Prof James HoustonBSc, PhD, DSc

Emeritus Professor

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Publications

  1. 2010
  2. Published

    Prediction of human intestinal first-pass metabolism of 25 CYP3A substrates from in vitro clearance and permeability data

    Gertz, M., Harrison, A., Houston, J. B. & Galetin, A., Jul 2010, In : Drug Metabolism and Disposition. 38, 7, p. 1147-1158 11 p.

    Research output: Contribution to journalArticle

  3. Published

    Transporters and cytochrome P450 interplay in defining hepatic drug clearance

    Houston, JB., Jun 2010.

    Research output: Contribution to conferenceOther

  4. Published

    IC50-based approaches as an alternative method for assessment of time-dependent inhibition of CYP3A4

    Burt, H. J., Galetin, A. & Houston, J. B., May 2010, In : Xenobiotica. 40, 5, p. 331-343 12 p.

    Research output: Contribution to journalArticle

  5. Published

    Pharmacokinetics of fexofenadine: Evaluation of a microdose and assessment of absolute oral bioavailability

    Lappin, G., Shishikura, Y., Jochemsen, R., Weaver, R. J., Gesson, C., Houston, B., Oosterhuis, B., Bjerrum, O. J., Rowland, M. & Garner, C., May 2010, In : European Journal of Pharmaceutical Sciences. 40, 2, p. 125-131 6 p.

    Research output: Contribution to journalArticle

  6. Published

    Application of different in vitro systems for prediction of in vivo induction drug-drug interactions

    Galetin, A. & Houston, J., 2010, host publication. Vol. 143.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  7. Published

    Contribution of intestinal cytochrome P450-mediated metabolism to drug-drug inhibition and induction interactions

    Galetin, A., Gertz, M. & Houston, J. B., 2010, In : Drug Metabolism and Pharmacokinetics. 25, 1, p. 28-47 19 p.

    Research output: Contribution to journalArticle

  8. Published

    In vitro techniques to study drug-drug interactions of drug metabolism: Cytochrome P450

    Houston, J. B. & Galetin, A., 2010, Enzyme- and Transporter-Based Drug-Drug Interactions: Progress and Future Challenges|Enz.- and Transporter-Based Drug-Drug Interac.: Progress and Fut. Chall.. USA: Springer Nature, p. 169-215 46 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  9. Published

    Inhibition of Drug Metabolizing Enzymes in Gastrointestinal Tract and its Influence on the Drug-Drug Interaction Prediction, in Enzyme Inhibition in Drug Discovery and Development

    Galetin, A., Houston, JB., Lu, C. (ed.) & A. P. Li, S. (ed.), 2010, host publication. John Wiley & Sons Ltd, p. 315-343

    Research output: Chapter in Book/Report/Conference proceedingChapter

  10. Published

    Physiologically-based pharmacokinetic modelling approach to assess the uptake transporter-mediated drug-drug interaction potential of cyclosporine.

    Galetin, A. & Houston, J., 2010, host publication. Vol. 149.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  11. Published

    Prediction of clearance from the HepaRG cell system: comparison with human hepatocytes for a range of substrates.

    Zanelli, U., Caradonna, NP., Hallifax, D. & Houston, JB., 2010, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  12. 2009
  13. Published

    . Physiologically-Based Pharmacokinetic Modelling of Hepatic Uptake of Pravastatin and Rosuvastatin

    Galetin, A., Houston, JB., Tate, S. & Jones, HM., 25 Nov 2009, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  14. Published

    Assessment of Algorithms for Predicting Drug-Drug Interactions via Inhibition Mechanisms.

    Rostami-Hochaghan, A., Guest, EJ., Rowland, Y. K., Rostami-Hodjegan, A., Tucker, GT., Houston, JB. & Galetin, A., 23 Sep 2009, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  15. Published

    Transporters and cytochrome P450 interplay in defining hepatic drug clearance

    Houston, JB., Sep 2009.

    Research output: Contribution to conferenceOther

  16. Published

    Methodology for development of a physiological model incorporating CYP3A and P-glycoprotein for the prediction of intestinal drug absorption

    Badhan, R., Penny, J., Galetin, A. & Houston, J. B., Jun 2009, In : Journal of Pharmaceutical Sciences. 98, 6, p. 2180-2197 17 p.

    Research output: Contribution to journalArticle

  17. Published

    How good is prediction of in vivo metabolic clearance from established in vitro systems?

    Foster, JA., Hallifax, D. & Houston, B., 17 May 2009.

    Research output: Contribution to conferencePoster

  18. Published

    Involvement of drug uptake in hepatic clearance

    Jigorel, EE. & Houston, B., 17 May 2009, Drug Metab Rev. Vol. Rev 41 (Suppl 1).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  19. Published

    Evaluation of recombinant cytochrome p450 enzymes as an in vitro system for metabolic clearance predictions

    Stringer, R. A., Strain-Damerell, C., Nicklin, P. & Houston, J. B., May 2009, In : Drug Metabolism and Disposition. 37, 5, p. 1025-1034 9 p.

    Research output: Contribution to journalArticle

  20. Published

    Relative Importance of Intestinal and Hepatic Glucuronidation-Impact on the Prediction of Drug Clearance

    Cubitt, H. E., Houston, J. B. & Galetin, A., May 2009, In : Pharmaceutical Research. 26, 5, p. 1073-1083 10 p.

    Research output: Contribution to journalArticle

  21. Published

    QGut Model as a Predictive Tool for Intestinal Availability in Human: Impact of In Vitro Permeability and Clearance

    Gertz, M., Fenner, KS., Harrison, A., Davis, J., Houston, JB. & Galetin, A., 6 Feb 2009, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  22. Published

    Prediction of drug clearance by glucuronidation from in vitro data: Use of combined cytochrome P450 and UDP-glucuronosyltransferase cofactors in alamethicin-activated human liver microsomes

    Kilford, P. J., Stringer, R., Sohal, B., Houston, J. B. & Galetin, A., Jan 2009, In : Drug Metabolism and Disposition. 37, 1, p. 82-89 7 p.

    Research output: Contribution to journalArticle

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