Specialising in solid phase peptide chemistry and lipid vesicles .
Current projects in the following areas:
- Therapeutic peptides
- Triggers for controlled drug release
- Cytolytic & Cell penetrating peptides
My research is centred on developing nanomedicines based on synthetic peptides and lipid based formulations. Key focus is not only to steer the delivery of drugs but also sense and utilise the specific biological microenvironment of the diseased state for improved and targeted therapeutic action. My group is also interested in studying peptide/protein therapeutics to identify stability issues which may compromise shelf-life or integrity in biological milieu and solve these through chemical modifications and formulation design.
Some of the current projects includes; delivery of antimicrobials to treat intracellular infections such as TB, improving the stability of an anti-inflammatory protein through formulation design and chemical modifications for stroke treatment, design, synthesis and evaluation neuropeptide antagonists as broad spectrum anticancer agents, improving penetration of drugs across biological barriers using cell penetrating peptides as drug carriers.
Projects for self-Funded PhD students are available all year round in the drug delivery and nanomedicines area.