. 1251-1262 11 p.

    Research output: Contribution to journalArticle

  48. Published

    Predictive models of CYP3A4 heteroactivation: In vitro-in vivo scaling and pharmacophore modeling

    Egnell, A. C., Houston, J. B. & Boyer, C. S., Mar 2005, In : Journal of Pharmacology and Experimental Therapeutics. 312, 3, p. 926-937 11 p.

    Research output: Contribution to journalArticle

  49. Published
  50. Published

    Defining the in vivo role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5

    Finn, R. D., McLaughlin, L. A., Ronseaux, S., Rosewell, I., Houston, J. B., Henderson, C. J. & Wolf, C. R., 14 Nov 2008, In : Journal of Biological Chemistry. 283, 46, p. 31385-31393 8 p.

    Research output: Contribution to journalArticle

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