Prof James HoustonBSc, PhD, DSc

Emeritus Professor

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Publications

  1. 2018
  2. Published

    Predicting human clearance of organic anion transporting polypeptide substrates using cynomolgus monkey: In vitro-in vivo scaling of hepatic uptake clearance

    De Bruyn, T., Ufuk, A., Cantrill, C., Kosa, R. E., Bi, Y. A., Niosi, M., Modi, S., Rodrigues, A. D., Tremaine, L. M., Varma, M. V. S., Galetin, A. & Houston, J. B., Jul 2018, In : Drug Metabolism and Disposition. 46, 7, p. 989-1000 12 p.

    Research output: Contribution to journalArticle

  3. Published

    In vitro–in vivo extrapolation of OATP1B-mediated drug–drug interactions in cynomolgus monkey

    Ufuk, A., Kosa, R. E., Gao, H., Bi, Y. A., Modi, S., Gates, D., Rodrigues, A. D., Tremaine, L. M., Varma, M. V. S., Houston, J. B. & Galetin, A., 1 Jun 2018, In : Journal of Pharmacology and Experimental Therapeutics. 365, 3, p. 688-699 12 p.

    Research output: Contribution to journalArticle

  4. Published

    Importance of the unstirred water layer and hepatocyte membrane integrity in vitro for quantification of intrinsic metabolic clearance

    Wood, F., Houston, J. & Hallifax, D., 1 Jan 2018, In : Drug Metabolism and Disposition. 46, 1

    Research output: Contribution to journalArticle

  5. Published

    Hepatic OATP-mediated clearance in the Beagle dog: assessing in vitro-in vivo relationships and applying cross species empirical scaling factors to improve prediction of human clearance

    Matsunaga, N., Ufuk, A., Morse, B. L., Bedwell, D. W., Bao, J., Mohutsky, M. A., Hillgren, K. M., Hall, S. D., Houston, J. B. & Galetin, A., 2018, In : Drug Metabolism and Disposition.

    Research output: Contribution to journalArticle

  6. Published

    Simultaneous Assessment in vitro of Transporter and Metabolic Processes in Hepatic Drug Clearance: Use of a media loss approach

    Harrison, J., De Bruyn, T., Darwich, A. & Houston, J., 2018, In : Drug Metabolism and Disposition.

    Research output: Contribution to journalArticle

  7. 2017
  8. Published

    Clearance prediction methodology needs fundamental improvement: Trends common to rat and human hepatocytes/microsomes and implications for experimental methodology

    Wood, F. L., Houston, J. B. & Hallifax, D., 1 Nov 2017, In : Drug Metabolism and Disposition. 45, 11, p. 1178-1188 11 p.

    Research output: Contribution to journalComment/debate

  9. Published

    Understanding the Interplay Between Uptake and Efflux Transporters Within In Vitro Systems in Defining Hepatocellular Drug Concentrations

    Cantrill, C. & Houston, J. B., Sep 2017, In : Journal of Pharmaceutical Sciences. 106, 9

    Research output: Contribution to journalArticle

  10. Published

    In vitro and in silico tools to assess extent of cellular uptake and lysosomal sequestration of respiratory drugs in human alveolar macrophages

    Ufuk, A., Assmus, F., Francis, L., Plumb, J., Damian, V., Gertz, M., Houston, J. & Galetin, A., 2017, In : Molecular Pharmaceutics. 14, 4

    Research output: Contribution to journalArticle

  11. Published

    Incorporation of lysosomal sequestration in the mechanistic model for prediction of tissue distribution of basic drugs

    Assmus, F., Houston, J. & Galetin, A., 2017, In : European Journal of Pharmaceutical Sciences.

    Research output: Contribution to journalArticle

  12. 2016
  13. Published

    Direct and quantitative evaluation of the human CYP3A4 contribution (fm) to drug clearance using the in vitro SILENSOMES model

    Parmentier, Y., Pothier, C., Delmas, A., Caradec, F., Trancart, M. M., Guillet, F., Bouaita, B., Chesne, C., Walther, B. & Houston, J., 2016, In : Xenobiotica. p. 1-14 14 p.

    Research output: Contribution to journalArticle

  14. 2015
  15. Published

    In vitro assessment of uptake and lysosomal sequestration of respiratory drugs in alveolar macrophage cell line NR8383

    Ufuk, A., Somers, G., Houston, J. & Galetin, A., Dec 2015, In : Pharmaceutical Research. 32, 12, p. 3937–3951 14 p.

