Prof James HoustonBSc, PhD, DSc

Emeritus Professor

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Publications

  1. 2018
  2. Published

    Predicting human clearance of organic anion transporting polypeptide substrates using cynomolgus monkey: In vitro-in vivo scaling of hepatic uptake clearance

    De Bruyn, T., Ufuk, A., Cantrill, C., Kosa, R. E., Bi, Y. A., Niosi, M., Modi, S., Rodrigues, A. D., Tremaine, L. M., Varma, M. V. S., Galetin, A. & Houston, J. B., Jul 2018, In : Drug Metabolism and Disposition. 46, 7, p. 989-1000 12 p.

    Research output: Contribution to journalArticle

  3. Published

    In vitro–in vivo extrapolation of OATP1B-mediated drug–drug interactions in cynomolgus monkey

    Ufuk, A., Kosa, R. E., Gao, H., Bi, Y. A., Modi, S., Gates, D., Rodrigues, A. D., Tremaine, L. M., Varma, M. V. S., Houston, J. B. & Galetin, A., 1 Jun 2018, In : Journal of Pharmacology and Experimental Therapeutics. 365, 3, p. 688-699 12 p.

    Research output: Contribution to journalArticle

  4. Published

    Importance of the unstirred water layer and hepatocyte membrane integrity in vitro for quantification of intrinsic metabolic clearance

    Wood, F., Houston, J. & Hallifax, D., 1 Jan 2018, In : Drug Metabolism and Disposition. 46, 1

    Research output: Contribution to journalArticle

  5. Published

    Hepatic OATP-mediated clearance in the Beagle dog: assessing in vitro-in vivo relationships and applying cross species empirical scaling factors to improve prediction of human clearance

    Matsunaga, N., Ufuk, A., Morse, B. L., Bedwell, D. W., Bao, J., Mohutsky, M. A., Hillgren, K. M., Hall, S. D., Houston, J. B. & Galetin, A., 2018, In : Drug Metabolism and Disposition.

    Research output: Contribution to journalArticle

  6. Published

    Simultaneous Assessment in vitro of Transporter and Metabolic Processes in Hepatic Drug Clearance: Use of a media loss approach

    Harrison, J., De Bruyn, T., Darwich, A. & Houston, J., 2018, In : Drug Metabolism and Disposition.

    Research output: Contribution to journalArticle

  7. 2017
  8. Published

    Clearance prediction methodology needs fundamental improvement: Trends common to rat and human hepatocytes/microsomes and implications for experimental methodology

    Wood, F. L., Houston, J. B. & Hallifax, D., 1 Nov 2017, In : Drug Metabolism and Disposition. 45, 11, p. 1178-1188 11 p.

    Research output: Contribution to journalComment/debate

  9. Published

    Understanding the Interplay Between Uptake and Efflux Transporters Within In Vitro Systems in Defining Hepatocellular Drug Concentrations

    Cantrill, C. & Houston, J. B., Sep 2017, In : Journal of Pharmaceutical Sciences. 106, 9

    Research output: Contribution to journalArticle

  10. Published

    In vitro and in silico tools to assess extent of cellular uptake and lysosomal sequestration of respiratory drugs in human alveolar macrophages

    Ufuk, A., Assmus, F., Francis, L., Plumb, J., Damian, V., Gertz, M., Houston, J. & Galetin, A., 2017, In : Molecular Pharmaceutics. 14, 4

    Research output: Contribution to journalArticle

  11. Published

    Incorporation of lysosomal sequestration in the mechanistic model for prediction of tissue distribution of basic drugs

    Assmus, F., Houston, J. & Galetin, A., 2017, In : European Journal of Pharmaceutical Sciences.

    Research output: Contribution to journalArticle

  12. 2016
  13. Published

    Direct and quantitative evaluation of the human CYP3A4 contribution (fm) to drug clearance using the in vitro SILENSOMES model

    Parmentier, Y., Pothier, C., Delmas, A., Caradec, F., Trancart, M. M., Guillet, F., Bouaita, B., Chesne, C., Walther, B. & Houston, J., 2016, In : Xenobiotica. p. 1-14 14 p.

    Research output: Contribution to journalArticle

  14. 2015
  15. Published

    In vitro assessment of uptake and lysosomal sequestration of respiratory drugs in alveolar macrophage cell line NR8383

    Ufuk, A., Somers, G., Houston, J. & Galetin, A., Dec 2015, In : Pharmaceutical Research. 32, 12, p. 3937–3951 14 p.

    Research output: Contribution to journalArticle

  16. Published

    Assessing metabolic competence in isolated hepatocytes: Exploring the relationship between enzyme function and plasma membrane integrity via Saponin treatment

    Wood, F., Hallifax, D. & Houston, B., Jun 2015, host publication. Vol. P10.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  17. Published

    In Silico Prediction of Hepatocellular Drug Binding

    Assmus, F., Houston, B. & Galetin, A., Jun 2015, host publication. Vol. A10.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  18. Published

    Characterization of the comparative drug binding to intra- (liver fatty acid binding protein) and extra- (human serum albumin) cellular proteins

    Rowland, A., Hallifax, D., Nussio, M., Shapter, J., Mackenzie, P., Houston, J. B., Knights, K. M. & Miners, J. O., 24 Mar 2015, In : Xenobiotica. 45, 10, p. 847-857 10 p.

    Research output: Contribution to journalArticle

  19. Published

    "Time dependent" inhibition of hepatic uptake transporters in hepatocytes and implications on the assessment of transporter-mediated drug-drug interactions

    Kageyama, M., Houston, B. & Galetin, A., 2015, host publication. Vol. P43.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  20. Published

    Comparison of respiratory drug accumulation and lysosomal sequestration in NR8383 and primary human al veolar macrophages

    Ufuk, A., Plumb, J., Houston, B. & Galetin, A., 2015, host publication. Vol. A11.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  21. Published

    Cynomoglus monkey as a preclinical model for the investigation of hepatic uptake of OATP substrates

    Bruyn, T. D., Barton, H. A., Bi, Y-A., Cantrill, C., Galetin, A., Houston, B., Lin, J. & Kosa, R., 2015, host publication. Vol. P11.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  22. Published

    Investigation into LiverChipTM as a 3D hepatocyte model for clearance prediction

    De Bruyn, T., Kageyama, M., Ufuk, A., Hallifax, D., Houston, J. B. & Galetin, A., 2015

    Research output: Other contribution

  23. 2014
  24. Published

    Passive lipoidal diffusion and carrier-mediated cell uptake are both important mechanisms of membrane permeation in drug disposition

    Smith, D., Artursson, P., Avdeef, A., Di, L., Ecker, G. F., Faller, B., Houston, J. B., Kansy, M., Kerns, E. H., Krämer, S. D., Lennernäs, H., Van De Waterbeemd, H., Sugano, K. & Testa, B., 2 Jun 2014, In : Molecular Pharmaceutics. 11, 6, p. 1727-1738 11 p.

    Research output: Contribution to journalArticle

  25. Published
  26. Published
  27. Published

    Intrinsic Clearance Predictions from Freshly Isolated Rat Hepatocytes: Effects of Assay Format and Cofactor Supplementation

    Wood, F., Hallifax, D. & Houston, J., 2014, Proceedings of 20th international symposium on microsomes and drug oxidations.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  28. Published
  29. 2013
  30. Published

    Special Section on Prediction of human pharmacokinetic parameters from in vitro systems-Commentary

    Houston, JB., Dec 2013, In : Drug Metab Dispos. 41, p. 1973-1974

    Research output: Contribution to journalEditorial

  31. Published
  32. Published

    Addressing the challenges of low clearance.

    Houston, J. B., Nov 2013.

    Research output: Contribution to conferenceOther

  33. Published

    Drug accumulation in alveolar macrophages: assessment of uptake and lysosomal distribution in vitro.

    Houston, JB., Ufuk, A., Gertz, M., Plumb, J., Somers, G. & Galetin, A., Sep 2013.

    Research output: Contribution to conferencePoster

  34. Published

    Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

    Godoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., Bode, J. G., Bolleyn, J., Borner, C., Böttger, J., Braeuning, A., Budinsky, R. A., Burkhardt, B., Cameron, N. R., Camussi, G., Cho, C. S., Choi, Y. J., Craig Rowlands, J., Dahmen, U., Damm, G. & 73 others, Dirsch, O., Donato, M. T., Dong, J., Dooley, S., Drasdo, D., Eakins, R., Ferreira, K. S., Fonsato, V., Fraczek, J., Gebhardt, R., Gibson, A., Glanemann, M., Goldring, C. E. P., Gómez-Lechón, M. J., Groothuis, G. M. M., Gustavsson, L., Guyot, C., Hallifax, D., Hammad, S., Hayward, A., Häussinger, D., Hellerbrand, C., Hewitt, P., Hoehme, S., Holzhütter, H. G., Houston, J. B., Hrach, J., Ito, K., Jaeschke, H., Keitel, V., Kelm, J. M., Kevin Park, B., Kordes, C., Kullak-Ublick, G. A., Lecluyse, E. L., Lu, P., Luebke-Wheeler, J., Lutz, A., Maltman, D. J., Matz-Soja, M., McMullen, P., Merfort, I., Messner, S., Meyer, C., Mwinyi, J., Naisbitt, D. J., Nussler, A. K., Olinga, P., Pampaloni, F., Pi, J., Pluta, L., Przyborski, S. A., Ramachandran, A., Rogiers, V., Rowe, C., Schelcher, C., Schmich, K., Schwarz, M., Singh, B., Stelzer, E. H. K., Stieger, B., Stöber, R., Sugiyama, Y., Tetta, C., Thasler, W. E., Vanhaecke, T., Vinken, M., Weiss, T. S., Widera, A., Woods, C. G., Xu, J. J., Yarborough, K. M. & Hengstler, J. G., Aug 2013, In : Archives of Toxicology. 87, 8, p. 1315-1530 215 p.

