To achieve my research goals, I apply powerful techniques aimed at understanding the molecular mechanims of disease: these include mass-spectrometry-based proteomics and metabolomics, and transcriptomics. I undertake work in parallel using both nonclinical models and human clinical trials, emphasising the links between the two. At present, through CADET in Manchester, I am leading a programme in which such methods are being applied to the main ageing-related diseases, including diabetes, common forms of heart failure, and neurodegenerative diseases.
I am also active in developing Intellectural Property related to my investigations. In addition to my publications in scientific journals, I have been awarded 47 international patents. I consider these patents to be just as important as the journal articles, because they underpin the processes by which my research can be translated into new medicines, and also because they provide independent evidence of the novelty, originality, and utility of the research.