    Research output: Contribution to journalArticle

  16. Published

    Assessing metabolic competence in isolated hepatocytes: Exploring the relationship between enzyme function and plasma membrane integrity via Saponin treatment

    Wood, F., Hallifax, D. & Houston, B., Jun 2015, host publication. Vol. P10.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  17. Published

    In Silico Prediction of Hepatocellular Drug Binding

    Assmus, F., Houston, B. & Galetin, A., Jun 2015, host publication. Vol. A10.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  18. Published

    Characterization of the comparative drug binding to intra- (liver fatty acid binding protein) and extra- (human serum albumin) cellular proteins

    Rowland, A., Hallifax, D., Nussio, M., Shapter, J., Mackenzie, P., Houston, J. B., Knights, K. M. & Miners, J. O., 24 Mar 2015, In : Xenobiotica. 45, 10, p. 847-857 10 p.

    Research output: Contribution to journalArticle

  19. Published

    "Time dependent" inhibition of hepatic uptake transporters in hepatocytes and implications on the assessment of transporter-mediated drug-drug interactions

    Kageyama, M., Houston, B. & Galetin, A., 2015, host publication. Vol. P43.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  20. Published

    Comparison of respiratory drug accumulation and lysosomal sequestration in NR8383 and primary human al veolar macrophages

    Ufuk, A., Plumb, J., Houston, B. & Galetin, A., 2015, host publication. Vol. A11.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  21. Published

    Cynomoglus monkey as a preclinical model for the investigation of hepatic uptake of OATP substrates

    Bruyn, T. D., Barton, H. A., Bi, Y-A., Cantrill, C., Galetin, A., Houston, B., Lin, J. & Kosa, R., 2015, host publication. Vol. P11.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  22. Published

    Investigation into LiverChipTM as a 3D hepatocyte model for clearance prediction

    De Bruyn, T., Kageyama, M., Ufuk, A., Hallifax, D., Houston, J. B. & Galetin, A., 2015

    Research output: Other contribution

  23. 2014
  24. Published

    Passive lipoidal diffusion and carrier-mediated cell uptake are both important mechanisms of membrane permeation in drug disposition

    Smith, D., Artursson, P., Avdeef, A., Di, L., Ecker, G. F., Faller, B., Houston, J. B., Kansy, M., Kerns, E. H., Krämer, S. D., Lennernäs, H., Van De Waterbeemd, H., Sugano, K. & Testa, B., 2 Jun 2014, In : Molecular Pharmaceutics. 11, 6, p. 1727-1738 11 p.

    Research output: Contribution to journalArticle

  25. Published
  26. Published
  27. Published

    Intrinsic Clearance Predictions from Freshly Isolated Rat Hepatocytes: Effects of Assay Format and Cofactor Supplementation

    Wood, F., Hallifax, D. & Houston, J., 2014, Proceedings of 20th international symposium on microsomes and drug oxidations.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  28. Published
  29. 2013
  30. Published

    Special Section on Prediction of human pharmacokinetic parameters from in vitro systems-Commentary

    Houston, JB., Dec 2013, In : Drug Metab Dispos. 41, p. 1973-1974

    Research output: Contribution to journalEditorial

  31. Published
  32. Published

    Addressing the challenges of low clearance.

    Houston, J. B., Nov 2013.

    Research output: Contribution to conferenceOther

  33. Published

    Drug accumulation in alveolar macrophages: assessment of uptake and lysosomal distribution in vitro.

    Houston, JB., Ufuk, A., Gertz, M., Plumb, J., Somers, G. & Galetin, A., Sep 2013.

    Research output: Contribution to conferencePoster

  34. Published

    Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

    Godoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., Bode, J. G., Bolleyn, J., Borner, C., Böttger, J., Braeuning, A., Budinsky, R. A., Burkhardt, B., Cameron, N. R., Camussi, G., Cho, C. S., Choi, Y. J., Craig Rowlands, J., Dahmen, U., Damm, G. & 73 others, Dirsch, O., Donato, M. T., Dong, J., Dooley, S., Drasdo, D., Eakins, R., Ferreira, K. S., Fonsato, V., Fraczek, J., Gebhardt, R., Gibson, A., Glanemann, M., Goldring, C. E. P., Gómez-Lechón, M. J., Groothuis, G. M. M., Gustavsson, L., Guyot, C., Hallifax, D., Hammad, S., Hayward, A., Häussinger, D., Hellerbrand, C., Hewitt, P., Hoehme, S., Holzhütter, H. G., Houston, J. B., Hrach, J., Ito, K., Jaeschke, H., Keitel, V., Kelm, J. M., Kevin Park, B., Kordes, C., Kullak-Ublick, G. A., Lecluyse, E. L., Lu, P., Luebke-Wheeler, J., Lutz, A., Maltman, D. J., Matz-Soja, M., McMullen, P., Merfort, I., Messner, S., Meyer, C., Mwinyi, J., Naisbitt, D. J., Nussler, A. K., Olinga, P., Pampaloni, F., Pi, J., Pluta, L., Przyborski, S. A., Ramachandran, A., Rogiers, V., Rowe, C., Schelcher, C., Schmich, K., Schwarz, M., Singh, B., Stelzer, E. H. K., Stieger, B., Stöber, R., Sugiyama, Y., Tetta, C., Thasler, W. E., Vanhaecke, T., Vinken, M., Weiss, T. S., Widera, A., Woods, C. G., Xu, J. J., Yarborough, K. M. & Hengstler, J. G., Aug 2013, In : Archives of Toxicology. 87, 8, p. 1315-1530 215 p.