    Research output: Contribution to journalArticle

  35. Published

    Application of a physiologically based pharmacokinetic model to assess propofol hepatic and renal glucuronidation in isolation: Utility of in vitro and in vivo data

    Gill, K. L., Gertz, M., Houston, J. B. & Galetin, A., Apr 2013, In : Drug Metabolism and Disposition. 41, 4, p. 744-753 9 p.

    Research output: Contribution to journalArticle

  36. Published

    Cyclosporine inhibition of hepatic and intestinal CYP3A4, uptake and efflux transporters: Application of PBPK Modeling in the assessment of drug-drug interaction potential

    Gertz, M., Cartwright, C. M., Hobbs, M. J., Kenworthy, K. E., Rowland, M., Houston, J. B. & Galetin, A., Mar 2013, In : Pharmaceutical Research. 30, 3, p. 761-780 19 p.

    Research output: Contribution to journalArticle

  37. 2012
  38. Published

    In vitro assessment of accumulation of inhaled drugs by alveolar macrophages

    Houston, JB., Ufuk, A., Somers, GI. & Galetin, A., Sep 2012.

    Research output: Contribution to conferencePoster

  39. Published

    Predictive hepatocellular activity: Cornerstone for PBPK modelling (B2)

    Houston, J. B., Sep 2012.

    Research output: Contribution to conferenceOther

  40. Published

    Progress curve mechanistic modeling approach for assessing time-dependent inhibition of CYP3A4

    Burt, H. J., Pertinez, H., Säll, C., Collins, C., Hyland, R., Houston, J. B. & Galetin, A., Sep 2012, In : Drug Metabolism and Disposition. 40, 9, p. 1658-1667 9 p.

    Research output: Contribution to journalArticle

  41. Published

    Use of mechanistic modeling to assess interindividual variability and interspecies differences in active uptake in human and rat hepatocytes

    Ménochet, K., Kenworthy, K. E., Houston, J. B. & Galetin, A., Sep 2012, In : Drug Metabolism and Disposition. 40, 9, p. 1744-1756 12 p.

    Research output: Contribution to journalArticle

  42. Published

    Evaluation of hepatic clearance prediction using in vitro data: Emphasis on fraction unbound in plasma and drug ionisation using a database of 107 drugs

    Hallifax, D. & Houston, J. B., Aug 2012, In : Journal of Pharmaceutical Sciences. 101, 8, p. 2645-2652 7 p.

    Research output: Contribution to journalArticle

  43. Published

    Evidence-based approach to assess passive diffusion and carrier-mediated drug transport

    Di, L., Artursson, P., Avdeef, A., Ecker, G. F., Faller, B., Fischer, H., Houston, J. B., Kansy, M., Kerns, E. H., Krämer, S. D., Lennernäs, H. & Sugano, K., Aug 2012, In : Drug discovery today. 17, 15-16, p. 905-912 7 p.

    Research output: Contribution to journalArticle

  44. Published

    Utility of drug depletion-time profiles in isolated hepatocytes for accessing hepatic uptake clearance: Identifying rate-limiting steps and role of passive processes

    Jigorel, E. & Houston, J. B., Aug 2012, In : Drug Metabolism and Disposition. 40, 8, p. 1596-1602 6 p.

    Research output: Contribution to journalArticle

  45. Published

    A comprehensive assessment of repaglinide metabolic pathways: Impact of choice of in vitro system and relative enzyme contribution to in vitro clearance

    Säll, C., Houston, J. B. & Galetin, A., Jul 2012, In : Drug Metabolism and Disposition. 40, 7, p. 1279-1289 10 p.

    Research output: Contribution to journalArticle

  46. Published

    Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data

    Jones, H. M., Barton, H. A., Lai, Y., Bi, Y. A., Kimoto, E., Kempshall, S., Tate, S. C., El-Kattan, A., Houston, J. B., Galetin, A. & Fenner, K. S., May 2012, In : Drug Metabolism and Disposition. 40, 5, p. 1007-1017 10 p.

    Research output: Contribution to journalArticle

  47. Published

    Clearance-dependent underprediction of in vivo intrinsic clearance from human hepatocytes: Comparison with permeabilities from artificial membrane (PAMPA) assay, in silico and caco-2 assay, for 65 drugs

    Hallifax, D., Turlizzi, E., Zanelli, U. & Houston, J. B., 11 Apr 2012, In : European Journal of Pharmaceutical Sciences. 45, 5, p. 570-574 4 p.

    Research output: Contribution to journalArticle

  48. Published
  49. Published

    Simultaneous assessment of uptake and metabolism in rat hepatocytes: A comprehensive mechanistic model

    Ménochet, K., Kenworthy, K. E., Houston, J. B. & Galetin, A., Apr 2012, In : Journal of Pharmacology and Experimental Therapeutics. 341, 1, p. 2-15 13 p.

    Research output: Contribution to journalArticle

  50. Published

    Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs

    Zanelli, U., Caradonna, N. P., Hallifax, D., Turlizzi, E. & Houston, J. B., Jan 2012, In : Drug Metabolism and Disposition. 40, 1, p. 104-110 6 p.

    Research output: Contribution to journalArticle

  51. Published

    Evaluation of the novel in vitro systems for hepatic drug clearance and assessment of their predictive utility

    Houston, J. B., Rowland-Yeo, K. & Zanelli, U., 2012, In : Toxicology in Vitro. 26, 8, p. 1265-71

    Research output: Contribution to journalArticle

  52. 2011
  53. Published

    Kinetic characterization of rat hepatic uptake of 16 actively transported drugs

    Yabe, Y., Galetin, A. & Houston, J. B., Oct 2011, In : Drug Metabolism and Disposition. 39, 10, p. 1808-1814 6 p.

    Research output: Contribution to journalArticle

  54. Published

    Predictive utility of in vitro rifampin induction data generated in fresh and cryopreserved human hepatocytes, Fa2N-4,and HepaRG cells

    Templeton, I. E., Houston, J. B. & Galetin, A., Oct 2011, In : Drug Metabolism and Disposition. 39, 10, p. 1921-1929 8 p.

    Research output: Contribution to journalArticle

  55. Published

    Physiologically based pharmacokinetic modeling of intestinal first-pass metabolism of CYP3A substrates with high intestinal extraction

    Gertz, M., Houston, J. B. & Galetin, A., Sep 2011, In : Drug Metabolism and Disposition. 39, 9, p. 1633-1642 9 p.

    Research output: Contribution to journalArticle

  56. Published

    Comparative pharmacokinetics between a microdose and therapeutic dose for clarithromycin, sumatriptan, propafenone, paracetamol (acetaminophen), and phenobarbital in human volunteers

    Lappin, G., Shishikura, Y., Jochemsen, R., Weaver, R. J., Gesson, C., Brian Houston, J., Oosterhuis, B., Bjerrum, O. J., Grynkiewicz, G., Alder, J., Rowland, M. & Garner, C., 14 Jun 2011, In : European Journal of Pharmaceutical Sciences. 43, 3, p. 141-150 9 p.

    Research output: Contribution to journalArticle

  57. Published

    A pragmatic randomized controlled trial of thiopurine methyltransferase genotyping prior to azathioprine treatment: The TARGET study

    Newman, W. G., Payne, K., Tricker, K., Roberts, S. A., Fargher, E., Pushpakom, S., Alder, J. E., Sidgwick, G. P., Payne, D., Elliott, R. A., Heise, M., Elles, R., Ramsden, S. C., Andrews, J., Houston, J. B., Qasim, F., Shaffer, J., Griffiths, C. E. M., Ray, D. W., Bruce, I. & 1 others, Ollier, W. E. R., Jun 2011, In : Pharmacogenomics. 12, 6, p. 815-826 11 p.

    Research output: Contribution to journalArticle

  58. Published

    Prediction of human drug clearance by multiple metabolic pathways: Integration of hepatic and intestinal microsomal and cytosolic data

    Cubitt, H. E., Houston, J. B. & Galetin, A., May 2011, In : Drug Metabolism and Disposition. 39, 5, p. 864-873 9 p.

    Research output: Contribution to journalArticle

  59. Published
  60. Published

    Critique of the two-fold measure of prediction success for ratios: Application for the assessment of drug-drug interactions

    Guest, E. J., Aarons, L., Houston, J. B., Rostami-Hodjegan, A. & Galetin, A., Feb 2011, In : Drug Metabolism and Disposition. 39, 2, p. 170-173 3 p.

    Research output: Contribution to journalArticle

  61. Published

    Assessment of algorithms for predicting drug-drug interactions via inhibition mechanisms: Comparison of dynamic and static models

    Guest, E. J., Rowland-Yeo, K., Rostami-Hodjegan, A., Tucker, G. T., Houston, J. B. & Galetin, A., Jan 2011, In : British Journal of Clinical Pharmacology. 71, 1, p. 72-87 15 p.

