Prof James HoustonBSc, PhD, DSc

Emeritus Professor

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Publications

  1. 2018
  2. Published

    Predicting human clearance of organic anion transporting polypeptide substrates using cynomolgus monkey: In vitro-in vivo scaling of hepatic uptake clearance

    De Bruyn, T., Ufuk, A., Cantrill, C., Kosa, R. E., Bi, Y. A., Niosi, M., Modi, S., Rodrigues, A. D., Tremaine, L. M., Varma, M. V. S., Galetin, A. & Houston, J. B., Jul 2018, In : Drug Metabolism and Disposition. 46, 7, p. 989-1000 12 p.

    Research output: Contribution to journalArticle

  3. Published

    In vitro–in vivo extrapolation of OATP1B-mediated drug–drug interactions in cynomolgus monkey

    Ufuk, A., Kosa, R. E., Gao, H., Bi, Y. A., Modi, S., Gates, D., Rodrigues, A. D., Tremaine, L. M., Varma, M. V. S., Houston, J. B. & Galetin, A., 1 Jun 2018, In : Journal of Pharmacology and Experimental Therapeutics. 365, 3, p. 688-699 12 p.

    Research output: Contribution to journalArticle

  4. Published

    Importance of the unstirred water layer and hepatocyte membrane integrity in vitro for quantification of intrinsic metabolic clearance

    Wood, F., Houston, J. & Hallifax, D., 1 Jan 2018, In : Drug Metabolism and Disposition. 46, 1

    Research output: Contribution to journalArticle

  5. Published

    Hepatic OATP-mediated clearance in the Beagle dog: assessing in vitro-in vivo relationships and applying cross species empirical scaling factors to improve prediction of human clearance

    Matsunaga, N., Ufuk, A., Morse, B. L., Bedwell, D. W., Bao, J., Mohutsky, M. A., Hillgren, K. M., Hall, S. D., Houston, J. B. & Galetin, A., 2018, In : Drug Metabolism and Disposition.

    Research output: Contribution to journalArticle

  6. Published

    Simultaneous Assessment in vitro of Transporter and Metabolic Processes in Hepatic Drug Clearance: Use of a media loss approach

    Harrison, J., De Bruyn, T., Darwich, A. & Houston, J., 2018, In : Drug Metabolism and Disposition.

    Research output: Contribution to journalArticle

  7. 2017
  8. Published

    Clearance prediction methodology needs fundamental improvement: Trends common to rat and human hepatocytes/microsomes and implications for experimental methodology

    Wood, F. L., Houston, J. B. & Hallifax, D., 1 Nov 2017, In : Drug Metabolism and Disposition. 45, 11, p. 1178-1188 11 p.

    Research output: Contribution to journalComment/debate

  9. Published

    Understanding the Interplay Between Uptake and Efflux Transporters Within In Vitro Systems in Defining Hepatocellular Drug Concentrations

    Cantrill, C. & Houston, J. B., Sep 2017, In : Journal of Pharmaceutical Sciences. 106, 9

    Research output: Contribution to journalArticle

  10. Published

    In vitro and in silico tools to assess extent of cellular uptake and lysosomal sequestration of respiratory drugs in human alveolar macrophages

    Ufuk, A., Assmus, F., Francis, L., Plumb, J., Damian, V., Gertz, M., Houston, J. & Galetin, A., 2017, In : Molecular Pharmaceutics. 14, 4

    Research output: Contribution to journalArticle

  11. Published

    Incorporation of lysosomal sequestration in the mechanistic model for prediction of tissue distribution of basic drugs

    Assmus, F., Houston, J. & Galetin, A., 2017, In : European Journal of Pharmaceutical Sciences.

    Research output: Contribution to journalArticle

  12. 2016
  13. Published

    Direct and quantitative evaluation of the human CYP3A4 contribution (fm) to drug clearance using the in vitro SILENSOMES model

    Parmentier, Y., Pothier, C., Delmas, A., Caradec, F., Trancart, M. M., Guillet, F., Bouaita, B., Chesne, C., Walther, B. & Houston, J., 2016, In : Xenobiotica. p. 1-14 14 p.

    Research output: Contribution to journalArticle

  14. 2015
  15. Published

    In vitro assessment of uptake and lysosomal sequestration of respiratory drugs in alveolar macrophage cell line NR8383

    Ufuk, A., Somers, G., Houston, J. & Galetin, A., Dec 2015, In : Pharmaceutical Research. 32, 12, p. 3937–3951 14 p.

    Research output: Contribution to journalArticle

  16. Published

    Assessing metabolic competence in isolated hepatocytes: Exploring the relationship between enzyme function and plasma membrane integrity via Saponin treatment

    Wood, F., Hallifax, D. & Houston, B., Jun 2015, host publication. Vol. P10.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  17. Published

    In Silico Prediction of Hepatocellular Drug Binding

    Assmus, F., Houston, B. & Galetin, A., Jun 2015, host publication. Vol. A10.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  18. Published

    Characterization of the comparative drug binding to intra- (liver fatty acid binding protein) and extra- (human serum albumin) cellular proteins

    Rowland, A., Hallifax, D., Nussio, M., Shapter, J., Mackenzie, P., Houston, J. B., Knights, K. M. & Miners, J. O., 24 Mar 2015, In : Xenobiotica. 45, 10, p. 847-857 10 p.

    Research output: Contribution to journalArticle

  19. Published

    "Time dependent" inhibition of hepatic uptake transporters in hepatocytes and implications on the assessment of transporter-mediated drug-drug interactions

    Kageyama, M., Houston, B. & Galetin, A., 2015, host publication. Vol. P43.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  20. Published

    Comparison of respiratory drug accumulation and lysosomal sequestration in NR8383 and primary human al veolar macrophages

    Ufuk, A., Plumb, J., Houston, B. & Galetin, A., 2015, host publication. Vol. A11.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  21. Published

    Cynomoglus monkey as a preclinical model for the investigation of hepatic uptake of OATP substrates

    Bruyn, T. D., Barton, H. A., Bi, Y-A., Cantrill, C., Galetin, A., Houston, B., Lin, J. & Kosa, R., 2015, host publication. Vol. P11.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  22. Published

    Investigation into LiverChipTM as a 3D hepatocyte model for clearance prediction

    De Bruyn, T., Kageyama, M., Ufuk, A., Hallifax, D., Houston, J. B. & Galetin, A., 2015

    Research output: Other contribution

  23. 2014
  24. Published

    Passive lipoidal diffusion and carrier-mediated cell uptake are both important mechanisms of membrane permeation in drug disposition

    Smith, D., Artursson, P., Avdeef, A., Di, L., Ecker, G. F., Faller, B., Houston, J. B., Kansy, M., Kerns, E. H., Krämer, S. D., Lennernäs, H., Van De Waterbeemd, H., Sugano, K. & Testa, B., 2 Jun 2014, In : Molecular Pharmaceutics. 11, 6, p. 1727-1738 11 p.

    Research output: Contribution to journalArticle

  25. Published
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