Prof James HoustonBSc, PhD, DSc

Emeritus Professor

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Publications

  1. Published

    Predicting human clearance of organic anion transporting polypeptide substrates using cynomolgus monkey: In vitro-in vivo scaling of hepatic uptake clearance

    De Bruyn, T., Ufuk, A., Cantrill, C., Kosa, R. E., Bi, Y. A., Niosi, M., Modi, S., Rodrigues, A. D., Tremaine, L. M., Varma, M. V. S., Galetin, A. & Houston, J. B., Jul 2018, In : Drug Metabolism and Disposition. 46, 7, p. 989-1000 12 p.

    Research output: Contribution to journalArticle

  2. Published

    An integrated approach to the prediction of systemic toxicity using computer-based biokinetic models and biological in vitro test methods: Overview of a prevalidation study based on the ECITTS project

    Dejongh, J., Forsby, A., Houston, J. B., Beckman, M., Combes, R. & Blaauboer, B. J., Aug 1999, In : Toxicology in Vitro. 13, 4-5, p. 549-554 5 p.

    Research output: Contribution to journalArticle

  3. Published

    Evidence-based approach to assess passive diffusion and carrier-mediated drug transport

    Di, L., Artursson, P., Avdeef, A., Ecker, G. F., Faller, B., Fischer, H., Houston, J. B., Kansy, M., Kerns, E. H., Krämer, S. D., Lennernäs, H. & Sugano, K., Aug 2012, In : Drug discovery today. 17, 15-16, p. 905-912 7 p.

    Research output: Contribution to journalArticle

  4. Published

    Metabolite formation kinetics and intrinsic clearance of phenacetin, tolbutamide, alprazolam, and midazolam in adenoviral cytochrome P450-transfected HepG2 cells and comparison with hepatocytes and in vivo

    Donato, M. T., Hallifax, D., Picazo, L., Castell, J. V., Houston, J. B., Gomez-Lechón, M. J. & Lahoz, A., Sep 2010, In : Drug Metabolism and Disposition. 38, 9, p. 1449-1455 6 p.

    Research output: Contribution to journalArticle

  5. Published

    Generation and Evaluation of a CYP2C9 Heteroactivation Pharmacophore

    Egnell, A. C., Eriksson, C., Albertson, N., Houston, B. & Boyer, S., Dec 2003, In : Journal of Pharmacology and Experimental Therapeutics. 307, 3, p. 878-887 9 p.

    Research output: Contribution to journalArticle

  6. Published

    Heteroactivation of cytochrome P450 by marked drugs at concentrations relevant in vivo - quantitative association with a clinical drug interaction.

    Egnell, A. C., Houston, B. & Boyer, S., 2002, Proceedings of Swedish Academy of Pharmaceutical Sciences Roseno meeting..

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  7. Published

    In vivo CYP3A4 heteroactivation is a possible mechanism for the drug interaction between felbamate and carbamazepine

    Egnell, A. C., Houston, B. & Boyer, S., 1 Jun 2003, In : Journal of Pharmacology and Experimental Therapeutics. 305, 3, p. 1251-1262 11 p.

    Research output: Contribution to journalArticle

  8. Published

    Predictive models of CYP3A4 heteroactivation: In vitro-in vivo scaling and pharmacophore modeling

    Egnell, A. C., Houston, J. B. & Boyer, C. S., Mar 2005, In : Journal of Pharmacology and Experimental Therapeutics. 312, 3, p. 926-937 11 p.

    Research output: Contribution to journalArticle

  9. Published
  10. Published

    Defining the in vivo role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5

    Finn, R. D., McLaughlin, L. A., Ronseaux, S., Rosewell, I., Houston, J. B., Henderson, C. J. & Wolf, C. R., 14 Nov 2008, In : Journal of Biological Chemistry. 283, 46, p. 31385-31393 8 p.

    Research output: Contribution to journalArticle

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