    Research output: Contribution to journalArticle

  62. 2010
  63. Published

    Comparative use of isolated hepatocytes and hepatic microsomes for cytochrome P450 inhibition studies: Transporter-enzyme interplay

    Brown, H. S., Wilby, A. J., Alder, J. & Houston, J. B., Dec 2010, In : Drug Metabolism and Disposition. 38, 12, p. 2139-2146 7 p.

    Research output: Contribution to journalArticle

  64. Published

    Prediction of human metabolic clearance from in vitro systems: Retrospective analysis and prospective view

    Hallifax, D., Foster, J. A. & Houston, J. B., Oct 2010, In : Pharmaceutical Research. 27, 10, p. 2150-2161 11 p.

    Research output: Contribution to journalArticle

  65. Published

    Contribution of active uptake to the hepatic clearance of seven OATP substrates in rat and human plated hepatocytes

    Menochet, K., Kenworthy, K., Houston, JB. & Galetin, A., Sep 2010, host publication. Vol. 487.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  66. Published

    Drug clearance in different in vitro systems as a preliminary indicator of hepatic uptake

    Houston, J., Rostami-Hochaghan, A. & Galetin, A., Sep 2010, host publication. Vol. 510.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  67. Published

    Metabolite formation kinetics and intrinsic clearance of phenacetin, tolbutamide, alprazolam, and midazolam in adenoviral cytochrome P450-transfected HepG2 cells and comparison with hepatocytes and in vivo

    Donato, M. T., Hallifax, D., Picazo, L., Castell, J. V., Houston, J. B., Gomez-Lechón, M. J. & Lahoz, A., Sep 2010, In : Drug Metabolism and Disposition. 38, 9, p. 1449-1455 6 p.

    Research output: Contribution to journalArticle

  68. Published

    Physiologically-based pharmacokinetic modelling of hepatic transporter substrate rosuvastatin

    Tate, S., Jones, HM., Houston, JB. & Galetin, A., Sep 2010, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  69. Published
  70. Published

    Prediction of human intestinal first-pass metabolism of 25 CYP3A substrates from in vitro clearance and permeability data

    Gertz, M., Harrison, A., Houston, J. B. & Galetin, A., Jul 2010, In : Drug Metabolism and Disposition. 38, 7, p. 1147-1158 11 p.

    Research output: Contribution to journalArticle

  71. Published

    Transporters and cytochrome P450 interplay in defining hepatic drug clearance

    Houston, JB., Jun 2010.

    Research output: Contribution to conferenceOther

  72. Published

    IC50-based approaches as an alternative method for assessment of time-dependent inhibition of CYP3A4

    Burt, H. J., Galetin, A. & Houston, J. B., May 2010, In : Xenobiotica. 40, 5, p. 331-343 12 p.

    Research output: Contribution to journalArticle

  73. Published

    Pharmacokinetics of fexofenadine: Evaluation of a microdose and assessment of absolute oral bioavailability

    Lappin, G., Shishikura, Y., Jochemsen, R., Weaver, R. J., Gesson, C., Houston, B., Oosterhuis, B., Bjerrum, O. J., Rowland, M. & Garner, C., May 2010, In : European Journal of Pharmaceutical Sciences. 40, 2, p. 125-131 6 p.

    Research output: Contribution to journalArticle

  74. Published

    Application of different in vitro systems for prediction of in vivo induction drug-drug interactions

    Galetin, A. & Houston, J., 2010, host publication. Vol. 143.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  75. Published

    Contribution of intestinal cytochrome P450-mediated metabolism to drug-drug inhibition and induction interactions

    Galetin, A., Gertz, M. & Houston, J. B., 2010, In : Drug Metabolism and Pharmacokinetics. 25, 1, p. 28-47 19 p.

    Research output: Contribution to journalArticle

  76. Published

    In vitro techniques to study drug-drug interactions of drug metabolism: Cytochrome P450

    Houston, J. B. & Galetin, A., 2010, Enzyme- and Transporter-Based Drug-Drug Interactions: Progress and Future Challenges|Enz.- and Transporter-Based Drug-Drug Interac.: Progress and Fut. Chall.. USA: Springer Nature, p. 169-215 46 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  77. Published

    Inhibition of Drug Metabolizing Enzymes in Gastrointestinal Tract and its Influence on the Drug-Drug Interaction Prediction, in Enzyme Inhibition in Drug Discovery and Development

    Galetin, A., Houston, JB., Lu, C. (ed.) & A. P. Li, S. (ed.), 2010, host publication. John Wiley & Sons Ltd, p. 315-343

    Research output: Chapter in Book/Report/Conference proceedingChapter

  78. Published

    Physiologically-based pharmacokinetic modelling approach to assess the uptake transporter-mediated drug-drug interaction potential of cyclosporine.

    Galetin, A. & Houston, J., 2010, host publication. Vol. 149.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  79. Published

    Prediction of clearance from the HepaRG cell system: comparison with human hepatocytes for a range of substrates.

    Zanelli, U., Caradonna, NP., Hallifax, D. & Houston, JB., 2010, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  80. 2009
  81. Published

    . Physiologically-Based Pharmacokinetic Modelling of Hepatic Uptake of Pravastatin and Rosuvastatin

    Galetin, A., Houston, JB., Tate, S. & Jones, HM., 25 Nov 2009, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  82. Published

    Assessment of Algorithms for Predicting Drug-Drug Interactions via Inhibition Mechanisms.

    Rostami-Hochaghan, A., Guest, EJ., Rowland, Y. K., Rostami-Hodjegan, A., Tucker, GT., Houston, JB. & Galetin, A., 23 Sep 2009, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  83. Published

    Transporters and cytochrome P450 interplay in defining hepatic drug clearance

    Houston, JB., Sep 2009.

    Research output: Contribution to conferenceOther

  84. Published

    Methodology for development of a physiological model incorporating CYP3A and P-glycoprotein for the prediction of intestinal drug absorption

    Badhan, R., Penny, J., Galetin, A. & Houston, J. B., Jun 2009, In : Journal of Pharmaceutical Sciences. 98, 6, p. 2180-2197 17 p.

    Research output: Contribution to journalArticle

  85. Published

    How good is prediction of in vivo metabolic clearance from established in vitro systems?

    Foster, JA., Hallifax, D. & Houston, B., 17 May 2009.

    Research output: Contribution to conferencePoster

  86. Published

    Involvement of drug uptake in hepatic clearance

    Jigorel, EE. & Houston, B., 17 May 2009, Drug Metab Rev. Vol. Rev 41 (Suppl 1).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  87. Published

    Evaluation of recombinant cytochrome p450 enzymes as an in vitro system for metabolic clearance predictions

    Stringer, R. A., Strain-Damerell, C., Nicklin, P. & Houston, J. B., May 2009, In : Drug Metabolism and Disposition. 37, 5, p. 1025-1034 9 p.

    Research output: Contribution to journalArticle

  88. Published

    Relative Importance of Intestinal and Hepatic Glucuronidation-Impact on the Prediction of Drug Clearance

    Cubitt, H. E., Houston, J. B. & Galetin, A., May 2009, In : Pharmaceutical Research. 26, 5, p. 1073-1083 10 p.

    Research output: Contribution to journalArticle

  89. Published

    QGut Model as a Predictive Tool for Intestinal Availability in Human: Impact of In Vitro Permeability and Clearance

    Gertz, M., Fenner, KS., Harrison, A., Davis, J., Houston, JB. & Galetin, A., 6 Feb 2009, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  90. Published

    Prediction of drug clearance by glucuronidation from in vitro data: Use of combined cytochrome P450 and UDP-glucuronosyltransferase cofactors in alamethicin-activated human liver microsomes

    Kilford, P. J., Stringer, R., Sohal, B., Houston, J. B. & Galetin, A., Jan 2009, In : Drug Metabolism and Disposition. 37, 1, p. 82-89 7 p.

    Research output: Contribution to journalArticle

  91. Published

    Assessment of the contribution of transporter-mediated active uptake to the overall hepatic uptake clearance for a range of drugs

    Yabe, Y., Galetin, A. & Houston, JB., 2009, host publication. Vol. 41 (Suppl. 3): 39..

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  92. Published

    Comparison of intestinal and hepatic sulphation and glucuronidation for a range of drugs

    Cubitt, H., Houston, JB. & Galetin, A., 2009, In : Drug Metabolism Reviews. 41 (Suppl. 1)

    Research output: Contribution to journalArticle

  93. Published

    Evaluation of the transporter-mediated hepatic uptake in fresh rat hepatocytes

    Yabe, Y., Galetin, A. & Houston, JB., 2009, host publication. Drug Metab Rev, Vol. 41 (Suppl. 1).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  94. Published

    Impact of saturation of CYP3A4 and P-glycoprotein in vivo on the prediction of intestinal availability

    Gertz, M., Harrison, A., Davis, J., Houston, JB. & Galetin, A., 2009, host publication. Vol. 41 (Suppl. 3): 29..

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  95. Published

    Methodological uncertainty in quantitative prediction of human hepatic clearance from in vitro experimental systems

    Hallifax, D. & Houston, J. B., 2009, In : Current Drug Metabolism. 10, 3, p. 307-321 14 p.