    Research output: Contribution to journalArticle

  35. Published

    Application of a physiologically based pharmacokinetic model to assess propofol hepatic and renal glucuronidation in isolation: Utility of in vitro and in vivo data

    Gill, K. L., Gertz, M., Houston, J. B. & Galetin, A., Apr 2013, In : Drug Metabolism and Disposition. 41, 4, p. 744-753 9 p.

    Research output: Contribution to journalArticle

  36. Published

    Cyclosporine inhibition of hepatic and intestinal CYP3A4, uptake and efflux transporters: Application of PBPK Modeling in the assessment of drug-drug interaction potential

    Gertz, M., Cartwright, C. M., Hobbs, M. J., Kenworthy, K. E., Rowland, M., Houston, J. B. & Galetin, A., Mar 2013, In : Pharmaceutical Research. 30, 3, p. 761-780 19 p.

    Research output: Contribution to journalArticle

  37. 2012
  38. Published

    In vitro assessment of accumulation of inhaled drugs by alveolar macrophages

    Houston, JB., Ufuk, A., Somers, GI. & Galetin, A., Sep 2012.

    Research output: Contribution to conferencePoster

  39. Published

    Predictive hepatocellular activity: Cornerstone for PBPK modelling (B2)

    Houston, J. B., Sep 2012.

    Research output: Contribution to conferenceOther

  40. Published

    Progress curve mechanistic modeling approach for assessing time-dependent inhibition of CYP3A4

    Burt, H. J., Pertinez, H., Säll, C., Collins, C., Hyland, R., Houston, J. B. & Galetin, A., Sep 2012, In : Drug Metabolism and Disposition. 40, 9, p. 1658-1667 9 p.

    Research output: Contribution to journalArticle

  41. Published

    Use of mechanistic modeling to assess interindividual variability and interspecies differences in active uptake in human and rat hepatocytes

    Ménochet, K., Kenworthy, K. E., Houston, J. B. & Galetin, A., Sep 2012, In : Drug Metabolism and Disposition. 40, 9, p. 1744-1756 12 p.

    Research output: Contribution to journalArticle

  42. Published

    Evaluation of hepatic clearance prediction using in vitro data: Emphasis on fraction unbound in plasma and drug ionisation using a database of 107 drugs

    Hallifax, D. & Houston, J. B., Aug 2012, In : Journal of Pharmaceutical Sciences. 101, 8, p. 2645-2652 7 p.

    Research output: Contribution to journalArticle

  43. Published

    Evidence-based approach to assess passive diffusion and carrier-mediated drug transport

    Di, L., Artursson, P., Avdeef, A., Ecker, G. F., Faller, B., Fischer, H., Houston, J. B., Kansy, M., Kerns, E. H., Krämer, S. D., Lennernäs, H. & Sugano, K., Aug 2012, In : Drug discovery today. 17, 15-16, p. 905-912 7 p.

    Research output: Contribution to journalArticle

  44. Published

    Utility of drug depletion-time profiles in isolated hepatocytes for accessing hepatic uptake clearance: Identifying rate-limiting steps and role of passive processes

    Jigorel, E. & Houston, J. B., Aug 2012, In : Drug Metabolism and Disposition. 40, 8, p. 1596-1602 6 p.

    Research output: Contribution to journalArticle

  45. Published

    A comprehensive assessment of repaglinide metabolic pathways: Impact of choice of in vitro system and relative enzyme contribution to in vitro clearance

    Säll, C., Houston, J. B. & Galetin, A., Jul 2012, In : Drug Metabolism and Disposition. 40, 7, p. 1279-1289 10 p.

