Prof James HoustonBSc, PhD, DSc

Emeritus Professor

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Publications

  1. 2018
  2. Published

    Predicting human clearance of organic anion transporting polypeptide substrates using cynomolgus monkey: In vitro-in vivo scaling of hepatic uptake clearance

    De Bruyn, T., Ufuk, A., Cantrill, C., Kosa, R. E., Bi, Y. A., Niosi, M., Modi, S., Rodrigues, A. D., Tremaine, L. M., Varma, M. V. S., Galetin, A. & Houston, J. B., Jul 2018, In : Drug Metabolism and Disposition. 46, 7, p. 989-1000 12 p.

    Research output: Contribution to journalArticle

  3. Published

    In vitro–in vivo extrapolation of OATP1B-mediated drug–drug interactions in cynomolgus monkey

    Ufuk, A., Kosa, R. E., Gao, H., Bi, Y. A., Modi, S., Gates, D., Rodrigues, A. D., Tremaine, L. M., Varma, M. V. S., Houston, J. B. & Galetin, A., 1 Jun 2018, In : Journal of Pharmacology and Experimental Therapeutics. 365, 3, p. 688-699 12 p.

    Research output: Contribution to journalArticle

  4. Published

    Importance of the unstirred water layer and hepatocyte membrane integrity in vitro for quantification of intrinsic metabolic clearance

    Wood, F., Houston, J. & Hallifax, D., 1 Jan 2018, In : Drug Metabolism and Disposition. 46, 1

    Research output: Contribution to journalArticle

  5. Published

    Hepatic OATP-mediated clearance in the Beagle dog: assessing in vitro-in vivo relationships and applying cross species empirical scaling factors to improve prediction of human clearance

    Matsunaga, N., Ufuk, A., Morse, B. L., Bedwell, D. W., Bao, J., Mohutsky, M. A., Hillgren, K. M., Hall, S. D., Houston, J. B. & Galetin, A., 2018, In : Drug Metabolism and Disposition.

    Research output: Contribution to journalArticle

  6. Published

    Simultaneous Assessment in vitro of Transporter and Metabolic Processes in Hepatic Drug Clearance: Use of a media loss approach

    Harrison, J., De Bruyn, T., Darwich, A. & Houston, J., 2018, In : Drug Metabolism and Disposition.

    Research output: Contribution to journalArticle

  7. 2017
  8. Published

    Clearance prediction methodology needs fundamental improvement: Trends common to rat and human hepatocytes/microsomes and implications for experimental methodology

    Wood, F. L., Houston, J. B. & Hallifax, D., 1 Nov 2017, In : Drug Metabolism and Disposition. 45, 11, p. 1178-1188 11 p.

    Research output: Contribution to journalComment/debate

  9. Published

    Understanding the Interplay Between Uptake and Efflux Transporters Within In Vitro Systems in Defining Hepatocellular Drug Concentrations

    Cantrill, C. & Houston, J. B., Sep 2017, In : Journal of Pharmaceutical Sciences. 106, 9

    Research output: Contribution to journalArticle

  10. Published

    In vitro and in silico tools to assess extent of cellular uptake and lysosomal sequestration of respiratory drugs in human alveolar macrophages

    Ufuk, A., Assmus, F., Francis, L., Plumb, J., Damian, V., Gertz, M., Houston, J. & Galetin, A., 2017, In : Molecular Pharmaceutics. 14, 4

    Research output: Contribution to journalArticle

  11. Published

    Incorporation of lysosomal sequestration in the mechanistic model for prediction of tissue distribution of basic drugs

    Assmus, F., Houston, J. & Galetin, A., 2017, In : European Journal of Pharmaceutical Sciences.

    Research output: Contribution to journalArticle

  12. 2016
  13. Published

    Direct and quantitative evaluation of the human CYP3A4 contribution (fm) to drug clearance using the in vitro SILENSOMES model

    Parmentier, Y., Pothier, C., Delmas, A., Caradec, F., Trancart, M. M., Guillet, F., Bouaita, B., Chesne, C., Walther, B. & Houston, J., 2016, In : Xenobiotica. p. 1-14 14 p.

