Prof James HoustonBSc, PhD, DSc

Emeritus Professor

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Publications

  1. Published

    Comparison of clearance for three benzodiazepines determined by metabolite formation and substrate depletion methods in rat hepatic microsomes.

    Ahmed, S. & Houston, B., 2000, Drug Metabolism Reviews. Vol. 32, Suppl. 1.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  2. Published

    Sigmoidal kinetics in rat hepatic microsomes: studies with dextromethorphan, alprazolam and triazolam.

    Ahmed, S. & Houston, B., 1999, Proceeding of 7th Stowe School Symposium on Drug Metabolism.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  3. Published

    Comparative study of the metabolism of drug substrates by human cytochrome P450 3A4 expressed in bacterial, yeast and human lymphoblastoid cells

    Andrews, J., Abd-Ellah, M. F., Randolph, N. L., Kenworthy, K. E., Carlile, D. J., Friedberg, T. & Houston, J. B., 1 Nov 2002, In : Xenobiotica. 32, 11, p. 937-947 10 p.

    Research output: Contribution to journalArticle

  4. Published

    Pharmacogencomics and predictive drug metabolism

    Andrews, J., Pasksaleva, E., Galetin, A. & Houston, B., 2003, Pharmacogencomics and predictive drug metabolism. Pharmacogenomics Workshop, Annual Human Genome Meeting, Cancun, Mexico.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  5. Published

    In Silico Prediction of Hepatocellular Drug Binding

    Assmus, F., Houston, B. & Galetin, A., Jun 2015, host publication. Vol. A10.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  6. Published

    Incorporation of lysosomal sequestration in the mechanistic model for prediction of tissue distribution of basic drugs

    Assmus, F., Houston, J. & Galetin, A., 2017, In : European Journal of Pharmaceutical Sciences.

    Research output: Contribution to journalArticle

  7. Published

    Methodology for development of a physiological model incorporating CYP3A and P-glycoprotein for the prediction of intestinal drug absorption

    Badhan, R., Penny, J., Galetin, A. & Houston, J. B., Jun 2009, In : Journal of Pharmaceutical Sciences. 98, 6, p. 2180-2197 17 p.

    Research output: Contribution to journalArticle

  8. Published

    Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: Reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver

    Barter, Z. E., Bayliss, M. K., Beaune, P. H., Boobis, A. R., Carlile, D. J., Edwards, R. J., Houston, J. B., Lake, B. G., Lipscomb, J. C., Pelkonen, O. R., Tucker, G. T. & Rostami-Hodjegan, A., Jan 2007, In : Current Drug Metabolism. 8, 1, p. 33-45 12 p.

    Research output: Contribution to journalArticle

  9. Published

    Prediction of drug kinetic properties:diazepam in human liver microsomes versus cDNA expressed CYP3A4 and 2C19.

    Bicknell, H. A., Worboys, P. D., Evans, D. & Houston, B., 1999, Proceeding of 7th Stowe School Symposium on Drug Metabolism.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  10. Published

    Regioselective and stereoselective hydroxylations of warfarin in human liver microsomes and cDNA expressed cytochrome P450.

    Bicknell, H. A., Worboys, P. D. & Houston, B., 2000, Drug Metabolism Reviews. Vol. 32, Suppl. 1.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  11. Published

    An integrated approach to prediction of systemic toxicity by using biokinetic models and biological in vitro test methods.

    Blaauboeer, B. J., Forsby, A., Houston, B., Beckman, M., Combes, R. D. & DeJongh, J., 2000, Progress in the Reduction, Refinement and Replacement of Animal Experimentation. Balls, M., Zeller, A-M. & Halder, M. (eds.). Elsevier BV

    Research output: Chapter in Book/Report/Conference proceedingChapter

  12. Published

    The integrated use of alternative methods in toxicological risk evaluation

    Blaauboer, B. J., Barratt, M. D. & Houston, B., 1998, In : ATLA. 26

    Research output: Contribution to journalArticle

  13. Published

    The Use of Biokinetics and In Vitro Methods in Toxicological Risk Evaluation: The Report and Recommendations of ECVAM Workshop 15

    Blaauboer, B. J., Bayliss, M. K., Castell, J. V., Evelo, C. T. A., Frazier, J. M., Groen, K., Gülden, M., Guillouzo, A., Hissink, A. M., Houston, J. B., Johanson, G., De Jongh, J., Kedderis, G. L., Reinhardt, C. A., Van De Sandt, J. J. M. & Semino, G., Jul 1996, In : Alternatives to Laboratory Animals . 24, 4, p. 473-497 24 p.

    Research output: Contribution to journalArticle

  14. Published

    The integrated use of alternative methods in toxicological risk evaluation: ECVAM Integrated Testing Strategies Task Force Report I

    Blaauboer, B. J., Barratt, M. D. & Houston, J. B., Apr 1999, In : Alternatives to Laboratory Animals . 27, 2, p. 229-237 8 p.

    Research output: Contribution to journalArticle

  15. Published

    Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices

    Brian Houston, J. & Carlile, D. J., 1997, In : Drug Metabolism Reviews. 29, 4, p. 891-922 31 p.

    Research output: Contribution to journalArticle

  16. Published

    Prediction of in vivo drug-drug interactions from in vitro data: Impact of incorporating parallel pathways of drug elimination and inhibitor absorption rate constant

    Brown, H. S., Ito, K., Galetin, A. & Houston, J. B., Nov 2005, In : British Journal of Clinical Pharmacology. 60, 5, p. 508-518 10 p.

    Research output: Contribution to journalArticle

  17. Published

    Evaluation of cryopreserved human hepatocytes as an alternative in vitro system to microsomes for the prediction of metabolic clearance

    Brown, H. S., Griffin, M. & Houston, J. B., Feb 2007, In : Drug Metabolism and Disposition. 35, 2, p. 293-301 8 p.

    Research output: Contribution to journalArticle

  18. Published
  19. Published

    Comparative use of isolated hepatocytes and hepatic microsomes for cytochrome P450 inhibition studies: Transporter-enzyme interplay

    Brown, H. S., Wilby, A. J., Alder, J. & Houston, J. B., Dec 2010, In : Drug Metabolism and Disposition. 38, 12, p. 2139-2146 7 p.

    Research output: Contribution to journalArticle

  20. Published

    Cynomoglus monkey as a preclinical model for the investigation of hepatic uptake of OATP substrates

    Bruyn, T. D., Barton, H. A., Bi, Y-A., Cantrill, C., Galetin, A., Houston, B., Lin, J. & Kosa, R., 2015, host publication. Vol. P11.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

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