Prof James HoustonBSc, PhD, DSc

Emeritus Professor

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Publications

  1. 2012
  2. Published

    In vitro assessment of accumulation of inhaled drugs by alveolar macrophages

    Houston, JB., Ufuk, A., Somers, GI. & Galetin, A., Sep 2012.

    Research output: Contribution to conferencePoster

  3. Published

    Predictive hepatocellular activity: Cornerstone for PBPK modelling (B2)

    Houston, J. B., Sep 2012.

    Research output: Contribution to conferenceOther

  4. Published

    Progress curve mechanistic modeling approach for assessing time-dependent inhibition of CYP3A4

    Burt, H. J., Pertinez, H., Säll, C., Collins, C., Hyland, R., Houston, J. B. & Galetin, A., Sep 2012, In : Drug Metabolism and Disposition. 40, 9, p. 1658-1667 9 p.

    Research output: Contribution to journalArticle

  5. Published

    Use of mechanistic modeling to assess interindividual variability and interspecies differences in active uptake in human and rat hepatocytes

    Ménochet, K., Kenworthy, K. E., Houston, J. B. & Galetin, A., Sep 2012, In : Drug Metabolism and Disposition. 40, 9, p. 1744-1756 12 p.

    Research output: Contribution to journalArticle

  6. Published

    Evaluation of hepatic clearance prediction using in vitro data: Emphasis on fraction unbound in plasma and drug ionisation using a database of 107 drugs

    Hallifax, D. & Houston, J. B., Aug 2012, In : Journal of Pharmaceutical Sciences. 101, 8, p. 2645-2652 7 p.

    Research output: Contribution to journalArticle

  7. Published

    Evidence-based approach to assess passive diffusion and carrier-mediated drug transport

    Di, L., Artursson, P., Avdeef, A., Ecker, G. F., Faller, B., Fischer, H., Houston, J. B., Kansy, M., Kerns, E. H., Krämer, S. D., Lennernäs, H. & Sugano, K., Aug 2012, In : Drug discovery today. 17, 15-16, p. 905-912 7 p.

    Research output: Contribution to journalArticle

  8. Published

    Utility of drug depletion-time profiles in isolated hepatocytes for accessing hepatic uptake clearance: Identifying rate-limiting steps and role of passive processes

    Jigorel, E. & Houston, J. B., Aug 2012, In : Drug Metabolism and Disposition. 40, 8, p. 1596-1602 6 p.

    Research output: Contribution to journalArticle

  9. Published

    A comprehensive assessment of repaglinide metabolic pathways: Impact of choice of in vitro system and relative enzyme contribution to in vitro clearance

    Säll, C., Houston, J. B. & Galetin, A., Jul 2012, In : Drug Metabolism and Disposition. 40, 7, p. 1279-1289 10 p.

    Research output: Contribution to journalArticle

  10. Published

    Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data

    Jones, H. M., Barton, H. A., Lai, Y., Bi, Y. A., Kimoto, E., Kempshall, S., Tate, S. C., El-Kattan, A., Houston, J. B., Galetin, A. & Fenner, K. S., May 2012, In : Drug Metabolism and Disposition. 40, 5, p. 1007-1017 10 p.

    Research output: Contribution to journalArticle

  11. Published

    Clearance-dependent underprediction of in vivo intrinsic clearance from human hepatocytes: Comparison with permeabilities from artificial membrane (PAMPA) assay, in silico and caco-2 assay, for 65 drugs

    Hallifax, D., Turlizzi, E., Zanelli, U. & Houston, J. B., 11 Apr 2012, In : European Journal of Pharmaceutical Sciences. 45, 5, p. 570-574 4 p.

    Research output: Contribution to journalArticle

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