    Research output: Contribution to journalArticle

  14. 2015
  15. Published

    In vitro assessment of uptake and lysosomal sequestration of respiratory drugs in alveolar macrophage cell line NR8383

    Ufuk, A., Somers, G., Houston, J. & Galetin, A., Dec 2015, In : Pharmaceutical Research. 32, 12, p. 3937–3951 14 p.

    Research output: Contribution to journalArticle

  16. Published

    Assessing metabolic competence in isolated hepatocytes: Exploring the relationship between enzyme function and plasma membrane integrity via Saponin treatment

    Wood, F., Hallifax, D. & Houston, B., Jun 2015, host publication. Vol. P10.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  17. Published

    In Silico Prediction of Hepatocellular Drug Binding

    Assmus, F., Houston, B. & Galetin, A., Jun 2015, host publication. Vol. A10.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  18. Published

    Characterization of the comparative drug binding to intra- (liver fatty acid binding protein) and extra- (human serum albumin) cellular proteins

    Rowland, A., Hallifax, D., Nussio, M., Shapter, J., Mackenzie, P., Houston, J. B., Knights, K. M. & Miners, J. O., 24 Mar 2015, In : Xenobiotica. 45, 10, p. 847-857 10 p.

    Research output: Contribution to journalArticle

  19. Published

    "Time dependent" inhibition of hepatic uptake transporters in hepatocytes and implications on the assessment of transporter-mediated drug-drug interactions

    Kageyama, M., Houston, B. & Galetin, A., 2015, host publication. Vol. P43.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  20. Published

    Comparison of respiratory drug accumulation and lysosomal sequestration in NR8383 and primary human al veolar macrophages

    Ufuk, A., Plumb, J., Houston, B. & Galetin, A., 2015, host publication. Vol. A11.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  21. Published

    Cynomoglus monkey as a preclinical model for the investigation of hepatic uptake of OATP substrates

    Bruyn, T. D., Barton, H. A., Bi, Y-A., Cantrill, C., Galetin, A., Houston, B., Lin, J. & Kosa, R., 2015, host publication. Vol. P11.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  22. Published

    Investigation into LiverChipTM as a 3D hepatocyte model for clearance prediction

    De Bruyn, T., Kageyama, M., Ufuk, A., Hallifax, D., Houston, J. B. & Galetin, A., 2015

    Research output: Other contribution

  23. 2014
  24. Published

    Passive lipoidal diffusion and carrier-mediated cell uptake are both important mechanisms of membrane permeation in drug disposition

    Smith, D., Artursson, P., Avdeef, A., Di, L., Ecker, G. F., Faller, B., Houston, J. B., Kansy, M., Kerns, E. H., Krämer, S. D., Lennernäs, H., Van De Waterbeemd, H., Sugano, K. & Testa, B., 2 Jun 2014, In : Molecular Pharmaceutics. 11, 6, p. 1727-1738 11 p.

    Research output: Contribution to journalArticle

  25. Published
  26. Published
  27. Published

    Intrinsic Clearance Predictions from Freshly Isolated Rat Hepatocytes: Effects of Assay Format and Cofactor Supplementation

    Wood, F., Hallifax, D. & Houston, J., 2014, Proceedings of 20th international symposium on microsomes and drug oxidations.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  28. Published
  29. 2013
  30. Published

    Special Section on Prediction of human pharmacokinetic parameters from in vitro systems-Commentary

    Houston, JB., Dec 2013, In : Drug Metab Dispos. 41, p. 1973-1974

    Research output: Contribution to journalEditorial

  31. Published
  32. Published

    Addressing the challenges of low clearance.

    Houston, J. B., Nov 2013.

    Research output: Contribution to conferenceOther

  33. Published

    Drug accumulation in alveolar macrophages: assessment of uptake and lysosomal distribution in vitro.

    Houston, JB., Ufuk, A., Gertz, M., Plumb, J., Somers, G. & Galetin, A., Sep 2013.