    Research output: Contribution to journalArticle

  96. Published

    Prediction of the intestinal availability and associated inter-individual variability for drugs with high intestinal first-pass metabolism

    Gertz, M., Harrison, A., Davis, J., Houston, JB. & Galetin, A., 2009, In : Drug Metabolism Reviews. 41 (Suppl. 1): 50

    Research output: Contribution to journalArticle

  97. 2008
  98. Published

    Defining the in vivo role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5

    Finn, R. D., McLaughlin, L. A., Ronseaux, S., Rosewell, I., Houston, J. B., Henderson, C. J. & Wolf, C. R., 14 Nov 2008, In : Journal of Biological Chemistry. 283, 46, p. 31385-31393 8 p.

    Research output: Contribution to journalArticle

  99. Published

    Kinetic modeling of the interactions between 4-methylumbelliferone, 1-naphthol, and zidovudine glucuronidation by UDP-glucuronosyltransferase 2B7 (UGT2B7) provides evidence for multiple substrate binding and effector sites

    Uchaipichat, V., Galetin, A., Houston, J. B., Mackenzie, P. I., Williams, J. A. & Miners, J. O., Oct 2008, In : Molecular pharmacology. 74, 4, p. 1152-1162 10 p.

    Research output: Contribution to journalArticle

  100. Published

    Reliability of human cryopreserved hepatocytes and liver microsomes as in vitro systems to predict metabolic clearance

    Stringer, R., Nicklin, P. L. & Houston, J. B., Oct 2008, In : Xenobiotica. 38, 10, p. 1313-1329 16 p.

    Research output: Contribution to journalArticle

  101. Published

    Transporters and enzyme interplay in defining hepatic clearance

    Houston, JB., Oct 2008.

    Research output: Contribution to conferenceOther

  102. Published

    Assessment of the QGut Model As Predictive Tool For Intestinal Availability in human: Impact of the In Vitro Permeability and Clearance.

    Galetin, A., Houston, JB., Gertz, M., Fenner, KS., Harrison, A. & Davis, J., 6 Jul 2008, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  103. Published

    Comparative analysis of CYP3A heteroactivation by steroid hormones and flavonoids in different in vitro systems and potential in vivo implications

    Henshall, J., Galetin, A., Harrison, A. & Houston, J. B., Jul 2008, In : Drug Metabolism and Disposition. 36, 7, p. 1332-1340 8 p.

    Research output: Contribution to journalArticle

  104. Published

    Effect of Albumin on Prediction of Glucuronidation Clearance Using Alamethicin Activated Human Liver Microsomes.

    Galetin, A., Houston, JB., Kilford, P., Stringer, R. & Sohal, B., Jul 2008, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  105. Published

    Hepatocellular binding of drugs: Correction for unbound fraction in hepatocyte incubations using microsomal binding or drug lipophilicity data

    Kilford, P. J., Gertz, M., Houston, J. B. & Galetin, A., Jul 2008, In : Drug Metabolism and Disposition. 36, 7, p. 1194-1197 3 p.

    Research output: Contribution to journalArticle

  106. Published

    Potential role of intestinal first-pass metabolism in the prediction of drug-drug interactions

    Galetin, A., Gertz, M. & Houston, J. B., Jul 2008, In : Expert Opinion on Drug Metabolism and Toxicology. 4, 7, p. 909-922 13 p.

    Research output: Contribution to journalArticle

  107. Published

    Rate-limiting steps in hepatic drug clearance: comparison of hepatocellular uptake and metabolism with microsomal metabolism of saquinavir, nelfinavir, and ritonavir

    Parker, A. J. & Houston, J. B., Jul 2008, In : Drug Metabolism and Disposition. 36, 7, p. 1375-1384 9 p.

    Research output: Contribution to journalArticle

  108. Published

    Comparison of hepatic and intestinal Glucuronidation

    Galetin, A. & Houston, J., May 2008, host publication. 10th European Regional ISSX Meeting, Vol. 37-38.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  109. Published

    Multiple inhibition mechanisms and prediction of drug-drug interactions: Status of metabolism and transporter models as exemplified by gemfibrozil-drug interactions

    Hinton, L. K., Galetin, A. & Houston, J. B., May 2008, In : Pharmaceutical Research. 25, 5, p. 1063-1074 11 p.

    Research output: Contribution to journalArticle

  110. Published

    Prediction of Glucuronidation (UGT) clearance using alamethicin activated human liver microsomes

    Kilford, P., Stringer, R., Sohal, B., Houston, JB. & Galetin, A., May 2008, Drug Metabolism Reviews. Suppl. 1 ed. Vol. 40 . p. 51-52 2 p. 79

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  111. Published
  112. Published

    Drug lipophilicity and microsomal protein concentration as determinants in the prediction of the fraction unbound in microsomal incubations

    Gertz, M., Kilford, P. J., Houston, J. B. & Galetin, A., Mar 2008, In : Drug Metabolism and Disposition. 36, 3, p. 535-542 7 p.

    Research output: Contribution to journalArticle

  113. Published

    Comparison of Hepatic and Intestinal Glucuronidation

    Cubitt, H., Houston, JB. & Galetin, A., 2008, host publication. Drug Metab Rev, Vol. 40 (Suppl. 1): 37..

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  114. Published

    Comparison of the extent of sulphation and glucuronidation in the intestine and liver for a range of drugs

    Cubitt, H., Houston, JB. & Galetin, A., 2008, host publication. Vol. 140.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  115. Published

    Grapefruit juice-drug interaction studies as a method to assess the extent of intestinal availability: Utility and limitations

    Gertz, M., Davis, J. D., Harrison, A., Houston, J. B. & Galetin, A., 2008, In : Current Drug Metabolism. 9, 8, p. 785-795 10 p.

    Research output: Contribution to journalArticle

  116. Published

    Impact of permeability on in vitro predictions of intestinal availability in the QGut model

    Gertz, M., Fenner, KS., Harrison, A., Davis, J., Houston, JB. & Galetin, A., 2008, host publication. Drug Metab Rev, Vol. 40 (Suppl. 1): 92.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  117. Published

    Methods for predicting in vivo pharmacokinetics using data from in vitro assays

    Houston, J. B. & Galetin, A., 2008, In : Current Drug Metabolism. 9, 9, p. 940-951 11 p.

    Research output: Contribution to journalArticle

  118. Published

    Uptake of repaglinide in HEK293 cells expressing OATP1B1 and plated human hepatocytes

    Hinton, LK., Thomas, JS., Kenworthy, KE., Somers, GI., Manchee, G., Galetin, A. & Houston, J., 2008, host publication. Drug Metab Rev, Vol. 40 (Suppl. 1):.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  119. 2007
  120. Published

    Maximal inhibition of intestinal first-pass metabolism as a pragmatic indicator of intestinal contribution to the drug-drug interactions for CYP3A4 cleared drugs

    Galetin, A., Hinton, L. K., Burt, H., Obach, R. S. & Houston, J. B., Oct 2007, In : Current Drug Metabolism. 8, 7, p. 685-693 8 p.

    Research output: Contribution to journalArticle

  121. Published

    Saturable uptake of lipophilic amine drugs into isolated hepatocytes: Mechanisms and consequences for quantitative clearance prediction

    Hallifax, D. & Houston, J. B., Aug 2007, In : Drug Metabolism and Disposition. 35, 8, p. 1325-1332 7 p.

    Research output: Contribution to journalArticle

  122. Published
  123. Published
  124. Published

    Evaluation of cryopreserved human hepatocytes as an alternative in vitro system to microsomes for the prediction of metabolic clearance

    Brown, H. S., Griffin, M. & Houston, J. B., Feb 2007, In : Drug Metabolism and Disposition. 35, 2, p. 293-301 8 p.

    Research output: Contribution to journalArticle

  125. Published

    Primary hepatocytes: Current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies

    Hewitt, N. J., Lechón, M. J. G., Houston, J. B., Hallifax, D., Brown, H. S., Maurel, P., Kenna, J. G., Gustavsson, L., Lohmann, C., Skonberg, C., Guillouzo, A., Tuschl, G., Li, A. P., Lecluyse, E., Groothuis, G. M. M. & Hengstler, J. G., Jan 2007, In : Drug Metabolism Reviews. 39, 1, p. 159-234 75 p.

    Research output: Contribution to journalArticle

  126. Published

    Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: Reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver

    Barter, Z. E., Bayliss, M. K., Beaune, P. H., Boobis, A. R., Carlile, D. J., Edwards, R. J., Houston, J. B., Lake, B. G., Lipscomb, J. C., Pelkonen, O. R., Tucker, G. T. & Rostami-Hodjegan, A., Jan 2007, In : Current Drug Metabolism. 8, 1, p. 33-45 12 p.

    Research output: Contribution to journalArticle

  127. Published

    Determination of the fraction metabolised by phase II (UGT) enzymes using human cryopreserved hepatocytes and 1-aminobenzo-triazole (ABT)

    Kilford, P., Stringer, R., Sohal, B., Houston, JB. & Galetin, A., 2007, host publication. Vol. 39(1).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  128. Published

    Prediction of hepatic uptake transporter (OATP1B1) drug-drug interactions

    Hinton, LK., Thomas, JS., Kenworthy, KE., Somers, GI., Manchee, G., Galetin, A. & Houston, JB., 2007, host publication. Vol. 39.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  129. Published

    Prediction of intestinal first-pass from in vitro metabolism and transport data.

    Gertz, M., Harrison, A., Davis, J., Houston, JB. & Galetin, A., 2007, host publication. Vol. 39 (1). 2 p.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  130. 2006
  131. Published

    Heteroactivation of carbamazepine metabolism by endogenous steroids in human liver microsomes and cryopreserved human hepatocytes.