    Research output: Contribution to journalArticle

  46. Published

    Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data

    Jones, H. M., Barton, H. A., Lai, Y., Bi, Y. A., Kimoto, E., Kempshall, S., Tate, S. C., El-Kattan, A., Houston, J. B., Galetin, A. & Fenner, K. S., May 2012, In : Drug Metabolism and Disposition. 40, 5, p. 1007-1017 10 p.

    Research output: Contribution to journalArticle

  47. Published

    Clearance-dependent underprediction of in vivo intrinsic clearance from human hepatocytes: Comparison with permeabilities from artificial membrane (PAMPA) assay, in silico and caco-2 assay, for 65 drugs

    Hallifax, D., Turlizzi, E., Zanelli, U. & Houston, J. B., 11 Apr 2012, In : European Journal of Pharmaceutical Sciences. 45, 5, p. 570-574 4 p.

    Research output: Contribution to journalArticle

  48. Published
  49. Published

    Simultaneous assessment of uptake and metabolism in rat hepatocytes: A comprehensive mechanistic model

    Ménochet, K., Kenworthy, K. E., Houston, J. B. & Galetin, A., Apr 2012, In : Journal of Pharmacology and Experimental Therapeutics. 341, 1, p. 2-15 13 p.

    Research output: Contribution to journalArticle

  50. Published

    Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs

    Zanelli, U., Caradonna, N. P., Hallifax, D., Turlizzi, E. & Houston, J. B., Jan 2012, In : Drug Metabolism and Disposition. 40, 1, p. 104-110 6 p.

    Research output: Contribution to journalArticle

  51. Published

    Evaluation of the novel in vitro systems for hepatic drug clearance and assessment of their predictive utility

    Houston, J. B., Rowland-Yeo, K. & Zanelli, U., 2012, In : Toxicology in Vitro. 26, 8, p. 1265-71

    Research output: Contribution to journalArticle

  52. 2011
  53. Published

    Kinetic characterization of rat hepatic uptake of 16 actively transported drugs

    Yabe, Y., Galetin, A. & Houston, J. B., Oct 2011, In : Drug Metabolism and Disposition. 39, 10, p. 1808-1814 6 p.

    Research output: Contribution to journalArticle

  54. Published

    Predictive utility of in vitro rifampin induction data generated in fresh and cryopreserved human hepatocytes, Fa2N-4,and HepaRG cells

    Templeton, I. E., Houston, J. B. & Galetin, A., Oct 2011, In : Drug Metabolism and Disposition. 39, 10, p. 1921-1929 8 p.

    Research output: Contribution to journalArticle

  55. Published

    Physiologically based pharmacokinetic modeling of intestinal first-pass metabolism of CYP3A substrates with high intestinal extraction

    Gertz, M., Houston, J. B. & Galetin, A., Sep 2011, In : Drug Metabolism and Disposition. 39, 9, p. 1633-1642 9 p.

    Research output: Contribution to journalArticle

  56. Published

    Comparative pharmacokinetics between a microdose and therapeutic dose for clarithromycin, sumatriptan, propafenone, paracetamol (acetaminophen), and phenobarbital in human volunteers

    Lappin, G., Shishikura, Y., Jochemsen, R., Weaver, R. J., Gesson, C., Brian Houston, J., Oosterhuis, B., Bjerrum, O. J., Grynkiewicz, G., Alder, J., Rowland, M. & Garner, C., 14 Jun 2011, In : European Journal of Pharmaceutical Sciences. 43, 3, p. 141-150 9 p.

    Research output: Contribution to journalArticle

  57. Published

    A pragmatic randomized controlled trial of thiopurine methyltransferase genotyping prior to azathioprine treatment: The TARGET study

    Newman, W. G., Payne, K., Tricker, K., Roberts, S. A., Fargher, E., Pushpakom, S., Alder, J. E., Sidgwick, G. P., Payne, D., Elliott, R. A., Heise, M., Elles, R., Ramsden, S. C., Andrews, J., Houston, J. B., Qasim, F., Shaffer, J., Griffiths, C. E. M., Ray, D. W., Bruce, I. & 1 others, Ollier, W. E. R., Jun 2011, In : Pharmacogenomics. 12, 6, p. 815-826 11 p.

    Research output: Contribution to journalArticle

  58. Published

    Prediction of human drug clearance by multiple metabolic pathways: Integration of hepatic and intestinal microsomal and cytosolic data

    Cubitt, H. E., Houston, J. B. & Galetin, A., May 2011, In : Drug Metabolism and Disposition. 39, 5, p. 864-873 9 p.

    Research output: Contribution to journalArticle

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