I am leading the preclinical brain PET imaging activity in the University at the Wolfson Molecular Imaging Centre.
I have been supervising and conducting the preclinical activity in Manchester for our contribution to the EU FP7 project INMiND, which started in March 2012 and ended in February 2017, with several publications in preparation. I am particularly interested in and leading independent projects on i) developing new biomarkers and contrast agents for both PET and MRI imaging, and ii) using these contrast agents to image neuroinflammation and investigate how peripheral inflammation or comorbidities influence neuroinflammation and neurodegeneration. To achieve this, I have established industrial collaborations (GE, Roche, GSK) as well as academic collaborations with Prof S. Allan on inflammation in stroke and Dr Brian Bigger on the role of inflammation in MPS diseases and Drs Marie-Claude Asselin and Rainer Hinz for PET data modelling, as well as numerous external collaborations with acadmic labs in Europe.
I have supervised the work of Dr Matthias Vandesquille (research associate) in our project aiming at developing nanobody-based imaging agents to visualise vascular adhesion molecules by SPECT and PET (funded by the EPSRC) as well as developing PET tracer to image neuronal/synaptic loss. These agents are developed in parallel of other MR measurements developed by Dr Laura Parkes' team within the same grant. I am also supervising PhD student Daniela Bochicchio on a project investigating change in protein synthesis in AD using PET imaging.
Over the years, I have supervised several post-docs, PhD students and project students. I am currently supervising Ms Daniela Bochicchio who started her PhD in January 2017.
Neurosciences, neuroinflammation, Alzheimer's disease, stroke & brain ischemia, cytokines, pharmacology, in vivo imaging (specialised in Positron Emission Tomography, interest in all others imaging techniques: MRI, optical, ..)