    Galetin, A., Houston, JB., Henshall, A. & Harrison, A., Sep 2006, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  132. Published

    Inhibition of Repaglinide Metabolism by Gemfibrozil in Microsomes and Hepatocytes.

    Galetin, A., Houston, JB. & Gibbons, LK., Sep 2006, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  133. Published

    Maximal FG ratio as a pragmatic indicator of the extent of intestinal CYP3A4 inhibition interactions.

    Galetin, A., Houston, JB., Gibbons, L., Burt, H. & Obach, RS., Sep 2006, host publication.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  134. Published
  135. Published
  136. Published

    In vitro-in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: Pitfalls and promises

    Miners, J. O., Knights, K. M., Houston, J. B. & Mackenzie, P. I., 28 May 2006, In : Biochemical Pharmacology. 71, 11, p. 1531-1539 8 p.

    Research output: Contribution to journalArticle

  137. Published

    Binding of drugs to hepatic microsomes: Comment and assessment of current prediction methodology with recommendation for improvement [1]

    Hallifax, D. & Houston, J. B., Apr 2006, In : Drug Metabolism and Disposition. 34, 4, p. 724-726 2 p.

    Research output: Contribution to journalArticle

  138. Published

    Determination of a human hepatic microsomal scaling factor for predicting in vivo drug clearance

    Hakooz, N., Ito, K., Rawden, H., Gill, H., Lemmers, L., Boobis, A. R., Edwards, R. J., Carlile, D. J., Lake, B. G. & Houston, J. B., Mar 2006, In : Pharmaceutical Research. 23, 3, p. 533-539 6 p.

    Research output: Contribution to journalArticle

  139. Published

    Prediction of time-dependent CYP3A4 drug-drug interactions: Impact of enzyme degradation, parallel elimination pathways, and intestinal inhibition

    Galetin, A., Burt, H., Gibbons, L. & Houston, J. B., Jan 2006, In : Drug Metabolism and Disposition. 34, 1, p. 166-175 9 p.

    Research output: Contribution to journalArticle

  140. Published

    The utility of in vitro cytochrome P450 inhibition data in the prediction of drug-drug interactions

    Obach, R. S., Walsky, R. L., Venkatakrishnan, K., Gaman, E. A., Houston, J. B. & Tremaine, L. M., Jan 2006, In : Journal of Pharmacology and Experimental Therapeutics. 316, 1, p. 336-348 12 p.

    Research output: Contribution to journalArticle

  141. Published

    Comparison of Metabolism and Transporter Models for Predicting Gemfibrozil Drug-Drug Interactions.

    Gibbons, LK., Galetin, A. & Houston, JB., 2006, host publication. Drug Metab Rev, Vol. 38 (Suppl. 1).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  142. Published

    Intestinal and hepatic metabolic activity of five cytochrome P450 enzymes: Impact on prediction of first-pass metabolism

    Galetin, A. & Houston, J. B., 2006, In : Journal of Pharmacology and Experimental Therapeutics. 318, 3, p. 1220-1229 9 p.

    Research output: Contribution to journalArticle

  143. Published

    Maximal FG ratio as a pragmatic indicator of the magnitude of intestinal CYP3A4 inhibition

    Galetin, A., Gibbons, LK., Burt, H., Obach, RS. & Houston, JB., 2006, host publication. Drug Metab Rev, Vol. 38 (Suppl. 1): 44.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  144. Published

    Multisite kinetic modelling of interactions between UDP-glucuronosyltransferase 2B7 (UGT2B7) substrates.

    Galetin, A., Uchaipichat, V., Mackenzie, PI., Houston, JB. & Miners, JO., 2006, host publication. Drug Metab Rev, Vol. 38 (Suppl. 1): 45.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  145. Published

    Time-dependent inhibition of CYP3A4 by mibefradil in recombinant CYP3A4 and human liver microsomes and impact on in vivo predictions.

    Burt, H., Galetin, A. & Houston, JB., 2006, host publication. Drug Metab Rev, Vol. 38 (Suppl. 1):.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  146. Published

    Uptake and intracellular binding of lipophilic amine drugs by isolated rat hepatocytes and implications for prediction of in vivo metabolic clearance

    Hallifax, D. & Houston, J. B., 2006, In : Drug Metabolism and Disposition. 34, 11, p. 1829-1836 7 p.

    Research output: Contribution to journalArticle

  147. Published

    Variability in Heteroactivation of Carbamazepine Metabolism by Endogenous Steroids: Comparison of CYP3A4 and CYP3A5 Response.

    Henshall, J., Galetin, A., Harrison, A. & Houston, JB., 2006, host publication. Drug Metab Rev, Vol. 38 (Suppl. 1):.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  148. 2005
  149. Published

    In vitro cytochrome P450 inhibition data and the prediction of drug-drug interactions: Qualitative relationships, quantitative predictions, and the rank-order approach

    Obach, R. S., Walsky, R. L., Venkatakrishnan, K., Houston, J. B. & Tremaine, L. M., Dec 2005, In : Clinical Pharmacology and Therapeutics. 78, 6, p. 582-e7

    Research output: Contribution to journalArticle

  150. Published

    Prediction of metabolic clearance using cryopreserved human hepatocytes: Kinetic characteristics for five benzodiazepines

    Hallifax, D., Rawden, H. C., Hakooz, N. & Houston, J. B., Dec 2005, In : Drug Metabolism and Disposition. 33, 12, p. 1852-1858 6 p.

    Research output: Contribution to journalArticle

  151. Published

    Prediction of in vivo drug-drug interactions from in vitro data: Impact of incorporating parallel pathways of drug elimination and inhibitor absorption rate constant

    Brown, H. S., Ito, K., Galetin, A. & Houston, J. B., Nov 2005, In : British Journal of Clinical Pharmacology. 60, 5, p. 508-518 10 p.

    Research output: Contribution to journalArticle

  152. Published

    CYP3A4 substrate selection and substitution in the prediction of potential drug-drug interactions

    Galetin, A., Ito, K., Hallifax, D. & Houston, J. B., Jul 2005, In : Journal of Pharmacology and Experimental Therapeutics. 314, 1, p. 180-190 10 p.

    Research output: Contribution to journalArticle

  153. Published

    Impact of parallel pathways of drug elimination and multiple cytochrome P450 involvement on drug-drug interactions: CYP2D6 paradigm

    Ito, K., Hallifax, D., Obach, R. S. & Houston, J. B., Jun 2005, In : Drug Metabolism and Disposition. 33, 6, p. 837-844 7 p.

    Research output: Contribution to journalArticle

  154. Published

    Microsomal prediction of in vivo clearance and associated interindividual variability of six benzodiazepines in humans

    Rawden, H. C., Carlile, D. J., Tindall, A., Hallifax, D., Galetin, A., Ito, K. & Houston, J. B., Jun 2005, In : Xenobiotica. 35, 6, p. 603-625 22 p.

    Research output: Contribution to journalArticle

  155. Published

    Role of hepatic cytochrome P450s in the pharmacokinetics and toxicity of cyclophosphamide: Studies with the hepatic cytochrome P450 reductase null mouse

    Pass, G. J., Carrie, D., Boylan, M., Lorimore, S., Wright, E., Houston, B., Henderson, C. J. & Wolf, C. R., 15 May 2005, In : Cancer Research. 65, 10, p. 4211-4217 6 p.

    Research output: Contribution to journalArticle

  156. Published

    Impact of end-product inhibition on the determination of in vitro metabolic clearance

    Jones, H. M., Nicholls, G. & Houston, J. B., May 2005, In : Xenobiotica. 35, 5, p. 439-454 15 p.

    Research output: Contribution to journalArticle

  157. Published

    Predictive models of CYP3A4 heteroactivation: In vitro-in vivo scaling and pharmacophore modeling

    Egnell, A. C., Houston, J. B. & Boyer, C. S., Mar 2005, In : Journal of Pharmacology and Experimental Therapeutics. 312, 3, p. 926-937 11 p.

    Research output: Contribution to journalArticle

  158. Published

    Modelling atypical CYP3A4 kinetics: Principles and pragmatism

    Houston, J. B. & Galetin, A., 15 Jan 2005, In : Archives of Biochemistry and Biophysics. 433, 2, p. 351-360 9 p.

    Research output: Contribution to journalArticle

  159. Published

    Prediction of human drug clearance from in vitro and preclinical data using physiologically based and empirical approaches

    Ito, K. & Houston, J. B., Jan 2005, In : Pharmaceutical Research. 22, 1, p. 103-112 9 p.

    Research output: Contribution to journalArticle

  160. Published

    Prediction of in vitro intrinsic clearance from hepatocytes: Comparison of suspensions and monolayer cultures

    Griffin, S. J. & Houston, J. B., Jan 2005, In : Drug Metabolism and Disposition. 33, 1, p. 115-120 5 p.

    Research output: Contribution to journalArticle

  161. Published
  162. Published

    Prediction of time-dependant drug-drug interactions - impact of parallel pathways, enzyme degradation and intestinal inhibition

    Galetin, A., Burt, H. & Houston, B., 2005, Drug Metabolism Reviews. Suppl 2 ed. Vol. 38.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  163. Published

    Research Governance: What is reasonable protection?

    Payne, K., Fargher, EA., Tricker, K., Newman, WG., Qasim, FF., Poulton, K., Andrews, J., Houston, J., Elliott, RA., Elles, R., Ray, D., Shaffer, JL., Griffiths, CEM., Bruce, I., Roberts, S. & Ollier, WER., 2005, In : BMJ Rapid response.

