Prof James HoustonBSc, PhD, DSc

Emeritus Professor

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Publications

  1. 2012
  2. Published
  3. Published

    Simultaneous assessment of uptake and metabolism in rat hepatocytes: A comprehensive mechanistic model

    Ménochet, K., Kenworthy, K. E., Houston, J. B. & Galetin, A., Apr 2012, In : Journal of Pharmacology and Experimental Therapeutics. 341, 1, p. 2-15 13 p.

    Research output: Contribution to journalArticle

  4. Published

    Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs

    Zanelli, U., Caradonna, N. P., Hallifax, D., Turlizzi, E. & Houston, J. B., Jan 2012, In : Drug Metabolism and Disposition. 40, 1, p. 104-110 6 p.

    Research output: Contribution to journalArticle

  5. Published

    Evaluation of the novel in vitro systems for hepatic drug clearance and assessment of their predictive utility

    Houston, J. B., Rowland-Yeo, K. & Zanelli, U., 2012, In : Toxicology in Vitro. 26, 8, p. 1265-71

    Research output: Contribution to journalArticle

  6. 2011
  7. Published

    Kinetic characterization of rat hepatic uptake of 16 actively transported drugs

    Yabe, Y., Galetin, A. & Houston, J. B., Oct 2011, In : Drug Metabolism and Disposition. 39, 10, p. 1808-1814 6 p.

    Research output: Contribution to journalArticle

  8. Published

    Predictive utility of in vitro rifampin induction data generated in fresh and cryopreserved human hepatocytes, Fa2N-4,and HepaRG cells

    Templeton, I. E., Houston, J. B. & Galetin, A., Oct 2011, In : Drug Metabolism and Disposition. 39, 10, p. 1921-1929 8 p.

    Research output: Contribution to journalArticle

  9. Published

    Physiologically based pharmacokinetic modeling of intestinal first-pass metabolism of CYP3A substrates with high intestinal extraction

    Gertz, M., Houston, J. B. & Galetin, A., Sep 2011, In : Drug Metabolism and Disposition. 39, 9, p. 1633-1642 9 p.

    Research output: Contribution to journalArticle

  10. Published

    Comparative pharmacokinetics between a microdose and therapeutic dose for clarithromycin, sumatriptan, propafenone, paracetamol (acetaminophen), and phenobarbital in human volunteers

    Lappin, G., Shishikura, Y., Jochemsen, R., Weaver, R. J., Gesson, C., Brian Houston, J., Oosterhuis, B., Bjerrum, O. J., Grynkiewicz, G., Alder, J., Rowland, M. & Garner, C., 14 Jun 2011, In : European Journal of Pharmaceutical Sciences. 43, 3, p. 141-150 9 p.

    Research output: Contribution to journalArticle

  11. Published

    A pragmatic randomized controlled trial of thiopurine methyltransferase genotyping prior to azathioprine treatment: The TARGET study

    Newman, W. G., Payne, K., Tricker, K., Roberts, S. A., Fargher, E., Pushpakom, S., Alder, J. E., Sidgwick, G. P., Payne, D., Elliott, R. A., Heise, M., Elles, R., Ramsden, S. C., Andrews, J., Houston, J. B., Qasim, F., Shaffer, J., Griffiths, C. E. M., Ray, D. W., Bruce, I. & 1 others, Ollier, W. E. R., Jun 2011, In : Pharmacogenomics. 12, 6, p. 815-826 11 p.

    Research output: Contribution to journalArticle

  12. Published

    Prediction of human drug clearance by multiple metabolic pathways: Integration of hepatic and intestinal microsomal and cytosolic data

    Cubitt, H. E., Houston, J. B. & Galetin, A., May 2011, In : Drug Metabolism and Disposition. 39, 5, p. 864-873 9 p.

    Research output: Contribution to journalArticle

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