    Research output: Contribution to conferencePoster

  34. Published

    Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

    Godoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., Bode, J. G., Bolleyn, J., Borner, C., Böttger, J., Braeuning, A., Budinsky, R. A., Burkhardt, B., Cameron, N. R., Camussi, G., Cho, C. S., Choi, Y. J., Craig Rowlands, J., Dahmen, U., Damm, G. & 73 others, Dirsch, O., Donato, M. T., Dong, J., Dooley, S., Drasdo, D., Eakins, R., Ferreira, K. S., Fonsato, V., Fraczek, J., Gebhardt, R., Gibson, A., Glanemann, M., Goldring, C. E. P., Gómez-Lechón, M. J., Groothuis, G. M. M., Gustavsson, L., Guyot, C., Hallifax, D., Hammad, S., Hayward, A., Häussinger, D., Hellerbrand, C., Hewitt, P., Hoehme, S., Holzhütter, H. G., Houston, J. B., Hrach, J., Ito, K., Jaeschke, H., Keitel, V., Kelm, J. M., Kevin Park, B., Kordes, C., Kullak-Ublick, G. A., Lecluyse, E. L., Lu, P., Luebke-Wheeler, J., Lutz, A., Maltman, D. J., Matz-Soja, M., McMullen, P., Merfort, I., Messner, S., Meyer, C., Mwinyi, J., Naisbitt, D. J., Nussler, A. K., Olinga, P., Pampaloni, F., Pi, J., Pluta, L., Przyborski, S. A., Ramachandran, A., Rogiers, V., Rowe, C., Schelcher, C., Schmich, K., Schwarz, M., Singh, B., Stelzer, E. H. K., Stieger, B., Stöber, R., Sugiyama, Y., Tetta, C., Thasler, W. E., Vanhaecke, T., Vinken, M., Weiss, T. S., Widera, A., Woods, C. G., Xu, J. J., Yarborough, K. M. & Hengstler, J. G., Aug 2013, In : Archives of Toxicology. 87, 8, p. 1315-1530 215 p.

    Research output: Contribution to journalArticle

  35. Published

    Application of a physiologically based pharmacokinetic model to assess propofol hepatic and renal glucuronidation in isolation: Utility of in vitro and in vivo data

    Gill, K. L., Gertz, M., Houston, J. B. & Galetin, A., Apr 2013, In : Drug Metabolism and Disposition. 41, 4, p. 744-753 9 p.

    Research output: Contribution to journalArticle

  36. Published

    Cyclosporine inhibition of hepatic and intestinal CYP3A4, uptake and efflux transporters: Application of PBPK Modeling in the assessment of drug-drug interaction potential

    Gertz, M., Cartwright, C. M., Hobbs, M. J., Kenworthy, K. E., Rowland, M., Houston, J. B. & Galetin, A., Mar 2013, In : Pharmaceutical Research. 30, 3, p. 761-780 19 p.

    Research output: Contribution to journalArticle

  37. 2012
  38. Published

    In vitro assessment of accumulation of inhaled drugs by alveolar macrophages

    Houston, JB., Ufuk, A., Somers, GI. & Galetin, A., Sep 2012.

    Research output: Contribution to conferencePoster

  39. Published

    Predictive hepatocellular activity: Cornerstone for PBPK modelling (B2)

    Houston, J. B., Sep 2012.

    Research output: Contribution to conferenceOther

  40. Published

    Progress curve mechanistic modeling approach for assessing time-dependent inhibition of CYP3A4

    Burt, H. J., Pertinez, H., Säll, C., Collins, C., Hyland, R., Houston, J. B. & Galetin, A., Sep 2012, In : Drug Metabolism and Disposition. 40, 9, p. 1658-1667 9 p.

    Research output: Contribution to journalArticle

  41. Published

    Use of mechanistic modeling to assess interindividual variability and interspecies differences in active uptake in human and rat hepatocytes

    Ménochet, K., Kenworthy, K. E., Houston, J. B. & Galetin, A., Sep 2012, In : Drug Metabolism and Disposition. 40, 9, p. 1744-1756 12 p.

    Research output: Contribution to journalArticle

  42. Published

    Evaluation of hepatic clearance prediction using in vitro data: Emphasis on fraction unbound in plasma and drug ionisation using a database of 107 drugs

    Hallifax, D. & Houston, J. B., Aug 2012, In : Journal of Pharmaceutical Sciences. 101, 8, p. 2645-2652 7 p.

