Prof James HoustonBSc, PhD, DSc

Emeritus Professor

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Publications

  1. Article › Research › Not peer-reviewed
  2. Published

    Comparison of intestinal and hepatic sulphation and glucuronidation for a range of drugs

    Cubitt, H., Houston, JB. & Galetin, A., 2009, In : Drug Metabolism Reviews. 41 (Suppl. 1)

    Research output: Contribution to journalArticle

  3. Published

    Prediction of the intestinal availability and associated inter-individual variability for drugs with high intestinal first-pass metabolism

    Gertz, M., Harrison, A., Davis, J., Houston, JB. & Galetin, A., 2009, In : Drug Metabolism Reviews. 41 (Suppl. 1): 50

    Research output: Contribution to journalArticle

  4. Article › Research › Peer-reviewed
  5. Published

    A comprehensive assessment of repaglinide metabolic pathways: Impact of choice of in vitro system and relative enzyme contribution to in vitro clearance

    Säll, C., Houston, J. B. & Galetin, A., Jul 2012, In : Drug Metabolism and Disposition. 40, 7, p. 1279-1289 10 p.

    Research output: Contribution to journalArticle

  6. Published

    A pragmatic randomized controlled trial of thiopurine methyltransferase genotyping prior to azathioprine treatment: The TARGET study

    Newman, W. G., Payne, K., Tricker, K., Roberts, S. A., Fargher, E., Pushpakom, S., Alder, J. E., Sidgwick, G. P., Payne, D., Elliott, R. A., Heise, M., Elles, R., Ramsden, S. C., Andrews, J., Houston, J. B., Qasim, F., Shaffer, J., Griffiths, C. E. M., Ray, D. W., Bruce, I. & 1 others, Ollier, W. E. R., Jun 2011, In : Pharmacogenomics. 12, 6, p. 815-826 11 p.

    Research output: Contribution to journalArticle

  7. Published

    Absorption of prednisolone in patients with Crohn's disease

    Shaffer, J. A., Williams, S. E., Turnberg, L. A., Houston, J. & Rowland, M., Mar 1983, In : Gut. 24, 3, p. 182-6 5 p.

    Research output: Contribution to journalArticle

  8. Published

    An integrated approach to the prediction of systemic toxicity using computer-based biokinetic models and biological in vitro test methods: Overview of a prevalidation study based on the ECITTS project

    Dejongh, J., Forsby, A., Houston, J. B., Beckman, M., Combes, R. & Blaauboer, B. J., Aug 1999, In : Toxicology in Vitro. 13, 4-5, p. 549-554 5 p.

    Research output: Contribution to journalArticle

  9. Published

    Application of a physiologically based pharmacokinetic model to assess propofol hepatic and renal glucuronidation in isolation: Utility of in vitro and in vivo data

    Gill, K. L., Gertz, M., Houston, J. B. & Galetin, A., Apr 2013, In : Drug Metabolism and Disposition. 41, 4, p. 744-753 9 p.

    Research output: Contribution to journalArticle

  10. Published

    Assessment of algorithms for predicting drug-drug interactions via inhibition mechanisms: Comparison of dynamic and static models

    Guest, E. J., Rowland-Yeo, K., Rostami-Hodjegan, A., Tucker, G. T., Houston, J. B. & Galetin, A., Jan 2011, In : British Journal of Clinical Pharmacology. 71, 1, p. 72-87 15 p.

    Research output: Contribution to journalArticle

  11. Published

    Binding of drugs to hepatic microsomes: Comment and assessment of current prediction methodology with recommendation for improvement [1]

    Hallifax, D. & Houston, J. B., Apr 2006, In : Drug Metabolism and Disposition. 34, 4, p. 724-726 2 p.

    Research output: Contribution to journalArticle

  12. Published
  13. Published

    Characterization of the comparative drug binding to intra- (liver fatty acid binding protein) and extra- (human serum albumin) cellular proteins

    Rowland, A., Hallifax, D., Nussio, M., Shapter, J., Mackenzie, P., Houston, J. B., Knights, K. M. & Miners, J. O., 24 Mar 2015, In : Xenobiotica. 45, 10, p. 847-857 10 p.

    Research output: Contribution to journalArticle

  14. Published

    Clearance-dependent underprediction of in vivo intrinsic clearance from human hepatocytes: Comparison with permeabilities from artificial membrane (PAMPA) assay, in silico and caco-2 assay, for 65 drugs

    Hallifax, D., Turlizzi, E., Zanelli, U. & Houston, J. B., 11 Apr 2012, In : European Journal of Pharmaceutical Sciences. 45, 5, p. 570-574 4 p.

    Research output: Contribution to journalArticle

  15. Published

    Comparative analysis of CYP3A heteroactivation by steroid hormones and flavonoids in different in vitro systems and potential in vivo implications

    Henshall, J., Galetin, A., Harrison, A. & Houston, J. B., Jul 2008, In : Drug Metabolism and Disposition. 36, 7, p. 1332-1340 8 p.

    Research output: Contribution to journalArticle

  16. Published

    Comparative pharmacokinetics between a microdose and therapeutic dose for clarithromycin, sumatriptan, propafenone, paracetamol (acetaminophen), and phenobarbital in human volunteers

    Lappin, G., Shishikura, Y., Jochemsen, R., Weaver, R. J., Gesson, C., Brian Houston, J., Oosterhuis, B., Bjerrum, O. J., Grynkiewicz, G., Alder, J., Rowland, M. & Garner, C., 14 Jun 2011, In : European Journal of Pharmaceutical Sciences. 43, 3, p. 141-150 9 p.

    Research output: Contribution to journalArticle

  17. Published

    Comparative study of the metabolism of drug substrates by human cytochrome P450 3A4 expressed in bacterial, yeast and human lymphoblastoid cells

    Andrews, J., Abd-Ellah, M. F., Randolph, N. L., Kenworthy, K. E., Carlile, D. J., Friedberg, T. & Houston, J. B., 1 Nov 2002, In : Xenobiotica. 32, 11, p. 937-947 10 p.

    Research output: Contribution to journalArticle

  18. Published

    Comparative use of isolated hepatocytes and hepatic microsomes for cytochrome P450 inhibition studies: Transporter-enzyme interplay

    Brown, H. S., Wilby, A. J., Alder, J. & Houston, J. B., Dec 2010, In : Drug Metabolism and Disposition. 38, 12, p. 2139-2146 7 p.

    Research output: Contribution to journalArticle

  19. Published

    Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs

    Zanelli, U., Caradonna, N. P., Hallifax, D., Turlizzi, E. & Houston, J. B., Jan 2012, In : Drug Metabolism and Disposition. 40, 1, p. 104-110 6 p.

    Research output: Contribution to journalArticle

  20. Published

    Comparison of fresh and cryopreserved rat hepatocyte suspensions for the prediction of in vitro intrinsic clearance

    Griffin, S. J. & Houston, J. B., May 2004, In : Drug Metabolism and Disposition. 32, 5, p. 552-558 6 p.

    Research output: Contribution to journalArticle

  21. Published
  22. Published
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