    Research output: Contribution to journalLetter

  164. Published

    The TARGET (TPMT: Azathioprine Response to Genotyping and Enzyme Testing) study

    Newman, WG., Payne, K., Poulton, K., Andrews, J., Houston, B., Elliott, RA., Elles, RG., Ray, DW., Shaffer, J., Griffiths, CEM., Bruce, IN., Roberts, S. A., Qasim, F. & Ollier, WER., 2005, In : Bmj.

    Research output: Contribution to journalLetter

  165. 2004
  166. Published

    Utility of recombinant enzyme kinetics in prediction of human clearance: Impact of variability, CYP3A5, and CYP2C19 on CYP3A4 probe substrates

    Galetin, A., Brown, C., Hallifax, D., Ito, K. & Houston, J. B., Dec 2004, In : Drug Metabolism and Disposition. 32, 12, p. 1411-1420 9 p.

    Research output: Contribution to journalArticle

  167. Published

    Substrate depletion approach for determining in vitro metabolic clearance: Time dependencies in hepatocyte and microsomal incubations

    Jones, H. M. & Houston, J. B., Sep 2004, In : Drug Metabolism and Disposition. 32, 9, p. 973-982 9 p.

    Research output: Contribution to journalArticle

  168. Published

    Comparison of fresh and cryopreserved rat hepatocyte suspensions for the prediction of in vitro intrinsic clearance

    Griffin, S. J. & Houston, J. B., May 2004, In : Drug Metabolism and Disposition. 32, 5, p. 552-558 6 p.

    Research output: Contribution to journalArticle

  169. Published

    Comparison of the use of liver models for predicting drug clearance using in vitro kinetic data from hepatic microsomes and isolated hepatocytes

    Ito, K. & Houston, J. B., May 2004, In : Pharmaceutical Research. 21, 5, p. 785-792 7 p.

    Research output: Contribution to journalArticle

  170. Published

    Quantitative prediction of the in vivo inhibition of diazepam metabolism by omeprazole using rat liver microsomes and hepatocytes

    Jones, H. M., Hallifax, D. & Houston, J. B., May 2004, In : Drug Metabolism and Disposition. 32, 5, p. 572-580 8 p.

    Research output: Contribution to journalArticle

  171. Published

    Auto- and heteroactivation of metabolism of a series of benzodiazepines in human hepatocytes.

    Hallifax, D., Rawden, H., Galetin, A., Brown, C. & Houston, JB., 2004.

    Research output: Contribution to conferencePoster

  172. 2003
  173. Published

    Generation and Evaluation of a CYP2C9 Heteroactivation Pharmacophore

    Egnell, A. C., Eriksson, C., Albertson, N., Houston, B. & Boyer, S., Dec 2003, In : Journal of Pharmacology and Experimental Therapeutics. 307, 3, p. 878-887 9 p.

    Research output: Contribution to journalArticle

  174. Published

    Isoform selectivity and kinetics of morphine 3- and 6-glucuronidation by human UDP-glucuronosyltransferases: Evidence for atypical glucuronidation kinetics by UGT2B7

    Stone, A. N., Mackenzie, P. I., Galetin, A., Houston, J. B. & Miners, J. O., 1 Sep 2003, In : Drug Metabolism and Disposition. 31, 9, p. 1086-1089 3 p.

    Research output: Contribution to journalArticle

  175. Published

    Multisite kinetic analysis of interactions between prototypical CYP3A4 subgroup substrates: Midazolam, testosterone, and nifedipine

    Galetin, A., Clarke, S. E. & Houston, J. B., 1 Sep 2003, In : Drug Metabolism and Disposition. 31, 9, p. 1108-1116 8 p.

    Research output: Contribution to journalArticle

  176. Published

    In vivo CYP3A4 heteroactivation is a possible mechanism for the drug interaction between felbamate and carbamazepine

    Egnell, A. C., Houston, B. & Boyer, S., 1 Jun 2003, In : Journal of Pharmacology and Experimental Therapeutics. 305, 3, p. 1251-1262 11 p.

    Research output: Contribution to journalArticle

  177. Published
  178. Published

    Bridging the gap between in vitro multi-site models and in vivo CYP3A4 drug-drug interactions

    Galetin, A. & Houston, B., 2003, Drug Metabolism Reviews. Suppl 2, Vol. 35.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  179. Published

    Database analysis for drug-drug interactions involving CYP2D6 inhibition.

    Ito, K., Hallifax, D., Obach, R. S. & Houston, B., 2003.

    Research output: Contribution to conferencePoster

  180. Published

    Evidence for atypical glucuronidation kinetics by human UDP-glucuronosyltransferase isoforms

    Miners, J. O., Uchaipichat, V., Mackenzie, PI., Galetin, A. & Houston, B., 2003, Evidence for atypical glucuronidation kinetics by human UDP-glucuronosyltransferase isoforms. ASCEPT, Sydney.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  181. Published

    Pharmacogencomics and predictive drug metabolism

    Andrews, J., Pasksaleva, E., Galetin, A. & Houston, B., 2003, Pharmacogencomics and predictive drug metabolism. Pharmacogenomics Workshop, Annual Human Genome Meeting, Cancun, Mexico.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  182. Published

    Progress Towards Prediction of Human Pharmacokinetic Parameters from In Vitro Technologies

    Houston, J. B. & Galetin, A., 2003, In : Drug Metabolism Reviews. 35, 4, p. 393-415 22 p.

    Research output: Contribution to journalArticle

  183. Published

    Quantative prediction of CYP3A4 drug-drug interactions: extending the strategy.

    Galetin, A., Hallifax, D., Ito, K. & Houston, B., 2003.

    Research output: Contribution to conferencePoster

  184. Published

    Typical and atypical enzyme kinetics, in Drug metabolism enzymes: Cytochrome P450 and other enzymes in drug discovery and development.

    Houston, B., Kenworthy, K. E. & Galetin, A., 2003, No publisher name. (Fontis Media, Lausanne.)

    Research output: Book/ReportBook

  185. 2002
  186. Published

    Comparative study of the metabolism of drug substrates by human cytochrome P450 3A4 expressed in bacterial, yeast and human lymphoblastoid cells

    Andrews, J., Abd-Ellah, M. F., Randolph, N. L., Kenworthy, K. E., Carlile, D. J., Friedberg, T. & Houston, J. B., 1 Nov 2002, In : Xenobiotica. 32, 11, p. 937-947 10 p.

    Research output: Contribution to journalArticle

  187. Published

    Comparison of liver models for predicting drug clearance in rats.

    Ito, K. & Houston, B., 2002, Proceedings of Swedish Academy of Pharmaceutical Sciences Roseno meeting..

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  188. Published

    Heteroactivation of cytochrome P450 by marked drugs at concentrations relevant in vivo - quantitative association with a clinical drug interaction.

    Egnell, A. C., Houston, B. & Boyer, S., 2002, Proceedings of Swedish Academy of Pharmaceutical Sciences Roseno meeting..

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  189. Published

    Incorporating measures of variability and uncertainty into the prediction of in vivo hepatic clearance from in vitro data

    Nestorov, I., Gueorguieva, I., Jones, H. M., Houston, B. & Rowland, M., 2002, In : Drug Metabolism and Disposition. 30, 3, p. 276-282 6 p.

    Research output: Contribution to journalArticle

  190. Published

    Prediction of human drug clearance from in vitro and preclinical data using physiological-based and empirical approaches.

    Ito, K. & Houston, B., 2002, Eur J Pharmac Sci. 17 (Supl.1 )

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  191. Published

    Prediction of ketoconazole and fluconazole drug-drug interactions with a range of CYP3A4 substrates.

    Galetin, A., Hallifax, D., Ito, K. & Houston, B., 2002.

    Research output: Contribution to conferencePoster

  192. Published

    Variability of intrinsic clearance: The effect of heteroactivation by testosterone in human liver microsomes.

    Rawden, H. C., Tindall, A. J., Hallifax, D. & Houston, B., 2002.

    Research output: Contribution to conferencePoster

  193. 2001
  194. Published

    Activation and inhibition of codeine metabolism by ketoconazole and quinine in rat liver microsomes.

    Proctor, N. J., Hallifax, D., Smith, D. A. & Houston, B., 2001.

    Research output: Contribution to conferencePoster

  195. Published

    Comparison of hepatocyte models for predicting in vitro intrinsic clearance using diazepam and tolbutamide.

    Griffin, S. J., Carlile, D. J. & Houston, B., 2001, Proceedings of the Hepatocyte User's Group, Stanstead.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  196. Published

    Comparison of hepatocyte models for predicting in vitro intrinsic clearance using diazepam and tolbutamide.

    Griffin, S. J., Carlile, D. & Houston, B., 2001, Drug Metabolism Reviews. Vol. 33, Suppl. 1.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  197. Published

    Heteroactivation of CYP3A4 substrates. Impact on intrinsic clearance and interindividual variability.

    Rawden, H. C., Tindall, A., Hallifax, D. & Houston, B., 2001.

    Research output: Contribution to conferencePoster

  198. Published

    In vitro human tissue models in risk assessment: Report of a consensus-building workshop

    MacGregor, J. T., Collins, J. M., Sugiyama, Y., Tyson, C. A., Dean, J., Smith, L., Andersen, M., Curren, R. D., Houston, J. B., Kadlubar, F. F., Kedderis, G. L., Krishnan, K., Li, A. P., Parchment, R. E., Thummel, K., Tomaszewski, J. E., Ulrich, R., Vickers, A. E. M. & Wrighton, S. A., 2001, In : Toxicological Sciences. 59, 1, p. 17-36 19 p.