    Research output: Contribution to journalArticle

  43. Published

    Evidence-based approach to assess passive diffusion and carrier-mediated drug transport

    Di, L., Artursson, P., Avdeef, A., Ecker, G. F., Faller, B., Fischer, H., Houston, J. B., Kansy, M., Kerns, E. H., Krämer, S. D., Lennernäs, H. & Sugano, K., Aug 2012, In : Drug discovery today. 17, 15-16, p. 905-912 7 p.

    Research output: Contribution to journalArticle

  44. Published

    Utility of drug depletion-time profiles in isolated hepatocytes for accessing hepatic uptake clearance: Identifying rate-limiting steps and role of passive processes

    Jigorel, E. & Houston, J. B., Aug 2012, In : Drug Metabolism and Disposition. 40, 8, p. 1596-1602 6 p.

    Research output: Contribution to journalArticle

  45. Published

    A comprehensive assessment of repaglinide metabolic pathways: Impact of choice of in vitro system and relative enzyme contribution to in vitro clearance

    Säll, C., Houston, J. B. & Galetin, A., Jul 2012, In : Drug Metabolism and Disposition. 40, 7, p. 1279-1289 10 p.

    Research output: Contribution to journalArticle

  46. Published

    Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data

    Jones, H. M., Barton, H. A., Lai, Y., Bi, Y. A., Kimoto, E., Kempshall, S., Tate, S. C., El-Kattan, A., Houston, J. B., Galetin, A. & Fenner, K. S., May 2012, In : Drug Metabolism and Disposition. 40, 5, p. 1007-1017 10 p.

    Research output: Contribution to journalArticle

  47. Published

    Clearance-dependent underprediction of in vivo intrinsic clearance from human hepatocytes: Comparison with permeabilities from artificial membrane (PAMPA) assay, in silico and caco-2 assay, for 65 drugs

    Hallifax, D., Turlizzi, E., Zanelli, U. & Houston, J. B., 11 Apr 2012, In : European Journal of Pharmaceutical Sciences. 45, 5, p. 570-574 4 p.

    Research output: Contribution to journalArticle

  48. Published
  49. Published

    Simultaneous assessment of uptake and metabolism in rat hepatocytes: A comprehensive mechanistic model

    Ménochet, K., Kenworthy, K. E., Houston, J. B. & Galetin, A., Apr 2012, In : Journal of Pharmacology and Experimental Therapeutics. 341, 1, p. 2-15 13 p.

    Research output: Contribution to journalArticle

  50. Published

    Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs

    Zanelli, U., Caradonna, N. P., Hallifax, D., Turlizzi, E. & Houston, J. B., Jan 2012, In : Drug Metabolism and Disposition. 40, 1, p. 104-110 6 p.

    Research output: Contribution to journalArticle

  51. Published

    Evaluation of the novel in vitro systems for hepatic drug clearance and assessment of their predictive utility

    Houston, J. B., Rowland-Yeo, K. & Zanelli, U., 2012, In : Toxicology in Vitro. 26, 8, p. 1265-71

    Research output: Contribution to journalArticle

  52. 2011
  53. Published

    Kinetic characterization of rat hepatic uptake of 16 actively transported drugs

    Yabe, Y., Galetin, A. & Houston, J. B., Oct 2011, In : Drug Metabolism and Disposition. 39, 10, p. 1808-1814 6 p.

    Research output: Contribution to journalArticle

  54. Published

    Predictive utility of in vitro rifampin induction data generated in fresh and cryopreserved human hepatocytes, Fa2N-4,and HepaRG cells

    Templeton, I. E., Houston, J. B. & Galetin, A., Oct 2011, In : Drug Metabolism and Disposition. 39, 10, p. 1921-1929 8 p.

    Research output: Contribution to journalArticle

  55. Published

    Physiologically based pharmacokinetic modeling of intestinal first-pass metabolism of CYP3A substrates with high intestinal extraction

    Gertz, M., Houston, J. B. & Galetin, A., Sep 2011, In : Drug Metabolism and Disposition. 39, 9, p. 1633-1642 9 p.

