Mitochondria are vitally important organelles within living cells and are often described as their powerhouses. They generate the primary energy for all biological activities, from ATP generation to cell growth and death (apoptosis). It is no surprise, therefore, mitochondrial dysfunction leads to life threatening diseases, such as cancer, diabetes, stroke, and various neurodegenerative diseases (e.g. Alzheimer’s and Parkinson’s diseases). Structurally, mitochondria have two membranes dividing the organelle into four sub-compartments: outer membrane (OM), intermembrane space (IMS), inner membrane (IM), and matrix. Mitochondria contain about 1500 proteins and ~99% of the proteins are synthesized in the cytosol and post-transnationally imported into the organelle for function. My research focuses on (1) understanding the molecular mechanisms of protein quality control and function of mitochondrial proteins; (2) using enzymes to enhance oxidative folding of industrial and therapeutically important high-value production proteins; and (3) exploring graphene assembly and its application in biology.
1997: D.Phil,Oxford Centre for Molecular Sciences, Oxford University
1997 -2000: Postdoctoral Researcher, Biochemistry Department, Imperial College, London
2000 -2001:Postdoctoral Researcher, Department of Medicine, University College of London
2001 -2003:Postdoctoral Researcher, Biochemistry Department, Manchester University
2003 - 2011: The Royal Society University Research Fellow, Faculty of Life Sciences, Manchester University
2011 – Lecturer of Biochemistry, Faculty of Life Sciences, Manchester University