    Research output: Contribution to journalArticle

  199. Published

    Metabolism in isolated rat hepatocyte suspensions, monolayer culture and hepatic microsomes: kinetics of nordiazepam metabolism.

    Parker, A. J. & Houston, B., 2001, Proceedings of the Hepatocyte User's Group, Stanstead.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  200. Published

    Multisite kinetic models for CYP3A4: Simultaneous activation and inhibition of diazepam and testosterone metabolism

    Kenworthy, K. E., Clarke, S. E., Andrews, J. & Houston, J. B., 2001, In : Drug Metabolism and Disposition. 29, 12, p. 1644-1651 7 p.

    Research output: Contribution to journalArticle

  201. Published

    Optimising drug development: Strategies to assess drug metabolism/transporter interaction potential - Towards a consensus

    Tucker, G. T., Houston, J. B. & Huang, S. M., 2001, In : European Journal of Pharmaceutical Sciences. 13, 4, p. 417-428 11 p.

    Research output: Contribution to journalArticle

  202. Published

    Optimizing drug development: Strategies to assess drug metabolism/transporter interaction potential - Toward a consensus

    Tucker, G. T., Houston, J. B. & Huang, S. M., 2001, In : Pharmaceutical Research. 18, 8, p. 1071-1080 9 p.

    Research output: Contribution to journalArticle

  203. Published

    Optimizing drug development: Strategies to assess drug metabolism/transporter interaction potential - Towards a consensus

    Tucker, G. T., Houston, J. B. & Huang, S. M., 2001, In : British Journal of Clinical Pharmacology. 52, 1, p. 107-117 10 p.

    Research output: Contribution to journalArticle

  204. Published

    The effects of product inhibition of product inhibition and cytochrome P450 loss on the depletion of triazolam in rat liver microsomes and hepatocytes.

    Jones, H. M. & Houston, B., 2001, Drug Metabolism Reviews. Vol. 33, Suppl. 1.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  205. 2000
  206. Published

    An integrated approach to prediction of systemic toxicity by using biokinetic models and biological in vitro test methods.

    Blaauboeer, B. J., Forsby, A., Houston, B., Beckman, M., Combes, R. D. & DeJongh, J., 2000, Progress in the Reduction, Refinement and Replacement of Animal Experimentation. Balls, M., Zeller, A-M. & Halder, M. (eds.). Elsevier BV

    Research output: Chapter in Book/Report/Conference proceedingChapter

  207. Published

    Comparison of clearance for three benzodiazepines determined by metabolite formation and substrate depletion methods in rat hepatic microsomes.

    Ahmed, S. & Houston, B., 2000, Drug Metabolism Reviews. Vol. 32, Suppl. 1.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  208. Published

    In vitro-in vivo scaling of cyp kinetic data not consistent with the classical Michaelis-Menten model

    Houston, J. B. & Kenworthy, K. E., 2000, In : Drug Metabolism and Disposition. 28, 3, p. 246-254 8 p.

    Research output: Contribution to journalArticle

  209. Published

    Incorporating variability and uncertainty into interspecies scaling of pharmacokinetics. In IFAC "Modelling and Control in Biomedical systems".(Edited by E.Carlson & E. Ssalzsieder)

    Nesterov, I., Carlile, D. J., Jones, H., Houston, B. & Rowland, M., 2000, IFAC "Modelling and Control in Biomedical systems. Carlson, E. & Ssalsieder, E. (eds.). Elsevier BV

    Research output: Chapter in Book/Report/Conference proceedingChapter

  210. Published

    Predicting the biological fate of methacrylate esters in rats using physiological based pharmacokinetic modelling and quantitative structure property relationships.

    Jones, O., Green, T. & Houston, B., 2000, Drug Metabolism Reviews. Vol. 32, Suppl. 1.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  211. Published

    Predicting the in vivo clearance of sildenafil from microsomal stability studies.

    Stringer, R. A., Howes, C., Nicklin, P. L. & Houston, B., 2000, Drug Metabolism Reviews. Vol. 32, Suppl. 1.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  212. Published

    Prediction of hepatic clearance of benzodiazapines from human liver microsomes via substrate depletion.

    Rawden, H. C. & Houston, B., 2000, Drug Metabolism Reviews. Vol. 32, Suppl. 1.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  213. Published

    Prediction of in vivo clearance from in vitro systems using rat hepatic microsomes and hepatocyte data.

    Jones, H. M., Carlile, D. J. & Houston, B., 2000, Drug Metabolism Reviews. Vol. 32, Suppl. 1.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  214. Published
  215. Published
  216. Published
  217. Published

    Regioselective and stereoselective hydroxylations of warfarin in human liver microsomes and cDNA expressed cytochrome P450.

    Bicknell, H. A., Worboys, P. D. & Houston, B., 2000, Drug Metabolism Reviews. Vol. 32, Suppl. 1.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  218. 1999
  219. Published

    An integrated approach to the prediction of systemic toxicity using computer-based biokinetic models and biological in vitro test methods: Overview of a prevalidation study based on the ECITTS project

    Dejongh, J., Forsby, A., Houston, J. B., Beckman, M., Combes, R. & Blaauboer, B. J., Aug 1999, In : Toxicology in Vitro. 13, 4-5, p. 549-554 5 p.

    Research output: Contribution to journalArticle

  220. Published

    Sigmoidal kinetics of CYP3A substrates: An approach for scaling dextromethorphan metabolism in hepatic microsomes and isolated hepatocytes to predict in vivo clearance in rat

    Witherow, L. E. & Houston, J. B., Jul 1999, In : Journal of Pharmacology and Experimental Therapeutics. 290, 1, p. 58-65 7 p.

    Research output: Contribution to journalArticle

  221. Published

    The integrated use of alternative methods in toxicological risk evaluation: ECVAM Integrated Testing Strategies Task Force Report I

    Blaauboer, B. J., Barratt, M. D. & Houston, J. B., Apr 1999, In : Alternatives to Laboratory Animals . 27, 2, p. 229-237 8 p.

    Research output: Contribution to journalArticle

  222. Published
  223. Published

    CYP3A4 drug interactions: correlation of ten in vitro probes substrates.

    Kenworthy, K. E., Bloomer, J., Clarke, S. E. & Houston, B., 1999, In : British Journal of Clinical Pharmacology. 48

    Research output: Contribution to journalArticle

  224. Published

    Inhibition of terfenadine metabolism by CYP3A4: evidence for substrate inhibition reflects multiple binding sites.

    Kenworthy, K. E., Bloomer, J., Clarke, S. E. & Houston, B., 1999, Proceeding of 7th Stowe School Symposium on Drug Metabolism.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  225. Published
  226. Published

    Microsomal prediction of in vivo clearance of CYP2C9 substrates in humans

    Carlile, D. J., Hakooz, N., Bayliss, M. K. & Houston, J. B., 1999, In : British Journal of Clinical Pharmacology. 47, 6, p. 625-635 10 p.

    Research output: Contribution to journalArticle

  227. Published

    No significant effects of sodium aurothiomalate on haem metabolism and mixed function oxidase activity in patients with rheumatoid arthritis.

    Herrick, A. L., Hodgkiss, R., Reed, P., Weinkove, C., Jayson, M. I. V. & Houston, B., 1999, In : Clin. Exper. Rheumatol.. 17

    Research output: Contribution to journalArticle

  228. Published

    Prediction of drug kinetic properties:diazepam in human liver microsomes versus cDNA expressed CYP3A4 and 2C19.

    Bicknell, H. A., Worboys, P. D., Evans, D. & Houston, B., 1999, Proceeding of 7th Stowe School Symposium on Drug Metabolism.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  229. Published

    Prediction of hepatic clearance of benzodiazepines in rats: comparison of isolated hepatocytes and microsomes.

    Hussein, Z., Carlile, D., Murby, S., Duffy, J., Houston, B. & Rowland, M., 1999, Eur. J. Pharm. Sci.. Vol. 8.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  230. Published

    Sigmoidal kinetics in rat hepatic microsomes: studies with dextromethorphan, alprazolam and triazolam.

    Ahmed, S. & Houston, B., 1999, Proceeding of 7th Stowe School Symposium on Drug Metabolism.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  231. 1998
  232. Published

    In vivo clearance of ethoxycoumarin and its prediction from in vitro systems: Use of drug depletion and metabolite formation methods in hepatic microsomes and isolated hepatocytes

    Carlile, D. J., Stevens, A. J., Ashforth, E. I. L., Waghela, D. & Houston, J. B., Mar 1998, In : Drug Metabolism and Disposition. 26, 3, p. 216-221 5 p.

    Research output: Contribution to journalArticle

  233. Published

    Incorporating Variability and Uncertainty into the In Vitro - In Vivo Predictioon of Hepatic Clearance. Proc. 5th EUFEPS Conference: Optimising Drug Development: Fastracking into Human, Wiesbaden, Germany, December 1998

    Nestorov, I., Carlile, D., Houston, B. & Rowland, M., 1998, Eur. J. Pharmac. Sci..

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  234. Published

    Influence of slice thickness and culture conditions on metabolism in precision-cut liver slices.