    Research output: Contribution to journalArticle

  56. Published

    Comparative pharmacokinetics between a microdose and therapeutic dose for clarithromycin, sumatriptan, propafenone, paracetamol (acetaminophen), and phenobarbital in human volunteers

    Lappin, G., Shishikura, Y., Jochemsen, R., Weaver, R. J., Gesson, C., Brian Houston, J., Oosterhuis, B., Bjerrum, O. J., Grynkiewicz, G., Alder, J., Rowland, M. & Garner, C., 14 Jun 2011, In : European Journal of Pharmaceutical Sciences. 43, 3, p. 141-150 9 p.

    Research output: Contribution to journalArticle

  57. Published

    A pragmatic randomized controlled trial of thiopurine methyltransferase genotyping prior to azathioprine treatment: The TARGET study

    Newman, W. G., Payne, K., Tricker, K., Roberts, S. A., Fargher, E., Pushpakom, S., Alder, J. E., Sidgwick, G. P., Payne, D., Elliott, R. A., Heise, M., Elles, R., Ramsden, S. C., Andrews, J., Houston, J. B., Qasim, F., Shaffer, J., Griffiths, C. E. M., Ray, D. W., Bruce, I. & 1 others, Ollier, W. E. R., Jun 2011, In : Pharmacogenomics. 12, 6, p. 815-826 11 p.

    Research output: Contribution to journalArticle

  58. Published

    Prediction of human drug clearance by multiple metabolic pathways: Integration of hepatic and intestinal microsomal and cytosolic data

    Cubitt, H. E., Houston, J. B. & Galetin, A., May 2011, In : Drug Metabolism and Disposition. 39, 5, p. 864-873 9 p.

    Research output: Contribution to journalArticle

  59. Published
  60. Published

    Critique of the two-fold measure of prediction success for ratios: Application for the assessment of drug-drug interactions

    Guest, E. J., Aarons, L., Houston, J. B., Rostami-Hodjegan, A. & Galetin, A., Feb 2011, In : Drug Metabolism and Disposition. 39, 2, p. 170-173 3 p.

    Research output: Contribution to journalArticle

  61. Published

    Assessment of algorithms for predicting drug-drug interactions via inhibition mechanisms: Comparison of dynamic and static models

    Guest, E. J., Rowland-Yeo, K., Rostami-Hodjegan, A., Tucker, G. T., Houston, J. B. & Galetin, A., Jan 2011, In : British Journal of Clinical Pharmacology. 71, 1, p. 72-87 15 p.

    Research output: Contribution to journalArticle

  62. 2010
  63. Published

    Comparative use of isolated hepatocytes and hepatic microsomes for cytochrome P450 inhibition studies: Transporter-enzyme interplay

    Brown, H. S., Wilby, A. J., Alder, J. & Houston, J. B., Dec 2010, In : Drug Metabolism and Disposition. 38, 12, p. 2139-2146 7 p.

    Research output: Contribution to journalArticle

  64. Published

    Prediction of human metabolic clearance from in vitro systems: Retrospective analysis and prospective view

    Hallifax, D., Foster, J. A. & Houston, J. B., Oct 2010, In : Pharmaceutical Research. 27, 10, p. 2150-2161 11 p.

    Research output: Contribution to journalArticle

  65. Published

    Contribution of active uptake to the hepatic clearance of seven OATP substrates in rat and human plated hepatocytes

    Menochet, K., Kenworthy, K., Houston, JB. & Galetin, A., Sep 2010, host publication. Vol. 487.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  66. Published

    Drug clearance in different in vitro systems as a preliminary indicator of hepatic uptake

    Houston, J., Rostami-Hochaghan, A. & Galetin, A., Sep 2010, host publication. Vol. 510.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  67. Published

    Metabolite formation kinetics and intrinsic clearance of phenacetin, tolbutamide, alprazolam, and midazolam in adenoviral cytochrome P450-transfected HepG2 cells and comparison with hepatocytes and in vivo

    Donato, M. T., Hallifax, D., Picazo, L., Castell, J. V., Houston, J. B., Gomez-Lechón, M. J. & Lahoz, A., Sep 2010, In : Drug Metabolism and Disposition. 38, 9, p. 1449-1455 6 p.

