Prof James HoustonBSc, PhD, DSc

Emeritus Professor

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Publications

  1. 2005
  2. Published

    Role of hepatic cytochrome P450s in the pharmacokinetics and toxicity of cyclophosphamide: Studies with the hepatic cytochrome P450 reductase null mouse

    Pass, G. J., Carrie, D., Boylan, M., Lorimore, S., Wright, E., Houston, B., Henderson, C. J. & Wolf, C. R., 15 May 2005, In : Cancer Research. 65, 10, p. 4211-4217 6 p.

    Research output: Contribution to journalArticle

  3. Published

    Impact of end-product inhibition on the determination of in vitro metabolic clearance

    Jones, H. M., Nicholls, G. & Houston, J. B., May 2005, In : Xenobiotica. 35, 5, p. 439-454 15 p.

    Research output: Contribution to journalArticle

  4. Published

    Predictive models of CYP3A4 heteroactivation: In vitro-in vivo scaling and pharmacophore modeling

    Egnell, A. C., Houston, J. B. & Boyer, C. S., Mar 2005, In : Journal of Pharmacology and Experimental Therapeutics. 312, 3, p. 926-937 11 p.

    Research output: Contribution to journalArticle

  5. Published

    Modelling atypical CYP3A4 kinetics: Principles and pragmatism

    Houston, J. B. & Galetin, A., 15 Jan 2005, In : Archives of Biochemistry and Biophysics. 433, 2, p. 351-360 9 p.

    Research output: Contribution to journalArticle

  6. Published

    Prediction of human drug clearance from in vitro and preclinical data using physiologically based and empirical approaches

    Ito, K. & Houston, J. B., Jan 2005, In : Pharmaceutical Research. 22, 1, p. 103-112 9 p.

    Research output: Contribution to journalArticle

  7. Published

    Prediction of in vitro intrinsic clearance from hepatocytes: Comparison of suspensions and monolayer cultures

    Griffin, S. J. & Houston, J. B., Jan 2005, In : Drug Metabolism and Disposition. 33, 1, p. 115-120 5 p.

    Research output: Contribution to journalArticle

  8. Published
  9. Published

    Prediction of time-dependant drug-drug interactions - impact of parallel pathways, enzyme degradation and intestinal inhibition

    Galetin, A., Burt, H. & Houston, B., 2005, Drug Metabolism Reviews. Suppl 2 ed. Vol. 38.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  10. Published

    Research Governance: What is reasonable protection?

    Payne, K., Fargher, EA., Tricker, K., Newman, WG., Qasim, FF., Poulton, K., Andrews, J., Houston, J., Elliott, RA., Elles, R., Ray, D., Shaffer, JL., Griffiths, CEM., Bruce, I., Roberts, S. & Ollier, WER., 2005, In : BMJ Rapid response.

    Research output: Contribution to journalLetter

  11. Published

    The TARGET (TPMT: Azathioprine Response to Genotyping and Enzyme Testing) study

    Newman, WG., Payne, K., Poulton, K., Andrews, J., Houston, B., Elliott, RA., Elles, RG., Ray, DW., Shaffer, J., Griffiths, CEM., Bruce, IN., Roberts, S. A., Qasim, F. & Ollier, WER., 2005, In : Bmj.

    Research output: Contribution to journalLetter

  12. 2004
  13. Published

    Utility of recombinant enzyme kinetics in prediction of human clearance: Impact of variability, CYP3A5, and CYP2C19 on CYP3A4 probe substrates

    Galetin, A., Brown, C., Hallifax, D., Ito, K. & Houston, J. B., Dec 2004, In : Drug Metabolism and Disposition. 32, 12, p. 1411-1420 9 p.

    Research output: Contribution to journalArticle

  14. Published

    Substrate depletion approach for determining in vitro metabolic clearance: Time dependencies in hepatocyte and microsomal incubations

    Jones, H. M. & Houston, J. B., Sep 2004, In : Drug Metabolism and Disposition. 32, 9, p. 973-982 9 p.

    Research output: Contribution to journalArticle

  15. Published

    Comparison of fresh and cryopreserved rat hepatocyte suspensions for the prediction of in vitro intrinsic clearance

    Griffin, S. J. & Houston, J. B., May 2004, In : Drug Metabolism and Disposition. 32, 5, p. 552-558 6 p.

    Research output: Contribution to journalArticle

  16. Published

    Comparison of the use of liver models for predicting drug clearance using in vitro kinetic data from hepatic microsomes and isolated hepatocytes

    Ito, K. & Houston, J. B., May 2004, In : Pharmaceutical Research. 21, 5, p. 785-792 7 p.

    Research output: Contribution to journalArticle

  17. Published

    Quantitative prediction of the in vivo inhibition of diazepam metabolism by omeprazole using rat liver microsomes and hepatocytes

    Jones, H. M., Hallifax, D. & Houston, J. B., May 2004, In : Drug Metabolism and Disposition. 32, 5, p. 572-580 8 p.

    Research output: Contribution to journalArticle

  18. Published

    Auto- and heteroactivation of metabolism of a series of benzodiazepines in human hepatocytes.

    Hallifax, D., Rawden, H., Galetin, A., Brown, C. & Houston, JB., 2004.

    Research output: Contribution to conferencePoster

  19. 2003
  20. Published

    Generation and Evaluation of a CYP2C9 Heteroactivation Pharmacophore

    Egnell, A. C., Eriksson, C., Albertson, N., Houston, B. & Boyer, S., Dec 2003, In : Journal of Pharmacology and Experimental Therapeutics. 307, 3, p. 878-887 9 p.

    Research output: Contribution to journalArticle

  21. Published

    Isoform selectivity and kinetics of morphine 3- and 6-glucuronidation by human UDP-glucuronosyltransferases: Evidence for atypical glucuronidation kinetics by UGT2B7

    Stone, A. N., Mackenzie, P. I., Galetin, A., Houston, J. B. & Miners, J. O., 1 Sep 2003, In : Drug Metabolism and Disposition. 31, 9, p. 1086-1089 3 p.

    Research output: Contribution to journalArticle

  22. Published

    Multisite kinetic analysis of interactions between prototypical CYP3A4 subgroup substrates: Midazolam, testosterone, and nifedipine

    Galetin, A., Clarke, S. E. & Houston, J. B., 1 Sep 2003, In : Drug Metabolism and Disposition. 31, 9, p. 1108-1116 8 p.

    Research output: Contribution to journalArticle

  23. Published

    In vivo CYP3A4 heteroactivation is a possible mechanism for the drug interaction between felbamate and carbamazepine

    Egnell, A. C., Houston, B. & Boyer, S., 1 Jun 2003, In : Journal of Pharmacology and Experimental Therapeutics. 305, 3, p. 1251-1262 11 p.

    Research output: Contribution to journalArticle

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