    Price, R. J., Renwick, A. B., Barton, P. T., Houston, B. & Lake, B. G., 1998, In : ATLA. 26

    Research output: Contribution to journalArticle

  235. Published

    Inhibition of rat cytochrome P450-dependent 1 metabolism by ketoconazole and fluconazole. 16th European Drug Metabolism Workshop, Copenhagen

    Chadwick, AA. P., McKillop, D. & Houston, B., 1998, Proceedings.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  236. Published

    Inhibition of rat cytochrome P450-dependent metabolism by ketoconazole and fluconazole

    Chadwick, AA. P., McKillop, D. & Houston, B., 1998, Br. J. Clin. Pharmacol.. Vol. 45.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  237. Published

    Prediction of intrinsic clearance of CYP2C9 substrates in man using hepatic microsomes: imortance of Km.

    Carlile, D. J., Bayliss, M. K. & Houston, B., 1998, Br. J. Clin. Pharmacol.. Vol. 45.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  238. Published

    Product inhibition of phenytoin and diazepam metabolism and its significance in predicting intrinsic clearance in vitro.

    Nichols, G. & Houston, B., 1998, Br. J. Pharmac.. Vol. 45.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  239. Published
  240. Published

    Sigmoidal kinetics of CYP3A substrates in rat.

    Witherow, L. E. & Houston, B., 1998, Br. J. Clin. Pharmacol.. Vol. 45.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  241. Published

    Sigmoidal kinetics of CYP3A4: the simultaneous metabolism and binding of testosterone and diazepam.

    Kenworthy, KK. E., Clarke, S. E., Andrews, J. & Houston, B., 1998, Br. J. Clin. Pharmacol.. Vol. 45.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  242. Published

    The integrated use of alternative methods in toxicological risk evaluation

    Blaauboer, B. J., Barratt, M. D. & Houston, B., 1998, In : ATLA. 26

    Research output: Contribution to journalArticle

  243. Published

    The simultaneous metabolism and binding of testosterone and diazepam in a recombinant CYP3A4 enzyme system. At 12th International Symposium on Microsomes and Drug Oxidations, Montpellier, France.

    Kenworthy, KK. E., Clarke, S. E., Andrews, J. & Houston, B., 1998, Proceedings.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  244. Published

    Validation of computational prediction techniques

    Worth, A. P., Barratt, M. D. & Houston, B., 1998, In : ATLA. 26

    Research output: Contribution to journalArticle

  245. 1997
  246. Published

    Incorporation of in vitro drug metabolism data into physiologically- based pharmacokinetic models

    Houston, J. B. & Carlile, D. J., Oct 1997, In : Toxicology in Vitro. 11, 5, p. 473-478 5 p.

    Research output: Contribution to journalArticle

  247. Published

    Scaling factors to relate drug metabolic clearance in hepatic microsomes, isolated hepatocytes, and the intact liver: Studies with induced livers involving diazepam

    Carlile, D. J., Zomorodi, K. & Houston, J. B., Aug 1997, In : Drug Metabolism and Disposition. 25, 8, p. 903-911 8 p.

    Research output: Contribution to journalArticle

  248. Published

    Kinetics of drug metabolism in rat liver slices: III. Relationship between metabolic clearance and slice uptake rate

    Worboys, P. D., Bradbury, A. & Houston, J. B., Apr 1997, In : Drug Metabolism and Disposition. 25, 4, p. 460-467 7 p.

    Research output: Contribution to journalArticle

  249. Published

    Microsomal prediction of intrinsic clearance for CYP2C9 substrates in man: Importance of Km.

    Carlile, DD. & Houston, B., 1997, ISSX Proceedings. Vol. 11.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  250. Published
  251. Published

    Pharmacokinetics in early drug discovery. The report recommendations of ECVAM Workshop 22.

    Leahy, D. E., Duncan, R., Ahr, H. J., Bayliss, M. K., de Boer, A. G., Darvas, F., Fentem, J. H., Fry, J. R., Hopkins, R., Houston, B., Karlsson, J., Kedderis, G. L., Pratten, M. K., Prieto, P., Smith, D. A. & Straughan, D. W., 1997, In : ATLA. 26

    Research output: Contribution to journalArticle

  252. Published

    Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices

    Brian Houston, J. & Carlile, D. J., 1997, In : Drug Metabolism Reviews. 29, 4, p. 891-922 31 p.

    Research output: Contribution to journalArticle

  253. Published

    Selectivity of omeprazole towards rat live cytochromes P450.

    Zomorodi, K. & Houston, B., 1997, In : Xenobiotica. 27

    Research output: Contribution to journalArticle

  254. Published

    Sigmoidal kinetics of CYP3A substrates: An approach for scaling dextromethorplan metabolism in rat microsomes and isolated heptatocytes to predict in vivo clearance.

    Witherow, LL. E. & Houston, B., 1997, ISSX Proceedings. Vol. 12.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  255. 1996
  256. Published

    Characteristics of nonlinear uptake of lipophilic amine drugs into isolated rat hepatocytes.

    Hallifax, D., Smith, D. A. & Houston, B., Jul 1996.

    Research output: Contribution to conferencePoster

  257. Published

    The Use of Biokinetics and In Vitro Methods in Toxicological Risk Evaluation: The Report and Recommendations of ECVAM Workshop 15

    Blaauboer, B. J., Bayliss, M. K., Castell, J. V., Evelo, C. T. A., Frazier, J. M., Groen, K., Gülden, M., Guillouzo, A., Hissink, A. M., Houston, J. B., Johanson, G., De Jongh, J., Kedderis, G. L., Reinhardt, C. A., Van De Sandt, J. J. M. & Semino, G., Jul 1996, In : Alternatives to Laboratory Animals . 24, 4, p. 473-497 24 p.

    Research output: Contribution to journalArticle

  258. Published
  259. Published

    Diazepam-omepazole inhibition interaction: An in vitro investigation using human liver microsomes.

    Zomorodi, K. & Houston, B., 1996, In : Br. J. Clin. Pharmacol.. 42

    Research output: Contribution to journalArticle

  260. Published

    Effect of aminobenzotraizole on diazepam metabolism, Stoke Rochford.

    Hakooz, N. & Houston, B., 1996, 6th Stowe Symposium on Drug Metabolism.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  261. Published

    Kinetics of CYP2D6 and CYP3A4 catalyzed reactions in heterologous expression systems

    Randolph, N., Andrews, J., Chenery, R. & Houston, B., 1996, ISSX Proceedings. Vol. 10.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  262. Published

    Kinetics of drug metabolism in rat liver II. Comparison of clearance by slices and isolated hepatocytes.

    Worboys, P. D., Bradbury, A. & Houston, B., 1996, In : Drug Metab. Dispos.. 24

    Research output: Contribution to journalArticle

  263. Published

    Metabolism of midazolam in various expression systems for human CYP3A4.

    Randolph, N., Andrews, J., Chenery, R. & Houston, B., 1996, 6th Stowe Symposium, Stoke Rochford.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  264. Published

    Metabolism of ondansetron in rat. Comparison of hepatic microsomes, isolated hepatocytees and liver slices with in vivo disposition.

    Worboys, P. D., Bradbury, A. & Houston, B., 1996, In : Xenobiotica. 26

    Research output: Contribution to journalArticle

  265. Published

    Predicting the pharmacokinetics of CYP2C9 substrates in man from in vitro studies. Stoke, Rochford

    Carlile, D., Bayliss, M. K., Tarbit, M. H. & Houston, B., 1996, 6th Stowe Symposium on Drug Metabolism.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  266. Published

    Prediction of in vivo intrinsic clearance of ethoxycoumarin using drug depletion data from freshly isolated hepatocytes, Stoke Rochford

    Stevens, A. J. & Houston, B., 1996, 6th Stowe Symposium.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  267. Published

    The metabolism of diazepam, phenytoin, p-nitrophenol and coumarin by pig hepatic microsomes.

    Witherow, LL. E. & Houston, B., 1996, 6th Stowe Symposium.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  268. 1994
  269. Published

    Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance’, Biochemical Pharmacology

    Houston, JB., 1994, In : Biochemical Pharmacology. 47, p. 1469-1479 10 p.

    Research output: Contribution to journalArticle

  270. 1986
  271. Published

    Disposition of metronidazole and its effects on sulphasalazine metabolism in patients with inflammatory bowel disease

    Shaffer, J. L., Kershaw, A. & Houston, J. B., Apr 1986, In : British Journal of Clinical Pharmacology. 21, 4, p. 431-5 5 p.

    Research output: Contribution to journalArticle

  272. 1985
  273. Published

    The effect of rifampicin on sulphapyridine plasma concentrations following sulphasalazine administration

    Shaffer, J. L. & Houston, J. B., Apr 1985, In : British Journal of Clinical Pharmacology. 19, 4, p. 526-8 3 p.

    Research output: Contribution to journalArticle

  274. 1983
  275. Published

    Absorption of prednisolone in patients with Crohn's disease

    Shaffer, J. A., Williams, S. E., Turnberg, L. A., Houston, J. & Rowland, M., Mar 1983, In : Gut. 24, 3, p. 182-6 5 p.

    Research output: Contribution to journalArticle

  276. Published

    Pharmacokinetics of promethazine and its sulphoxide metabolite after intravenous and oral administration to man

    Taylor, G., Houston, J. B., Shaffer, J. & Mawer, G., Mar 1983, In : British Journal of Clinical Pharmacology. 15, 3, p. 287-93 7 p.

    Research output: Contribution to journalArticle