    Research output: Contribution to journalArticle

  68. Published

    Physiologically-based pharmacokinetic modelling of hepatic transporter substrate rosuvastatin

    Tate, S., Jones, HM., Houston, JB. & Galetin, A., Sep 2010, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  69. Published
  70. Published

    Prediction of human intestinal first-pass metabolism of 25 CYP3A substrates from in vitro clearance and permeability data

    Gertz, M., Harrison, A., Houston, J. B. & Galetin, A., Jul 2010, In : Drug Metabolism and Disposition. 38, 7, p. 1147-1158 11 p.

    Research output: Contribution to journalArticle

  71. Published

    Transporters and cytochrome P450 interplay in defining hepatic drug clearance

    Houston, JB., Jun 2010.

    Research output: Contribution to conferenceOther

  72. Published

    IC50-based approaches as an alternative method for assessment of time-dependent inhibition of CYP3A4

    Burt, H. J., Galetin, A. & Houston, J. B., May 2010, In : Xenobiotica. 40, 5, p. 331-343 12 p.

    Research output: Contribution to journalArticle

  73. Published

    Pharmacokinetics of fexofenadine: Evaluation of a microdose and assessment of absolute oral bioavailability

    Lappin, G., Shishikura, Y., Jochemsen, R., Weaver, R. J., Gesson, C., Houston, B., Oosterhuis, B., Bjerrum, O. J., Rowland, M. & Garner, C., May 2010, In : European Journal of Pharmaceutical Sciences. 40, 2, p. 125-131 6 p.

    Research output: Contribution to journalArticle

  74. Published

    Application of different in vitro systems for prediction of in vivo induction drug-drug interactions

    Galetin, A. & Houston, J., 2010, host publication. Vol. 143.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  75. Published

    Contribution of intestinal cytochrome P450-mediated metabolism to drug-drug inhibition and induction interactions

    Galetin, A., Gertz, M. & Houston, J. B., 2010, In : Drug Metabolism and Pharmacokinetics. 25, 1, p. 28-47 19 p.

    Research output: Contribution to journalArticle

  76. Published

    In vitro techniques to study drug-drug interactions of drug metabolism: Cytochrome P450

    Houston, J. B. & Galetin, A., 2010, Enzyme- and Transporter-Based Drug-Drug Interactions: Progress and Future Challenges|Enz.- and Transporter-Based Drug-Drug Interac.: Progress and Fut. Chall.. USA: Springer Nature, p. 169-215 46 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  77. Published

    Inhibition of Drug Metabolizing Enzymes in Gastrointestinal Tract and its Influence on the Drug-Drug Interaction Prediction, in Enzyme Inhibition in Drug Discovery and Development

    Galetin, A., Houston, JB., Lu, C. (ed.) & A. P. Li, S. (ed.), 2010, host publication. John Wiley & Sons Ltd, p. 315-343

    Research output: Chapter in Book/Report/Conference proceedingChapter

  78. Published

    Physiologically-based pharmacokinetic modelling approach to assess the uptake transporter-mediated drug-drug interaction potential of cyclosporine.

    Galetin, A. & Houston, J., 2010, host publication. Vol. 149.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  79. Published

    Prediction of clearance from the HepaRG cell system: comparison with human hepatocytes for a range of substrates.

    Zanelli, U., Caradonna, NP., Hallifax, D. & Houston, JB., 2010, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  80. 2009
  81. Published

    . Physiologically-Based Pharmacokinetic Modelling of Hepatic Uptake of Pravastatin and Rosuvastatin

    Galetin, A., Houston, JB., Tate, S. & Jones, HM., 25 Nov 2009, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  82. Published

    Assessment of Algorithms for Predicting Drug-Drug Interactions via Inhibition Mechanisms.

    Rostami-Hochaghan, A., Guest, EJ., Rowland, Y. K., Rostami-Hodjegan, A., Tucker, GT., Houston, JB. & Galetin, A., 23 Sep 2009, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  83. Published

    Transporters and cytochrome P450 interplay in defining hepatic drug clearance

    Houston, JB., Sep 2009.

