Prof James HoustonBSc, PhD, DSc

Emeritus Professor

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Publications

  1. 2014
  2. Published
  3. Published

    Intrinsic Clearance Predictions from Freshly Isolated Rat Hepatocytes: Effects of Assay Format and Cofactor Supplementation

    Wood, F., Hallifax, D. & Houston, J., 2014, Proceedings of 20th international symposium on microsomes and drug oxidations.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  4. Published
  5. 2013
  6. Published

    Special Section on Prediction of human pharmacokinetic parameters from in vitro systems-Commentary

    Houston, JB., Dec 2013, In : Drug Metab Dispos. 41, p. 1973-1974

    Research output: Contribution to journalEditorial

  7. Published
  8. Published

    Addressing the challenges of low clearance.

    Houston, J. B., Nov 2013.

    Research output: Contribution to conferenceOther

  9. Published

    Drug accumulation in alveolar macrophages: assessment of uptake and lysosomal distribution in vitro.

    Houston, JB., Ufuk, A., Gertz, M., Plumb, J., Somers, G. & Galetin, A., Sep 2013.

    Research output: Contribution to conferencePoster

  10. Published

    Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

    Godoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., Bode, J. G., Bolleyn, J., Borner, C., Böttger, J., Braeuning, A., Budinsky, R. A., Burkhardt, B., Cameron, N. R., Camussi, G., Cho, C. S., Choi, Y. J., Craig Rowlands, J., Dahmen, U., Damm, G. & 73 others, Dirsch, O., Donato, M. T., Dong, J., Dooley, S., Drasdo, D., Eakins, R., Ferreira, K. S., Fonsato, V., Fraczek, J., Gebhardt, R., Gibson, A., Glanemann, M., Goldring, C. E. P., Gómez-Lechón, M. J., Groothuis, G. M. M., Gustavsson, L., Guyot, C., Hallifax, D., Hammad, S., Hayward, A., Häussinger, D., Hellerbrand, C., Hewitt, P., Hoehme, S., Holzhütter, H. G., Houston, J. B., Hrach, J., Ito, K., Jaeschke, H., Keitel, V., Kelm, J. M., Kevin Park, B., Kordes, C., Kullak-Ublick, G. A., Lecluyse, E. L., Lu, P., Luebke-Wheeler, J., Lutz, A., Maltman, D. J., Matz-Soja, M., McMullen, P., Merfort, I., Messner, S., Meyer, C., Mwinyi, J., Naisbitt, D. J., Nussler, A. K., Olinga, P., Pampaloni, F., Pi, J., Pluta, L., Przyborski, S. A., Ramachandran, A., Rogiers, V., Rowe, C., Schelcher, C., Schmich, K., Schwarz, M., Singh, B., Stelzer, E. H. K., Stieger, B., Stöber, R., Sugiyama, Y., Tetta, C., Thasler, W. E., Vanhaecke, T., Vinken, M., Weiss, T. S., Widera, A., Woods, C. G., Xu, J. J., Yarborough, K. M. & Hengstler, J. G., Aug 2013, In : Archives of Toxicology. 87, 8, p. 1315-1530 215 p.

    Research output: Contribution to journalArticle

  11. Published

    Application of a physiologically based pharmacokinetic model to assess propofol hepatic and renal glucuronidation in isolation: Utility of in vitro and in vivo data

    Gill, K. L., Gertz, M., Houston, J. B. & Galetin, A., Apr 2013, In : Drug Metabolism and Disposition. 41, 4, p. 744-753 9 p.

    Research output: Contribution to journalArticle

  12. Published

    Cyclosporine inhibition of hepatic and intestinal CYP3A4, uptake and efflux transporters: Application of PBPK Modeling in the assessment of drug-drug interaction potential

    Gertz, M., Cartwright, C. M., Hobbs, M. J., Kenworthy, K. E., Rowland, M., Houston, J. B. & Galetin, A., Mar 2013, In : Pharmaceutical Research. 30, 3, p. 761-780 19 p.

    Research output: Contribution to journalArticle

  13. 2012
  14. Published

    In vitro assessment of accumulation of inhaled drugs by alveolar macrophages

    Houston, JB., Ufuk, A., Somers, GI. & Galetin, A., Sep 2012.

    Research output: Contribution to conferencePoster

  15. Published

    Predictive hepatocellular activity: Cornerstone for PBPK modelling (B2)

    Houston, J. B., Sep 2012.

    Research output: Contribution to conferenceOther

  16. Published

    Progress curve mechanistic modeling approach for assessing time-dependent inhibition of CYP3A4

    Burt, H. J., Pertinez, H., Säll, C., Collins, C., Hyland, R., Houston, J. B. & Galetin, A., Sep 2012, In : Drug Metabolism and Disposition. 40, 9, p. 1658-1667 9 p.

    Research output: Contribution to journalArticle

  17. Published

    Use of mechanistic modeling to assess interindividual variability and interspecies differences in active uptake in human and rat hepatocytes

    Ménochet, K., Kenworthy, K. E., Houston, J. B. & Galetin, A., Sep 2012, In : Drug Metabolism and Disposition. 40, 9, p. 1744-1756 12 p.

    Research output: Contribution to journalArticle

  18. Published

    Evaluation of hepatic clearance prediction using in vitro data: Emphasis on fraction unbound in plasma and drug ionisation using a database of 107 drugs

    Hallifax, D. & Houston, J. B., Aug 2012, In : Journal of Pharmaceutical Sciences. 101, 8, p. 2645-2652 7 p.

    Research output: Contribution to journalArticle

  19. Published

    Evidence-based approach to assess passive diffusion and carrier-mediated drug transport

    Di, L., Artursson, P., Avdeef, A., Ecker, G. F., Faller, B., Fischer, H., Houston, J. B., Kansy, M., Kerns, E. H., Krämer, S. D., Lennernäs, H. & Sugano, K., Aug 2012, In : Drug discovery today. 17, 15-16, p. 905-912 7 p.

    Research output: Contribution to journalArticle

  20. Published

    Utility of drug depletion-time profiles in isolated hepatocytes for accessing hepatic uptake clearance: Identifying rate-limiting steps and role of passive processes

    Jigorel, E. & Houston, J. B., Aug 2012, In : Drug Metabolism and Disposition. 40, 8, p. 1596-1602 6 p.

    Research output: Contribution to journalArticle

  21. Published

    A comprehensive assessment of repaglinide metabolic pathways: Impact of choice of in vitro system and relative enzyme contribution to in vitro clearance

    Säll, C., Houston, J. B. & Galetin, A., Jul 2012, In : Drug Metabolism and Disposition. 40, 7, p. 1279-1289 10 p.

    Research output: Contribution to journalArticle

  22. Published

    Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data

    Jones, H. M., Barton, H. A., Lai, Y., Bi, Y. A., Kimoto, E., Kempshall, S., Tate, S. C., El-Kattan, A., Houston, J. B., Galetin, A. & Fenner, K. S., May 2012, In : Drug Metabolism and Disposition. 40, 5, p. 1007-1017 10 p.

    Research output: Contribution to journalArticle

  23. Published

    Clearance-dependent underprediction of in vivo intrinsic clearance from human hepatocytes: Comparison with permeabilities from artificial membrane (PAMPA) assay, in silico and caco-2 assay, for 65 drugs

    Hallifax, D., Turlizzi, E., Zanelli, U. & Houston, J. B., 11 Apr 2012, In : European Journal of Pharmaceutical Sciences. 45, 5, p. 570-574 4 p.

    Research output: Contribution to journalArticle

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