Prof James HoustonBSc, PhD, DSc

Emeritus Professor

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Publications

  1. Published

    Progress curve mechanistic modeling approach for assessing time-dependent inhibition of CYP3A4

    Burt, H. J., Pertinez, H., Säll, C., Collins, C., Hyland, R., Houston, J. B. & Galetin, A., Sep 2012, In : Drug Metabolism and Disposition. 40, 9, p. 1658-1667 9 p.

    Research output: Contribution to journalArticle

  2. Published

    Time-dependent inhibition of CYP3A4 by mibefradil in recombinant CYP3A4 and human liver microsomes and impact on in vivo predictions.

    Burt, H., Galetin, A. & Houston, JB., 2006, host publication. Drug Metab Rev, Vol. 38 (Suppl. 1):.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  3. Published

    IC50-based approaches as an alternative method for assessment of time-dependent inhibition of CYP3A4

    Burt, H. J., Galetin, A. & Houston, J. B., May 2010, In : Xenobiotica. 40, 5, p. 331-343 12 p.

    Research output: Contribution to journalArticle

  4. Published

    Understanding the Interplay Between Uptake and Efflux Transporters Within In Vitro Systems in Defining Hepatocellular Drug Concentrations

    Cantrill, C. & Houston, J. B., Sep 2017, In : Journal of Pharmaceutical Sciences. 106, 9

    Research output: Contribution to journalArticle

  5. Published

    Scaling factors to relate drug metabolic clearance in hepatic microsomes, isolated hepatocytes, and the intact liver: Studies with induced livers involving diazepam

    Carlile, D. J., Zomorodi, K. & Houston, J. B., Aug 1997, In : Drug Metabolism and Disposition. 25, 8, p. 903-911 8 p.

    Research output: Contribution to journalArticle

  6. Published

    Prediction of intrinsic clearance of CYP2C9 substrates in man using hepatic microsomes: imortance of Km.

    Carlile, D. J., Bayliss, M. K. & Houston, B., 1998, Br. J. Clin. Pharmacol.. Vol. 45.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  7. Published

    Predicting the pharmacokinetics of CYP2C9 substrates in man from in vitro studies. Stoke, Rochford

    Carlile, D., Bayliss, M. K., Tarbit, M. H. & Houston, B., 1996, 6th Stowe Symposium on Drug Metabolism.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  8. Published

    Microsomal prediction of intrinsic clearance for CYP2C9 substrates in man: Importance of Km.

    Carlile, DD. & Houston, B., 1997, ISSX Proceedings. Vol. 11.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  9. Published
  10. Published

    In vivo clearance of ethoxycoumarin and its prediction from in vitro systems: Use of drug depletion and metabolite formation methods in hepatic microsomes and isolated hepatocytes

    Carlile, D. J., Stevens, A. J., Ashforth, E. I. L., Waghela, D. & Houston, J. B., Mar 1998, In : Drug Metabolism and Disposition. 26, 3, p. 216-221 5 p.

    Research output: Contribution to journalArticle

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