    Research output: Contribution to conferenceOther

  84. Published

    Methodology for development of a physiological model incorporating CYP3A and P-glycoprotein for the prediction of intestinal drug absorption

    Badhan, R., Penny, J., Galetin, A. & Houston, J. B., Jun 2009, In : Journal of Pharmaceutical Sciences. 98, 6, p. 2180-2197 17 p.

    Research output: Contribution to journalArticle

  85. Published

    How good is prediction of in vivo metabolic clearance from established in vitro systems?

    Foster, JA., Hallifax, D. & Houston, B., 17 May 2009.

    Research output: Contribution to conferencePoster

  86. Published

    Involvement of drug uptake in hepatic clearance

    Jigorel, EE. & Houston, B., 17 May 2009, Drug Metab Rev. Vol. Rev 41 (Suppl 1).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  87. Published

    Evaluation of recombinant cytochrome p450 enzymes as an in vitro system for metabolic clearance predictions

    Stringer, R. A., Strain-Damerell, C., Nicklin, P. & Houston, J. B., May 2009, In : Drug Metabolism and Disposition. 37, 5, p. 1025-1034 9 p.

    Research output: Contribution to journalArticle

  88. Published

    Relative Importance of Intestinal and Hepatic Glucuronidation-Impact on the Prediction of Drug Clearance

    Cubitt, H. E., Houston, J. B. & Galetin, A., May 2009, In : Pharmaceutical Research. 26, 5, p. 1073-1083 10 p.

    Research output: Contribution to journalArticle

  89. Published

    QGut Model as a Predictive Tool for Intestinal Availability in Human: Impact of In Vitro Permeability and Clearance

    Gertz, M., Fenner, KS., Harrison, A., Davis, J., Houston, JB. & Galetin, A., 6 Feb 2009, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  90. Published

    Prediction of drug clearance by glucuronidation from in vitro data: Use of combined cytochrome P450 and UDP-glucuronosyltransferase cofactors in alamethicin-activated human liver microsomes

    Kilford, P. J., Stringer, R., Sohal, B., Houston, J. B. & Galetin, A., Jan 2009, In : Drug Metabolism and Disposition. 37, 1, p. 82-89 7 p.

    Research output: Contribution to journalArticle

  91. Published

    Assessment of the contribution of transporter-mediated active uptake to the overall hepatic uptake clearance for a range of drugs

    Yabe, Y., Galetin, A. & Houston, JB., 2009, host publication. Vol. 41 (Suppl. 3): 39..

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  92. Published

    Comparison of intestinal and hepatic sulphation and glucuronidation for a range of drugs

    Cubitt, H., Houston, JB. & Galetin, A., 2009, In : Drug Metabolism Reviews. 41 (Suppl. 1)

    Research output: Contribution to journalArticle

  93. Published

    Evaluation of the transporter-mediated hepatic uptake in fresh rat hepatocytes

    Yabe, Y., Galetin, A. & Houston, JB., 2009, host publication. Drug Metab Rev, Vol. 41 (Suppl. 1).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  94. Published

    Impact of saturation of CYP3A4 and P-glycoprotein in vivo on the prediction of intestinal availability

    Gertz, M., Harrison, A., Davis, J., Houston, JB. & Galetin, A., 2009, host publication. Vol. 41 (Suppl. 3): 29..

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  95. Published

    Methodological uncertainty in quantitative prediction of human hepatic clearance from in vitro experimental systems

    Hallifax, D. & Houston, J. B., 2009, In : Current Drug Metabolism. 10, 3, p. 307-321 14 p.

    Research output: Contribution to journalArticle

  96. Published

    Prediction of the intestinal availability and associated inter-individual variability for drugs with high intestinal first-pass metabolism

    Gertz, M., Harrison, A., Davis, J., Houston, JB. & Galetin, A., 2009, In : Drug Metabolism Reviews. 41 (Suppl. 1): 50

    Research output: Contribution to journalArticle

  97. 2008
  98. Published

    Defining the in vivo role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5

    Finn, R. D., McLaughlin, L. A., Ronseaux, S., Rosewell, I., Houston, J. B., Henderson, C. J. & Wolf, C. R., 14 Nov 2008, In : Journal of Biological Chemistry. 283, 46, p. 31385-31393 8 p.

