Prof James HoustonBSc, PhD, DSc

Emeritus Professor

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Publications

  1. Published

    Metabolism of ondansetron in rat. Comparison of hepatic microsomes, isolated hepatocytees and liver slices with in vivo disposition.

    Worboys, P. D., Bradbury, A. & Houston, B., 1996, In : Xenobiotica. 26

    Research output: Contribution to journalArticle

  2. Published

    Assessing metabolic competence in isolated hepatocytes: Exploring the relationship between enzyme function and plasma membrane integrity via Saponin treatment

    Wood, F., Hallifax, D. & Houston, B., Jun 2015, host publication. Vol. P10.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  3. Published

    Clearance prediction methodology needs fundamental improvement: Trends common to rat and human hepatocytes/microsomes and implications for experimental methodology

    Wood, F. L., Houston, J. B. & Hallifax, D., 1 Nov 2017, In : Drug Metabolism and Disposition. 45, 11, p. 1178-1188 11 p.

    Research output: Contribution to journalComment/debate

  4. Published

    Intrinsic Clearance Predictions from Freshly Isolated Rat Hepatocytes: Effects of Assay Format and Cofactor Supplementation

    Wood, F., Hallifax, D. & Houston, J., 2014, Proceedings of 20th international symposium on microsomes and drug oxidations.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  5. Published

    Importance of the unstirred water layer and hepatocyte membrane integrity in vitro for quantification of intrinsic metabolic clearance

    Wood, F., Houston, J. & Hallifax, D., 1 Jan 2018, In : Drug Metabolism and Disposition. 46, 1

    Research output: Contribution to journalArticle

  6. Published

    Sigmoidal kinetics of CYP3A substrates: An approach for scaling dextromethorphan metabolism in hepatic microsomes and isolated hepatocytes to predict in vivo clearance in rat

    Witherow, L. E. & Houston, J. B., Jul 1999, In : Journal of Pharmacology and Experimental Therapeutics. 290, 1, p. 58-65 7 p.

    Research output: Contribution to journalArticle

  7. Published

    The metabolism of diazepam, phenytoin, p-nitrophenol and coumarin by pig hepatic microsomes.

    Witherow, LL. E. & Houston, B., 1996, 6th Stowe Symposium.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  8. Published

    Sigmoidal kinetics of CYP3A substrates in rat.

    Witherow, L. E. & Houston, B., 1998, Br. J. Clin. Pharmacol.. Vol. 45.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  9. Published

    Sigmoidal kinetics of CYP3A substrates: An approach for scaling dextromethorplan metabolism in rat microsomes and isolated heptatocytes to predict in vivo clearance.

    Witherow, LL. E. & Houston, B., 1997, ISSX Proceedings. Vol. 12.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  10. Published

    In vitro assessment of uptake and lysosomal sequestration of respiratory drugs in alveolar macrophage cell line NR8383

    Ufuk, A., Somers, G., Houston, J. & Galetin, A., Dec 2015, In : Pharmaceutical Research. 32, 12, p. 3937–3951 14 p.

    Research output: Contribution to journalArticle

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