Prof James HoustonBSc, PhD, DSc

Emeritus Professor

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Publications

  1. 2006
  2. Published
  3. Published
  4. Published

    In vitro-in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: Pitfalls and promises

    Miners, J. O., Knights, K. M., Houston, J. B. & Mackenzie, P. I., 28 May 2006, In : Biochemical Pharmacology. 71, 11, p. 1531-1539 8 p.

    Research output: Contribution to journalArticle

  5. Published

    Binding of drugs to hepatic microsomes: Comment and assessment of current prediction methodology with recommendation for improvement [1]

    Hallifax, D. & Houston, J. B., Apr 2006, In : Drug Metabolism and Disposition. 34, 4, p. 724-726 2 p.

    Research output: Contribution to journalArticle

  6. Published

    Determination of a human hepatic microsomal scaling factor for predicting in vivo drug clearance

    Hakooz, N., Ito, K., Rawden, H., Gill, H., Lemmers, L., Boobis, A. R., Edwards, R. J., Carlile, D. J., Lake, B. G. & Houston, J. B., Mar 2006, In : Pharmaceutical Research. 23, 3, p. 533-539 6 p.

    Research output: Contribution to journalArticle

  7. Published

    Prediction of time-dependent CYP3A4 drug-drug interactions: Impact of enzyme degradation, parallel elimination pathways, and intestinal inhibition

    Galetin, A., Burt, H., Gibbons, L. & Houston, J. B., Jan 2006, In : Drug Metabolism and Disposition. 34, 1, p. 166-175 9 p.

    Research output: Contribution to journalArticle

  8. Published

    The utility of in vitro cytochrome P450 inhibition data in the prediction of drug-drug interactions

    Obach, R. S., Walsky, R. L., Venkatakrishnan, K., Gaman, E. A., Houston, J. B. & Tremaine, L. M., Jan 2006, In : Journal of Pharmacology and Experimental Therapeutics. 316, 1, p. 336-348 12 p.

    Research output: Contribution to journalArticle

  9. Published

    Comparison of Metabolism and Transporter Models for Predicting Gemfibrozil Drug-Drug Interactions.

    Gibbons, LK., Galetin, A. & Houston, JB., 2006, host publication. Drug Metab Rev, Vol. 38 (Suppl. 1).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  10. Published

    Intestinal and hepatic metabolic activity of five cytochrome P450 enzymes: Impact on prediction of first-pass metabolism

    Galetin, A. & Houston, J. B., 2006, In : Journal of Pharmacology and Experimental Therapeutics. 318, 3, p. 1220-1229 9 p.

    Research output: Contribution to journalArticle

  11. Published

    Maximal FG ratio as a pragmatic indicator of the magnitude of intestinal CYP3A4 inhibition

    Galetin, A., Gibbons, LK., Burt, H., Obach, RS. & Houston, JB., 2006, host publication. Drug Metab Rev, Vol. 38 (Suppl. 1): 44.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  12. Published

    Multisite kinetic modelling of interactions between UDP-glucuronosyltransferase 2B7 (UGT2B7) substrates.

    Galetin, A., Uchaipichat, V., Mackenzie, PI., Houston, JB. & Miners, JO., 2006, host publication. Drug Metab Rev, Vol. 38 (Suppl. 1): 45.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  13. Published

    Time-dependent inhibition of CYP3A4 by mibefradil in recombinant CYP3A4 and human liver microsomes and impact on in vivo predictions.

    Burt, H., Galetin, A. & Houston, JB., 2006, host publication. Drug Metab Rev, Vol. 38 (Suppl. 1):.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  14. Published

    Uptake and intracellular binding of lipophilic amine drugs by isolated rat hepatocytes and implications for prediction of in vivo metabolic clearance

    Hallifax, D. & Houston, J. B., 2006, In : Drug Metabolism and Disposition. 34, 11, p. 1829-1836 7 p.

    Research output: Contribution to journalArticle

  15. Published

    Variability in Heteroactivation of Carbamazepine Metabolism by Endogenous Steroids: Comparison of CYP3A4 and CYP3A5 Response.

    Henshall, J., Galetin, A., Harrison, A. & Houston, JB., 2006, host publication. Drug Metab Rev, Vol. 38 (Suppl. 1):.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  16. 2005
  17. Published

    In vitro cytochrome P450 inhibition data and the prediction of drug-drug interactions: Qualitative relationships, quantitative predictions, and the rank-order approach

    Obach, R. S., Walsky, R. L., Venkatakrishnan, K., Houston, J. B. & Tremaine, L. M., Dec 2005, In : Clinical Pharmacology and Therapeutics. 78, 6, p. 582-e7

    Research output: Contribution to journalArticle

  18. Published

    Prediction of metabolic clearance using cryopreserved human hepatocytes: Kinetic characteristics for five benzodiazepines

    Hallifax, D., Rawden, H. C., Hakooz, N. & Houston, J. B., Dec 2005, In : Drug Metabolism and Disposition. 33, 12, p. 1852-1858 6 p.

    Research output: Contribution to journalArticle

  19. Published

    Prediction of in vivo drug-drug interactions from in vitro data: Impact of incorporating parallel pathways of drug elimination and inhibitor absorption rate constant

    Brown, H. S., Ito, K., Galetin, A. & Houston, J. B., Nov 2005, In : British Journal of Clinical Pharmacology. 60, 5, p. 508-518 10 p.

    Research output: Contribution to journalArticle

  20. Published

    CYP3A4 substrate selection and substitution in the prediction of potential drug-drug interactions

    Galetin, A., Ito, K., Hallifax, D. & Houston, J. B., Jul 2005, In : Journal of Pharmacology and Experimental Therapeutics. 314, 1, p. 180-190 10 p.

    Research output: Contribution to journalArticle

  21. Published

    Impact of parallel pathways of drug elimination and multiple cytochrome P450 involvement on drug-drug interactions: CYP2D6 paradigm

    Ito, K., Hallifax, D., Obach, R. S. & Houston, J. B., Jun 2005, In : Drug Metabolism and Disposition. 33, 6, p. 837-844 7 p.

    Research output: Contribution to journalArticle

  22. Published

    Microsomal prediction of in vivo clearance and associated interindividual variability of six benzodiazepines in humans

    Rawden, H. C., Carlile, D. J., Tindall, A., Hallifax, D., Galetin, A., Ito, K. & Houston, J. B., Jun 2005, In : Xenobiotica. 35, 6, p. 603-625 22 p.

    Research output: Contribution to journalArticle

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