    Research output: Contribution to journalArticle

  99. Published

    Kinetic modeling of the interactions between 4-methylumbelliferone, 1-naphthol, and zidovudine glucuronidation by UDP-glucuronosyltransferase 2B7 (UGT2B7) provides evidence for multiple substrate binding and effector sites

    Uchaipichat, V., Galetin, A., Houston, J. B., Mackenzie, P. I., Williams, J. A. & Miners, J. O., Oct 2008, In : Molecular pharmacology. 74, 4, p. 1152-1162 10 p.

    Research output: Contribution to journalArticle

  100. Published

    Reliability of human cryopreserved hepatocytes and liver microsomes as in vitro systems to predict metabolic clearance

    Stringer, R., Nicklin, P. L. & Houston, J. B., Oct 2008, In : Xenobiotica. 38, 10, p. 1313-1329 16 p.

    Research output: Contribution to journalArticle

  101. Published

    Transporters and enzyme interplay in defining hepatic clearance

    Houston, JB., Oct 2008.

    Research output: Contribution to conferenceOther

  102. Published

    Assessment of the QGut Model As Predictive Tool For Intestinal Availability in human: Impact of the In Vitro Permeability and Clearance.

    Galetin, A., Houston, JB., Gertz, M., Fenner, KS., Harrison, A. & Davis, J., 6 Jul 2008, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  103. Published

    Comparative analysis of CYP3A heteroactivation by steroid hormones and flavonoids in different in vitro systems and potential in vivo implications

    Henshall, J., Galetin, A., Harrison, A. & Houston, J. B., Jul 2008, In : Drug Metabolism and Disposition. 36, 7, p. 1332-1340 8 p.

    Research output: Contribution to journalArticle

  104. Published

    Effect of Albumin on Prediction of Glucuronidation Clearance Using Alamethicin Activated Human Liver Microsomes.

    Galetin, A., Houston, JB., Kilford, P., Stringer, R. & Sohal, B., Jul 2008, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  105. Published

    Hepatocellular binding of drugs: Correction for unbound fraction in hepatocyte incubations using microsomal binding or drug lipophilicity data

    Kilford, P. J., Gertz, M., Houston, J. B. & Galetin, A., Jul 2008, In : Drug Metabolism and Disposition. 36, 7, p. 1194-1197 3 p.

    Research output: Contribution to journalArticle

  106. Published

    Potential role of intestinal first-pass metabolism in the prediction of drug-drug interactions

    Galetin, A., Gertz, M. & Houston, J. B., Jul 2008, In : Expert Opinion on Drug Metabolism and Toxicology. 4, 7, p. 909-922 13 p.

    Research output: Contribution to journalArticle

  107. Published

    Rate-limiting steps in hepatic drug clearance: comparison of hepatocellular uptake and metabolism with microsomal metabolism of saquinavir, nelfinavir, and ritonavir

    Parker, A. J. & Houston, J. B., Jul 2008, In : Drug Metabolism and Disposition. 36, 7, p. 1375-1384 9 p.

    Research output: Contribution to journalArticle

  108. Published

    Comparison of hepatic and intestinal Glucuronidation

    Galetin, A. & Houston, J., May 2008, host publication. 10th European Regional ISSX Meeting, Vol. 37-38.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  109. Published

    Multiple inhibition mechanisms and prediction of drug-drug interactions: Status of metabolism and transporter models as exemplified by gemfibrozil-drug interactions

    Hinton, L. K., Galetin, A. & Houston, J. B., May 2008, In : Pharmaceutical Research. 25, 5, p. 1063-1074 11 p.

    Research output: Contribution to journalArticle

  110. Published

    Prediction of Glucuronidation (UGT) clearance using alamethicin activated human liver microsomes

    Kilford, P., Stringer, R., Sohal, B., Houston, JB. & Galetin, A., May 2008, Drug Metabolism Reviews. Suppl. 1 ed. Vol. 40 . p. 51-52 2 p. 79

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  111. Published
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