Prof James HoustonBSc, PhD, DSc

Emeritus Professor

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Publications

  1. 1997
  2. Published

    Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices

    Brian Houston, J. & Carlile, D. J., 1997, In : Drug Metabolism Reviews. 29, 4, p. 891-922 31 p.

    Research output: Contribution to journalArticle

  3. Published

    Selectivity of omeprazole towards rat live cytochromes P450.

    Zomorodi, K. & Houston, B., 1997, In : Xenobiotica. 27

    Research output: Contribution to journalArticle

  4. Published

    Sigmoidal kinetics of CYP3A substrates: An approach for scaling dextromethorplan metabolism in rat microsomes and isolated heptatocytes to predict in vivo clearance.

    Witherow, LL. E. & Houston, B., 1997, ISSX Proceedings. Vol. 12.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  5. Published

    Kinetics of drug metabolism in rat liver slices: III. Relationship between metabolic clearance and slice uptake rate

    Worboys, P. D., Bradbury, A. & Houston, J. B., Apr 1997, In : Drug Metabolism and Disposition. 25, 4, p. 460-467 7 p.

    Research output: Contribution to journalArticle

  6. Published

    Scaling factors to relate drug metabolic clearance in hepatic microsomes, isolated hepatocytes, and the intact liver: Studies with induced livers involving diazepam

    Carlile, D. J., Zomorodi, K. & Houston, J. B., Aug 1997, In : Drug Metabolism and Disposition. 25, 8, p. 903-911 8 p.

    Research output: Contribution to journalArticle

  7. Published

    Incorporation of in vitro drug metabolism data into physiologically- based pharmacokinetic models

    Houston, J. B. & Carlile, D. J., Oct 1997, In : Toxicology in Vitro. 11, 5, p. 473-478 5 p.

    Research output: Contribution to journalArticle

  8. 1998
  9. Published

    Incorporating Variability and Uncertainty into the In Vitro - In Vivo Predictioon of Hepatic Clearance. Proc. 5th EUFEPS Conference: Optimising Drug Development: Fastracking into Human, Wiesbaden, Germany, December 1998

    Nestorov, I., Carlile, D., Houston, B. & Rowland, M., 1998, Eur. J. Pharmac. Sci..

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  10. Published

    Influence of slice thickness and culture conditions on metabolism in precision-cut liver slices.

    Price, R. J., Renwick, A. B., Barton, P. T., Houston, B. & Lake, B. G., 1998, In : ATLA. 26

    Research output: Contribution to journalArticle

  11. Published

    Inhibition of rat cytochrome P450-dependent 1 metabolism by ketoconazole and fluconazole. 16th European Drug Metabolism Workshop, Copenhagen

    Chadwick, AA. P., McKillop, D. & Houston, B., 1998, Proceedings.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  12. Published

    Inhibition of rat cytochrome P450-dependent metabolism by ketoconazole and fluconazole

    Chadwick, AA. P., McKillop, D. & Houston, B., 1998, Br. J. Clin. Pharmacol.. Vol. 45.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

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