Prof Hector Chinoy PhD FRCP BMBS MSc BMedSci

Research interests

My current research interest is in the immunogenetics of idiopathic inflammatory myopathy (IIM).

Objectives:

• Further analysis of GWAS and Immunochip data generated from a UK-based and international cohort of IIM patients.
• To facilitate and oversee replication association studies of disease susceptibility signals from GWAS and pan-autoimmune loci
• To facilitate and oversee the identification of potential disease-causal variants within IIM susceptibility genes via genetic re-sequencing and high-throughput genotyping.
• Coordinating a prospective collection of IIM data in the UK (MYOPROSP)
• NHS England registry collection of IIM patients commencing rituximab (MYOACT)
• Novel imaging modalities in IIM
• Use of PROMS to measure disease activity in IIM
• Dissemination of Euromyositis, a European-wide standardised web-based IIM database facility (collaboration)
• To study subclinical atherosclerosis and endothelial dysfunction in IIM
• To facilitate collection of blood and tissue as part of a muscle biobank and UKMYONET, a nationwide UK Clinical Research Network IIM study
  
• To investigate the interaction of smoking and HLA-DRB1*03 for the development of myositis antibodies in IIM (collaboration)
• To assist in the clinical and genetic phenotypic characterisation of IIM cases with novel autoantibody profiles (collaboration)
• Management of idiopathic inflammatory myopathies: adult patients and professional specialists’ perspectives on current care in the UK (collaboration)