Prof Holly Shiels BSc, MSc, PhD

Research interests

Integrative and Environmental Physiology

Our research explores molecular and cellular mechanisms that impact cardiac function in response to environmental change and links these with altered organismal metabolism, locomotion and behaviour to determine the intersection of the cardiovascular system and the environment on fitness.  We investigate the interplay between temperature and hypoxia on cardiac health working across species to identify conserved and fundamental biological pathways.  Recent work has focused on the effects of air and water pollution on cardiac health using whole animal models (mice), tissue models (fish, sheep, mouse) and hiPSCs.